Proteins > Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Page last updated: 2024-08-07 13:30:47

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

A protein phosphatase 3 catalytic subunit alpha that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q08209]

Synonyms

EC 3.1.3.16;
CAM-PRP catalytic subunit;
Calmodulin-dependent calcineurin A subunit alpha isoform

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (50.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (3)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tacrolimus	Homo sapiens (human)	IC50	0.0148	1	1
tamoxifen	Homo sapiens (human)	IC50	30.5730	1	0
cyclosporine	Homo sapiens (human)	IC50	0.1830	1	1

Enables

This protein enables 11 target(s):

Target	Category	Definition
protein serine/threonine phosphatase activity	molecular function	Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. [GOC:bf]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
cyclosporin A binding	molecular function	Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. [GOC:mb]
myosin phosphatase activity	molecular function	Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate. [EC:3.1.3.16]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
calmodulin-dependent protein phosphatase activity	molecular function	Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin. [GOC:mah, PMID:15359118]
protein-containing complex binding	molecular function	Binding to a macromolecular complex. [GOC:jl]
protein dimerization activity	molecular function	The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. [ISBN:0198506732]
ATPase binding	molecular function	Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]

Located In

This protein is located in 12 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
extrinsic component of plasma membrane	cellular component	The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:curators, GOC:dos]
Z disc	cellular component	Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached. [GOC:mtg_muscle, ISBN:0815316194]
slit diaphragm	cellular component	A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration. [GOC:mtg_kidney_jan10, GOC:rph, PMID:12386277, PMID:15994232, PMID:18971929, PMID:19478094]
sarcolemma	cellular component	The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers. [ISBN:0198506732]
dendritic spine	cellular component	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln]
Schaffer collateral - CA1 synapse	cellular component	A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. [PMID:16399689]
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
calcineurin complex	cellular component	A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin. [PMID:26794871]
protein serine/threonine phosphatase complex	cellular component	A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. [GOC:bf]

Involved In

This protein is involved in 46 target(s):

Target	Category	Definition
G1/S transition of mitotic cell cycle	biological process	The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. [GOC:mtg_cell_cycle]
response to amphetamine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine. [GOC:dph, GOC:ef]
protein dephosphorylation	biological process	The process of removing one or more phosphoric residues from a protein. [GOC:hb]
protein import into nucleus	biological process	The directed movement of a protein from the cytoplasm to the nucleus. [GOC:jl]
calcium ion transport	biological process	The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
epidermis development	biological process	The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species. [GOC:go_curators, UBERON:0001003]
positive regulation of gene expression	biological process	Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
negative regulation of gene expression	biological process	Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]
transition between fast and slow fiber	biological process	The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation. [GOC:ef, GOC:mtg_muscle]
cardiac muscle hypertrophy in response to stress	biological process	The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]
dephosphorylation	biological process	The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732]
negative regulation of signaling	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process. [GOC:mtg_signal]
keratinocyte differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte. [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb]
positive regulation of cell migration	biological process	Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
calcineurin-NFAT signaling cascade	biological process	Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). [GOC:lm, GOC:mah, PMID:12975316, PMID:15928679]
multicellular organismal response to stress	biological process	Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). [GOC:mah]
wound healing	biological process	The series of events that restore integrity to a damaged tissue, following an injury. [GOC:bf, PMID:15269788]
positive regulation of activated T cell proliferation	biological process	Any process that activates or increases the rate or extent of activated T cell proliferation. [GOC:jl]
T cell activation	biological process	The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]
skeletal muscle tissue regeneration	biological process	The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage. [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119]
positive regulation of osteoblast differentiation	biological process	Any process that activates or increases the frequency, rate or extent of osteoblast differentiation. [GOC:go_curators]
positive regulation of osteoclast differentiation	biological process	Any process that activates or increases the frequency, rate or extent of osteoclast differentiation. [GOC:go_curators]
positive regulation of cell adhesion	biological process	Any process that activates or increases the frequency, rate or extent of cell adhesion. [GOC:go_curators]
positive regulation of endocytosis	biological process	Any process that activates or increases the frequency, rate or extent of endocytosis. [GOC:go_curators]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
negative regulation of insulin secretion	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin. [GOC:ai]
positive regulation of saliva secretion	biological process	Any process that activates or increases the frequency, rate or extent of the regulated release of saliva. [GOC:ai]
skeletal muscle fiber development	biological process	The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast. [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle]
dendrite morphogenesis	biological process	The process in which the anatomical structures of a dendrite are generated and organized. [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681]
negative regulation of dendrite morphogenesis	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis. [GOC:ai]
modulation of chemical synaptic transmission	biological process	Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. [GOC:ai]
response to calcium ion	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. [GOC:ai]
excitatory postsynaptic potential	biological process	A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. [GOC:dph, GOC:ef]
regulation of cell proliferation involved in kidney morphogenesis	biological process	Any process that modulates the frequency, rate or extent of cell proliferation that contributes to the shaping of the kidney. [GOC:dph, GOC:mtg_kidney_jan10]
peptidyl-serine dephosphorylation	biological process	The removal of phosphoric residues from peptidyl-O-phospho-L-serine to form peptidyl-serine. [GOC:bf]
positive regulation of calcineurin-NFAT signaling cascade	biological process	Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade. [GOC:mah]
cellular response to glucose stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:mah]
positive regulation of glomerulus development	biological process	Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney. [GOC:dph, GOC:tb, GOC:yaf]
renal filtration	biological process	A renal system process in which fluid circulating through the body is filtered through a barrier system. [GOC:pr, GOC:sart]
calcineurin-mediated signaling	biological process	Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression. [GOC:di, PMID:25655284, PMID:25878052, PMID:26851544]
postsynaptic modulation of chemical synaptic transmission	biological process	Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. [GOC:dos]
negative regulation of angiotensin-activated signaling pathway	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the angiotensin-activated signaling pathway. [GOC:lf, PMID:28784619]
positive regulation of cardiac muscle hypertrophy in response to stress	biological process	Any process that activates or increases the frequency, rate or extent of cardiac muscle hypertrophy in response to stress. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19287093]
positive regulation of connective tissue replacement	biological process	Any process that activates or increases the frequency, rate or extent of connective tissue replacement. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:25590961]
positive regulation of calcium ion import across plasma membrane	biological process	Any process that activates or increases the frequency, rate or extent of calcium ion import across plasma membrane. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527]
negative regulation of calcium ion import across plasma membrane	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of calcium ion import across plasma membrane. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:17640527]