Page last updated: 2024-08-07 15:31:18
Tyrosine-protein kinase ABL1
A tyrosine-protein kinase ABL1 that is encoded in the genome of mouse. [OMA:P00520, PRO:DNx]
Synonyms
EC 2.7.10.2;
Abelson murine leukemia viral oncogene homolog 1;
Abelson tyrosine-protein kinase 1;
Proto-oncogene c-Abl;
p150
Research
Bioassay Publications (7)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| imatinib | Mus musculus (house mouse) | IC50 | 6.9236 | 3 | 3 |
| birb 796 | Mus musculus (house mouse) | IC50 | 14.6000 | 1 | 1 |
| sorafenib | Mus musculus (house mouse) | IC50 | 0.2259 | 1 | 1 |
| repsox | Mus musculus (house mouse) | IC50 | 21.0000 | 1 | 1 |
| dasatinib | Mus musculus (house mouse) | GI50 | 0.0010 | 1 | 1 |
| vx680 | Mus musculus (house mouse) | IC50 | 5.0000 | 1 | 1 |
| crizotinib | Mus musculus (house mouse) | IC50 | 1.1590 | 1 | 1 |
| kx-01 | Mus musculus (house mouse) | GI50 | 0.0850 | 1 | 1 |
| thiopental sodium | Mus musculus (house mouse) | IC50 | 12.9850 | 2 | 2 |
Drugs with Activation Measurements
Design, synthesis and biological evaluation of WZ4002 analogues as EGFR inhibitors.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 27, Issue:21, 2017
The design, synthesis, and evaluation of 8 hybrid DFG-out allosteric kinase inhibitors: a structural analysis of the binding interactions of Gleevec, Nexavar, and BIRB-796.Bioorganic & medicinal chemistry, , Aug-01, Volume: 18, Issue:15, 2010