A monoglyceride lipase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q99685]
MGL;
EC 3.1.1.23;
HU-K5;
Lysophospholipase homolog;
Lysophospholipase-like;
Monoacylglycerol lipase;
MAGL
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (13.33) | 29.6817 |
| 2010's | 18 (60.00) | 24.3611 |
| 2020's | 8 (26.67) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| benzo(b)thiophene-2-boronic acid | Homo sapiens (human) | IC50 | 21.3833 | 2 | 3 |
| disulfiram | Homo sapiens (human) | IC50 | 0.8095 | 2 | 2 |
| ethylmaleimide | Homo sapiens (human) | IC50 | 16.6000 | 1 | 1 |
| thiram | Homo sapiens (human) | IC50 | 0.9772 | 1 | 1 |
| bis(1-piperidylthiocarbonyl)disulfide | Homo sapiens (human) | IC50 | 0.3162 | 1 | 1 |
| tetramethylthiuram monosulfide | Homo sapiens (human) | IC50 | 12.3027 | 1 | 1 |
| 4,4'-dithiodimorpholine | Homo sapiens (human) | IC50 | 11.2202 | 1 | 1 |
| methyl diethyldithiocarbamate | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| diphenyl disulfide | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| n-phenylmaleimide | Homo sapiens (human) | IC50 | 15.9000 | 1 | 1 |
| dronabinol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 1,6-bismaleimidohexane | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| diacerein | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| phenylethane boronic acid | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| n-methylmaleimide | Homo sapiens (human) | IC50 | 24.5000 | 1 | 1 |
| n-benzylmaleimide | Homo sapiens (human) | IC50 | 5.1400 | 1 | 1 |
| n,n'-4-phenylenedimaleimide | Homo sapiens (human) | IC50 | 2.2200 | 1 | 1 |
| n-(2-methoxyphenyl)maleimide | Homo sapiens (human) | IC50 | 6.9200 | 1 | 1 |
| n-(4-bromophenyl)maleimide | Homo sapiens (human) | IC50 | 4.3700 | 1 | 1 |
| 1,1'-biphenyl-4-yl-boronic acid | Homo sapiens (human) | IC50 | 12.6737 | 2 | 3 |
| 4-methoxyphenylboronic acid | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| arachidonyltrifluoromethane | Homo sapiens (human) | IC50 | 6.3833 | 2 | 2 |
| [2-(1-piperidinyl)-1,3-benzothiazol-6-yl]-[4-(2-pyridinyl)-1-piperazinyl]methanone | Homo sapiens (human) | IC50 | 33.3000 | 1 | 1 |
| guineensine | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| cay 10499 | Homo sapiens (human) | IC50 | 0.1725 | 21 | 21 |
| methyl arachidonylfluorophosphonate | Homo sapiens (human) | IC50 | 0.0261 | 6 | 6 |
| urb602 | Homo sapiens (human) | IC50 | 14.2750 | 4 | 4 |
| ly2183240 | Homo sapiens (human) | IC50 | 0.1331 | 3 | 3 |
| 1-(4-chlorophenyl)-3-(3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl)urea | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| omdm 169 | Homo sapiens (human) | IC50 | 0.8900 | 1 | 1 |
| am 6701 | Homo sapiens (human) | IC50 | 0.0034 | 2 | 2 |
| jzl 184 | Homo sapiens (human) | IC50 | 0.4872 | 17 | 17 |
| jzl195 | Homo sapiens (human) | IC50 | 0.0708 | 3 | 3 |
| sar127303 | Homo sapiens (human) | IC50 | 0.0290 | 1 | 1 |
| mjn110 | Homo sapiens (human) | IC50 | 0.0091 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| lysophospholipase activity | molecular function | Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine. [EC:3.1.1.5] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| acylglycerol lipase activity | molecular function | Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN] |
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| lipid metabolic process | biological process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma] |
| fatty acid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. [GOC:mah, ISBN:0198506732] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| regulation of signal transduction | biological process | Any process that modulates the frequency, rate or extent of signal transduction. [GOC:sm] |
| arachidonic acid metabolic process | biological process | The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732] |
| triglyceride catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol. [ISBN:0198506732] |
| acylglycerol catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids. [GOC:ai] |
| regulation of inflammatory response | biological process | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai] |
| regulation of sensory perception of pain | biological process | Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. [GOC:ai] |
| monoacylglycerol catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified. [PMID:25290914] |
| regulation of endocannabinoid signaling pathway | biological process | Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway. [GOC:mah, PMID:15550444] |