Page last updated: 2024-08-07 23:57:11
Sonic hedgehog protein
A sonic hedgehog protein that is encoded in the genome of mouse. [OMA:Q62226, PRO:DNx]
Synonyms
SHH;
HHG-1;
Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains;
ShhNC
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (11)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| gant58 | Mus musculus (house mouse) | IC50 | 5.0000 | 1 | 1 |
| gant 61 | Mus musculus (house mouse) | IC50 | 5.0000 | 1 | 1 |
| cyclopamine | Mus musculus (house mouse) | IC50 | 0.7373 | 3 | 3 |
| jk184 | Mus musculus (house mouse) | IC50 | 0.0300 | 1 | 1 |
| cur 61414 | Mus musculus (house mouse) | IC50 | 0.2000 | 2 | 2 |
| lde225 | Mus musculus (house mouse) | IC50 | 0.0055 | 1 | 1 |
| gdc 0449 | Mus musculus (house mouse) | IC50 | 0.0077 | 3 | 3 |
| robotnikinin | Mus musculus (house mouse) | IC50 | 4.0000 | 1 | 1 |
| tak-441 | Mus musculus (house mouse) | IC50 | 0.0044 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| cyclopamine | Mus musculus (house mouse) | EC50 | 0.5000 | 1 | 1 |
| purmorphamine | Mus musculus (house mouse) | EC50 | 1.0000 | 1 | 1 |
| sag compound | Mus musculus (house mouse) | EC50 | 0.0353 | 1 | 2 |
| robotnikinin | Mus musculus (house mouse) | EC50 | 4.0000 | 2 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| robotnikinin | Mus musculus (house mouse) | ECmax | 62.5000 | 1 | 1 |
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
GDC-0449-a potent inhibitor of the hedgehog pathway.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 19, Issue:19, 2009
Hedgehog-Gli signaling pathway inhibitors as anticancer agents.Journal of medicinal chemistry, , Jul-09, Volume: 52, Issue:13, 2009
Inhibiting Hedgehog: An Update on Pharmacological Compounds and Targeting Strategies.Journal of medicinal chemistry, , 09-26, Volume: 62, Issue:18, 2019
Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.Journal of medicinal chemistry, , Apr-14, Volume: 54, Issue:7, 2011
Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 19, Issue:22, 2009