Page last updated: 2024-08-07 23:05:10
Bile salt export pump
A bile salt export pump that is encoded in the genome of rat. [OMA:O70127, PRO:DNx]
Synonyms
EC 7.6.2.-;
ATP-binding cassette sub-family B member 11;
Sister of P-glycoprotein
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 5 (55.56) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (89)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| betaine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| salicylic acid | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| pyridoxine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| tacrine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| acetaminophen | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| azathioprine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| buspirone | Rattus norvegicus (Norway rat) | IC50 | 369.8000 | 1 | 1 |
| verapamil | Rattus norvegicus (Norway rat) | Ki | 92.5000 | 1 | 1 |
| carbamazepine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| carmustine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| chlorpromazine | Rattus norvegicus (Norway rat) | IC50 | 122.3000 | 1 | 1 |
| chlorpropamide | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| ciprofibrate | Rattus norvegicus (Norway rat) | IC50 | 189.9000 | 1 | 1 |
| cromolyn | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| dapsone | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| valproic acid | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| donepezil | Rattus norvegicus (Norway rat) | IC50 | 519.3000 | 1 | 1 |
| felbamate | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| flumazenil | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| flutamide | Rattus norvegicus (Norway rat) | IC50 | 78.7000 | 1 | 1 |
| furosemide | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| glafenine | Rattus norvegicus (Norway rat) | IC50 | 32.2000 | 1 | 1 |
| gliclazide | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| glyburide | Rattus norvegicus (Norway rat) | IC50 | 9.0333 | 3 | 3 |
| glyburide | Rattus norvegicus (Norway rat) | Ki | 6.1000 | 1 | 1 |
| ibuprofen | Rattus norvegicus (Norway rat) | IC50 | 290.9000 | 1 | 1 |
| iproniazid | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| isoniazid | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| isoproterenol | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| ketoconazole | Rattus norvegicus (Norway rat) | IC50 | 15.6000 | 1 | 1 |
| ketotifen | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| leflunomide | Rattus norvegicus (Norway rat) | IC50 | 111.6000 | 1 | 1 |
| methapyrilene | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| nefazodone | Rattus norvegicus (Norway rat) | IC50 | 17.4000 | 1 | 1 |
| nifedipine | Rattus norvegicus (Norway rat) | IC50 | 45.4000 | 1 | 1 |
| nomifensine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| pargyline | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| picotamide | Rattus norvegicus (Norway rat) | IC50 | 636.5000 | 1 | 1 |
| pinacidil | Rattus norvegicus (Norway rat) | IC50 | 221.6000 | 1 | 1 |
| pioglitazone | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| practolol | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| praziquantel | Rattus norvegicus (Norway rat) | IC50 | 153.3000 | 1 | 1 |
| probenecid | Rattus norvegicus (Norway rat) | IC50 | 509.9000 | 1 | 1 |
| propranolol | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| ranitidine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| sulpiride | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| ticlopidine | Rattus norvegicus (Norway rat) | IC50 | 49.0000 | 1 | 1 |
| tolbutamide | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| troglitazone | Rattus norvegicus (Norway rat) | IC50 | 7.2500 | 2 | 2 |
| penicillamine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| physostigmine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| cloxacillin | Rattus norvegicus (Norway rat) | IC50 | 376.7000 | 1 | 1 |
| cycloserine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| cinchophen | Rattus norvegicus (Norway rat) | IC50 | 295.8000 | 1 | 1 |
| dihydralazine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| dicloxacillin | Rattus norvegicus (Norway rat) | IC50 | 111.1000 | 1 | 1 |
| streptomycin | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| floxacillin | Rattus norvegicus (Norway rat) | IC50 | 429.1000 | 1 | 1 |
| fenclozic acid | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| clobetasol propionate | Rattus norvegicus (Norway rat) | IC50 | 35.0000 | 1 | 1 |
| amoxicillin | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| methyldopa | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| bezafibrate | Rattus norvegicus (Norway rat) | IC50 | 391.0000 | 1 | 1 |
| benoxaprofen | Rattus norvegicus (Norway rat) | IC50 | 99.1000 | 1 | 1 |
| fialuridine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| alpidem | Rattus norvegicus (Norway rat) | IC50 | 23.0000 | 1 | 1 |
| zileuton | Rattus norvegicus (Norway rat) | IC50 | 564.4000 | 1 | 1 |
| rosiglitazone | Rattus norvegicus (Norway rat) | IC50 | 40.0000 | 1 | 1 |
| bosentan anhydrous | Rattus norvegicus (Norway rat) | IC50 | 30.6000 | 1 | 1 |
| bosentan anhydrous | Rattus norvegicus (Norway rat) | Ki | 12.0000 | 1 | 1 |
| methotrexate | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| levofloxacin | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| erythromycin estolate | Rattus norvegicus (Norway rat) | IC50 | 11.4000 | 1 | 1 |
| methimazole | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| sulindac | Rattus norvegicus (Norway rat) | IC50 | 87.5000 | 1 | 1 |
| fusidic acid | Rattus norvegicus (Norway rat) | IC50 | 17.4000 | 1 | 1 |
| fusidic acid | Rattus norvegicus (Norway rat) | Ki | 2.2000 | 1 | 1 |
| tolcapone | Rattus norvegicus (Norway rat) | IC50 | 47.2000 | 1 | 1 |
| clavulanic acid | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| cyclosporine | Rattus norvegicus (Norway rat) | IC50 | 0.6000 | 1 | 1 |
| cyclosporine | Rattus norvegicus (Norway rat) | Ki | 0.3000 | 1 | 1 |
| acitretin | Rattus norvegicus (Norway rat) | IC50 | 19.7000 | 1 | 1 |
| famotidine | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| rifamycin sv | Rattus norvegicus (Norway rat) | IC50 | 3.1000 | 1 | 1 |
| rifamycin sv | Rattus norvegicus (Norway rat) | Ki | 3.8000 | 1 | 1 |
| nitrofurantoin | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| troglitazone sulfate | Rattus norvegicus (Norway rat) | IC50 | 0.5000 | 2 | 2 |
| acyclovir | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 1 |
| rifampin | Rattus norvegicus (Norway rat) | IC50 | 34.7000 | 1 | 1 |
| rifampin | Rattus norvegicus (Norway rat) | Ki | 11.9000 | 1 | 1 |
| clozapine | Rattus norvegicus (Norway rat) | IC50 | 196.5000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ppi 2458 | Rattus norvegicus (Norway rat) | EC50 | 0.0001 | 1 | 1 |
Drugs with Other Measurements
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:1, 2012
Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt Toxicology, , Oct-05, Volume: 167, Issue:1, 2001
Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver.Gastroenterology, , Volume: 118, Issue:2, 2000
Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bile salt Toxicology, , Oct-05, Volume: 167, Issue:1, 2001
Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump.Biochimica et biophysica acta, , Mar-09, Volume: 1511, Issue:1, 2001
The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver.The Journal of biological chemistry, , Apr-17, Volume: 273, Issue:16, 1998