An NAD(+) hydrolase SARM1 that is encoded in the genome of human. [PRO:CNA]
NADase SARM1; This protein enables 5 target(s): This protein is located in 9 target(s): This protein is active in 1 target(s): This protein is part of 1 target(s): This protein is involved in 12 target(s):
hSARM1;
EC 3.2.2.6;
NADP(+) hydrolase SARM1;
3.2.2.-;
Sterile alpha and Armadillo repeat protein;
Sterile alpha and TIR motif-containing protein 1;
Sterile alpha motif domain-containing protein 2;
MyD88-5;Research
Bioassay Publications (1)
Timeframe Studies on this Protein(%) All Drugs % pre-1990 0 (0.00) 18.7374 1990's 0 (0.00) 18.2507 2000's 0 (0.00) 29.6817 2010's 0 (0.00) 24.3611 2020's 1 (100.00) 2.80 Compounds (7)
Drugs with Inhibition Measurements
Drug Taxonomy Measurement Average (mM) Bioassay(s) Publication(s) niacinamide Homo sapiens (human) IC50 43.8000 1 0 rabeprazole Homo sapiens (human) IC50 3.2500 2 0 phenazopyridine hydrochloride Homo sapiens (human) IC50 145.0000 1 1 phenazopyridine hydrochloride Homo sapiens (human) Ki 70.0000 1 1 Berberine chloride (TN) Homo sapiens (human) IC50 116.7500 4 4 Berberine chloride (TN) Homo sapiens (human) Ki 130.0000 1 1 tenatoprazole Homo sapiens (human) IC50 8.0500 2 0 nitrofurazone Homo sapiens (human) IC50 90.0000 1 1 nitrofurazone Homo sapiens (human) Ki 120.0000 1 1 dexlansoprazole Homo sapiens (human) IC50 3.4000 2 0 Enables
Target Category Definition NAD+ nucleosidase activity molecular function Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose. [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847] protein binding molecular function Binding to a protein. [GOC:go_curators] signaling adaptor activity molecular function The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. [GOC:bf, PMID:19104498] NADP+ nucleosidase activity molecular function Catalysis of the reaction: NADP+ + H2O = ADP-D-ribose-2-phosphate + nicotinamide. [RHEA:19849] NAD+ nucleotidase, cyclic ADP-ribose generating molecular function Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose, in a two steps reaction: first an ADP-ribosyl cyclase reaction, followed by a cyclic ADP-ribose hydrolase reaction. [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528] Located In
Target Category Definition cytoplasm cellular component The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] mitochondrion cellular component A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] mitochondrial outer membrane cellular component The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai] cytosol cellular component The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] microtubule cellular component Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. [ISBN:0879693568] cell surface cellular component The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] axon cellular component The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732] dendrite cellular component A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] synapse cellular component The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] Active In
Target Category Definition dendrite cellular component A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] Part Of
Target Category Definition protein-containing complex cellular component A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah] Involved In
Target Category Definition signal transduction biological process The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11] nervous system development biological process The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh] response to glucose biological process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. [GOC:jl] NAD catabolic process biological process The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH. [GOC:jl, ISBN:0618254153] cell differentiation biological process The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732] negative regulation of MyD88-independent toll-like receptor signaling pathway biological process Any process that stops, prevents, or reduces the frequency, rate, or extent of MyD88-independent toll-like receptor signaling pathway. [GOC:add, PMID:16551253, PMID:17328678] regulation of neuron apoptotic process biological process Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons. [GOC:go_curators, GOC:mtg_apoptosis] innate immune response biological process Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] response to axon injury biological process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an axon injury stimulus. [GOC:dgh, GOC:dph, GOC:jid, GOC:lm] regulation of dendrite morphogenesis biological process Any process that modulates the frequency, rate or extent of dendrite morphogenesis. [GOC:ai] nervous system process biological process A organ system process carried out by any of the organs or tissues of neurological system. [GOC:ai, GOC:mtg_cardio] protein localization to mitochondrion biological process A process in which a protein is transported to, or maintained in, a location within the mitochondrion. [GOC:ecd]