Compounds > trimethyltin
Page last updated: 2024-09-21

trimethyltin

Description

trimethyltin : An organotin compound that consists of stannane in which three of the four hydrogens are substituted by methyl groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5358116
MeSH IDM0134655

Synonyms (10)

Synonym
(ch3)3snh
stannane, trimethyl-
trimethyltin
1631-73-8
LYRCQNDYYRPFMF-UHFFFAOYSA-N
trimethyltin(iv)
stannyl, trimethyl-
DTXSID6035102
zn8 ,
DTXSID801315666

Research

Studies (325)

TimeframeStudies, This Drug (%)All Drugs %
pre-199042 (12.92)18.7374
1990's80 (24.62)18.2507
2000's95 (29.23)29.6817
2010's84 (25.85)24.3611
2020's24 (7.38)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews15 (4.23%)6.00%
Case Studies7 (1.97%)4.05%
Observational0 (0.00%)0.25%
Other333 (93.80%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
sinomenine[no description available]medium10morphinane alkaloid
morphinans[no description available]medium10isoquinoline alkaloid fundamental parent;
morphinane alkaloid
rottlerin[no description available]medium30aromatic ketone;
benzenetriol;
chromenol;
enone;
methyl ketone		anti-allergic agent;
antihypertensive agent;
antineoplastic agent;
apoptosis inducer;
K-ATP channel agonist;
metabolite
curcumin[no description available]medium10aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol		anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger
baclofen[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid;
monochlorobenzenes;
primary amino compound		central nervous system depressant;
GABA agonist;
muscle relaxant
memantine[no description available]medium10adamantanes;
primary aliphatic amine		antidepressant;
antiparkinson drug;
dopaminergic agent;
neuroprotective agent;
NMDA receptor antagonist
beta-escin[no description available]medium10
bacopaside i[no description available]medium10
malondialdehyde[no description available]medium40dialdehydebiomarker
cytidine diphosphate choline[no description available]medium10nucleotide-(amino alcohol)s;
phosphocholines		human metabolite;
mouse metabolite;
neuroprotective agent;
psychotropic drug;
Saccharomyces cerevisiae metabolite
ginsenoside re[no description available]medium1012beta-hydroxy steroid;
3beta-hydroxy-4,4-dimethylsteroid;
3beta-hydroxy steroid;
beta-D-glucoside;
disaccharide derivative;
ginsenoside;
tetracyclic triterpenoid		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
nephroprotective agent;
neuroprotective agent;
plant metabolite
ginsenosides[no description available]medium20
bradykinin[no description available]medium10oligopeptidehuman blood serum metabolite;
vasodilator agent
clavulanic acid[no description available]medium10oxapenamantibacterial drug;
anxiolytic drug;
bacterial metabolite;
EC 3.5.2.6 (beta-lactamase) inhibitor
erucyl amide[no description available]medium1013-docosenamideEC 3.1.1.7 (acetylcholinesterase) inhibitor;
human metabolite;
mammalian metabolite;
plant metabolite;
rat metabolite
ginsenoside rh2[no description available]medium1012beta-hydroxy steroid;
20-hydroxy steroid;
beta-D-glucoside;
ginsenoside;
tetracyclic triterpenoid		antineoplastic agent;
apoptosis inducer;
bone density conservation agent;
cardioprotective agent;
hepatoprotective agent;
plant metabolite
ginsenoside rg3[no description available]medium10ginsenoside;
glycoside;
tetracyclic triterpenoid		angiogenesis modulating agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite
methyltin[no description available]medium20
dicyclomine[no description available]medium10carboxylic ester;
tertiary amine		antispasmodic drug;
muscarinic antagonist;
parasympatholytic
ag-490[no description available]medium10catechols;
enamide;
monocarboxylic acid amide;
nitrile;
secondary carboxamide		anti-inflammatory agent;
antioxidant;
apoptosis inducer;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
geroprotector;
STAT3 inhibitor
stannin[no description available]medium100
rutin[no description available]medium40disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite
tin[no description available]medium40carbon group element atom;
elemental tin;
metal atom		micronutrient
bromodeoxyuridine[no description available]medium70pyrimidine 2'-deoxyribonucleosideantimetabolite;
antineoplastic agent
aripiprazole[no description available]medium10aromatic ether;
delta-lactam;
dichlorobenzene;
N-alkylpiperazine;
N-arylpiperazine;
quinolone		drug metabolite;
H1-receptor antagonist;
second generation antipsychotic;
serotonergic agonist
carbostyril[no description available]medium10monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
lithium[no description available]medium30alkali metal atom
neuropeptide y[no description available]medium30
cilostazol[no description available]medium10lactam;
tetrazoles		anticoagulant;
bronchodilator agent;
EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor;
fibrin modulating drug;
neuroprotective agent;
platelet aggregation inhibitor;
vasodilator agent
valproic acid[no description available]medium10branched-chain fatty acid;
branched-chain saturated fatty acid		anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent
fenton's reagent[no description available]medium10
gamma-aminobutyric acid[no description available]medium90amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
sirolimus[no description available]medium20antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
lignans[no description available]medium10
magnolol[no description available]medium10biphenyls
nitrites[no description available]medium20monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		human metabolite
pd 98059[no description available]medium20aromatic amine;
monomethoxyflavone		EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector
u 0126[no description available]medium10aryl sulfide;
dinitrile;
enamine;
substituted aniline		antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
osteogenesis regulator;
vasoconstrictor agent
transforming growth factor beta[no description available]medium30
triphenyltin[no description available]medium40
chlorogenic acid[no description available]medium10cinnamate ester;
tannin		food component;
plant metabolite
indigo carmine[no description available]medium10
bisbenzimidazole[no description available]medium10bibenzimidazole;
N-methylpiperazine		anthelminthic drug;
fluorochrome
dimethyltin[no description available]medium60organotin compound
potassium borohydride[no description available]medium10
acetic acid[no description available]medium10monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
cyclo(alanine-(1-amino-1-cyclopentane)carbonyl)[no description available]medium10
n-methylaspartate[no description available]medium30amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound		neurotransmitter agent
dizocilpine maleate[no description available]medium50maleate salt;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist
pyrazolanthrone[no description available]medium10anthrapyrazole;
aromatic ketone;
cyclic ketone		antineoplastic agent;
c-Jun N-terminal kinase inhibitor;
geroprotector
glutamic acid[no description available]medium80glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
triethyltin[no description available]medium190
calpain[no description available]medium20
myelin basic protein[no description available]medium40
leptin[no description available]medium10
4-hydroxy-2-nonenal[no description available]medium104-hydroxynon-2-enal;
4-hydroxynonenal
antipyrine[no description available]medium10pyrazoloneantipyretic;
cyclooxygenase 3 inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic
edaravone[no description available]medium10pyrazoloneantioxidant;
radical scavenger
methoxsalen[no description available]medium10aromatic ether;
psoralens		antineoplastic agent;
cross-linking reagent;
dermatologic drug;
photosensitizing agent;
plant metabolite
lycopene[no description available]medium10acyclic caroteneantioxidant;
plant metabolite
cytochrome c-t[no description available]medium20
fluorodeoxyglucose f18[no description available]medium102-deoxy-2-((18)F)fluoro-D-glucose;
2-deoxy-2-fluoro-aldehydo-D-glucose
corticosterone[no description available]medium7011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
aldosterone[no description available]medium2011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
spironolactone[no description available]medium103-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester		aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
thiazolyl blue[no description available]medium30organic bromide saltcolorimetric reagent;
dye
lithium chloride[no description available]medium10inorganic chloride;
lithium salt		antimanic drug;
geroprotector
serine[no description available]medium20L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
adenine[no description available]medium106-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
asparagine[no description available]medium10amino acid zwitterion;
asparagine;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
3-methyladenine[no description available]medium10
thiazoles[no description available]medium301,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
mitotracker green fm[no description available]medium10
erythrosine[no description available]medium40
cresyl violet[no description available]medium20
phenobarbital[no description available]medium20barbituratesanticonvulsant;
drug allergen;
excitatory amino acid antagonist;
sedative
piperidines[no description available]medium20
bdp 12[no description available]medium10N-acylpiperidine
kainic acid[no description available]medium50dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone[no description available]medium20
cyclin d1[no description available]medium10
n,n'-bis(1-decylnipecotoyl)piperazine[no description available]medium10
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid[no description available]medium10non-proteinogenic alpha-amino acid
soman[no description available]medium10phosphonic ester
cortisone[no description available]medium1011-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
cysteine[no description available]medium10cysteiniumfundamental metabolite
hydroxyl radical[no description available]medium20oxygen hydride;
oxygen radical;
reactive oxygen species
ascorbic acid[no description available]medium10ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
glutathione disulfide[no description available]medium10glutathione derivative;
organic disulfide		Escherichia coli metabolite;
mouse metabolite
oxiracetam[no description available]medium10organonitrogen compound;
organooxygen compound
bay 11-7082[no description available]medium10nitrile;
sulfone		apoptosis inducer;
EC 2.7.11.10 (IkappaB kinase) inhibitor;
EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor;
non-steroidal anti-inflammatory drug;
platelet aggregation inhibitor
dibutyldichlorotin[no description available]medium20
n-methyl-n-(tert-butyldimethylsilyl)trifluoroacetamide[no description available]medium10monocarboxylic acid amide;
N-silyl compound;
trifluoroacetamide		chromatographic reagent
deuterium[no description available]medium10dihydrogen
trifluoroacetic acid[no description available]medium10fluoroalkanoic acidhuman xenobiotic metabolite;
NMR chemical shift reference compound;
reagent
ammonium hydroxide[no description available]medium30azane;
gas molecular entity;
mononuclear parent hydride		EC 3.5.1.4 (amidase) inhibitor;
metabolite;
mouse metabolite;
neurotoxin;
NMR chemical shift reference compound;
nucleophilic reagent;
refrigerant
ng-nitroarginine methyl ester[no description available]medium20alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
phenyl-n-tert-butylnitrone[no description available]medium10
cyclosporine[no description available]medium10
tacrolimus[no description available]medium20macrolide lactambacterial metabolite;
immunosuppressive agent
dextromethorphan[no description available]medium106-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthreneantitussive;
environmental contaminant;
neurotoxin;
NMDA receptor antagonist;
oneirogen;
prodrug;
xenobiotic
ifenprodil[no description available]medium10piperidines
bd 1047[no description available]medium10primary amine
phytic acid[no description available]medium10inositol phosphate
2-cyclohexen-1-one[no description available]medium10cyclohexenone
tiletamine hydrochloride[no description available]medium10
glycylglycine[no description available]medium10dipeptide zwitterion;
dipeptide		human metabolite
hydrogen[no description available]medium10elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
glycylhistidine[no description available]medium10dipeptide zwitterion;
dipeptide		metabolite
veratrine[no description available]medium20alkaloid
potassium chloride[no description available]medium20inorganic chloride;
inorganic potassium salt;
potassium salt		fertilizer
aspartic acid[no description available]medium30aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
mouse metabolite;
neurotransmitter
ouabain[no description available]medium3011alpha-hydroxy steroid;
14beta-hydroxy steroid;
5beta-hydroxy steroid;
alpha-L-rhamnoside;
cardenolide glycoside;
steroid hormone		anti-arrhythmia drug;
cardiotonic drug;
EC 2.3.3.1 [citrate (Si)-synthase] inhibitor;
EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
ion transport inhibitor;
plant metabolite
taurine[no description available]medium40amino sulfonic acid;
zwitterion		antioxidant;
Escherichia coli metabolite;
glycine receptor agonist;
human metabolite;
mouse metabolite;
nutrient;
radical scavenger;
Saccharomyces cerevisiae metabolite
glutamine[no description available]medium30amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
sodium glutamate[no description available]medium10monosodium glutamateflavouring agent
methionine sulfoximine[no description available]medium10methionine derivative;
non-proteinogenic alpha-amino acid;
sulfoximide
domoic acid[no description available]medium10L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid;
tricarboxylic acid		algal metabolite;
hapten;
marine metabolite;
neuromuscular agent;
neurotoxin
silver[no description available]medium20copper group element atom;
elemental silver		Escherichia coli metabolite
quinolinic acid[no description available]medium10pyridinedicarboxylic acidEscherichia coli metabolite;
human metabolite;
mouse metabolite;
NMDA receptor agonist
ethylcholine aziridinium[no description available]medium10
choline[no description available]medium10cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
chelerythrine[no description available]medium20benzophenanthridine alkaloid;
organic cation		antibacterial agent;
antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor
oxotremorine[no description available]medium10N-alkylpyrrolidine
pirenzepine[no description available]medium10pyridobenzodiazepineanti-ulcer drug;
antispasmodic drug;
muscarinic antagonist
tacrine[no description available]medium10acridines;
aromatic amine		EC 3.1.1.7 (acetylcholinesterase) inhibitor
pentylenetetrazole[no description available]medium10organic heterobicyclic compound;
organonitrogen heterocyclic compound
1-naphthylacetylspermine[no description available]medium10naphthalenes
spermine[no description available]medium10polyazaalkane;
tetramine		antioxidant;
fundamental metabolite;
immunosuppressive agent
pk 11195[no description available]medium20aromatic amide;
isoquinolines;
monocarboxylic acid amide;
monochlorobenzenes		antineoplastic agent
u 74389f[no description available]medium10
fura-2[no description available]medium10
nifedipine[no description available]medium20C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
igmesine[no description available]medium10
lead[no description available]medium30carbon group element atom;
elemental lead;
metal atom		neurotoxin
cadmium chloride[no description available]medium10cadmium coordination entity
3-hydroxyaspartic acid[no description available]medium10amino dicarboxylic acid;
aspartic acid derivative;
C4-dicarboxylic acid;
hydroxy-amino acid
furosemide[no description available]medium10chlorobenzoic acid;
furans;
sulfonamide		environmental contaminant;
loop diuretic;
xenobiotic
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid[no description available]medium20
bumetanide[no description available]medium10amino acid;
benzoic acids;
sulfonamide		diuretic;
EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor
toluene[no description available]medium20methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
inositol 1,4,5-trisphosphate[no description available]medium10myo-inositol trisphosphatemouse metabolite
glycine[no description available]medium20alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
atropine[no description available]medium10
alpha-methyl-4-carboxyphenylglycine[no description available]medium10non-proteinogenic alpha-amino acidmetabotropic glutamate receptor antagonist
u 73122[no description available]medium10aromatic ether;
aza-steroid;
maleimides		EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor
cobalt[no description available]medium10cobalt group element atom;
metal allergen		micronutrient
propidium[no description available]medium20phenanthridines;
quaternary ammonium ion		fluorochrome;
intercalator
atipamezole[no description available]medium10
caseins[no description available]medium10
tetrodotoxin[no description available]medium20azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
egtazic acid[no description available]medium20diether;
tertiary amino compound;
tetracarboxylic acid		chelator
desipramine[no description available]medium10dibenzoazepine;
secondary amino compound		adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
cholinergic antagonist;
drug allergen;
EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
serotonin uptake inhibitor
chlorine[no description available]medium10halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
n-methyl-3,4-methylenedioxyamphetamine[no description available]medium10amphetamines;
benzodioxoles		neurotoxin
methamphetamine[no description available]medium10amphetamines;
secondary amine		central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine[no description available]medium10methylpyridines;
phenylpyridine;
tetrahydropyridine		neurotoxin
benzene[no description available]medium10aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
tolonium chloride[no description available]medium10
platinum[no description available]medium10elemental platinum;
nickel group element atom;
platinum group metal atom
silicon nitride[no description available]medium10
dinoprostone[no description available]medium10prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
arachidonic acid[no description available]medium20icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
n-chlorotaurine[no description available]medium10
gentamicin[no description available]medium10
enkephalin, methionine[no description available]medium10
dynorphins[no description available]medium10
tetradecanoylphorbol acetate[no description available]medium10acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
hydroxyindoleacetic acid[no description available]medium20indole-3-acetic acidsdrug metabolite;
human metabolite;
mouse metabolite
levodopa[no description available]medium10amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug
2'-hydroxy-5,9-dimethyl-2-allyl-6,7-benzomorphan[no description available]medium10
phencyclidine[no description available]medium10benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
ketamine[no description available]medium10cyclohexanones;
monochlorobenzenes;
secondary amino compound		analgesic;
environmental contaminant;
intravenous anaesthetic;
neurotoxin;
NMDA receptor antagonist;
xenobiotic
phenazocine[no description available]medium10
diphenyltin[no description available]medium10
diacetyldichlorofluorescein[no description available]medium10
veratridine[no description available]medium10
rotenone[no description available]medium10organic heteropentacyclic compound;
rotenones		antineoplastic agent;
metabolite;
mitochondrial NADH:ubiquinone reductase inhibitor;
phytogenic insecticide;
piscicide;
toxin
oligomycins[no description available]medium10
triethyllead[no description available]medium20
chlorine[no description available]medium10diatomic chlorine;
gas molecular entity		bleaching agent
vasoactive intestinal peptide[no description available]medium10
atrial natriuretic factor[no description available]medium10polypeptide
captopril[no description available]medium10alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid		antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor
dronabinol[no description available]medium10benzochromene;
diterpenoid;
phytocannabinoid;
polyketide		cannabinoid receptor agonist;
epitope;
hallucinogen;
metabolite;
non-narcotic analgesic
strophanthidin[no description available]medium1014beta-hydroxy steroid;
19-oxo steroid;
3beta-hydroxy steroid;
5beta-hydroxy steroid;
cardenolides;
steroid aldehyde
triphenyltin hydroxide[no description available]medium10
dihydroalprenolol[no description available]medium10
arginine vasopressin[no description available]medium10vasopressincardiovascular drug;
hematologic agent;
mitogen
argipressin, des-glynh2(9)-[no description available]medium10
dextroamphetamine[no description available]medium101-phenylpropan-2-amineadrenergic agent;
adrenergic uptake inhibitor;
dopamine uptake inhibitor;
dopaminergic agent;
neurotoxin;
sympathomimetic agent
chlorpromazine[no description available]medium10organochlorine compound;
phenothiazines;
tertiary amine		anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug
morphine[no description available]medium10morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
scopolamine hydrobromide[no description available]medium10
amphetamine[no description available]medium10primary amine
3-hydroxybutyric acid[no description available]medium10(omega-1)-hydroxy fatty acid;
3-hydroxy monocarboxylic acid;
hydroxybutyric acid		human metabolite
lead nitrate[no description available]medium10inorganic nitrate salt;
lead coordination entity
nitrates[no description available]medium10monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
bromine[no description available]medium10diatomic bromine
bromperidol[no description available]medium10aromatic ketone
haloperidol[no description available]medium10aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
cadmium[no description available]medium10cadmium molecular entity;
zinc group element atom
di-n-octyltin dichloride[no description available]medium10
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Autosome0low10
Abnormalities, Chromosomal0low10
Abnormalities, Chromosome0low10
Absence Seizure0low140
Absence Seizures0low140
Academic Disorder, Developmental0low30
Action Tremor0low40
Acute Brain Injuries0low20
Acute Confusional Senile Dementia0low20
Acute Disease0low20
Adenocarcinoma0low10
Adenocarcinoma, Basal Cell0low10
Adenocarcinoma, Granular Cell0low10
Adenocarcinoma, Oxyphilic0low10
Adenocarcinoma, Tubular0low10
Adenoma, Malignant0low10
Adipocere0low10
Adult Learning Disabilities0low30
Adult Learning Disorders0low30
Adverse Drug Event0low10
Adverse Drug Reaction0low10
Age-Related Memory Disorders0low200
Aggression0low30
Aging0low60
Algor Mortis0low10
Alzheimer Dementia0low20
Alzheimer Disease0low20
Alzheimer Disease, Early Onset0low20
Alzheimer Disease, Late Onset0low20
Alzheimer Sclerosis0low20
Alzheimer Syndrome0low20
Alzheimer Type Senile Dementia0low20
Alzheimer-Type Dementia (ATD)0low20
Alzheimer's Disease0low20
Alzheimer's Disease, Focal Onset0low20
Alzheimer's Diseases0low20
Amentia0low10
Amnesia, Pre-Ictal0low10
Amnesia, Retrograde0low10
Anaplastic Astrocytoma0low10
Aneuploid0low10
Aneuploid Cell0low10
Aneuploidy0low10
Anoxemia0low10
Anoxia0low10
Anoxia, Brain0low10
Anoxia, Cerebral0low10
Anoxic Brain Damage0low10
Anoxic Encephalopathy0low10
Arterial Obstructive Diseases0low10
Arterial Occlusive Diseases0low10
Astrocytoma0low10
Astrocytoma, Grade I0low10
Astrocytoma, Grade II0low10
Astrocytoma, Grade III0low10
Astrocytoma, Protoplasmic0low10
Astrocytoma, Subependymal Giant Cell0low10
Astrocytosis0low80
Astroglioma0low10
Astrogliosis0low80
Ataxia0low10
Ataxia, Appendicular0low10
Ataxia, Limb0low10
Ataxia, Motor0low10
Ataxia, Sensory0low10
Ataxia, Truncal0low10
Ataxy0low10
Atonic Absence Seizure0low140
Atonic Absence Seizures0low140
Atonic Seizure0low140
Atonic Seizures0low140
Atrophy0low20
Aura0low30
Autosome Abnormalities0low10
Awakening Epilepsy0low30
Behavior Disorders0low10
Benign Psychomotor Epilepsy, Childhood0low20
Bewilderment0low10
Body Weight0low100
Brachial Paresis0low10
Brain Anoxia0low10
Brain Damage, Chronic0low20
Brain Diseases0low70
Brain Disorders0low70
Brain Edema0low10
Brain Hypoxia0low10
Brain Inflammation0low20
Brain Injuries0low20
Brain Injuries, Acute0low20
Brain Injuries, Focal0low20
Brain Lacerations0low20
Brain Swelling0low10
Carcinoma, Cribriform0low10
Carcinoma, Granular Cell0low10
Carcinoma, Tubular0low10
Cardiometabolic Syndrome0low10
Central Nervous System Disease0low10
Central Nervous System Diseases0low10
Central Nervous System Disorder0low10
Central Nervous System Disorders0low10
Central Nervous System Disorders, Intracranial0low70
Central Nervous System Intracranial Disorders0low70
Centrala nervsystemets sjukdomar@sv0low10
Cerebellar Diseases0low10
Cerebellar Disorders0low10
Cerebellar Dysfunction0low10
Cerebellar Syndromes0low10
Cerebellum Diseases0low10
Cerebral Anoxia0low10
Cerebral Astrocytoma0low10
Cerebral Edema0low10
Cerebral Edema, Cytotoxic0low10
Cerebral Edema, Vasogenic0low10
Cerebral Hypoxia0low10
Child Development Deviations0low10
Child Development Disorders0low10
Child Development Disorders, Specific0low10
Childhood Benign Psychomotor Epilepsy0low20
Childhood Cerebral Astrocytoma0low10
Choroby OUN@pl0low10
Chromosomal Aberrations0low10
Chromosome Aberrations0low10
Chromosome Abnormalities0low10
Chronic Encephalopathy0low20
Clonic Seizure0low140
Clonic Seizures0low140
CNS Disease0low10
CNS Diseases0low10
CNS Disorders, Intracranial0low70
Coarse Tremor0low40
Cognition Disorders0low50
Cognitive Decline0low50
Cognitive Dysfunction0low50
Cognitive Impairments0low50
Complex Partial Seizure0low140
Complex Partial Seizures0low140
Confusion0low10
Confusion, Post-Ictal0low10
Confusion, Reactive0low10
Confusional State0low10
Continuous Tremor0low40
Convulsion0low140
Convulsion, Non-Epileptic0low140
Convulsions0low140
Convulsive Seizure0low140
Convulsive Seizures0low140
Coordination Impairment0low10
Cruor0low10
Crural Paresis0low10
Cytogenetic Aberrations0low10
Cytogenetic Abnormalities0low10
Cytotoxic Brain Edema0low10
Cytotoxic Cerebral Edema0low10
Darkness Tremor0low40
Deafness, Transitory0low10
Deficiency, Oxygen0low10
Degenerative Diseases, Central Nervous System0low120
Degenerative Diseases, Nervous System0low120
Degenerative Diseases, Neurologic0low120
Degenerative Diseases, Spinal Cord0low120
Degenerative Neurologic Diseases0low120
Degenerative Neurologic Disorders0low120
Delayed Effects, Prenatal Exposure0low30
Dementia0low10
Dementia, Alzheimer Type0low20
Dementia, Presenile0low20
Dementia, Primary Senile Degenerative0low20
Dementia, Senile0low20
Depression0low20
Development Disorders, Child0low10
Developmental Academic Disability0low30
Developmental Academic Disorder0low30
Developmental Delay Disorders0low10
Developmental Disabilities0low10
Developmental Disabilities of Scholastic Skills0low30
Developmental Disorders of Scholastic Skills0low30
Diagnosis, Psychiatric0low10
Disabilities, Developmental0low10
Disease Exacerbation0low20
Disease Models, Animal0low170
Disease Progression0low20
Diseases, Occupational0low10
Disorientation0low10
Dizziness0low10
Dizzyness0low10
Doenu00E7as do Sistema Nervoso Central@pt0low10
Drug Side Effects0low10
Drug Toxicity0low10
Drug-Related Side Effects and Adverse Reactions0low10
Dysarthosis0low10
Dysarthria0low10
Dysarthria, Flaccid0low10
Dysarthria, Guttural0low10
Dysarthria, Mixed0low10
Dysarthria, Scanning0low10
Dysarthria, Spastic0low10
Dyscoordination0low10
Dyskinesia, Drug-Induced0low10
Dyskinesia, Medication-Induced0low10
Dysmetabolic Syndrome X0low10
Dyssynergia0low10
Early Onset Alzheimer Disease0low20
Encephalitis0low20
Encephalitis, Rasmussen0low20
Encephalon Diseases0low70
Encephalopathy0low70
Encephalopathy, Chronic0low20
Encephalopathy, Hypoxic0low10
Encephalopathy, Toxic0low160
Enfermedades del Sistema Nervioso Central@es0low10
Epilepsy0low30
Epilepsy, Benign Psychomotor, Childhood0low20
Epilepsy, Cryptogenic0low30
Epilepsy, Lateral Temporal0low20
Epilepsy, Temporal Lobe0low20
Epilepsy, Uncinate0low20
Epileptic Seizure0low140
Epileptic Seizures0low140
Familial Alzheimer Disease (FAD)0low20
Familial Dementia0low10
Fibrillary Astrocytoma0low10
Fine Tremor0low40
Focal Brain Injuries0low20
Focal Onset Alzheimer's Disease0low20
Gemistocytic Astrocytoma0low10
Generalized Absence Seizure0low140
Generalized Absence Seizures0low140
Generalized Tonic-Clonic Seizures0low140
Genetic Predisposition0low10
Genetic Predisposition to Disease0low10
Genetic Susceptibility0low10
Glial Cell Tumors0low10
Glial Scar0low80
Glioma0low10
Glioma, Astrocytic0low10
Gliosis0low80
Hallucination of Body Sensation0low10
Hallucinations0low10
Hallucinations, Auditory0low10
Hallucinations, Dissociative0low10
Hallucinations, Elementary0low10
Hallucinations, Formed, of People0low10
Hallucinations, Gustatory0low10
Hallucinations, Hypnagogic0low10
Hallucinations, Hypnapompic0low10
Hallucinations, Internal Body Sensation0low10
Hallucinations, Kinesthetic0low10
Hallucinations, Mood Congruent0low10
Hallucinations, Mood Incongruent0low10
Hallucinations, Olfactory0low10
Hallucinations, Organic0low10
Hallucinations, Reflex0low10
Hallucinations, Sensory0low10
Hallucinations, Somatic0low10
Hallucinations, Tactile0low10
Hallucinations, Verbal Auditory0low10
Hallucinations, Visual0low10
Hallucinations, Visual, Formed0low10
Hallucinations, Visual, Unformed0low10
Hearing Impairment0low10
Hearing Loss0low10
Hearing Loss, Transitory0low10
Heavy Metal Poisoning, Nervous System0low10
Hemiparesis0low10
Hyperactivity, Motor0low20
Hyperkinesia0low20
Hyperkinesia, Generalized0low20
Hyperkinesis0low20
Hyperkinetic Movements0low20
Hypoacusis0low10
Hypokalemia0low20
Hypopotassemia0low20
Hypoxemia0low10
Hypoxia0low10
Hypoxia, Brain0low10
Hypoxia, Cerebral0low10
Hypoxic Brain Damage0low10
Hypoxic Encephalopathy0low10
Incoordination0low10
Inflammation0low100
Inflammation, Brain0low20
Injuries, Acute Brain0low20
Injuries, Brain0low20
Innate Inflammatory Response0low100
Insulin Resistance Syndrome X0low10
Intention Tremor0low40
Intermittent Tremor0low40
Intracranial Astrocytoma0low10
Intracranial Central Nervous System Disorders0low70
Intracranial CNS Disorders0low70
Intracranial Edema0low10
Involuntary Quiver0low40
Jacksonian Seizure0low140
Juvenile Pilocytic Astrocytoma0low10
Keskushermoston sairaudet@fi0low10
Lack of Coordination0low10
Late Effects, Prenatal Exposure0low30
Late Onset Alzheimer Disease0low20
Learning Disabilities0low30
Learning Disorders0low30
Learning Disorders, Adult0low30
Learning Disturbance0low30
Light-Headedness0low10
Lightheadedness0low10
Livor Mortis0low10
Lower Extremity Paresis0low10
Maladie du systu00E8me nerveux central@fr0low10
Malattie del sistema nervoso centrale@it0low10
Malignant Glioma0low10
Massive Tremor0low40
Medication-Induced Dyskinesia0low10
Memory Deficits0low200
Memory Disorder, Semantic0low200
Memory Disorder, Spatial0low200
Memory Disorders0low200
Memory Disorders, Age-Related0low200
Memory Loss0low200
Memory Loss, Retrograde0low10
Mental Deterioration0low50
Mental Disorders0low10
Mental Disorders, Severe0low10
Mental Illness0low10
Mercury Poisoning0low10
Metabolic Cardiovascular Syndrome0low10
Metabolic Syndrome0low10
Metabolic Syndrome X0low10
Metabolic X Syndrome0low10
Mild Cognitive Impairment0low50
Mild Neurocognitive Disorder0low50
Mixed Glioma0low10
Monoparesis0low10
MPTP Neurotoxicity Syndrome0low10
MPTP Poisoning0low10
MPTP-Induced Degeneration of the Striatum0low10
MPTP-Induced Parkinsonism0low10
Muscle Paresis0low10
Muscular Paresis0low10
Myoclonic Seizure0low140
Myoclonic Seizures0low140
Necrosis0low40
nemoci centru00E1lnu00EDho nervovu00E9ho systu00E9mu@cs0low10
Nephrolithiasis0low10
Nerve Degeneration0low470
Nervous System Degenerative Diseases0low120
Nervous System Diseases0low30
Nervous System Disorders0low30
Nervous System Poisoning0low160
Neuroblastoma0low40
Neurodegenerative Diseases0low120
Neurodegenerative Disorders0low120
Neurologic Degenerative Conditions0low120
Neurologic Degenerative Diseases0low120
Neurologic Diseases, Degenerative0low120
Neurologic Disorders0low30
Neurological Disorders0low30
Neuron Degeneration0low470
Neurotoxic Disorders0low160
Neurotoxicity Syndrome, MPTP0low10
Neurotoxicity Syndromes0low160
Neurotoxin Diseases0low160
Neurotoxin Disorders0low160
Non-Epileptic Seizure0low140
Non-Epileptic Seizures0low140
Nonepileptic Seizure0low140
Nonepileptic Seizures0low140
Occupational Diseases0low10
Occupational Illnesses0low10
Oligoastrocytoma, Mixed0low10
Orthostasis0low10
Overinclusion0low50
Oxygen Deficiency0low10
Paresis0low10
Partial Seizure0low140
Partial Seizures0low140
Passive Tremor0low40
Persistent Tremor0low40
Petit Mal Convulsion0low140
Pill Rolling Tremor0low40
Pilocytic Astrocytoma0low10
Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine0low10
Poisoning, Heavy Metals, Nervous System0low10
Poisoning, Mercury0low10
Poisoning, Nervous System0low160
Postmortem Changes0low10
Pre-Ictal Memory Loss0low10
Predisposition, Genetic0low10
Pregnancy0low70
Prenatal Exposure Delayed Effects0low30
Presenile Alzheimer Dementia0low20
Primary Senile Degenerative Dementia0low20
Psychiatric Diagnosis0low10
Psychiatric Diseases0low10
Psychiatric Disorders0low10
Psychiatric Illness0low10
Rasmussen Encephalitis0low20
Rasmussen Syndrome0low20
Rasmussen's Syndrome0low20
Reaven Syndrome X0low10
Rest Tremor0low40
Resting Tremor0low40
Retention Disorders, Cognitive0low200
Retrograde Amnesia0low10
Saturnine Tremor0low40
Scholastic Skills Development Disorders0low30
Seizure0low140
Seizure Disorder0low30
Seizures0low140
Seizures, Auditory0low140
Seizures, Clonic0low140
Seizures, Convulsive0low140
Seizures, Epileptic0low140
Seizures, Focal0low140
Seizures, Generalized0low140
Seizures, Gustatory0low140
Seizures, Motor0low140
Seizures, Olfactory0low140
Seizures, Sensory0low140
Seizures, Somatosensory0low140
Seizures, Tonic0low140
Seizures, Tonic-Clonic0low140
Seizures, Vertiginous0low140
Seizures, Vestibular0low140
Seizures, Visual0low140
Semantic Memory Disorder0low200
Senile Dementia, Acute Confusional0low20
Senile Dementia, Alzheimer Type0low20
Senile Paranoid Dementia0low10
Senile Tremor0low40
Sensitivity and Specificity0low20
Side Effects of Drugs0low10
Single Seizure0low140
Spatial Memory Disorder0low200
SREDIu0160NJI u017DIVu010CANI SUSTAV, BOLESTI@hr0low10
Static Tremor0low40
Subependymal Giant Cell Astrocytoma0low10
Susceptibility, Genetic0low10
Sykdommer i sentralnervesystemet@no0low10
Symptom Cluster0low10
Syndrome0low10
Syndrome X, Insulin Resistance0low10
Syndrome X, Metabolic0low10
Tonic Clonic Seizure0low140
Tonic Seizure0low140
Tonic Seizures0low140
Tonic-Clonic Seizure0low140
Tonic-Clonic Seizures0low140
Toxic Encephalitis0low160
Toxicity, Drug0low10
Transitory Hearing Loss0low10
Tremor0low40
Tremor, Limb0low40
Tremor, Muscle0low40
Tremor, Neonatal0low40
Tremor, Nerve0low40
Tremor, Perioral0low40
Tremor, Rubral0low10
Tremor, Semirhythmic0low40
u041Du0415u0420u0412u041Du041Eu0419 u0421u0418u0421u0422u0415u041Cu042B u0426u0415u041Du0422u0420u0410u041Bu042Cu041Du041Eu0419 u0411u041Eu041Bu0415u0417u041Du0418@ru0low10
u4E2Du67A2u795Eu7D4Cu7CFBu75BEu60A3@ja0low10
Upper Extremity Paresis0low10
Vasogenic Brain Edema0low10
Vasogenic Cerebral Edema0low10
Weight Loss0low10
Weight Reduction0low10
Zentralnervensystemkrankheiten@de0low10
Ziekte, centraalzenuwstelsel-@nl0low10

Research Highlights

Safety/Toxicity (42)

ArticleYear
The main mechanisms of trimethyltin chloride-induced neurotoxicity: Energy metabolism disorder and peroxidation damage.
Toxicology letters, Jul-01, Volume: 345		2021
Ginsenoside Rg3 and Rh2 protect trimethyltin-induced neurotoxicity via prevention on neuronal apoptosis and neuroinflammation.
Phytotherapy research : PTR, Volume: 32, Issue: 12		2018
Neuroprotective effect of clavulanic acid on trimethyltin (TMT)-induced cytotoxicity in PC12 cells.
Drug and chemical toxicology, Volume: 42, Issue: 2		2019
Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.
Experimental biology and medicine (Maywood, N.J.), Volume: 243, Issue: 3		2018
Ginsenoside Re Protects Trimethyltin-Induced Neurotoxicity via Activation of IL-6-Mediated Phosphoinositol 3-Kinase/Akt Signaling in Mice.
Neurochemical research, Volume: 42, Issue: 11		2017
Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice.
Brain research bulletin, Volume: 121		2016
Neurotoxicity of trimethyltin in rat cochlear organotypic cultures.
Neurotoxicity research, Volume: 28, Issue: 1		2015
Protein kinase Cδ mediates trimethyltin-induced neurotoxicity in mice in vivo via inhibition of glutathione defense mechanism.
Archives of toxicology, Volume: 90, Issue: 4		2016
Glial activation with concurrent up-regulation of inflammatory mediators in trimethyltin-induced neurotoxicity in mice.
Acta histochemica, Volume: 116, Issue: 8		2014
Circulating miR-9* and miR-384-5p as potential indicators for trimethyltin-induced neurotoxicity.
Toxicologic pathology, Volume: 43, Issue: 2		2015
Toxicity of trimethyltin and dimethyltin in rats and mice.
Bulletin of environmental contamination and toxicology, Volume: 90, Issue: 5		2013
Role of autophagy inhibitors and inducers in modulating the toxicity of trimethyltin in neuronal cell cultures.
Journal of neural transmission (Vienna, Austria : 1996), Volume: 119, Issue: 11		2012
Opposing roles of glucocorticoid receptor and mineralocorticoid receptor in trimethyltin-induced cytotoxicity in the mouse hippocampus.
Neuroscience letters, Mar-09, Volume: 511, Issue: 2		2012
Protective potential of IL-6 against trimethyltin-induced neurotoxicity in vivo.
Free radical biology & medicine, Apr-01, Volume: 52, Issue: 7		2012
Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway.
Neurochemistry international, Volume: 59, Issue: 8		2011
Neural stem cells modified to express BDNF antagonize trimethyltin-induced neurotoxicity through PI3K/Akt and MAP kinase pathways.
Journal of cellular physiology, Volume: 224, Issue: 3		2010
Methylated tin toxicity a reappraisal using rodents models.
Archives italiennes de biologie, Volume: 147, Issue: 4		2009
FK506-protective effects against trimethyltin neurotoxicity in rats: hippocampal expression analyses reveal the involvement of periarterial osteopontin.
Neuroscience, Jun-02, Volume: 153, Issue: 4		2008
Autoantibodies to neurotypic and gliotypic proteins as biomarkers of neurotoxicity: assessment of trimethyltin (TMT).
Neurotoxicology, Volume: 29, Issue: 1		2008
Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats.
Neurochemistry international, Volume: 50, Issue: 6		2007
Detection of electrophysiological indicators of neurotoxicity in human and rat brain slices by a three-dimensional microelectrode array.
Alternatives to laboratory animals : ATLA, Volume: 33, Issue: 6		2005
Changes in extracellular action potential detect kainic acid and trimethyltin toxicity in hippocampal slice preparations earlier than do MAP2 density measurements.
Alternatives to laboratory animals : ATLA, Volume: 33, Issue: 4		2005
Neurotoxic effects of trimethyltin and triethyltin on human fetal neuron and astrocyte cultures: a comparative study with rat neuronal cultures and human cell lines.
Toxicology letters, Aug-30, Volume: 152, Issue: 1		2004
Stannin, a protein that localizes to the mitochondria and sensitizes NIH-3T3 cells to trimethyltin and dimethyltin toxicity.
Molecular pharmacology, Volume: 66, Issue: 4		2004
In vivo neuroprotective role of NMDA receptors against kainate-induced excitotoxicity in murine hippocampal pyramidal neurons.
Journal of neurochemistry, Volume: 85, Issue: 5		2003
Role of astrocytes in trimethyltin neurotoxicity.
Journal of biochemical and molecular toxicology, Volume: 15, Issue: 5		2001
Toxicity of organotin compounds in primary cultures of rat cortical astrocytes.
Cell biology and toxicology, Volume: 17, Issue: 1		2001
Quantification of acute neurotoxic effects of trimethyltin using neuronal networks cultured on microelectrode arrays.
Neurotoxicology, Volume: 21, Issue: 3		2000
Quantitating silver-stained neurodegeneration: the neurotoxicity of trimethlytin (TMT) in aged rats.
Journal of neuroscience methods, May-15, Volume: 98, Issue: 1		2000
Expression of AP-1 transcription factors in rat hippocampus and cerebellum after trimethyltin neurotoxicity.
Neurotoxicology, Volume: 20, Issue: 5		1999
Glutathione modifies the toxicity of triethyltin and trimethyltin in C6 glioma cells.
Archives of toxicology, Volume: 72, Issue: 4		1998
Trimethyltin (TMT) neurotoxicity in organotypic rat hippocampal slice cultures.
Brain research, Feb-09, Volume: 783, Issue: 2		1998
Enhanced expression of peripheral benzodiazepine receptors in trimethyltin-exposed rat brain: a biomarker of neurotoxicity.
Neurotoxicology,Fall, Volume: 16, Issue: 3		1995
Induction of trimethyltin neurotoxicity by dietary administration.
Neurotoxicology,Fall, Volume: 15, Issue: 3		1994
Activation of protein kinase C by trimethyltin: relevance to neurotoxicity.
Journal of neurochemistry, Volume: 65, Issue: 5		1995
Microglial responsiveness as a sensitive marker for trimethyltin (TMT) neurotoxicity.
Brain research, Aug-28, Volume: 690, Issue: 1		1995
Trimethyltin as a selective adrenal chemosympatholytic agent in vivo: effect precedes both clinical and histopathological evidence of toxicity.
Toxicology, Volume: 40, Issue: 2		1986
Risk assessment for neurobehavioral toxicity.
Environmental health perspectives, Volume: 76		1987
Enhanced expression of glial fibrillary acidic protein and the cupric silver degeneration reaction can be used as sensitive and early indicators of neurotoxicity.
Neurotoxicology,Spring, Volume: 13, Issue: 1		1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (1)

ArticleYear
Brain Targeted Curcumin Loaded Turmeric Oil Microemulsion Protects Against Trimethyltin Induced Neurodegeneration in Adult Zebrafish: A Pharmacokinetic and Pharmacodynamic Insight.
Pharmaceutical research, Volume: 40, Issue: 3		2023
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

ArticleYear
Brain Targeted Curcumin Loaded Turmeric Oil Microemulsion Protects Against Trimethyltin Induced Neurodegeneration in Adult Zebrafish: A Pharmacokinetic and Pharmacodynamic Insight.
Pharmaceutical research, Volume: 40, Issue: 3		2023
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (26)

ArticleYear
Turmeric (Curcuma longa L.) extract may prevent the deterioration of spatial memory and the deficit of estimated total number of hippocampal pyramidal cells of trimethyltin-exposed rats.
Drug and chemical toxicology, Volume: 41, Issue: 1		2018
In vivo molecular markers for pro-inflammatory cytokine M1 stage and resident microglia in trimethyltin-induced hippocampal injury.
Neurotoxicity research, Volume: 25, Issue: 1		2014
Gene expression profiling as a tool to investigate the molecular machinery activated during hippocampal neurodegeneration induced by trimethyltin (TMT) administration.
International journal of molecular sciences, Aug-15, Volume: 14, Issue: 8		2013
Trimethyltin-induced hippocampal degeneration as a tool to investigate neurodegenerative processes.
Neurochemistry international, Volume: 58, Issue: 7		2011
Structure-activity comparison of organotin species: dibutyltin is a developmental neurotoxicant in vitro and in vivo.
Brain research. Developmental brain research, Jul-19, Volume: 151, Issue: 1-2		2004
Chemically induced neuronal damage and gliosis: enhanced expression of the proinflammatory chemokine, monocyte chemoattractant protein (MCP)-1, without a corresponding increase in proinflammatory cytokines(1).
Neuroscience, Volume: 115, Issue: 1		2002
Quantitating silver-stained neurodegeneration: the neurotoxicity of trimethlytin (TMT) in aged rats.
Journal of neuroscience methods, May-15, Volume: 98, Issue: 1		2000
Cellular localization and temporal elevation of tumor necrosis factor-alpha, interleukin-1 alpha, and transforming growth factor-beta 1 mRNA in hippocampal injury response induced by trimethyltin.
Journal of neurochemistry, Volume: 71, Issue: 4		1998
Rat strain- and gender-related differences in neurobehavioral screening: acute trimethyltin neurotoxicity.
Journal of toxicology and environmental health, Apr-19, Volume: 47, Issue: 6		1996
Developmental differences in neural damage following trimethyl-tin as demonstrated with GFAP immunohistochemistry.
Annals of the New York Academy of Sciences, May-28, Volume: 679		1993
Neuropathological and behavioral toxicology of trimethyltin exposure.
Annali dell'Istituto superiore di sanita, Volume: 29, Issue: 1		1993
Effects of trimethyltin (TMT) on choline acetyltransferase activity in the rat hippocampus. Influence of dose and time following exposure.
Molecular and chemical neuropathology, Volume: 23, Issue: 1		1994
Nephrotoxic effect of trimethyltin in rats.
Toxicology letters, Volume: 27, Issue: 1-3		1985
Effects of trimethyltin on homecage behavior of rats.
Toxicology and applied pharmacology, Jun-15, Volume: 79, Issue: 1		1985
Development of locomotor activity of rat pups exposed to heavy metals.
Toxicology and applied pharmacology, Mar-30, Volume: 78, Issue: 1		1985
Acute trimethyltin intoxication in the monkey (Macaca fascicularis).
Toxicology and applied pharmacology, Volume: 79, Issue: 3		1985
Effects of chemicals on delayed matching in pigeons IV: Effects of trimethyltin.
Neurotoxicology,Fall, Volume: 7, Issue: 3		1986
Fetomaternal kinetics of 14C-trimethyltin.
Neurotoxicology,Summer, Volume: 7, Issue: 2		1986
Effect of triethyl lead chloride on delta-aminolevulinic acid dehydratase.
Journal of toxicology and environmental health, Volume: 18, Issue: 4		1986
Quantitative assessment of trimethyltin induced pathology of the hippocampus.
Toxicologic pathology, Volume: 15, Issue: 1		1987
Quantitative changes in the synaptic vesicle proteins synapsin I and p38 and the astrocyte-specific protein glial fibrillary acidic protein are associated with chemical-induced injury to the rat central nervous system.
The Journal of neuroscience : the official journal of the Society for Neuroscience, Volume: 7, Issue: 4		1987
Trimethyltin-induced alterations in brain amino acids, amines and amine metabolites: relationship to hyperammonemia.
Neurotoxicology,Fall, Volume: 7, Issue: 3		1986
Effect of trimethyltin on amino acid concentrations in different regions of the mouse brain.
Pharmacology & toxicology, Volume: 68, Issue: 6		1991
Enhanced expression of glial fibrillary acidic protein and the cupric silver degeneration reaction can be used as sensitive and early indicators of neurotoxicity.
Neurotoxicology,Spring, Volume: 13, Issue: 1		1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]