Page last updated: 2024-08-07 16:10:03

ATP-dependent translocase ABCB1

An ATP-dependent translocase ABCB1a that is encoded in the genome of mouse. [PRO:DAN]

Synonyms

ATP-binding cassette sub-family B member 1A;
MDR1A;
Multidrug resistance protein 1A;
7.6.2.2;
Multidrug resistance protein 3;
P-glycoprotein 3;
Phospholipid transporter ABCB1;
7.6.2.1

Research

Bioassay Publications (6)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (83.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Compounds (47)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
amiodaroneMus musculus (house mouse)Ki2.100011
astemizoleMus musculus (house mouse)IC501.300022
verapamilMus musculus (house mouse)IC5064.333333
cimetidineMus musculus (house mouse)IC5050.000022
clotrimazoleMus musculus (house mouse)IC504.800022
clotrimazoleMus musculus (house mouse)Ki18.300011
fluconazoleMus musculus (house mouse)Ki1,000.000011
itraconazoleMus musculus (house mouse)IC500.200022
ketoconazoleMus musculus (house mouse)IC503.800022
ketoconazoleMus musculus (house mouse)Ki12.800011
miconazoleMus musculus (house mouse)IC507.800022
miconazoleMus musculus (house mouse)Ki22.200011
midazolamMus musculus (house mouse)IC5050.000022
nicardipineMus musculus (house mouse)IC502.500022
ranitidineMus musculus (house mouse)IC5050.000022
terfenadineMus musculus (house mouse)IC5023.000022
reserpineMus musculus (house mouse)Ki4.030011
colchicineMus musculus (house mouse)IC5050.000022
ergotamineMus musculus (house mouse)Ki188.800011
dihydroergotamineMus musculus (house mouse)Ki1,000.000011
erythromycinMus musculus (house mouse)IC5046.500022
erythromycinMus musculus (house mouse)Ki1,000.000011
vinblastineMus musculus (house mouse)IC5050.000022
pimozideMus musculus (house mouse)IC504.900022
bromocriptineMus musculus (house mouse)Ki7.480011
ergocristineMus musculus (house mouse)Ki39.400011
paclitaxelMus musculus (house mouse)IC50327.000011
etoposideMus musculus (house mouse)IC5050.000022
mibefradilMus musculus (house mouse)IC507.400022
nelfinavirMus musculus (house mouse)IC502.300022
ergocornineMus musculus (house mouse)Ki271.500011
dihydroergocristineMus musculus (house mouse)Ki111.500011
dihydroergocryptineMus musculus (house mouse)Ki333.400011
alpha-ergocryptineMus musculus (house mouse)Ki43.500011
troleandomycinMus musculus (house mouse)Ki217.400011
vincaleukoblastineMus musculus (house mouse)IC5013.150012
ritonavirMus musculus (house mouse)IC5050.000022
quinidineMus musculus (house mouse)IC5013.000022
saquinavirMus musculus (house mouse)IC5050.000022
ergonovineMus musculus (house mouse)Ki117.500011
digoxinMus musculus (house mouse)IC5050.000022
cyclosporineMus musculus (house mouse)IC504.800022
cyclosporineMus musculus (house mouse)Ki3.650011
morphineMus musculus (house mouse)IC5050.000022

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
mifepristoneMus musculus (house mouse)Kd20.000011
naringeninMus musculus (house mouse)Kd28.500011
taxifolinMus musculus (house mouse)Kd37.400011
silybinMus musculus (house mouse)Kd6.800011
kaempferolMus musculus (house mouse)Kd6.700011
galanginMus musculus (house mouse)Kd5.900011
kaempferideMus musculus (house mouse)Kd4.750022
2,3-dehydrosilybinMus musculus (house mouse)Kd2.200011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
verapamilMus musculus (house mouse)Km10.000011