Proteins > Neuronal acetylcholine receptor subunit alpha-7
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Neuronal acetylcholine receptor subunit alpha-7
A neuronal acetylcholine receptor subunit alpha-7 that is encoded in the genome of rat. [PANTHER:PTHR18945:SF71, PRO:DNx]
Synonyms
Research
Bioassay Publications (67)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (2.99) | 18.7374 |
| 1990's | 11 (16.42) | 18.2507 |
| 2000's | 25 (37.31) | 29.6817 |
| 2010's | 27 (40.30) | 24.3611 |
| 2020's | 2 (2.99) | 2.80 |
Compounds (60)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| epibatidine | Rattus norvegicus (Norway rat) | Activity | 0.5000 | 1 | 1 |
| epibatidine | Rattus norvegicus (Norway rat) | K app | 0.0000 | 1 | 3 |
| nicotine | Rattus norvegicus (Norway rat) | K app | 0.0062 | 1 | 3 |
| abt 594 | Rattus norvegicus (Norway rat) | Rmax | 83.0000 | 1 | 1 |
Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine.Journal of natural products, , 04-27, Volume: 81, Issue:4, 2018
Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes.Bioorganic & medicinal chemistry, , Jun-15, Volume: 18, Issue:12, 2010
Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 18, Issue:16, 2008
Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
exo-2-(Pyridazin-4-yl)-7-azabicyclo[2.2.1]heptanes: syntheses and nicotinic acetylcholine receptor agonist activity of potent pyridazine analogues of (+/-)-epibatidine.Journal of medicinal chemistry, , Jan-04, Volume: 44, Issue:1, 2001
Synthesis and nicotinic acetylcholine receptor binding properties of exo-2-(2'-fluoro-5'-pyridinyl)-7-azabicyclo-[2.2.1]heptane: a new positron emission tomography ligand for nicotinic receptors.Journal of medicinal chemistry, , Jul-18, Volume: 40, Issue:15, 1997
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors.Journal of medicinal chemistry, , Feb-16, Volume: 39, Issue:4, 1996
Pyridine alkaloids with activity in the central nervous system.Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes.Bioorganic & medicinal chemistry, , Jun-15, Volume: 18, Issue:12, 2010
Deconstructing cytisine: The syntheses of (+/-)-cyfusine and (+/-)-cyclopropylcyfusine, fused ring analogs of cytisine.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 18, Issue:7, 2008
Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.Journal of medicinal chemistry, , May-19, Volume: 48, Issue:10, 2005
Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Modifications at C(5) of 2-(2-Pyrrolidinyl)-Substituted 1,4-Benzodioxane Elicit Potent α4β2 Nicotinic Acetylcholine Receptor Partial Agonism with High Selectivity over the α3β4 Subtype.Journal of medicinal chemistry, , 12-24, Volume: 63, Issue:24, 2020
Pyridine alkaloids with activity in the central nervous system.Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Pharmacological profile of zacopride and new quaternarized fluorobenzamide analogues on mammalian α7 nicotinic acetylcholine receptor.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
Tying up Nicotine: New Selective Competitive Antagonist of the Neuronal Nicotinic Acetylcholine Receptors.ACS medicinal chemistry letters, , Apr-09, Volume: 6, Issue:4, 2015
Derivatives of dibenzothiophene for positron emission tomography imaging of α7-nicotinic acetylcholine receptors.Journal of medicinal chemistry, , Oct-10, Volume: 56, Issue:19, 2013
Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.Journal of medicinal chemistry, , Apr-11, Volume: 56, Issue:7, 2013
N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.European journal of medicinal chemistry, , Volume: 45, Issue:12, 2010
Novel acetylcholine and carbamoylcholine analogues: development of a functionally selective alpha4beta2 nicotinic acetylcholine receptor agonist.Journal of medicinal chemistry, , Dec-11, Volume: 51, Issue:23, 2008
Parallel synthesis of a series of potentially brain penetrant aminoalkyl benzoimidazoles.Bioorganic & medicinal chemistry, , Mar-01, Volume: 16, Issue:5, 2008
Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.Journal of medicinal chemistry, , May-19, Volume: 48, Issue:10, 2005
The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 15, Issue:17, 2005
Synthesis and alpha4beta2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
Neuronal nicotinic acetylcholine receptor binding affinities of boron-containing nicotine analogues.Bioorganic & medicinal chemistry letters, , May-07, Volume: 11, Issue:9, 2001
(-)-Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin-2'-one], a conformationally restricted analogue of acetylcholine, is a highly selective full agonist at the alpha 7 nicotinic acetylcholine receptor.Journal of medicinal chemistry, , Nov-02, Volume: 43, Issue:22, 2000
Binding affinities of 3-(3-phenylisoxazol-5-yl)methylidene-1-azabicycles to acetylcholine receptors.Bioorganic & medicinal chemistry letters, , Oct-04, Volume: 9, Issue:19, 1999
Synthesis and nicotinic acetylcholine receptor binding properties of exo-2-(2'-fluoro-5'-pyridinyl)-7-azabicyclo-[2.2.1]heptane: a new positron emission tomography ligand for nicotinic receptors.Journal of medicinal chemistry, , Jul-18, Volume: 40, Issue:15, 1997
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors.Journal of medicinal chemistry, , Feb-16, Volume: 39, Issue:4, 1996
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.Journal of medicinal chemistry, , Aug-16, Volume: 39, Issue:17, 1996
Synthesis and evaluation of nicotine analogs as neuronal nicotinic acetylcholine receptor ligands.Journal of medicinal chemistry, , Oct-14, Volume: 37, Issue:21, 1994
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.Journal of medicinal chemistry, , Volume: 31, Issue:3, 1988
Structure-activity relationships of some pyridine, piperidine, and pyrrolidine analogues for enhancing and inhibiting the binding of (+/-)-[3H]nicotine to the rat brain P2 preparation.Journal of medicinal chemistry, , Volume: 28, Issue:9, 1985
Synthesis of novel chiral Δ2-isoxazoline derivatives related to ABT-418 and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.European journal of medicinal chemistry, , Volume: 45, Issue:12, 2010
Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 18, Issue:16, 2008
Synthesis and alpha4beta2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2'-fluoro-3'-(substituted pyridinyl)-7-deschloroepibatidine analogues.Journal of medicinal chemistry, , Feb-13, Volume: 57, Issue:3, 2014
Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.Journal of medicinal chemistry, , Apr-11, Volume: 56, Issue:7, 2013
Identification of novel α4β2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.Journal of medicinal chemistry, , Jan-26, Volume: 55, Issue:2, 2012
Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Synthesis and pharmacological characterization of novel analogues of the nicotinic acetylcholine receptor agonist (+/-)-UB-165.Journal of medicinal chemistry, , Jul-18, Volume: 45, Issue:15, 2002
Neuronal nicotinic acetylcholine receptors as targets for drug discovery.Journal of medicinal chemistry, , Dec-19, Volume: 40, Issue:26, 1997
Synthesis and biological characterization of pyridohomotropanes. Structure-activity relationships of conformationally restricted nicotinoids.Journal of medicinal chemistry, , Volume: 31, Issue:3, 1988
Pharmacological profile of zacopride and new quaternarized fluorobenzamide analogues on mammalian α7 nicotinic acetylcholine receptor.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine α4β2 receptors: unique role of halogen bonding revealed.The Journal of biological chemistry, , Feb-03, Volume: 287, Issue:6, 2012
Epibatidine structure-activity relationships.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
Pharmacology of the agonist binding sites of rat neuronal nicotinic receptor subtypes expressed in HEK 293 cells.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
Novel 3-Pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors.Journal of medicinal chemistry, , Feb-16, Volume: 39, Issue:4, 1996
Design and Synthesis of a New Series of 4-Heteroarylamino-1'-azaspiro[oxazole-5,3'-bicyclo[2.2.2]octanes as α7 Nicotinic Receptor Agonists. 1. Development of Pharmacophore and Early Structure-Activity Relationship.Journal of medicinal chemistry, , 12-22, Volume: 59, Issue:24, 2016
Discovery and development of α7 nicotinic acetylcholine receptor modulators.Journal of medicinal chemistry, , Dec-08, Volume: 54, Issue:23, 2011
Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
Docking studies of benzylidene anabaseine interactions with α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of related α7 selective ligands.European journal of medicinal chemistry, , Volume: 46, Issue:11, 2011
Discovery of the alpha7 nicotinic acetylcholine receptor agonists. (R)-3'-(5-Chlorothiophen-2-yl)spiro-1-azabicyclo[2.2.2]octane-3,5'-[1',3']oxazolidin-2'-one as a novel, potent, selective, and orally bioavailable ligand.Journal of medicinal chemistry, , Apr-07, Volume: 48, Issue:7, 2005
Design and synthesis of a novel series of (1'S,2R,4'S)-3H-4'-azaspiro[benzo[4,5]imidazo[2,1-b]oxazole-2,2'-bicyclo[2.2.2]octanes] with high affinity for the α7 neuronal nicotinic receptor.Bioorganic & medicinal chemistry letters, , 11-15, Volume: 27, Issue:22, 2017
Design of α7 nicotinic acetylcholine receptor ligands using the (het)Aryl-1,2,3-triazole core: Synthesis, in vitro evaluation and SAR studies.European journal of medicinal chemistry, , Jan-01, Volume: 107, 2016
Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationshJournal of medicinal chemistry, , Jul-13, Volume: 49, Issue:14, 2006
Discovery and development of α7 nicotinic acetylcholine receptor modulators.Journal of medicinal chemistry, , Dec-08, Volume: 54, Issue:23, 2011
Synthesis and SAR studies of 1,4-diazabicyclo[3.2.2]nonane phenyl carbamates--subtype selective, high affinity alpha7 nicotinic acetylcholine receptor agonists.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 19, Issue:16, 2009
Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.Journal of medicinal chemistry, , Nov-14, Volume: 56, Issue:21, 2013
Chemistry and pharmacological studies of 3-alkoxy-2,5-disubstituted-pyridinyl compounds as novel selective α4β2 nicotinic acetylcholine receptor ligands that reduce alcohol intake in rats.Journal of medicinal chemistry, , Apr-11, Volume: 56, Issue:7, 2013
Structure-activity relationship studies of SEN12333 analogues: determination of the optimal requirements for binding affinities at α7 nAChRs through incorporation of known structural motifs.European journal of medicinal chemistry, , May-05, Volume: 95, 2015
Investigations of amide bond variation and biaryl modification in analogues of α7 nAChR agonist SEN12333.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 22, Issue:7, 2012
Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625/WYE-Journal of medicinal chemistry, , Jun-10, Volume: 53, Issue:11, 2010