procarbazine has been researched along with Necrosis in 4 studies
Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "AOA tumors with necrosis are to be considered WHO grade IV tumors (GBM)." | 2.74 | Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: A report from EORTC study 26951. ( Allgeier, A; Brandes, AA; Bromberg, JE; Gorlia, T; Grisold, W; Ibdaih, A; Kouwenhoven, MC; Kros, JM; Lacombe, D; Mirimanoff, R; Mokhtari, K; Sipos, L; Teepen, JL; van den Bent, MJ; van Duinen, SG; Vandenbos, F; Vecht, CJ; Wesseling, P, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kouwenhoven, MC | 1 |
| Gorlia, T | 1 |
| Kros, JM | 1 |
| Ibdaih, A | 1 |
| Brandes, AA | 1 |
| Bromberg, JE | 1 |
| Mokhtari, K | 1 |
| van Duinen, SG | 1 |
| Teepen, JL | 1 |
| Wesseling, P | 1 |
| Vandenbos, F | 1 |
| Grisold, W | 1 |
| Sipos, L | 1 |
| Mirimanoff, R | 1 |
| Vecht, CJ | 1 |
| Allgeier, A | 1 |
| Lacombe, D | 1 |
| van den Bent, MJ | 1 |
| Sobol, RE | 1 |
| Fakhrai, H | 1 |
| Shawler, D | 1 |
| Gjerset, R | 1 |
| Dorigo, O | 1 |
| Carson, C | 1 |
| Khaleghi, T | 1 |
| Koziol, J | 1 |
| Shiftan, TA | 1 |
| Royston, I | 1 |
| Gumerlock, MK | 1 |
| Belshe, BD | 1 |
| Madsen, R | 1 |
| Watts, C | 1 |
| Sharer, LR | 1 |
| Barondess, JA | 1 |
| Silver, RT | 1 |
| Gray, GF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| PHASE III STUDY OF ADJUVANT PROCARBAZINE, CCNU AND VINCRISTINE CHEMOTHERAPY IN PATIENTS WITH HIGHLY ANAPLASTIC OLIGODENDROGLIOMA[NCT00002840] | Phase 3 | 350 participants (Anticipated) | Interventional | 1996-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for procarbazine and Necrosis
| Article | Year |
|---|---|
Molecular analysis of anaplastic oligodendroglial tumors in a prospective randomized study: A report from EORTC study 26951.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cell Proliferation; Ch | 2009 |
3 other studies available for procarbazine and Necrosis
| Article | Year |
|---|---|
Interleukin-2 gene therapy in a patient with glioblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cells, Cultured; Combined Modality | 1995 |
Osmotic blood-brain barrier disruption and chemotherapy in the treatment of high grade malignant glioma: patient series and literature review.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood-Brain Barrier; Brain Neoplasms; Cyclophosphami | 1992 |
Association of Hodgkin disease and Gaucher disease.
Topics: Adult; Autopsy; Biopsy; Gaucher Disease; Hodgkin Disease; Humans; Liver; Lymph Nodes; Lymphocytes; M | 1974 |