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Matrix protein 2
An influenzavirus matrix protein 2 that is encoded in the genome of the H1N1 strain A/Puerto Rico/8/1934. [PRO:CNA, PRO:DAN, UniProtKB:P06821]
Synonyms
Proton channel protein M2
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (3)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| amantadine | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 153.9250 | 4 | 4 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| amantadine | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Kd | 0.3200 | 1 | 1 |
| rimantadine | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Kd | 0.0160 | 1 | 1 |
| 2-aminoadamantane | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Kd | 2.3600 | 1 | 1 |
Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus.Journal of medicinal chemistry, , Jul-10, Volume: 57, Issue:13, 2014
3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus.Journal of medicinal chemistry, , Apr-28, Volume: 54, Issue:8, 2011
Interaction of aminoadamantane derivatives with the influenza A virus M2 channel-docking using a pore blocking model.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 20, Issue:14, 2010