Proteins > ATP-dependent translocase ABCB1
Page last updated: 2024-08-07 16:10:03
ATP-dependent translocase ABCB1
An ATP-dependent translocase ABCB1a that is encoded in the genome of mouse. [PRO:DAN]
Synonyms
ATP-binding cassette sub-family B member 1A;
MDR1A;
Multidrug resistance protein 1A;
7.6.2.2;
Multidrug resistance protein 3;
P-glycoprotein 3;
Phospholipid transporter ABCB1;
7.6.2.1
Research
Bioassay Publications (6)
Timeframe | Studies on this Protein(%) | All Drugs % |
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 5 (83.33) | 29.6817 |
2010's | 1 (16.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Compounds (47)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
mifepristone | Mus musculus (house mouse) | Kd | 20.0000 | 1 | 1 |
naringenin | Mus musculus (house mouse) | Kd | 28.5000 | 1 | 1 |
taxifolin | Mus musculus (house mouse) | Kd | 37.4000 | 1 | 1 |
silybin | Mus musculus (house mouse) | Kd | 6.8000 | 1 | 1 |
kaempferol | Mus musculus (house mouse) | Kd | 6.7000 | 1 | 1 |
galangin | Mus musculus (house mouse) | Kd | 5.9000 | 1 | 1 |
kaempferide | Mus musculus (house mouse) | Kd | 4.7500 | 2 | 2 |
2,3-dehydrosilybin | Mus musculus (house mouse) | Kd | 2.2000 | 1 | 1 |
Drugs with Other Measurements
Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
verapamil | Mus musculus (house mouse) | Km | 10.0000 | 1 | 1 |
Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs.Biochemistry, , 05-16, Volume: 56, Issue:19, 2017
Rhodamine inhibitors of P-glycoprotein: an amide/thioamide "switch" for ATPase activity.Journal of medicinal chemistry, , May-28, Volume: 52, Issue:10, 2009
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.Journal of medicinal chemistry, , Apr-24, Volume: 46, Issue:9, 2003
B-ring substituted 5,7-dihydroxyflavonols with high-affinity binding to P-glycoprotein responsible for cell multidrug resistance.Bioorganic & medicinal chemistry letters, , Jan-08, Volume: 11, Issue:1, 2001
The flavanolignan silybin and its hemisynthetic derivatives, a novel series of potential modulators of P-glycoprotein.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 10, Issue:2, 2000