Page last updated: 2024-12-06

protoanemonin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

protoanemonin: a furanone found in RANUNCULACEAE plants; structure given in first source; has antifungal & antibiotic properties; ranunculine is hydrolyzed to protoanemonin which dimerizes to anemonin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
RanunculaceaefamilyThe buttercup plant family of the order RANUNCULALES, class MAGNOLIOPSIDA. The leaves are usually alternate and stalkless. The flowers usually have two to five free sepals and may be radially symmetrical or irregular.[MeSH]RanunculaceaeThe buttercup plant family of the order RANUNCULALES, class MAGNOLIOPSIDA. The leaves are usually alternate and stalkless. The flowers usually have two to five free sepals and may be radially symmetrical or irregular.[MeSH]

Cross-References

ID SourceID
PubMed CID66948
CHEBI ID28906
MeSH IDM0113109

Synonyms (25)

Synonym
2(5h)-furanone, 5-methylene-
5-methylene-2(5h)-furanone
5-methylenefuran-2(5h)-one
CHEBI:28906
C07090
cis-4-methylenebut-2-en-4-olide
108-28-1
4-methylenebut-2-en-4-olide
protoanemonin
5-methylidenefuran-2-one
mfcd00236167
AKOS006272494
unii-66fqz1a5so
einecs 203-567-4
66fqz1a5so ,
FT-0619081
isomycin
protoanemonin [mi]
2,4-pentadien-4-olide
5-methylene-2,5-dihydrofuran-2-one
RNYZJZKPGHQTJR-UHFFFAOYSA-N
protoanemonene
DTXSID10148346
Q421294
A937279

Research Excerpts

Overview

Protoanemonin (PrA) is an antimicrobial agent whose mechanism of action has not been clearly described. It may be formed during the degradation of some chloroaromatic compounds, such as polychlorinated biphenyls.

ExcerptReferenceRelevance
"Protoanemonin is a toxic metabolite which may be formed during the degradation of some chloroaromatic compounds, such as polychlorinated biphenyls, by natural microbial consortia. "( Detoxification of protoanemonin by dienelactone hydrolase.
Blasco, R; Brückmann, M; Pieper, DH; Timmis, KN, 1998
)
2.08
"Protoanemonin (PrA) is an antimicrobial agent whose mechanism of action has not been clearly described. "( Ultrastructural alterations in Epidermophyton floccosum and Trichophyton mentagrophytes exposed in vitro to protoanemonin.
Fasulo, MP; Mares, D, 1990
)
1.93
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
butenolideA gamma-lactone that consists of a 2-furanone skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
chlorosalicylate degradation317

Research

Studies (45)

TimeframeStudies, This Drug (%)All Drugs %
pre-199019 (42.22)18.7374
1990's10 (22.22)18.2507
2000's7 (15.56)29.6817
2010's7 (15.56)24.3611
2020's2 (4.44)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 35.85

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index35.85 (24.57)
Research Supply Index3.85 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index50.49 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (35.85)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (4.35%)6.00%
Case Studies1 (2.17%)4.05%
Observational0 (0.00%)0.25%
Other43 (93.48%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]