Leukotriene B4 receptor 2

A leukotriene B4 receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NPC1]

LTB4-R 2;
LTB4-R2;
LTB4 receptor JULF2;
Leukotriene B4 receptor BLT2;
Seven transmembrane receptor BLTR2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
gentian violet	Homo sapiens (human)	Potency	0.1800	1
1-(10h-phenothiazin-2-yl)ethanone	Homo sapiens (human)	Potency	7.7300	1
spiro[1,3-dihydroperimidine-2,1'-cycloheptane]	Homo sapiens (human)	Potency	13.5000	1
5-(2-furanyl)-N-[1-[(2-methylphenyl)methyl]-3-pyrazolyl]-7-(trifluoromethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide	Homo sapiens (human)	Potency	46.2200	1
1-methyl-N-[4-(4-morpholinyl)phenyl]-2-quinolinimine	Homo sapiens (human)	Potency	95.2400	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sc 41930	Homo sapiens (human)	IC50	2.0450	2	2
sc 41930	Homo sapiens (human)	Ki	0.0120	1	1
ly 255283	Homo sapiens (human)	IC50	1.5250	2	2
ly 255283	Homo sapiens (human)	Ki	0.0850	1	1
rg 14893	Homo sapiens (human)	IC50	0.0047	1	1
ly 293111	Homo sapiens (human)	IC50	0.0033	1	1
ly 293111	Homo sapiens (human)	Ki	0.0170	1	1
cocaine	Homo sapiens (human)	Ki	0.5240	1	1
leukotriene b4	Homo sapiens (human)	Ki	0.0019	1	1
cp 195543	Homo sapiens (human)	IC50	0.0525	3	7
cp 105696	Homo sapiens (human)	IC50	25.7128	3	3

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
candesartan	Homo sapiens (human)	EC50	15.0000	1	1
avapro	Homo sapiens (human)	EC50	0.4100	1	1
bw-755c	Homo sapiens (human)	EC50	6.8000	1	1
tepoxalin	Homo sapiens (human)	EC50	0.0700	1	1
zileuton	Homo sapiens (human)	EC50	0.4700	1	1
valsartan	Homo sapiens (human)	EC50	16.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
nifedipine	Homo sapiens (human)	ID50	0.0100	1	1

This protein enables 3 target(s):

Target	Category	Definition
leukotriene receptor activity	molecular function	Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine. [GOC:ai, ISBN:0198506732]
leukotriene B4 receptor activity	molecular function	Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate. [GOC:ai, ISBN:0198506732]
G protein-coupled peptide receptor activity	molecular function	Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:dph, GOC:tb]

This protein is located in 3 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

This protein is involved in 5 target(s):

Target	Category	Definition
chemotaxis	biological process	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732]
negative regulation of adenylate cyclase activity	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity. [GOC:go_curators]
keratinocyte migration	biological process	The directed movement of a keratinocyte, epidermal cells which synthesize keratin, from one site to another. [ISBN:0721662544]
leukotriene signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by leukotriene binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:dph, PMID:21771892]
neuropeptide signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]