papaverine has been researched along with Necrosis in 13 studies
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomized, double-blind prospective study involving 495 patients, we investigated whether the addition of papaverine, 60 mg, to our existing regimen of cold cardioplegia would reduce myocardial necrosis during elective coronary artery bypass operations." | 9.06 | Addition of papaverine to cardioplegia does not reduce myocardial necrosis. ( Cooley, DA; Duncan, JM; Frazier, OH; Keats, AS; Livesay, JJ; Ott, DA; Reul, GJ; Slogoff, S, 1986) |
| " Our results demonstrate that iodide in excess, after being oxidized or organified, is directly toxic for iodine-deficient thyroid cells." | 5.27 | Direct toxic effect of iodide in excess on iodine-deficient thyroid glands: epithelial necrosis and inflammation associated with lipofuscin accumulation. ( Colin, I; Denef, JF; Mahmoud, I; Many, MC, 1986) |
| "In a randomized, double-blind prospective study involving 495 patients, we investigated whether the addition of papaverine, 60 mg, to our existing regimen of cold cardioplegia would reduce myocardial necrosis during elective coronary artery bypass operations." | 5.06 | Addition of papaverine to cardioplegia does not reduce myocardial necrosis. ( Cooley, DA; Duncan, JM; Frazier, OH; Keats, AS; Livesay, JJ; Ott, DA; Reul, GJ; Slogoff, S, 1986) |
| " The IL-6 antagonist LMT-28 prevented impairment of cerebral autoregulation and hippocampal CA1 and CA3 neuronal necrosis after FPI." | 3.91 | Inhaled Nitric Oxide Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis After Traumatic Brain Injury Through Inhibition of ET-1, ERK MAPK and IL-6 Upregulation in Pigs. ( Armstead, WM; Curvello, V; Hekierski, H; Pastor, P, 2019) |
| " Using an ischemic ventral pedicled island cutaneous flap model, 30 adult Sprague-Dawley rats were divided into groups and treated with BTX, papaverine, or saline to the intact vascular pedicle to determine the percentage of tissue necrosis and ischemia." | 3.75 | Effects of perivascular Botulinum Toxin-A application on vascular smooth muscle and flap viability in the rat. ( Arnold, PB; Campbell, CA; Drake, DB; Merritt, W; Morgan, RF; Rodeheaver, GT, 2009) |
| " Our results demonstrate that iodide in excess, after being oxidized or organified, is directly toxic for iodine-deficient thyroid cells." | 1.27 | Direct toxic effect of iodide in excess on iodine-deficient thyroid glands: epithelial necrosis and inflammation associated with lipofuscin accumulation. ( Colin, I; Denef, JF; Mahmoud, I; Many, MC, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (69.23) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ricci, JA | 1 |
| Singhal, D | 1 |
| Fukudome, EY | 1 |
| Tobias, AM | 1 |
| Lin, SJ | 1 |
| Lee, BT | 1 |
| Curvello, V | 1 |
| Pastor, P | 1 |
| Hekierski, H | 1 |
| Armstead, WM | 1 |
| Arnold, PB | 1 |
| Merritt, W | 1 |
| Rodeheaver, GT | 1 |
| Campbell, CA | 1 |
| Morgan, RF | 1 |
| Drake, DB | 1 |
| YERASIMIDES, TG | 1 |
| MARGOLIS, G | 1 |
| PONTON, HJ | 1 |
| Schlack, W | 1 |
| Uebing, A | 1 |
| Schäfer, M | 1 |
| Bier, F | 1 |
| Grunert, S | 1 |
| Ebel, D | 1 |
| Piper, HM | 1 |
| Thämer, V | 1 |
| Cifaldi, S | 1 |
| Viglietto, A | 1 |
| Marone, G | 1 |
| Azzinnari, G | 1 |
| Colantuoni, A | 1 |
| Slogoff, S | 1 |
| Keats, AS | 1 |
| Cooley, DA | 1 |
| Reul, GJ | 1 |
| Frazier, OH | 1 |
| Ott, DA | 1 |
| Duncan, JM | 1 |
| Livesay, JJ | 1 |
| García-Porrero, JA | 1 |
| Colvee, E | 1 |
| Ojeda, JL | 1 |
| Mahmoud, I | 1 |
| Colin, I | 1 |
| Many, MC | 1 |
| Denef, JF | 1 |
| Severin, SE | 1 |
| Keen, TE | 1 |
| Mac Gowan, WA | 1 |
| Holland, PD | 1 |
| Browne, HI | 1 |
| Byrnes, DP | 1 |
| Bour, H | 1 |
| Renoux, M | 1 |
| Guy-Grand, B | 1 |
| Tutin, M | 1 |
| Costil, J | 1 |
| Escande, C | 1 |
1 trial available for papaverine and Necrosis
| Article | Year |
|---|---|
Addition of papaverine to cardioplegia does not reduce myocardial necrosis.
Topics: Clinical Trials as Topic; Constriction; Coronary Artery Bypass; Creatine Kinase; Double-Blind Method | 1986 |
12 other studies available for papaverine and Necrosis
| Article | Year |
|---|---|
Topical nitroglycerin for the treatment of intraoperative microsurgical vasospasm.
Topics: Administration, Topical; Adult; Anastomosis, Surgical; Breast; Cohort Studies; Female; Follow-Up Stu | 2018 |
Inhaled Nitric Oxide Protects Cerebral Autoregulation and Reduces Hippocampal Necrosis After Traumatic Brain Injury Through Inhibition of ET-1, ERK MAPK and IL-6 Upregulation in Pigs.
Topics: Administration, Inhalation; Animals; Animals, Newborn; Brain Injuries, Traumatic; Disease Models, An | 2019 |
Effects of perivascular Botulinum Toxin-A application on vascular smooth muscle and flap viability in the rat.
Topics: Animals; Botulinum Toxins, Type A; Ischemia; Muscle, Smooth, Vascular; Necrosis; Papaverine; Rats; R | 2009 |
PROPHYLAXIS OF EXPERIMENTAL CONTRAST MEDIUM INJURY TO THE SPINAL CORD BY VASODEPRESSOR DRUGS.
Topics: Acetrizoic Acid; Angiography; Blood Circulation; Blood Pressure; Blood Pressure Determination; Contr | 1963 |
Intracoronary SIN-1C during reperfusion reduces infarct size in dog.
Topics: Acetonitriles; Animals; Coronary Circulation; Dogs; Electrocardiography; Female; Infusions, Intraven | 1995 |
[Hyperbaric oxygen and coronary dilator agents in experimental necrosis of the myocardium in rats].
Topics: Animals; Dipyridamole; Hyperbaric Oxygenation; Myocardial Infarction; Necrosis; Papaverine; Rats; Va | 1975 |
Retinal cell death occurs in the absence of retinal disc invagination: experimental evidence in papaverine-treated chicken embryos.
Topics: Animals; Calcium; Cell Survival; Chick Embryo; Lens, Crystalline; Morphogenesis; Necrosis; Papaverin | 1987 |
Direct toxic effect of iodide in excess on iodine-deficient thyroid glands: epithelial necrosis and inflammation associated with lipofuscin accumulation.
Topics: Animals; Epithelium; Humans; Iodides; Iodine; Lipofuscin; Male; Mice; Mice, Inbred ICR; Microscopy, | 1986 |
[Basic directions in the study of the biochemistry of the myocardium].
Topics: Adaptation, Physiological; Animals; Camphor; Cardiac Glycosides; Cardiomegaly; Cardiovascular Diseas | 1967 |
Recent investigations on sea-wasp stingings in Australia.
Topics: Animals; Antitoxins; Atropine; Bites and Stings; Cnidaria; Epinephrine; Gluconates; Hemolysis; Hydro | 1970 |
The local effects of intra-arterial injections of sodium tetradecyl sulphate (S.T.D) 3 per cent. An experimental study.
Topics: Angiography; Animals; Arterial Occlusive Diseases; Blood; Contrast Media; Disease Models, Animal; Do | 1972 |
[Horton's disease with bilateral eye involvment, cutaneous and lingual necrosis].
Topics: Aged; Angiography; Blindness; Cortisone; Dexamethasone; Ergotamine; Female; Gangrene; Giant Cell Art | 1969 |