Proteins > Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

Page last updated: 2024-08-07 15:25:49

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

A retinal rod rhodopsin-sensitive cGMP 3,5-cyclic phosphodiesterase subunit delta that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43924]

GMP-PDE delta;
Protein p17

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
dipyridamole	Homo sapiens (human)	Ki	0.1250	1	1
tadalafil	Homo sapiens (human)	IC50	2.9280	5	5
fluconazole	Homo sapiens (human)	IC50	0.0210	1	1
sildenafil	Homo sapiens (human)	IC50	0.0188	4	4
sildenafil	Homo sapiens (human)	Ki	0.0500	1	1
zaprinast	Homo sapiens (human)	Ki	0.4000	1	1
vardenafil	Homo sapiens (human)	IC50	0.0077	3	3

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
rosuvastatin	Homo sapiens (human)	Kd	1.2500	1	1
1-benzyl-2-phenylbenzimidazole	Homo sapiens (human)	Kd	1.8217	3	3
fluconazole	Homo sapiens (human)	Kd	0.0183	4	4

This protein enables 3 target(s):

Target	Category	Definition
GTPase inhibitor activity	molecular function	Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
small GTPase binding	molecular function	Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782]

This protein is located in 5 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
cytoskeleton	cellular component	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, PMID:16959967, PMID:27419875]
cilium	cellular component	A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998]
cytoplasmic vesicle membrane	cellular component	The lipid bilayer surrounding a cytoplasmic vesicle. [GOC:mah]
cytoplasmic vesicle	cellular component	A vesicle found in the cytoplasm of a cell. [GOC:ai, GOC:mah, GOC:vesicles]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 1 target(s):

Target	Category	Definition
visual perception	biological process	The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image. [GOC:ai]