A 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51993]
EC 2.4.1.152;
Fucosyltransferase 6;
Fucosyltransferase VI;
Fuc-TVI;
FucT-VI;
Galactoside 3-L-fucosyltransferase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2,3-dihydroxybenzoic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| protocatechuic acid | Homo sapiens (human) | IC50 | 137.0000 | 1 | 1 |
| gallic acid | Homo sapiens (human) | IC50 | 65.0086 | 1 | 7 |
| beta-resorcylic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 2,5-dihydroxybenzoic acid | Homo sapiens (human) | IC50 | 115.0000 | 1 | 1 |
| veratric acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| methyl gallate | Homo sapiens (human) | IC50 | 26.5000 | 1 | 2 |
| 3,4,5-trimethoxybenzoic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| syringic acid | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| epigallocatechin gallate | Homo sapiens (human) | IC50 | 7.2833 | 1 | 6 |
| guanosine diphosphate | Homo sapiens (human) | IC50 | 125.2600 | 1 | 5 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| fucosyltransferase activity | molecular function | Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai] |
| 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity | molecular function | Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R. [EC:2.4.1.152, RHEA:14257] |
| alpha-(1->3)-fucosyltransferase activity | molecular function | Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage. [GOC:ai] |
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| Golgi membrane | cellular component | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] |
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| Golgi cisterna membrane | cellular component | The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex. [GOC:ecd, GOC:mah] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| methylosome | cellular component | A large (20 S) protein complex that possesses protein arginine methyltransferase activity and modifies specific arginines to dimethylarginines in the arginine- and glycine-rich domains of several spliceosomal Sm proteins, thereby targeting these proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein (snRNP) core particles. Proteins found in the methylosome include the methyltransferase JBP1 (PRMT5), pICln (CLNS1A), MEP50 (WDR77), and unmethylated forms of SM proteins that have RG domains. [PMID:11713266, PMID:11756452] |
This protein is involved in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| protein glycosylation | biological process | A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. [GOC:curators, GOC:pr] |
| protein N-linked glycosylation | biological process | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327] |
| protein O-linked glycosylation | biological process | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212] |
| ceramide metabolic process | biological process | The chemical reactions and pathways involving ceramides, any N-acylated sphingoid. [ISBN:0198547684] |
| glycosphingolipid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [GOC:go_curators] |
| oligosaccharide biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732] |
| N-glycan fucosylation | biological process | The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains. [GOC:sart, PMID:19948734] |
| L-fucose catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose). [GOC:jl] |
| oocyte axis specification | biological process | The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster. [GOC:mtg_sensu, ISBN:0879694238] |