La-related protein 7

A La-related protein 7 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q4G0J3]

Synonyms

La ribonucleoprotein domain family member 7;
hLARP7;
P-TEFb-interaction protein for 7SK stability;
PIP7S

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
alvocidib	Homo sapiens (human)	Ki	0.0030	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
U6 snRNA binding	molecular function	Binding to a U6 small nuclear RNA (U6 snRNA). [GOC:mah]
7SK snRNA binding	molecular function	Binding to a 7SK small nuclear RNA (7SK snRNA). [GOC:nhn, PMID:21853533]
mRNA binding	molecular function	Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. [GOC:kmv, GOC:pr, SO:0000234]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
7SK snRNP	cellular component	A ribonucleoprotein complex that contains the 7SK snRNA. The 7SK snRNP plays a central role in RNA polymerase II elongation control by regulating the availability of active P-TEFb. [PMID:18249148, PMID:28431135]
ribonucleoprotein complex	cellular component	A macromolecular complex that contains both RNA and protein molecules. [GOC:krc, GOC:vesicles]

Involved In

This protein is involved in 12 target(s):

Target	Category	Definition
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
box C/D sno(s)RNA 3'-end processing	biological process	Any process involved in forming the mature 3' end of a box C/D RNA molecule. [GOC:krc]
mRNA processing	biological process	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. [GOC:mah]
spermatogenesis	biological process	The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821]
RNA splicing	biological process	The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. [GOC:krc, GOC:mah]
cell differentiation	biological process	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
negative regulation of viral transcription	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription. [GOC:mah]
negative regulation of transcription elongation by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH]
regulation of mRNA splicing, via spliceosome	biological process	Any process that modulates the frequency, rate or extent of mRNA splicing via a spliceosomal mechanism. [GOC:jid]
positive regulation of protein localization to Cajal body	biological process	Any process that activates or increases the frequency, rate or extent of protein localization to Cajal body. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:25467444]
positive regulation of snRNA transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of snRNA transcription mediated by RNA polymerase II. [GO_REF:0000058, GOC:bhm, GOC:TermGenie, PMID:10022900]
U6 2'-O-snRNA methylation	biological process	The posttranscriptional addition a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule. [PMID:11842100, PMID:9844635]