Protein arginine N-methyltransferase 3

A protein arginine N-methyltransferase 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60678]

Synonyms

EC 2.1.1.-;
Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3

Research

Bioassay Publications (7)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (85.71)	24.3611
2020's	1 (14.29)	2.80

Compounds (6)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
c.i. direct red 23	Homo sapiens (human)	IC50	7.1000	1	1
s-adenosylhomocysteine	Homo sapiens (human)	IC50	0.9567	3	3
unc 0321	Homo sapiens (human)	IC50	40.0000	1	1
gsk343	Homo sapiens (human)	IC50	74.0000	1	1
6,7-dimethoxy-2-(pyrrolidin-1-yl)-n-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine	Homo sapiens (human)	IC50	100.0000	1	1
sgc707	Homo sapiens (human)	IC50	0.1065	4	3

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sgc707	Homo sapiens (human)	EC50	1.9000	2	2
sgc707	Homo sapiens (human)	Kd	0.0690	2	0

Enables

This protein enables 8 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
methyltransferase activity	molecular function	Catalysis of the transfer of a methyl group to an acceptor molecule. [ISBN:0198506732]
protein-arginine N-methyltransferase activity	molecular function	Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine. [GOC:mah, PMID:12351636, PMID:31284549]
protein-arginine omega-N monomethyltransferase activity	molecular function	Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine. [EC:2.1.1.321, PMID:14705965, RESID:AA0069]
protein-arginine omega-N asymmetric methyltransferase activity	molecular function	Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues. [PMID:14705965]
ribosome binding	molecular function	Binding to a ribosome. [GOC:go_curators]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
histone methyltransferase activity	molecular function	Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue. [GOC:curators]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
negative regulation of protein ubiquitination	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein. [GOC:mah]
methylation	biological process	The process in which a methyl group is covalently attached to a molecule. [GOC:mah]
negative regulation of retinoic acid biosynthetic process	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of retinoic acid biosynthetic process. [GOC:TermGenie, GOC:yaf]
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine	biological process	The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine. [RESID:AA0068, RESID:AA0069]
chromatin remodeling	biological process	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]