Compounds > silver nitrate

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silver nitrate

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Description

Silver Nitrate: A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	24470
CHEMBL ID	177367
CHEBI ID	32130
MeSH ID	M0019869

Synonyms (118)

Synonym
AKOS015833341
silver(i) nitrate
agno3
CHEBI:32130 ,
argenti nitras
uts silverator water treatment unit
nitrato de plata [spanish]
hsdb 685
nitrate d'argent [french]
argerol
caswell no. 737
epa pesticide chemical code 072503
einecs 231-853-9
silver nitrate(dot)
nsc 135800
silver nitrate [jan]
un1493
silbernitrat
silver nitrate
7761-88-8
silver nitrate, bioreagent, suitable for plant cell culture, >99% (titration)
silver nitrate, bioxtra, >99% (titration)
silver(1+) nitrate
nitric acid silver(i) salt
silver mononitrate
nitric acid silver(1+) salt
nsc-135800
nitrate d'argent
silver nitrate (jp17/usp)
D01730
silver nitrate (tn)
silver nitrate on silica gel, extent of labeling: ~10 wt. % loading, +230 mesh
silver nitrate, 99.9999% trace metals basis
silver nitrate, acs
CHEMBL177367
argentum nitricum
silver nitrate [usp:jan]
unii-95it3w8jze
95it3w8jze ,
silver nitrate [un1493] [oxidizer]
ec 231-853-9
nitrato de plata
nitric acid silver(1+) salt (1:1)
toughened silver nitrate [usp monograph]
silver nitrate [who-ip]
silver nitrate [mart.]
silver nitrate [usp impurity]
silver nitrate [mi]
silver nitrate [vandf]
argenti nitras [who-ip latin]
silver nitrate [inci]
silver nitrate [hsdb]
silver(1+) nitrate [who-ip]
silver nitrate [ep monograph]
silver nitrate [who-dd]
argentum nitricum [hpus]
BP-30056
silver(i)nitrate
silver (i) nitrate
silver nitrate-
silvernitrate
SQGYOTSLMSWVJD-UHFFFAOYSA-N
silver (1) nitrate
DTXSID3032042 ,
nitric acid, silver (1+) salt
silver nitrate, anhydrous, 99.999% trace metals basis
silver nitrate, tested according to ph.eur.
silver standard for aas, ready-to-use, traceable to bam, in nitric acid
silver nitrate, puriss. p.a., >=99.5% (at)
mfcd00003414
silver nitrate, premion?
SR-01000944542-1
sr-01000944542
silver nitrate, saj first grade, >=99.8%
silver nitrate, puriss. p.a., acs reagent, reag. iso, reag. ph. eur., >=99.8%
silver nitrate, meets analytical specification of ph. eur., bp, usp, 99.8-100.5%
silver standard for icp, for icp, ready-to-use, in nitric acid
silver nitrate, jis special grade, >=99.8%
silver nitrate, acs reagent, >=99.0%
silver nitrate, reagentplus(r), >=99.0% (titration)
silver nitrate, acs reagent
silver nitrate, meets usp testing specifications
silver nitrate, p.a., acs reagent, reag. iso, 99.8%
silver nitrate, lr, >=99.5%
assay-isotopic standard for silver, nist(r) srm(r) 978a
silver nitrate, ar, >=99.9%
silver nitrate, trace metals grade,99.995%
silver nitrate acs grade
DB11080
Q207442
ag (n o3)
AT27248
silver;nitrate
silver nitrate, ag 63.3%
silver nitrate ip
silver nitrate bp
silver (1+) nitrate
nitrato de prata
silver nitrate usp
nitrato d'argento
silver (1+) salt
toughened silver nitrate (usp monograph)
silver (i) nitrate (1:1)
silver nitrate (usp impurity)
argentum nitricum kit refill
argentum nitricum 1m
argentum nitricum 200c
silver nitrate (usp:jan)
dtxcid1012042
arg nit
silver nitrate (agno3)
caswell no 737
silver nitrate (mart.)
silver nitrate (ep monograph)
avoca flexible caustic applicator
argentum nitricum200ck
argentum nitricum 6x
for pesticide code: 072503

Research Excerpts

Overview

Silver nitrate (SN) is an alternative to talc pleurodesis in patients with malignant pleural effusion (MPE) Silver nitrate ointment is an effective and safe medicament for the clinical management of partial-thickness burn wounds.

Excerpt	Reference	Relevance
"Silver nitrate (SN) is an alternative to talc pleurodesis in patients with malignant pleural effusion (MPE). "	( Safety and systemic consequences of pleurodesis with three different doses of silver nitrate in patients with malignant pleural effusion. Bellato, RT; Chate, RC; Pego-Fernandes, PM; Teixeira, LR; Terra, RM, 2015)	2.09
"Silver nitrate ointment is an effective and safe medicament for the clinical management of partial-thickness burn wounds."	( [Multi-center clinical study of the effect of silver nitrate ointment on the partial-thickness burn wounds]. Huan, JN; Liao, ZJ; Lv, GZ; Shou, YM; Wang, ZY, 2006)	2.03
"Silver nitrate is a widely used substance and has been applied topically for cauterizing bleeding and healing wounds. "	( Unusual edge effect in patch testing with silver nitrate. Elsner, P; Iliev, D, 1998)	2.01
"Silver nitrate is a possible alternative agent."	( Silver nitrate is superior to talc slurry in producing pleurodesis in rabbits. Carmo, AO; Cury, PM; Light, RW; Marchi, E; Teixeira, LR; Vargas, FS; Vaz, MA, 2000)	2.47
"Silver nitrate was found to be an appropriate inorganic binder for the Ti powder-based skeleton, and the optimum sintering parameters for full densification were determined."	( A new Ti-5Ag alloy for customized prostheses by three-dimensional printing (3DP). Allen, SM; Eliaz, N; Hong, SB; Latanision, RM; Leisk, GG; Sach, EM, 2001)	1.03
"Silver nitrate, AgNO3, is a highly toxic compound for bacteria and fungi."	( Melanization of Cryptococcus neoformans reduces its susceptibility to the antimicrobial effects of silver nitrate. Casadevall, A; García-Rivera, J, 2001)	1.25
"Silver nitrate (AgNO3) is a sulfhydryl oxidizing agent that induces a biphasic Ca2+ release from isolated sarcoplasmic reticulum (SR) vesicles by presumably oxidizing critical sulfhydryl groups in the Ca2+ release channel (CRC), causing the channel to open. "	( Silver ions induce Ca2+ release from the SR in vitro by acting on the Ca2+ release channel and the Ca2+ pump. Green, H; Tupling, R, 2002)	1.76

Effects

Silver nitrate has been adopted for medical use as a disinfectant for eye disease and burned wounds. Silver nitrate sticks have been used for a long time to provide pain relief for the duration of an aphthous ulceration.

Excerpt	Reference	Relevance
"Silver nitrate has a high density and a high mass attenuation coefficient, and it is therefore highly radio-opaque."	( The misleading appearance of silver nitrate on plain radiography. Latimer, MD; Littlewood, A; Narayan, N; Nogaro, MC, 2014)	1.41
"The silver nitrate spray has the same level of specificity and sensitivity for olefins, particularly cholesterol, and has shown to be capable of IMS experiments down to 10-μm spatial resolution."	( Silver spray deposition for AgLDI imaging MS of cholesterol and other olefins on thin tissue sections. Chaurand, P; Fournelle, F; Yang, E, 2020)	1.04
"Silver nitrate has been adopted for medical use as a disinfectant for eye disease and burned wounds. "	( Revitalising Silver Nitrate for Caries Management. Chu, CH; Duangthip, D; Duffin, S; Gao, SS; Lo, ECM; Zhao, IS, 2018)	2.29
"Silver nitrate has a high density and a high mass attenuation coefficient, and it is therefore highly radio-opaque."	( The misleading appearance of silver nitrate on plain radiography. Latimer, MD; Littlewood, A; Narayan, N; Nogaro, MC, 2014)	1.41
"Silver nitrate has been shown to be a safe and effective treatment for verruca pedis, with equal success rates when compared between home and clinical applications."	( A randomized comparative evaluation of clinical and home application to investigate the effectiveness of silver nitrate (AgNO Concannon, M; Forrest, J; Keogh, L; Parfitt, G; Stephenson, J, 2017)	2.11
"Silver nitrate has promising activity against a wide variety of ocular pathogenic fungi in vitro, and may have a role in future studies of antifungal eye drops and treating fungal keratitis."	( [Comparison of the activities of silver nitrate with those of three antifungal agents against ocular pathogenic fungi in vitro]. Chen, ZJ; DU, LX; Gao, CW; Pang, GR; Sun, ST; Wang, BL; Xu, Y; Zhao, DQ; Zhou, LT, 2009)	2.08
"Silver nitrate sticks have been used for a long time to provide pain relief for the duration of an aphthous ulceration, with only one application."	( Silver nitrate cautery in aphthous stomatitis: a randomized controlled trial. Alidaee, MR; Ghodsi, SZ; Mansoori, P; Taheri, A, 2005)	2.49
"Silver nitrate ointment has the same antibacterial effect as 1% SD-Ag cream, but it was less painful when applied to the open wounds."	( [Multi-center clinical study of the effect of silver nitrate ointment on the partial-thickness burn wounds]. Huan, JN; Liao, ZJ; Lv, GZ; Shou, YM; Wang, ZY, 2006)	1.31
"Silver nitrate solution has been used since the 1880s for newborn prophylaxis against Neisseria gonorrhoeae ocular infections. "	( Unit dose erythromycin ophthalmic ointment for neonatal ocular prophylaxis. Bryant, BG, )	1.57
"Silver nitrate has been used to demonstrate the chromosomal location of ribosomal cistrons in nine tissue-culture lines derived from human tumors of various pathological origins. "	( Identification of nucleolus organizer regions (NORs) in normal and neoplastic human cells by the silver-staining technique. Hsu, TC; Hubbell, HR, 1977)	1.7
"Silver nitrate has been used as a stain to study the permeability, degradation, and marginal integrity of dental composite restorations. "	( The colors of silver with silver nitrate staining in dental materials. Mair, LH, 1992)	2.03
"Silver nitrate treatment has been successfully applied in 13 cases of phosphorus burns."	( Treatment of yellow phosphorus skin burns with silver nitrate instead of copper sulfate. Gu, XQ; Lu, YP; Song, ZY, 1985)	1.25

Actions

Silver nitrate treatment had lower procedure times, costs, and better satisfaction and comfort scale scores. Silver nitrate failed to increase GJIC and the expression of Cx43 protein.

Excerpt	Reference	Relevance
"Silver nitrate treatment had lower procedure times, costs, and better satisfaction and comfort scale scores. "	( Comparison of the Efficacy of Combined Silver Nitrate Coagulation and Shave Excision With Surgical Excision and Linear Closure in the Treatment of Pyogenic Granuloma. Çaydere, M; Çelik, M; Kara, M; Kocer, U; Özdemir, AG, 2023)	2.62
"Silver nitrate failed to increase GJIC and the expression of Cx43 protein."	( Silver nanoparticles up-regulate Connexin43 expression and increase gap junctional intercellular communication in human lung adenocarcinoma cell line A549. Autrup, H; Dang, DA; Deng, F; Foldbjerg, R; Guo, X; Olesen, P, 2010)	1.08

Treatment

Silver nitrate treatments induced apoptosis in all cell types, including keratinocytes, resulting in delayed wound healing. Silver nitrate treatment has been successfully applied in 13 cases of phosphorus burns.

Excerpt	Reference	Relevance
"Silver nitrate treatment had lower procedure times, costs, and better satisfaction and comfort scale scores. "	( Comparison of the Efficacy of Combined Silver Nitrate Coagulation and Shave Excision With Surgical Excision and Linear Closure in the Treatment of Pyogenic Granuloma. Çaydere, M; Çelik, M; Kara, M; Kocer, U; Özdemir, AG, 2023)	2.62
"Silver nitrate treatments induced apoptosis in all cell types, including keratinocytes, resulting in delayed wound healing."	( Anti-inflammatory activity of nanocrystalline silver in a porcine contact dermatitis model. Burrell, RE; Nadworny, PL; Tredget, EE; Wang, J, 2008)	1.07
"Silver nitrate treatment has been successfully applied in 13 cases of phosphorus burns."	( Treatment of yellow phosphorus skin burns with silver nitrate instead of copper sulfate. Gu, XQ; Lu, YP; Song, ZY, 1985)	1.25

Toxicity

Silver nitrate was more toxic than AgNPs when the viability "egg-to-adult" was determined. Opportunity is taken herein to review the uses of silver nitrate in clinical situations.

Excerpt	Reference	Relevance
" The results show that silver-coating had no toxic effect whereas silvernitrate and silversulphate coating did have a toxic effect."	( Assessment of silver-coated urinary catheter toxicity by cell culture. Liedberg, H; Lundeberg, T, 1989)	0.28
"44% of 61 toxic samples of waste water showed cytotoxicity, only 60."	( [Use of fish cell cultures for toxicity determination in order to reduce and replace the fish tests]. Ahne, W, 1985)	0.27
" The parallel study of DNA synthesis and cell protein content suggests that the toxic damage produced by silver in different phases of the cell cycle may lead to destruction of the entire cell population and therefore hinder the tissue regeneration process."	( Study of cytotoxicity mechanisms of silver nitrate in human dermal fibroblasts. Domínguez, C; Hidalgo, E, 1998)	0.58
" Opportunity is taken herein to review the uses of silver nitrate in clinical situations--and of silver in any of its many other forms--together with their respective adverse effects."	( Lessons to be learned: a case study approach. Finger discoloration due to silver nitrate exposure: review of uses and toxicity of silver in clinical practice. Donaldson, D; Sankar, NS, 1998)	0.78
"Copper ion homeostasis is complicated in that copper is an essential element needed for a variety of cellular processes but is toxic at excess levels."	( Role of a Candida albicans P1-type ATPase in resistance to copper and silver ion toxicity. Kumamoto, CA; Riggle, PJ, 2000)	0.31
"3) but achieves the correct sensitivity of the model for daphnids by reducing the saturation of toxic sites needed to cause toxicity."	( Mechanism of acute silver toxicity in Daphnia magna. Bianchini, A; Wood, CM, 2003)	0.32
" This appears to be a safe and effective technique that eliminates the need for surgery and has not been previously reported."	( Endoscopic chemical cautery of piriform sinus tracts: a safe new technique. Pereira, KD; Smith, SL, 2008)	0.35
" Plus, the silver nanoparticle powders subsequently suspended in the exposure water were much less toxic than the previously prepared silver nanoparticle colloids, whereas the colloidal silver nanoparticles and AgNO(3) were almost similar in terms of mortality."	( Toxicity of various silver nanoparticles compared to silver ions in Daphnia magna. Asghari, S; Choi, HJ; Jeon, YB; Johari, SA; Kim, YS; Lee, JH; Moon, MC; Yu, IJ, 2012)	0.38
" However, all AgNPs were about three to ten times less toxic than AgNO(3) when their toxicities were compared on a mass-concentration basis."	( Uptake of silver nanoparticles and toxicity to early life stages of Japanese medaka (Oryzias latipes): effect of coating materials. Auffan, M; Badireddy, AR; Chilkoti, A; Hinton, DE; Kwok, KW; Liu, J; Marinakos, SM; Nelson, CM; Wiesner, MR, 2012)	0.38
" Median effective concentration (EC50) values for Chl a and phosphate content showed that AgNO(3) was more toxic than AgNPs (EC50 values: 16."	( Physiological analysis of silver nanoparticles and AgNO3 toxicity to Spirodela polyrhiza. Chang, FY; Jiang, HS; Li, M; Li, W; Yin, LY, 2012)	0.38
" This paper studies the adverse effects of silver NPs to two aquatic crustaceans, Daphnia magna and Thamnocephalus platyurus."	( Toxicity of two types of silver nanoparticles to aquatic crustaceans Daphnia magna and Thamnocephalus platyurus. Blinova, I; Kahru, A; Kajankari, P; Käkinen, A; Kanarbik, L; Niskanen, J; Penttinen, OP; Tenhu, H, 2013)	0.39
"An increased understanding of nanoparticle toxicity and its impact on human health is essential to enable a safe use of nanoparticles in our society."	( Intracellular uptake and toxicity of Ag and CuO nanoparticles: a comparison between nanoparticles and their corresponding metal ions. Cronholm, P; Elihn, K; Hedberg, J; Karlsson, HL; Lowe, TA; Möller, L; Wallinder, IO; Winnberg, L, 2013)	0.39
" So, it is imperative to know the adverse effects of AgNPs in man."	( Toxic effects of repeated oral exposure of silver nanoparticles on small intestine mucosa of mice. Shahare, B; Yashpal, M, 2013)	0.39
" The Ag(+) was more toxic than AgNPs but both lead to death and delayed hatching in surviving embryos."	( Assessment of nanosilver toxicity during zebrafish (Danio rerio) development. Dupuis, L; Eisa-Beygi, S; Massarsky, A; Moon, TW; Strek, L; Taylor, J; Trudeau, VL, 2013)	0.39
" AgNPs were found to be ten times less toxic by mass than silver ions, and most of this toxicity was removed by ultracentrifuging."	( Proteomic evaluation of citrate-coated silver nanoparticles toxicity in Daphnia magna. Carolan, D; Doyle, H; Rainville, LC; Sheehan, D; Varela, AC, 2014)	0.4
" Moreover, it remains unclear if toxic effects are particle-specific or mediated by released silver ions."	( Toxicity of silver nanoparticles and ionic silver: Comparison of adverse effects and potential toxicity mechanisms in the freshwater clam Sphaerium corneum. Boedicker, C; Kämpken, I; Oehlmann, J; Oetken, M; Völker, C, 2015)	0.42
"To evaluate frequent adverse events (AE) of SN treatment at three different doses for pleurodesis in patients with MPE."	( Safety and systemic consequences of pleurodesis with three different doses of silver nitrate in patients with malignant pleural effusion. Bellato, RT; Chate, RC; Pego-Fernandes, PM; Teixeira, LR; Terra, RM, 2015)	0.65
" However, most conventional AgNPs syntheses require the use of hazardous chemicals and generate toxic organic waste."	( 'Chocolate' silver nanoparticles: Synthesis, antibacterial activity and cytotoxicity. Chowdhury, NR; MacGregor-Ramiasa, M; Majewski, P; Vasilev, K; Zilm, P, 2016)	0.43
" This study aimed to investigate the toxic effects of AgNPs with different particle sizes (40 and 110 nm) and different surface coatings (sodium citrate and polyvinylpyrrolidone, PVP) on Daphnia magna and their mechanisms of action."	( Toxic Effects and Molecular Mechanism of Different Types of Silver Nanoparticles to the Aquatic Crustacean Daphnia magna. Hou, J; Li, S; Wang, C; Wang, X; Zhou, Y, 2017)	0.46
"Silver nanoparticles (AgNPs) are one of the most widely-used nanomaterials, which are toxic and can cause physiological disorders in plants."	( Alterations in HO-1 expression, heme oxygenase activity and endogenous NO homeostasis modulate antioxidant responses of Brassica nigra against nano silver toxicity. Ahadi, A; Amooaghaie, R; Tabatabaei, F, 2018)	0.48
" Results indicated that silver nitrate was more toxic than AgNPs when the viability "egg-to-adult" was determined."	( Toxic and Genotoxic Effects of Silver Nanoparticles in Drosophila. Alaraby, M; Hernández, A; Marcos, R; Romero, S, 2019)	0.82
" Product mislabeling and long-term use of these products may put consumers at risk for adverse health outcomes including argyria."	( In vitro intestinal toxicity of commercially available spray disinfectant products advertised to contain colloidal silver. Bowers, L; Bradham, KD; Henson, TE; Hughes, MF; Knepp, AK; Navratilova, J; Rogers, KR; Stefaniak, AB; Surette, M, 2020)	0.56

Compound-Compound Interactions

Excerpt	Reference	Relevance
"6-fold and 3-fold increase, respectively, in combination with silver nanoparticles selectively against multidrug-resistant Acinetobacter baumannii."	( Synthesis of silver nanoparticles using Dioscorea bulbifera tuber extract and evaluation of its synergistic potential in combination with antimicrobial agents. Ahire, M; Bellare, J; Cameotra, SS; Chopade, BA; Dhavale, DD; Ghosh, S; Jabgunde, A; Kale, S; Kitture, R; Pardesi, K; Patil, S, 2012)	0.38
"The aim of this study was to evaluate the sealing ability of mineral trioxide aggregate (MTA Bio) combined with different mixing agents (distilled water, chlorhexidine, doxycycline), used as an apical root-end filling material."	( Sealing ability of mineral trioxide aggregate (MTA) combined with distilled water, chlorhexidine, and doxycycline. Arruda, RA; Bueno, CE; Cunha, RS; De Martin, AS; Miguita, KB; Pinheiro, SL; Rocha, DG; Silveira, CF, 2012)	0.38
" In this study, silver ion, a conventional inorganic biocide, was combined with norspermidine and used for control and removal of multi-species biofilms formed by a mixed culture from wastewater treatment systems."	( A small molecule norspermidine in combination with silver ion enhances dispersal and disinfection of multi-species wastewater biofilms. Quan, X; Si, X; Wang, X; Wu, Y, 2016)	0.43
"This study was conducted to investigate the effects of orally administered propolis (a resinous substance found in beehives), alone and in combination with silver nanoparticles (SNPs), on the wound healing process in male rats."	( The Effect of Oral Consumption of Propolis Alone and in Combination With Silver Nanoparticles on Wound Healing in Male Wistar Rats. Farzam, A; Gheib, N; Habibian, Z; Samiee-Rad, F, 2020)	0.56
"Oral propolis alone and in combination with 30 ppm SNPs appears to provide anti-inflammatory effects and increase fibroblast proliferation and collagen deposition in experimental wounds, which may explain the observed differences in healing."	( The Effect of Oral Consumption of Propolis Alone and in Combination With Silver Nanoparticles on Wound Healing in Male Wistar Rats. Farzam, A; Gheib, N; Habibian, Z; Samiee-Rad, F, 2020)	0.56

Bioavailability

Excerpt	Reference	Relevance
" In laboratory studies, silver partitioning to particulates, sediment pore water, and overlying water was measured and bioavailability of silver was determined using Hyalella azteca in 10-day sediment toxicity tests."	( Partitioning and effects of silver in amended freshwater sediments. Deaver, E; Rodgers, JH; Rogers, PL, 1997)	0.3
" This phase 1 study assessed the safety, pharmacokinetics and bioavailability of silver ions delivered intracrevicularly with a resorbable LDD (PocketGuard) in a group of 9 volunteers affected with periodontitis."	( Phase 1 evaluation of a local delivery device releasing silver ions in periodontal pockets: safety, pharmacokinetics and bioavailability. Braman, V; Friden, P; Lang, NP; Massaro, J; Mombelli, A; Straub, AM; Suvan, J; Tonetti, MS, 2001)	0.31
" The results show that (1) when the concentration of AgNO3 is less then 50 mg/L, with the increase of AgNO3 concentration, the absorption rate of some metal ions is increasing, but when the concentration is excess of such concentration, the effects on the absorption rate are different."	( [The effects of Ag+ on the absorption of trace metal ion during the somatic embryogenesis of Lycium barbarum. L]. Dai, RL; Li, S; Qin, Z; Shen, ZH; Wang, YF, 2001)	0.31
" The results of this study suggest that: (1) physiological regulation of silver movement may explain the pattern of gill silver accumulation observed in rainbow trout, although not by a mechanism coupled to Na(+)K(+)-ATPase inhibition as originally proposed; (2) alternatively or additionally, a decreased bioavailability of silver, due to the static exposure conditions, may explain the pattern of gill accumulation; (3) the early inhibition of whole body Na(+) uptake observed during silver exposure occurs via a mechanism other than Na(+)K(+)-ATPase inhibition; and (4) gill silver accumulation may be an appropriate endpoint for biotic ligand modeling."	( The time course of silver accumulation in rainbow trout during static exposure to silver nitrate: physiological regulation or an artifact of the exposure conditions? Grosell, M; Morgan, TP; Playle, RC; Wood, CM, 2004)	0.55
" Silver accumulation in toadfish gills and plasma decreased as salinity increased, indicating low bioavailability of AgCl complexes."	( Influence of salinity and organic matter on silver accumulation in Gulf toadfish (Opsanus beta). Brown, S; Nichols, JW; Playle, RC; Walsh, PJ; Wood, CM, 2006)	0.33
" The bioavailability of AgNP was calculated to be low in both strains relative to Ag(+), suggesting that AgNP internalization across the cell membrane was limited."	( Intracellular silver accumulation in Chlamydomonas reinhardtii upon exposure to carbonate coated silver nanoparticles and silver nitrate. Allué, CG; Behra, R; Piccapietra, F; Sigg, L, 2012)	0.59
" Most previous studies have focused on the toxicity of AgNPs while their bioavailability has been seldom investigated."	( Salinity influences on the uptake of silver nanoparticles and silver nitrate by marine medaka (Oryzias melastigma). Wang, J; Wang, WX, 2014)	0.64
" However, such low bioavailability of dietary AgNPs could inhibit the whole-body Na+/K+-ATPase and superoxide dismutase (SOD) activity in the fish within the first 2 weeks of exposure."	( Low bioavailability of silver nanoparticles presents trophic toxicity to marine medaka (Oryzias melastigma). Wang, J; Wang, WX, 2014)	0.4
" Here, we characterize the bioavailability of Ag from AgNO(3) and from AgNPs capped with polyvinylpyrrolidone (PVP AgNP) and thiolated polyethylene glycol (PEG AgNP) in the freshwater snail, Lymnaea stagnalis, after short waterborne exposures."	( Influence of hardness on the bioavailability of silver to a freshwater snail after waterborne exposure to silver nitrate and silver nanoparticles. Croteau, MN; Lead, JR; Luoma, SN; Römer, I; Stoiber, T; Tejamaya, M, 2015)	0.63
" The present study aimed to (i) characterize the bioaccumulation dynamics of PVP-, PEG-, and citrate-AgNPs, in comparison to dissolved Ag, in Daphnia magna and Lumbriculus variegatus; and (ii) investigate whether parameters of bioavailability and accumulation predict acute toxicity."	( Accumulation dynamics and acute toxicity of silver nanoparticles to Daphnia magna and Lumbriculus variegatus: implications for metal modeling approaches. Dybowska, AD; Fernandes, TF; Khan, FR; Lead, JR; Paul, KB; Stone, V; Valsami-Jones, E, 2015)	0.42
" This suggests that the relation between toxicity and bioavailability of Ag-NPs differs from that of ionic Ag in soils."	( Effects of soil and dietary exposures to Ag nanoparticles and AgNO₃ in the terrestrial isopod Porcellionides pruinosus. Jurkschat, K; Loureiro, S; Soares, AM; Tourinho, PS; van Gestel, CA, 2015)	0.42
" However, little is known about the relationship between Ag NP exposure and their bioavailability for soil organisms."	( Toxicokinetics of Ag in the terrestrial isopod Porcellionides pruinosus exposed to Ag NPs and AgNO₃ via soil and food. Jurkschat, K; Kille, P; Loureiro, S; Morgan, AJ; Mosselmans, JF; Soares, AM; Svendsen, C; Tourinho, PS; van Gestel, CA, 2016)	0.43
" However, the relative uptake ratio and bioavailability of the two different forms is not well known due to a lack of sensitive and effective assessment systems."	( A novel assessment system of toxicity and stability of CuO nanoparticles via copper super sensitive Saccharomyces cerevisiae mutants. Chen, X; Ke, Q; Lee, J; Simth, N; Sun, J; Wu, X; Zhang, R; Zhao, M, 2020)	0.56

Dosage Studied

Excerpt	Relevance	Reference
" A complete dose-response curve was performed for a representative compound from each class."	( Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat. Haynes, WL; Klintworth, GK; Proia, AD, 1989)	0.28
" In dose-response and time-course studies, approximately 60-70% of the Ag increments in hepatic cytosol and approximately 30% of the Ag increments in renal cytosol were bound to metallothionein."	( Role of metallothionein on Ag accumulation in hepatic and renal cytosol after Ag injection to rats. Kurasaki, M; Okabe, M; Saito, S; Yoshida, K, 1999)	0.3
"0 mg of sulphamethoxazole in pure and dosage forms."	( Indirect potentiometric titration of sulphamethoxazole in the presence of trimethoprim in co-trimazole tablets using copper based mercury film electrode. Abdul Kamal Nazer, M; Riyazuddin, P; Shabeer, TK, 2001)	0.31
"A simple and rapid potentiometric method for the estimation of ascorbic acid in pharmaceutical dosage forms has been developed."	( Indirect potentiometric titration of ascorbic acid in pharmaceutical preparations using copper based mercury film electrode. Abdul Kamal Nazer, MM; Hameed, AR; Riyazuddin, P, 2004)	0.32
" In the chinchilla, co-administration of GM and EA can produce hair cell lesions ranging from a small loss of outer hair cells (OHCs) in the base of the cochlea to complete destruction of all hair cells, depending on dosing parameters."	( Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla. Ding, D; Jiang, H; McFadden, SL; Salvi, RJ, 2004)	0.32
" However, although fecundity was unaffected at all five tested concentrations during the test with silver in water only, it was significantly reduced at the two highest waterborne silver concentrations (12 and 24 microg/L) during the test with silver dosed into food and water."	( Influence of salinity and organic carbon on the chronic toxicity of silver to mysids (Americamysis bahia) and silversides (Menidia beryllina). Boeri, RL; Gorsuch, JW; Hogstrand, C; Kramer, JR; Lussier, SM; Stubblefield, WA; Ward, TJ; Wyskiel, DC, 2006)	0.33
" Single pellet dissolution measurements demonstrated that the release profile of the encapsulated dosage form, containing approximately 400 pellets per capsule, is a combination of different release profiles of all individual pellets."	( Visualization and analysis of the release mechanism of shellac coated ascorbic acid pellets. Förmer, P; Müller, A; Schmidt, PC; Theurer, C, 2006)	0.33
" Dose-response curves for the decrease in TR following exposure to each inhibitor were developed."	( Transpiration response of 'slow-wilting' and commercial soybean (Glycine max (L.) Merr.) genotypes to three aquaporin inhibitors. Sadok, W; Sinclair, TR, 2010)	0.36
" Dose-response curves were generated and median lethal concentration (LC50) values calculated."	( Effects from filtration, capping agents, and presence/absence of food on the toxicity of silver nanoparticles to Daphnia magna. Allen, HJ; Govindaswamy, S; Heckman, JL; Impellitteri, CA; Lazorchak, JM; Macke, DA; Nadagouda, MN; Poynton, HC; Roose, DL, 2010)	0.36
"Animals were dosed by gavage from gestation day 7 - 20."	( Effects of developmental exposure to silver in ionic and nanoparticle form: A study in rats. Aydin, A; Bucurgat, ÜÜ; Charehsaz, M; Culha, M; Ekici, AI; Hougaard, KS; Kaspar, Ç; Sipahi, H, 2016)	0.43
" Ag NM300K caused higher genotoxicity after 7 d for the lowest concentration, highlighting a potential nonmonotonic dose-response effect."	( Silver (nano)materials cause genotoxicity in Enchytraeus crypticus, as determined by the comet assay. Amorim, MJB; Guilherme, S; Maria, VL; Ribeiro, MJ; Scott-Fordsmand, JJ; Soares, AMVM, 2018)	0.48
"001) after chronic dosing in Staphysagria and Ignatia amara treated groups."	( Comparison of the antidepressant like activity of homeopathic remedies (Argentum nitricum, Staphysagria and Ignatia amara) and their effect on the behavior of rodents. Anser, H; Ikram, R; Imam, S; Ishaque, S; Khan, SS; Khatoon, H; Naeem, S; Nazim, U; Shafiq, Y, 2020)	0.56

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (8 Product(s))

Product Categories

Product Category	Products
Beauty & Personal Care	7
Vitamins & Supplements	1

Products

Product	Brand	Category	Compounds Matched from Ingredients	Date Retrieved
Godefroy 28 Day Mascara Eyelash Gel Tint - Black -- 25 Applications	Godefroy	Beauty & Personal Care	ammonia, ascorbic acid, sodium laureth sulfate, pyrogallol, silver nitrate	2024-11-29 10:47:42
Godefroy 28 Day Mascara Eyelash Gel Tint - Brown -- 25 Applications	Godefroy	Beauty & Personal Care	ammonia, ascorbic acid, sodium laureth sulfate, pyrogallol, silver nitrate	2024-11-29 10:47:42
Godefroy Instant Eyebrow Tint - Light Brown -- 3 Application Kit	Godefroy	Beauty & Personal Care	carbomer, silver nitrate	2024-11-29 10:47:42
Godefroy Instant Eyebrow Tint - Medium Brown -- 3 Application Kit	Godefroy	Beauty & Personal Care	carbomer, silver nitrate	2024-11-29 10:47:42
Godefroy Instant Eyebrow Tint Singles - Dark Brown -- 1 Kit	Godefroy	Beauty & Personal Care	carbomer, silver nitrate	2024-11-29 10:47:42
Godefroy Instant Eyebrow Tint Singles - Light Brown -- 1 Kit	Godefroy	Beauty & Personal Care	carbomer, silver nitrate	2024-11-29 10:47:42
Godefroy Instant Eyebrow Tint Singles - Medium Brown -- 1 Kit	Godefroy	Beauty & Personal Care	carbomer, silver nitrate	2024-11-29 10:47:42
Natural Care RefluxAway Homeopathic -- 60 Tablets	Natural Care	Vitamins & Supplements	lactose, argentum nitricum 6X	2024-11-29 10:47:42

Role	Description
astringent	A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID207981	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Staphylococcus aureus at 4 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID559741	Antibacterial activity against Micrococcus luteus DSM 1790	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides.
AID556645	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Aspergillus sp. after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID163097	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Pseudomonas aeruginosa at 2 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID556643	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Aspergillus versicolor after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID69352	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Escherichia coli at 3 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID559735	Antibacterial activity against Enterobacter helveticus DSM 18396	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides.
AID556465	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Fusarium solani after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID556644	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Aspergillus niger after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID556642	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Aspergillus oryzae after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID559760	Toxicity in human erythrocytes assessed as hemolysis by serial dilution method	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides.
AID556639	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Fusarium sp. after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID1607619	Toxicity in human	2019	Journal of medicinal chemistry, 07-11, Volume: 62, Issue:13	Medical Uses of Silver: History, Myths, and Scientific Evidence.
AID163091	Minimum inhibitory concentration of compound (3176 mg/mL) at day 1 in freshly grown culture (20 uL per day) of Pseudomonas aeruginosa; (- = No growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID556640	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Aspergillus flavus after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID556466	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Fusarium moniliforme after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID69338	Minimum inhibitory concentration of compound (3176 mg/mL) at day 2 in freshly grown culture (20 uL per day) of Escherichia coli; (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID163098	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Pseudomonas aeruginosa at 3 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID556638	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Fusarium poae after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID559738	Antibacterial activity against Pseudomonas fluorescens DSM 50090	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides.
AID559739	Antibacterial activity against Bacillus subtilis DSM 347	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides.
AID163099	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Pseudomonas aeruginosa at 4 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID556636	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Fusarium avenaceum after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID556641	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Aspergillus fumigatus after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID207978	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Staphylococcus aureus at 1 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID207972	Minimum inhibitory concentration of compound (3176 mg/mL) at day 1 in freshly grown culture (20 uL per day) of Staphylococcus aureus; (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID207980	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Staphylococcus aureus at 3 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID561113	Antibacterial activity against Escherichia coli DSM 498	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides.
AID163763	Sensitivity test of compound (0.5% w/v) was determined as diameter of the zone of inhibition of Pseudomonas aeruginosa growth	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID559737	Antibacterial activity against Proteus myxofaciens DSM 4482	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides.
AID69349	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Escherichia coli at 1 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID163092	Minimum inhibitory concentration of compound (3176 mg/mL) at day 2 in freshly grown culture (20 uL per day) of Pseudomonas aeruginosa; (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID207979	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Staphylococcus aureus at 2 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID70315	Sensitivity test of compound (0.5% w/v) was determined as diameter of the zone of inhibition of Escherichia coli growth	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID69337	Minimum inhibitory concentration of compound (3176 mg/mL) at day 1 in freshly grown culture (20 uL per day) of Escherichia coli; ( - = No growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID559734	Antibacterial activity against Acinetobacter calcoaceticus DSM 586	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides.
AID207112	Sensitivity test of compound (0.5% w/v) was determined as diameter of the zone of inhibition of Staphylococcus aureus growth	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID69351	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Escherichia coli at 2 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID556637	Antifungal activity against 0.4x10'4 to 5x10'4 CFU/ml Fusarium oxysporum after 48 hrs by CLSI M38-A broth microdilution method	2009	Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4	In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
AID559740	Antibacterial activity against Kocuria rhizophila DSM 348	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides.
AID163095	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Pseudomonas aeruginosa at 1 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
AID559736	Antibacterial activity against Aeromonas bestiarum DSM 13956	2009	Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8	Synergistic interaction between silver nanoparticles and membrane-permeabilizing antimicrobial peptides.
AID69353	Minimum inhibitory concentration of compound at day 1 in freshly grown culture (20 uL per day) of Escherichia coli at 4 dilution factor (1 mL); (+ = Growth)	2004	Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4	Formation of water-soluble pincer silver(I)-carbene complexes: a novel antimicrobial agent.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1531 (49.36)	18.7374
1990's	298 (9.61)	18.2507
2000's	424 (13.67)	29.6817
2010's	703 (22.66)	24.3611
2020's	146 (4.71)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	97 (2.93%)	5.53%
Reviews	122 (3.68%)	6.00%
Case Studies	192 (5.80%)	4.05%
Observational	2 (0.06%)	0.25%
Other	2,898 (87.53%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Trial	Phase	Enrollment	Study Type	Start Date	Status
Management Of Malignant Pleural Effusion With Indwelling Pleural Catheter Versus Silver Nitrate Pleurodesis [NCT03781908]	Phase 1/Phase 2	50 participants (Anticipated)	Interventional	2019-01-01	Not yet recruiting
Treatment of Granuloma Umbilical in Newborn Babies - Comparison of Treatment With Silver Nitrate Versus Alcohol Swaps Versus Steroid Creme Group IV [NCT01567215]	Phase 2	90 participants (Actual)	Interventional	2012-05-31	Completed
Evaluation of Chest Pain, Effectiveness and Safety of Pleurodesis With Pleural Catheters and Silver Nitrate for Malignant Pleural Effusion. [NCT01125124]	Phase 2	60 participants (Anticipated)	Interventional	2009-08-31	Recruiting
A Prospective Evaluation of Non-Operative Treatments for Gastrocutaneous Fistulae in Children [NCT03920306]	Phase 4	100 participants (Anticipated)	Interventional	2019-04-01	Recruiting
Granulation Tissue at G Tube Site: Treatment With Kenalog vs Chemical Cauterization With Silver Nitrate vs Soap Washcloth Abrasion [NCT02519738]	Phase 3	52 participants (Actual)	Interventional	2015-01-15	Terminated(stopped due to enrollment difficulties)
Randomized Clinical Trial Comparing Silver Nitrate Application With Topical Corticosteroids for Hypergranulation Tissue at Gastrostomy Sites [NCT02398539]	Phase 4	50 participants (Anticipated)	Interventional	2015-04-30	Recruiting
The Treatment of Bartholin´s Cyst or Abscess With Silver Nitrate [NCT00786461]	Phase 4	30 participants (Anticipated)	Interventional	2007-03-31	Recruiting
Comparison of Double Ligation and Topical Silver Nitrate for Treatment of Umbilical Granuloma in Children: A Randomized Control Trial [NCT04248101]	Phase 2	176 participants (Actual)	Interventional	2016-07-01	Completed
Medical Management of Caries in the Primary Dentition Using Silver Nitrate: A Pilot Study [NCT02604134]	Early Phase 1	122 participants (Actual)	Interventional	2014-07-31	Completed
[NCT00000120]	Phase 3	0 participants	Interventional	1985-01-31	Completed
Reduction of Bacteriuria in Subjects Practicing Intermittent Catheterization [NCT01143116]		20 participants (Actual)	Interventional	2010-11-30	Completed
A Prospective, Randomised Controlled Trial to Determine the Safety and Efficacy of Steroid Impregnated Tape Compared to Standard Therapy With Silver Nitrate in the Treatment of Over-granulating Peritoneal Dialysis Catheter Exit Sites [NCT01996930]	Phase 3	32 participants (Actual)	Interventional	2013-12-31	Completed
Effectiveness of Biannual Application of Silver Nitrate Solution Followed by Sodium Fluoride Varnish in Arresting Early Childhood Caries in Preschool Children: a 30-month, Randomised, Double-blind, Non-inferiority Trial [NCT02019160]	Phase 3	1,070 participants (Actual)	Interventional	2014-09-30	Completed
An Observational Multi-cite Study to Evaluate and Compare the Effectiveness of Various Tooth Specific Treatments in the Management of Early Caries Lesions [NCT04933331]		744 participants (Anticipated)	Observational	2020-12-07	Active, not recruiting
Randomized Clinical Trial on Traditional Healing Versus Moist Healing Environment (MHE) Applied to Minor Surgery in the Exeresis of Skin Tags [NCT04161274]		275 participants (Actual)	Interventional	2019-01-01	Completed
Comparison of Phenol and Silver Nitrate Application in the Sacrococcygeal Pilonidal Sinus: A Prospective Randomized Controlled Study [NCT04560049]	Phase 4	140 participants (Anticipated)	Interventional	2020-06-03	Recruiting
Treatment of Tracheostomy Granulomas [NCT02116608]	Phase 4	26 participants (Actual)	Interventional	2014-09-30	Completed
Comparing the Use of Sulfamylon 5%, Dakins 0.025%, Cerium, Silver Nitrate 5% and/or Other Topical Antimicrobial Products for the Treatment of Excised and/or Grafted Burn Wounds [NCT00675922]	Phase 2/Phase 3	98 participants (Actual)	Interventional	1995-07-31	Terminated(stopped due to Data inconclusive.)
Pivotal Multi Center, Randomized, Controlled, Single-Blinded Study Comparing the Silver Nitrate Coated Indwelling Pleural Catheter to the Uncoated PleurX Catheter for the Management of Symptomatic, Recurrent, Malignant Pleural Effusions [NCT02649894]		119 participants (Actual)	Interventional	2016-05-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Class	Description
silver salt
inorganic nitrate salt
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
podophyllotoxin glucosides metabolism	0	14
podophyllotoxin glucosides metabolism	0	17
rutin degradation	2	30

Trial	Outcome
NCT00675922 (1) [back to overview]	Infection Rate
NCT01143116 (13) [back to overview]	Blood Silver Concentration Change From Baseline and After 24 Hours
NCT01143116 (13) [back to overview]	Blood Silver Concentration Change From Baseline and After 48 Hours
NCT01143116 (13) [back to overview]	Blood Silver Concentration Change From Baseline and After 7-14 Days
NCT01143116 (13) [back to overview]	Enterococcus Faecalis Mean Bacteria Count Change From Baseline to 12 Hours
NCT01143116 (13) [back to overview]	Enterococcus Faecalis Mean Bacteria Count Change From Baseline to 24 Hours
NCT01143116 (13) [back to overview]	Escherichia Coli Mean Bacteria Count Change From Baseline to 12 Hours
NCT01143116 (13) [back to overview]	Escherichia Coli Mean Bacteria Count Change From Baseline to 24 Hours
NCT01143116 (13) [back to overview]	Total Bacteria Count Change From Baseline and After 24 Hours.
NCT01143116 (13) [back to overview]	Total Bacteria Count Change From Baseline and After 48 Hours.
NCT01143116 (13) [back to overview]	Total Bacteria Count Change From Baseline and After 7-14 Days.
NCT01143116 (13) [back to overview]	Urine Silver Concentration Change From Baseline and After 48 Hours
NCT01143116 (13) [back to overview]	Urine Silver Concentration Change From Baseline to 24 Hours
NCT01143116 (13) [back to overview]	Urine Silver Concentration Change From Baseline to 7-14 Days
NCT02116608 (2) [back to overview]	Categorical Improvement (Degree of Improvement)
NCT02116608 (2) [back to overview]	Success and Failure Rates for Each Treatment Method
NCT02519738 (1) [back to overview]	Decrease in Size (mm) of Granulation Tissue
NCT02649894 (8) [back to overview]	Incidence of Empyema and Cellulitis
NCT02649894 (8) [back to overview]	Incidence of IPC Occlusion
NCT02649894 (8) [back to overview]	The Proportion of Subjects Achieving Pleurodesis Without Recurrence.
NCT02649894 (8) [back to overview]	Time to Confirmed Pleurodesis
NCT02649894 (8) [back to overview]	Time to Recurrence
NCT02649894 (8) [back to overview]	Pain Using 100 mm Visual Analog Scale (VAS)
NCT02649894 (8) [back to overview]	Proportion of Subjects With Confirmed Pleurodesis and Without Recurrence 30 Days After IPC Placement by Cancer Type (Lung, Breast and Others).
NCT02649894 (8) [back to overview]	Proportion of Surviving Subjects Without a Trapped Lung Diagnosis Following IPC Placement Who Have Confirmed Pleurodesis Without Recurrence at 14, 30, 60, 90 Days.

Intervention	percentage of participants (Number)
Percent Infections:Sulfamylon Site	72
Percent Infections: Silver Nitrate Site	74

Intervention	Participants (Count of Participants)
	Worsening	No improvement	Minimal improvement: < 50% improvement	Improvement: 50-90% improvement	Complete resolution: >90% improvement
Group 1: Betadine	0	1	2	2	4
Group 2: Hydrocortisone Butyrate Cream, 1.0%	2	1	1	0	3
Group 3: Silver Nitrate	2	0	0	0	5

Intervention	Participants (Count of Participants)
	Success	Failure
Group 1: Betadine	6	3
Group 2: Hydrocortisone Butyrate Cream, 1.0%	3	4
Group 3: Silver Nitrate	5	2

Intervention	mm^2 (Mean)
	Pre-Treatment	Post-Treatment	Change from pre-post
Kenalog (Triamcinolone)	83.14	45.06	37.95
Silver Nitrate	101.12	22.36	78.77
Washcloth Abrasion	121.72	140.54	-18.81

Intervention	Participants (Count of Participants)
Silver Nitrate Coated Indwelling Pleural Catheter (SNCIPC)	3
Approved Uncoated PleurX Indwelling Pleural Catheter	2

Intervention	days (Mean)
Silver Nitrate Coated Indwelling Pleural Catheter (SNCIPC)	11.4
Approved Uncoated PleurX Indwelling Pleural Catheter	18.7

Intervention	units on a scale (Mean)
	Baseline	Day 7	Day 14	Day 30	Day 45	Day 60	Day 75	Day 90
Approved Uncoated PleurX Indwelling Pleural Catheter	18.0	10.3	4.6	10.2	8.6	12.9	6.4	9.2
Silver Nitrate Coated Indwelling Pleural Catheter (SNCIPC)	22.7	16.9	9.8	10.0	8.4	10.7	7.4	9.6

Intervention	nmol Ag/mmol creatinine (Mean)
Catheter A	-0.02
Catheter B	-0.02

Intervention	nmol Ag/mmol creatinine (Mean)
Catheter A	5.15
Catheter B	6.20

Intervention	proportion of participants (Number)
	Lung Cancer	Breast Cancer	Other Cancer
Approved Uncoated PleurX Indwelling Pleural Catheter	0.4545	0.1429	0.3158
Silver Nitrate Coated Indwelling Pleural Catheter (SNCIPC)	0.2222	0.2000	0.2273

chemdatabank.com

silver nitrate

Description

Cross-References

Synonyms (118)

Research Excerpts

Overview

Effects

Actions

Treatment

Toxicity

Compound-Compound Interactions

Bioavailability

Dosage Studied

Occurs in Manufacturing (8 Product(s))

Product Categories

Products

Roles (1)

Drug Classes (2)

Pathways (2)

Bioassays (43)

Research

Studies (3,102)

Market Indicators

Research Demand Index: 86.46

Study Types

Clinical Trials (19)

Trial Overview

Trial Outcomes

Infection Rate

Blood Silver Concentration Change From Baseline and After 24 Hours

Blood Silver Concentration Change From Baseline and After 48 Hours

Blood Silver Concentration Change From Baseline and After 7-14 Days

Enterococcus Faecalis Mean Bacteria Count Change From Baseline to 12 Hours

Enterococcus Faecalis Mean Bacteria Count Change From Baseline to 24 Hours

Escherichia Coli Mean Bacteria Count Change From Baseline to 12 Hours

Escherichia Coli Mean Bacteria Count Change From Baseline to 24 Hours

Total Bacteria Count Change From Baseline and After 24 Hours.

Total Bacteria Count Change From Baseline and After 48 Hours.

Total Bacteria Count Change From Baseline and After 7-14 Days.

Urine Silver Concentration Change From Baseline and After 48 Hours

Urine Silver Concentration Change From Baseline to 24 Hours

Urine Silver Concentration Change From Baseline to 7-14 Days

Categorical Improvement (Degree of Improvement)

Success and Failure Rates for Each Treatment Method

Decrease in Size (mm) of Granulation Tissue

Incidence of Empyema and Cellulitis

Incidence of IPC Occlusion

The Proportion of Subjects Achieving Pleurodesis Without Recurrence.

Time to Confirmed Pleurodesis

Time to Recurrence

Pain Using 100 mm Visual Analog Scale (VAS)

Proportion of Subjects With Confirmed Pleurodesis and Without Recurrence 30 Days After IPC Placement by Cancer Type (Lung, Breast and Others).

Proportion of Surviving Subjects Without a Trapped Lung Diagnosis Following IPC Placement Who Have Confirmed Pleurodesis Without Recurrence at 14, 30, 60, 90 Days.

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Related Conditions (1,084)