aspirin has been researched along with Necrosis in 110 studies
Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.
acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conducted a randomized controlled trial to investigate whether an additional platelet inhibition with tirofiban would reduce the extent of myocardial damage and prevent periprocedural myonecrosis in patients with Non-ST-elevation acute coronary syndrome (NSTE-ACS) with a high residual platelet activity (HPR)." | 9.27 | Effect of tailored use of tirofiban in patients with Non-ST-elevation acute coronary syndrome undergoing percutaneous coronary intervention: a randomized controlled trial. ( Chae, IH; Cho, YS; Lee, W; Park, JJ; Suh, JW; Yoon, CH; Youn, TJ, 2018) |
| "There is uncertainty about the benefit of a higher loading dose (LD) of clopidogrel in patients with non-ST elevation acute coronary syndrome (NSTEACS) undergoing early percutaneous coronary intervention (PCI)." | 9.14 | Randomized trial comparing 600- with 300-mg loading dose of clopidogrel in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: results of the Platelet Responsiveness to Aspirin and Clopidogrel and Troponin ( Brieger, D; Chew, DP; Dick, R; Eccleston, D; Eikelboom, JW; Ferguson, L; French, J; Hockings, B; Rankin, J; Thom, J; Walters, D; Whelan, A; Yong, G, 2009) |
| "Inadequate platelet response to aspirin is associated with increased incidence of peri-procedural myonecrosis." | 9.13 | The effect of high-dose aspirin pre-treatment on the incidence of myonecrosis following elective coronary stenting. ( Duzen, V; Erol, C; Gulec, S; Ozdemir, AO; Ozdol, C; Ozturk, S; Selcuk, T; Temizhan, A; Turhan, S; Vurgun, K, 2008) |
| "Aspirin and clopidogrel response did not affect myonecrosis prevalence amongst patients who received eptifibatide for PCI." | 9.13 | The effects of aspirin and clopidogrel response on myonecrosis after percutaneous coronary intervention: a BRIEF-PCI (Brief Infusion of Intravenous Eptifibatide Following Successful Percutaneous Coronary Intervention) trial substudy. ( Buller, C; Densem, C; Fox, R; Fung, A; Jokhi, P; Mancini, GB; Ricci, D; Saw, J; Starovoytov, A; Walsh, S; Wong, G, 2008) |
| "To investigate the occurrence of aspirin resistance in coronary heart disease (CHD) patients and its influence on myonecrosis among patients undergoing non-emergent percutaneous coronary intervention (PCI)." | 9.11 | [Study on the relationship between aspirin resistance and incidence of myonecrosis after non-emergent percutaneous coronary intervention]. ( Dong, L; Liang, J; Yuan, H; Zhang, Y; Zhang, YZ; Zhou, YJ, 2005) |
| "Parenteral administration of gold thioglucose to mice produces an area or necrosis in the ventromedial portion of the hypothalamus." | 8.75 | Gold thioglucose obesity syndrome. ( Debons, AF; Fani, K; Jemenez, FA; Krimsky, I; Maayan, ML, 1977) |
| "Aspirin has a clear anti-inflammatory effect and is used as an anti-inflammatory agent for both acute and long-term inflammation." | 7.83 | Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice. ( Ding, Y; Gao, L; Li, W; Liu, G; Liu, J; Lu, G; Pan, Y; Tong, Z; Tu, J; Wang, Y, 2016) |
| "In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction." | 7.75 | The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes. ( Acikel, S; Aydinalp, A; Bal, U; Kaynar, G; Muderrisoglu, H; Ozin, B; Yildirir, A, 2009) |
| "Heterogeneity in response to aspirin (ASA) treatment, or "aspirin resistance," could be of importance in patients with ST-segment elevation myocardial infarction (STEMI)." | 7.74 | Partial inhibition of platelet thromboxane A2 synthesis by aspirin is associated with myonecrosis in patients with ST-segment elevation myocardial infarction. ( Aznar, J; Breña, S; Fuset, MP; Moscardo, A; Perez, F; Piñon, M; Ruano, M; Santos, MT; Valles, J, 2007) |
| " Cardiac lesions induced by isoproterenol (ISO) are characterized by myocardial necrosis and exudative infiltration." | 7.72 | Effect of D-003 on isoproterenol-induced myocardial necrosis in rats. ( Arruzazabala, ML; Carbajal, D; González, J; Más, R; Mendoza, S; Molina, V; Noa, M, 2003) |
| "Arjunolic acid, a new triterpene and a potent principle from the bark of Terminalia arjuna, has been shown to provide significant cardiac protection in isoproterenol induced myocardial necrosis in rats." | 7.71 | Experimental myocardial necrosis in rats: role of arjunolic acid on platelet aggregation, coagulation and antioxidant status. ( Arutselvan, N; Balakrishna, K; Kumar, DA; Manikandan, P; Manohar, BM; Puvanakrishnan, R; Sumitra, M, 2001) |
| "Isoproterenol hydrochloride (ISO), a beta adrenergic agonist, is known to cause ischemic necrosis in rats." | 7.70 | Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis. ( Jayakumar, R; Jayasundar, S; Malarvannan, P; Puvanakrishnan, R; Ramesh, CV, 1998) |
| "The efficacy of pentoxifylline--a haemorrheologic agent along with aspirin--an analgesic agent was evaluated in the amelioration of the tissue damage due to experimentally induced frostbite in 5 groups (20 each) of rats with body weights ranging between 175 and 200 g." | 7.70 | Efficacy of pentoxifylline with aspirin in the treatment of frostbite in rats. ( Chauhan, SK; Purkayastha, SS; Roy, A; Selvamurthy, W; Verma, SS, 1998) |
| "The effects of several inhibitors of arachidonic acid metabolism on gastric necrosis, hypotension, haemoconcentration, leukopenia and plasma exudation induced by platelet-activating factor (Paf) were studied in the rat." | 7.67 | Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration. ( Wallace, JL; Whittle, BJ, 1986) |
| "To investigate the possible role of pepsin in ulceration induced by hydrogen ion back-diffusion, the ratio of alkali-labile pepsinogen to total pepsinogen was studied during the course of aspirin- and taurocholate-induced gastric ulceration in comparison with the changes in the ion permeability and histological findings." | 7.66 | Increase in pepsin content in gastric mucosa during the course of aspirin- and taurocholate-induced gastric ulceration in rats. ( Kitaura, T; Kunita, T; Miyoshi, A; Ohe, K; Yokoya, H, 1980) |
| "Prophylactic effects of sulfinpyrazone (100 mg/Kg), aspirin (5 mg/Kg, 50 mg/Kg), and propranolol (2 mg/Kg, 10 mg/Kg) on myocardial necrosis and hypertrophy induced by isoproterenol were examined." | 7.66 | Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis. ( Hashimoto, H; Ogawa, K, 1981) |
| "Aspirin response was assessed by measuring the residual ability of platelets to generate thromboxane, calculated as the difference between thromboxane B2 levels in serum and plasma, [TxB2]S-P." | 5.42 | Dual antiplatelet response during PCI: VerifyNow P2Y12 predicts myocardial necrosis and thromboxane B2 generation confirms wide variation in aspirin response. ( Good, RI; Goodall, AH; James, TE; McConnachie, A; McGarrity, A; Miller, H; Oldroyd, KG, 2015) |
| " Collectively, these two events, necrosis and cell cycle arrest, may contribute to the chemopreventive effect that seems to result from long-term administration of aspirin in vivo." | 5.30 | Aspirin toxicity for human colonic tumor cells results from necrosis and is accompanied by cell cycle arrest. ( Frommel, TO; Subbegowda, R, 1998) |
| "We conducted a randomized controlled trial to investigate whether an additional platelet inhibition with tirofiban would reduce the extent of myocardial damage and prevent periprocedural myonecrosis in patients with Non-ST-elevation acute coronary syndrome (NSTE-ACS) with a high residual platelet activity (HPR)." | 5.27 | Effect of tailored use of tirofiban in patients with Non-ST-elevation acute coronary syndrome undergoing percutaneous coronary intervention: a randomized controlled trial. ( Chae, IH; Cho, YS; Lee, W; Park, JJ; Suh, JW; Yoon, CH; Youn, TJ, 2018) |
| "There is uncertainty about the benefit of a higher loading dose (LD) of clopidogrel in patients with non-ST elevation acute coronary syndrome (NSTEACS) undergoing early percutaneous coronary intervention (PCI)." | 5.14 | Randomized trial comparing 600- with 300-mg loading dose of clopidogrel in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: results of the Platelet Responsiveness to Aspirin and Clopidogrel and Troponin ( Brieger, D; Chew, DP; Dick, R; Eccleston, D; Eikelboom, JW; Ferguson, L; French, J; Hockings, B; Rankin, J; Thom, J; Walters, D; Whelan, A; Yong, G, 2009) |
| "Aspirin and clopidogrel response did not affect myonecrosis prevalence amongst patients who received eptifibatide for PCI." | 5.13 | The effects of aspirin and clopidogrel response on myonecrosis after percutaneous coronary intervention: a BRIEF-PCI (Brief Infusion of Intravenous Eptifibatide Following Successful Percutaneous Coronary Intervention) trial substudy. ( Buller, C; Densem, C; Fox, R; Fung, A; Jokhi, P; Mancini, GB; Ricci, D; Saw, J; Starovoytov, A; Walsh, S; Wong, G, 2008) |
| "Inadequate platelet response to aspirin is associated with increased incidence of peri-procedural myonecrosis." | 5.13 | The effect of high-dose aspirin pre-treatment on the incidence of myonecrosis following elective coronary stenting. ( Duzen, V; Erol, C; Gulec, S; Ozdemir, AO; Ozdol, C; Ozturk, S; Selcuk, T; Temizhan, A; Turhan, S; Vurgun, K, 2008) |
| "1% male) patients receiving 300 mg daily enteric coated aspirin for at least 7 days with documented coronary artery disease were included in the study." | 5.13 | Effects of persistent platelet reactivity despite aspirin therapy on cardiac troponin I and creatine kinase-MB levels after elective percutaneous coronary interventions. ( Aydinalp, A; Ertan, C; Gulmez, O; Kaynar, G; Konas, D; Muderrisoglu, H; Ozin, B; Yildirir, A, 2008) |
| "To investigate the occurrence of aspirin resistance in coronary heart disease (CHD) patients and its influence on myonecrosis among patients undergoing non-emergent percutaneous coronary intervention (PCI)." | 5.11 | [Study on the relationship between aspirin resistance and incidence of myonecrosis after non-emergent percutaneous coronary intervention]. ( Dong, L; Liang, J; Yuan, H; Zhang, Y; Zhang, YZ; Zhou, YJ, 2005) |
| " Some local complications are destruction of teeth due to the intake of medicines with high sugar content; erosive lesions of the oral mucosa; paraformaldehyde necrosis; and those arising from the use of chlorhexidine." | 4.77 | Complications in patients on therapeutic drugs. ( Petersen, JK, 1986) |
| "Parenteral administration of gold thioglucose to mice produces an area or necrosis in the ventromedial portion of the hypothalamus." | 4.75 | Gold thioglucose obesity syndrome. ( Debons, AF; Fani, K; Jemenez, FA; Krimsky, I; Maayan, ML, 1977) |
| "Aspirin has a clear anti-inflammatory effect and is used as an anti-inflammatory agent for both acute and long-term inflammation." | 3.83 | Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice. ( Ding, Y; Gao, L; Li, W; Liu, G; Liu, J; Lu, G; Pan, Y; Tong, Z; Tu, J; Wang, Y, 2016) |
| "The injection of aspirin on lymph nodes caused necrosis and an increase of apoptosis after 24 hours and after seven days of treatment there was regeneration of the lymph nodes, with intense decrease of necrosis and a great elevation of apoptosis." | 3.78 | Effects of aspirin on mesenteric lymph nodes of rabbits as basis for its use on lymph nodes metastases. ( Batista, RP; Denadai, R; Saad-Hossne, R, 2012) |
| "We describe a protocol utilizing hyaluronidase, nitroglycerin paste, aspirin, antacid and a topical oxygen therapy that may be used to treat impending necrosis subsequent to injection with soft tissue fillers." | 3.77 | Management of impending necrosis associated with soft tissue filler injections. ( Arkins, JP; Dayan, SH; Mathison, CC, 2011) |
| "In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction." | 3.75 | The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes. ( Acikel, S; Aydinalp, A; Bal, U; Kaynar, G; Muderrisoglu, H; Ozin, B; Yildirir, A, 2009) |
| "Heterogeneity in response to aspirin (ASA) treatment, or "aspirin resistance," could be of importance in patients with ST-segment elevation myocardial infarction (STEMI)." | 3.74 | Partial inhibition of platelet thromboxane A2 synthesis by aspirin is associated with myonecrosis in patients with ST-segment elevation myocardial infarction. ( Aznar, J; Breña, S; Fuset, MP; Moscardo, A; Perez, F; Piñon, M; Ruano, M; Santos, MT; Valles, J, 2007) |
| " Thus, we assessed whether platelet function under high shear rates (collagen adenosine diphosphate closure times [CADP-CTs]) measured with the platelet function analyzer (PFA-100) may be enhanced in patients with myocardial infarction (MI) and whether it may predict the extent of myocardial damage as measured by creatine kinase (CK-MB) or troponin T (TnT) levels." | 3.72 | Platelet function predicts myocardial damage in patients with acute myocardial infarction. ( Domanovits, H; Frossard, M; Fuchs, I; Hsieh, K; Jilma, B; Laggner, AN; Leitner, JM; Losert, H; Schreiber, W; Vlcek, M, 2004) |
| " Cardiac lesions induced by isoproterenol (ISO) are characterized by myocardial necrosis and exudative infiltration." | 3.72 | Effect of D-003 on isoproterenol-induced myocardial necrosis in rats. ( Arruzazabala, ML; Carbajal, D; González, J; Más, R; Mendoza, S; Molina, V; Noa, M, 2003) |
| "Arjunolic acid, a new triterpene and a potent principle from the bark of Terminalia arjuna, has been shown to provide significant cardiac protection in isoproterenol induced myocardial necrosis in rats." | 3.71 | Experimental myocardial necrosis in rats: role of arjunolic acid on platelet aggregation, coagulation and antioxidant status. ( Arutselvan, N; Balakrishna, K; Kumar, DA; Manikandan, P; Manohar, BM; Puvanakrishnan, R; Sumitra, M, 2001) |
| "The cardioprotective involvement of bradykinin was evaluated using the ACE inhibitor, lisinopril, and the APP inhibitor, 2-mercaptoethanol alone and in combination in rats with experimental myocardial infarction." | 3.71 | Studies on the signal cascade mechanism mediating the cardioprotective actions of bradykinin. ( Akula, A; Kota, MK; Potharaju, S; Veeravalli, KK, 2002) |
| "The efficacy of pentoxifylline--a haemorrheologic agent along with aspirin--an analgesic agent was evaluated in the amelioration of the tissue damage due to experimentally induced frostbite in 5 groups (20 each) of rats with body weights ranging between 175 and 200 g." | 3.70 | Efficacy of pentoxifylline with aspirin in the treatment of frostbite in rats. ( Chauhan, SK; Purkayastha, SS; Roy, A; Selvamurthy, W; Verma, SS, 1998) |
| "Isoproterenol hydrochloride (ISO), a beta adrenergic agonist, is known to cause ischemic necrosis in rats." | 3.70 | Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis. ( Jayakumar, R; Jayasundar, S; Malarvannan, P; Puvanakrishnan, R; Ramesh, CV, 1998) |
| " The first dose of ASA produced numerous gastric lesions and deep histological necrosis accompanied by a fall in the gastric blood flow, negligible expression of epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) or their receptors, and no evidence of mucosal proliferation." | 3.69 | Gastric adaptation to injury by repeated doses of aspirin strengthens mucosal defence against subsequent exposure to various strong irritants in rats. ( Brzozowski, T; Ernst, H; Hahn, EG; Konturek, PC; Konturek, SJ; Stachura, J, 1995) |
| "The thromboxane A2 (TXA2) plasma level in kappa-carrageenin (KC)-induced acronecrosis in the rat tail has been studied." | 3.68 | Thromboxane plasma level in kappa-carrageenin-induced acronecrosis of the tail in rats. ( Abbas, NA; Hirschelmann, R; Mest, HJ; Taube, C, 1991) |
| "The effects of several inhibitors of arachidonic acid metabolism on gastric necrosis, hypotension, haemoconcentration, leukopenia and plasma exudation induced by platelet-activating factor (Paf) were studied in the rat." | 3.67 | Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration. ( Wallace, JL; Whittle, BJ, 1986) |
| "Prophylactic effects of sulfinpyrazone (100 mg/Kg), aspirin (5 mg/Kg, 50 mg/Kg), and propranolol (2 mg/Kg, 10 mg/Kg) on myocardial necrosis and hypertrophy induced by isoproterenol were examined." | 3.66 | Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis. ( Hashimoto, H; Ogawa, K, 1981) |
| "To investigate the possible role of pepsin in ulceration induced by hydrogen ion back-diffusion, the ratio of alkali-labile pepsinogen to total pepsinogen was studied during the course of aspirin- and taurocholate-induced gastric ulceration in comparison with the changes in the ion permeability and histological findings." | 3.66 | Increase in pepsin content in gastric mucosa during the course of aspirin- and taurocholate-induced gastric ulceration in rats. ( Kitaura, T; Kunita, T; Miyoshi, A; Ohe, K; Yokoya, H, 1980) |
| "Aspirin response was assessed by measuring the residual ability of platelets to generate thromboxane, calculated as the difference between thromboxane B2 levels in serum and plasma, [TxB2]S-P." | 1.42 | Dual antiplatelet response during PCI: VerifyNow P2Y12 predicts myocardial necrosis and thromboxane B2 generation confirms wide variation in aspirin response. ( Good, RI; Goodall, AH; James, TE; McConnachie, A; McGarrity, A; Miller, H; Oldroyd, KG, 2015) |
| "Injection-induced necrosis is a rare but dreaded consequence of soft tissue augmentation with filler agents." | 1.42 | Treatment of Hyaluronic Acid Filler-Induced Impending Necrosis With Hyaluronidase: Consensus Recommendations. ( Biesman, BS; Cohen, JL; Dayan, SH; DeLorenzi, C; Lambros, VS; Nestor, MS; Sadick, N; Sykes, J, 2015) |
| "Cannabis arteritis is a serious peripheral vascular disease affecting young adults consuming cannabis." | 1.35 | Cannabis arteritis. ( Noël, B; Panizzon, RG; Ruf, I, 2008) |
| "Envenomation may induce a generalized exanthem known clinically but not described histologically." | 1.34 | Generalized vasculitic exanthem following Loxosceles reclusa envenomation. ( Boyd, AS; Hayes, BB; Robb, CW, 2007) |
| " Collectively, these two events, necrosis and cell cycle arrest, may contribute to the chemopreventive effect that seems to result from long-term administration of aspirin in vivo." | 1.30 | Aspirin toxicity for human colonic tumor cells results from necrosis and is accompanied by cell cycle arrest. ( Frommel, TO; Subbegowda, R, 1998) |
| "The hepatotoxicity of acetaminophen (APAP) overdose depends on metabolic activation to a toxic reactive metabolite via hepatic mixed function oxidase." | 1.28 | Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis? ( Ben-Zvi, Z; Danon, A; Katz, S; Weissman-Teitellman, B, 1990) |
| " Male Wistar rats (n = 30) were starved for 24 h, then dosed orally with aspirin suspension (300 mg/kg body weight)." | 1.27 | Gastric epithelial mucus--a densitometric histochemical study of aspirin-induced damage in the rat. ( Berrisford, RG; Dixon, MF; Wells, M, 1985) |
| "Two severe anaphylactoid reactions were seen under dextran prophylaxis resulting in the death of one newborn." | 1.26 | [Side effects of drug for thromboembolism prophylaxis. Results from the University Women's Clinic Freiburg/Br]. ( Ardelt, W; Hillemanns, HG; Pasold, K, 1979) |
| " Dose-response curves in fasted and fed rats indicated that the fed rat was about eight times more susceptible to aspirin-induced intestinal damage than was the fasted rat, while the fasted rat was about 13 times more susceptible to aspirin-induced gastric damage than was the fed rat." | 1.25 | Aspirin: intestinal damage in rats. ( Brodie, DA; Hooke, KF; Tate, CL, 1970) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (31.82) | 18.7374 |
| 1990's | 22 (20.00) | 18.2507 |
| 2000's | 29 (26.36) | 29.6817 |
| 2010's | 19 (17.27) | 24.3611 |
| 2020's | 5 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, FC | 1 |
| Miller, TJ | 1 |
| Henn, D | 1 |
| Nguyen, D | 1 |
| Momeni, A | 1 |
| Lorenzoni, AG | 1 |
| Rojas-Núñez, I | 1 |
| Moore, AF | 1 |
| Arimura, A | 1 |
| Fujii, K | 1 |
| Hayashida, M | 1 |
| Higashi, Y | 1 |
| Hashiguchi, T | 1 |
| Kanekura, T | 1 |
| Ho, JP | 1 |
| Galex, IA | 1 |
| Sadeghi, NB | 1 |
| Weledji, N | 1 |
| Cabello Bermudez, SI | 1 |
| Mitchell, BA | 1 |
| Bush, DM | 1 |
| Yap, E | 1 |
| Davis, NC | 1 |
| Catalino, MP | 1 |
| Godfrey, V | 1 |
| Nielsen, JN | 1 |
| Lee, YZ | 1 |
| Sasaki-Adams, DM | 1 |
| Macciò, A | 1 |
| Oppi, S | 1 |
| Madeddu, C | 1 |
| Chuchvara, N | 1 |
| Alamgir, M | 1 |
| John, AM | 1 |
| Rao, B | 1 |
| Dhanjal, S | 1 |
| Saso, A | 1 |
| Eleftheriou, D | 1 |
| Laurent, S | 1 |
| Khardenavis, V | 1 |
| Karthik, DK | 1 |
| Kulkarni, S | 1 |
| Deshpande, A | 1 |
| Lee, W | 1 |
| Suh, JW | 1 |
| Park, JJ | 1 |
| Yoon, CH | 1 |
| Cho, YS | 1 |
| Youn, TJ | 1 |
| Chae, IH | 1 |
| Guenzle, J | 1 |
| Garrelfs, NWC | 1 |
| Goeldner, JM | 1 |
| Weyerbrock, A | 1 |
| McGuire, LK | 1 |
| Hale, EK | 1 |
| Godwin, LS | 1 |
| Good, RI | 1 |
| McGarrity, A | 1 |
| James, TE | 1 |
| Miller, H | 1 |
| McConnachie, A | 1 |
| Goodall, AH | 1 |
| Oldroyd, KG | 1 |
| Holinstat, M | 1 |
| Reheman, A | 1 |
| Cohen, JL | 1 |
| Biesman, BS | 1 |
| Dayan, SH | 2 |
| DeLorenzi, C | 1 |
| Lambros, VS | 1 |
| Nestor, MS | 1 |
| Sadick, N | 1 |
| Sykes, J | 1 |
| Ogata, H | 1 |
| Teixeira, MM | 1 |
| Sousa, RC | 1 |
| Silva, MV | 1 |
| Correia, D | 1 |
| Rodrigues Junior, V | 1 |
| Levy, BD | 1 |
| Rogério, Ade P | 1 |
| Smilowitz, NR | 1 |
| Weiss, MC | 1 |
| Mauricio, R | 1 |
| Mahajan, AM | 1 |
| Dugan, KE | 1 |
| Devanabanda, A | 1 |
| Pulgarin, C | 1 |
| Gianos, E | 1 |
| Shah, B | 1 |
| Sedlis, SP | 1 |
| Radford, M | 1 |
| Reynolds, HR | 1 |
| Lu, G | 1 |
| Tong, Z | 1 |
| Ding, Y | 1 |
| Liu, J | 1 |
| Pan, Y | 1 |
| Gao, L | 1 |
| Tu, J | 1 |
| Wang, Y | 1 |
| Liu, G | 1 |
| Li, W | 1 |
| Ouyang, N | 1 |
| Williams, JL | 1 |
| Rigas, B | 2 |
| Zhou, H | 1 |
| Huang, L | 1 |
| Sun, Y | 1 |
| Ivandic, BT | 1 |
| Kurz, K | 1 |
| Keck, F | 1 |
| Staritz, P | 1 |
| Lehrke, S | 1 |
| Katus, HA | 1 |
| Giannitsis, E | 1 |
| Yong, G | 1 |
| Rankin, J | 1 |
| Ferguson, L | 1 |
| Thom, J | 1 |
| French, J | 1 |
| Brieger, D | 1 |
| Chew, DP | 1 |
| Dick, R | 1 |
| Eccleston, D | 1 |
| Hockings, B | 1 |
| Walters, D | 1 |
| Whelan, A | 1 |
| Eikelboom, JW | 1 |
| Ishibashi, M | 1 |
| Miyamoto, J | 1 |
| Nagasaka, T | 1 |
| Chen, KR | 1 |
| Saw, J | 1 |
| Densem, C | 1 |
| Walsh, S | 1 |
| Jokhi, P | 1 |
| Starovoytov, A | 1 |
| Fox, R | 1 |
| Wong, G | 1 |
| Buller, C | 1 |
| Ricci, D | 1 |
| Mancini, GB | 1 |
| Fung, A | 1 |
| Acikel, S | 1 |
| Yildirir, A | 2 |
| Aydinalp, A | 2 |
| Bal, U | 1 |
| Kaynar, G | 2 |
| Ozin, B | 2 |
| Muderrisoglu, H | 2 |
| Araujo, Ap | 1 |
| Araujo, M | 1 |
| Swoboda, KJ | 1 |
| Stellos, K | 1 |
| Bigalke, B | 1 |
| Stakos, D | 1 |
| Henkelmann, N | 1 |
| Gawaz, M | 1 |
| Vieth, M | 2 |
| Görgens, D | 1 |
| Langner, C | 1 |
| Jenkins, J | 1 |
| Babu, K | 1 |
| Hsu-Hung, E | 1 |
| Robinson-Bostom, L | 1 |
| Kroumpouzos, G | 1 |
| Arkins, JP | 1 |
| Mathison, CC | 1 |
| Yazbek, MA | 1 |
| Velho, P | 1 |
| Nadruz, W | 1 |
| Mahayri, N | 1 |
| Appenzeller, S | 1 |
| Costallat, LT | 1 |
| Darshan, J | 1 |
| Shaw, E | 1 |
| Green, B | 1 |
| Gallagher, PJ | 1 |
| Gadola, SD | 1 |
| Batista, RP | 1 |
| Denadai, R | 1 |
| Saad-Hossne, R | 1 |
| Müller, H | 1 |
| Stolte, M | 2 |
| Cena, C | 1 |
| Lolli, ML | 1 |
| Lazzarato, L | 1 |
| Guaita, E | 1 |
| Morini, G | 1 |
| Coruzzi, G | 1 |
| McElroy, SP | 1 |
| Megson, IL | 1 |
| Fruttero, R | 1 |
| Gasco, A | 1 |
| Carbajal, D | 1 |
| Noa, M | 2 |
| Molina, V | 1 |
| Arruzazabala, ML | 1 |
| Más, R | 2 |
| Mendoza, S | 1 |
| González, J | 1 |
| Frossard, M | 1 |
| Fuchs, I | 1 |
| Leitner, JM | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Tailored Use of Tirofiban in Patients With Non-ST-elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention[NCT03114995] | Phase 4 | 140 participants (Actual) | Interventional | 2012-02-01 | Completed | ||
| Brief Infusion of Eptifibatide Following Percutaneous Coronary Intervention[NCT00111566] | Phase 4 | 624 participants (Actual) | Interventional | 2004-12-31 | Completed | ||
| A Phase II, Randomized, Single-Blind, Controlled Clinical Trial to Evaluate the Efficacy and Safety of Hemolink[Tm] (o-Raffinose Cross-Linked Human Hemoglobin) in Subjects Undergoing Primary Coronary Artery Bypass Grafting Surgery[NCT00038454] | Phase 2/Phase 3 | 180 participants | Interventional | Suspended | |||
| A Full-Factorial, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Single-Dose Efficacy and Safety Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen, and Naproxen Sodium in Postoperative Dental Pain[NCT05761574] | Phase 3 | 440 participants (Anticipated) | Interventional | 2023-05-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
An area under the curve of serial levels of Troponin I and creatine kinase-MB isoenzyme during 36 hours (NCT03114995)
Timeframe: 0,6,12,18,24,30,36 hours
| Intervention | Hours*ng/ml (Median) | |
|---|---|---|
| Troponin I | creatine kinase-MB isoenzyme | |
| Control C1 (High Platelet Reactivity - no Tirofiban) | 38.0 | 92.7 |
| Control C2 (Low Platelet Reactivity - no Tirofiban) | 121.4 | 185.6 |
| Group A (High Platelet Reactivity - Tirofiban) | 197.2 | 252.5 |
"Percentage of participants with periprocedural myonecrosis under the criteria described below.~When the cardiac biomarkers before the procedure were within the 99th percentile upper reference limit (URL), more than a 5-fold elevation in the URL within 12 hours after percutaneous coronary intervention (PCI) was defined as periprocedural myonecrosis. If the cardiac biomarker level was already above the 99th percentile URL before the procedure and the trend was stationary or decreasing, a ≥20% increase compared to the previous level was considered periprocedural myonecrosis. If the trend was still increasing, the levels at the post-6 hour and 12-hour were compared to determine periprocedural myonecrosis." (NCT03114995)
Timeframe: 0,6,12,18,24,30,36 hours
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Troponin I | creatine kinase-MB isoenzyme | |
| Control C1 (High Platelet Reactivity - no Tirofiban) | 15 | 10 |
| Control C2 (Low Platelet Reactivity - no Tirofiban) | 26 | 25 |
| Group A (High Platelet Reactivity - Tirofiban) | 16 | 11 |
8 reviews available for aspirin and Necrosis
| Article | Year |
|---|---|
COVID-19 and cytokine storm syndrome: can what we know about interleukin-6 in ovarian cancer be applied?
Topics: Adrenal Cortex Hormones; Aspirin; COVID-19; COVID-19 Drug Treatment; COVID-19 Serotherapy; COVID-19 | 2021 |
Review of hemoglobin-induced myocardial lesions.
Topics: Animals; Aspirin; Dogs; Drug Evaluation, Preclinical; Enzymes; Haplorhini; Heart Atria; Heart Injuri | 2004 |
[Paracetamol: overdose and hepatic lesions].
Topics: Acetaminophen; Aspirin; Chemical and Drug Induced Liver Injury; Fever; Humans; Liver; Necrosis; Pain | 1981 |
Acetaminophen/aspirin mixtures: experimental data.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; | 1996 |
Gold thioglucose obesity syndrome.
Topics: Adrenalectomy; Animals; Appetite Regulation; Aspirin; Aurothioglucose; Biological Transport; Capilla | 1977 |
The third Lilly Prize Lecture. University of London, January, 1979. The nephrotoxicity and hepatotoxicity of antipyretic analgesics.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induced Liver Inj | 1979 |
Heparin-induced thrombocytopenia and arterial thrombosis: alternative therapies.
Topics: Aspirin; Cardiopulmonary Bypass; Chondroitin Sulfates; Dermatan Sulfate; Epoprostenol; Fibrinolytic | 1990 |
Complications in patients on therapeutic drugs.
Topics: Adrenal Cortex Hormones; Anemia, Aplastic; Anti-Inflammatory Agents; Anticoagulants; Aspirin; Catech | 1986 |
9 trials available for aspirin and Necrosis
| Article | Year |
|---|---|
Effect of tailored use of tirofiban in patients with Non-ST-elevation acute coronary syndrome undergoing percutaneous coronary intervention: a randomized controlled trial.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Aspirin; Biomarkers; Clopidogrel; Coronary Angiogr | 2018 |
Tirofiban optimizes platelet inhibition for immediate percutaneous coronary intervention in high-risk acute coronary syndromes.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease | 2008 |
Randomized trial comparing 600- with 300-mg loading dose of clopidogrel in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: results of the Platelet Responsiveness to Aspirin and Clopidogrel and Troponin
Topics: Acute Coronary Syndrome; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Fema | 2009 |
The effects of aspirin and clopidogrel response on myonecrosis after percutaneous coronary intervention: a BRIEF-PCI (Brief Infusion of Intravenous Eptifibatide Following Successful Percutaneous Coronary Intervention) trial substudy.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Blood Platelets; Clopidogrel; Coronary Artery Disease | 2008 |
[Study on the relationship between aspirin resistance and incidence of myonecrosis after non-emergent percutaneous coronary intervention].
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Coronary Disease; Creatine Kinase, MB Form; Drug Resi | 2005 |
The effect of high-dose aspirin pre-treatment on the incidence of myonecrosis following elective coronary stenting.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Combined Modality Therapy; Coronary Disease; Creatine | 2008 |
Effects of persistent platelet reactivity despite aspirin therapy on cardiac troponin I and creatine kinase-MB levels after elective percutaneous coronary interventions.
Topics: Aged; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; Clopidogrel; Coronary Artery Disease; Cre | 2008 |
Can NSAID/ASA-induced erosions of the gastric mucosa be identified at histology?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Endoscopy, Gastrointestinal; Female; Gastr | 1999 |
Drug therapy. Acetaminophen.
Topics: Acetaminophen; Adolescent; Adult; Aspirin; Body Temperature; Chemical and Drug Induced Liver Injury; | 1976 |
93 other studies available for aspirin and Necrosis
| Article | Year |
|---|---|
Acetylsalicylic Acid Is Not Associated With Improved Clinical Outcomes After Microsurgical Breast Reconstruction.
Topics: Aspirin; Breast Neoplasms; Female; Humans; Mammaplasty; Mastectomy; Middle Aged; Necrosis; Postopera | 2023 |
Effect of Aspirin on the Intestinal Response to a Necrotic Enteritis Challenge.
Topics: Animal Nutritional Physiological Phenomena; Animals; Aspirin; Chickens; Clostridium Infections; Clos | 2019 |
Anagrelide with low-dose aspirin promptly epithelized ulceronecrotic lesion secondary to essential thrombocythemia.
Topics: Aspirin; Bone Marrow; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Janus Kin | 2020 |
Rabbit Elastase Aneurysm: Imaging and Histology Correlates for Inflammation and Healing.
Topics: Animals; Aspirin; Carotid Artery Diseases; Carotid Artery, Common; Disease Models, Animal; Disease P | 2021 |
Dermal Filler-Induced Vascular Occlusion Successfully Treated With Tadalafil, Hyaluronidase, and Aspirin.
Topics: Adult; Arterial Occlusive Diseases; Aspirin; Cosmetic Techniques; Dermal Fillers; Drug Therapy, Comb | 2021 |
Necrotic cutaneous vasculitic skin lesions: a case of atypical Henoch-Schönlein purpura in a child with heterozygosity for factor V Leiden.
Topics: Aspirin; Azathioprine; Biopsy; Child, Preschool; Factor V; Humans; IgA Vasculitis; Immunosuppressive | 2017 |
Cortical laminar necrosis in a case of migrainous cerebral infarction.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Aspirin; Cerebral Cortex; Cerebral | 2018 |
Cyclooxygenase (COX) Inhibition by Acetyl Salicylic Acid (ASA) Enhances Antitumor Effects of Nitric Oxide in Glioblastoma In Vitro.
Topics: Antineoplastic Agents; Aspirin; Azo Compounds; Cell Line, Tumor; Cell Survival; Cyclooxygenase Inhib | 2019 |
Post-filler vascular occlusion: a cautionary tale and emphasis for early intervention.
Topics: Adult; Aspirin; Cosmetic Techniques; Female; Humans; Hyaluronic Acid; Hyaluronoglucosaminidase; Hype | 2013 |
Dual antiplatelet response during PCI: VerifyNow P2Y12 predicts myocardial necrosis and thromboxane B2 generation confirms wide variation in aspirin response.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Platelets; Clopidogrel; Cohort Studies | 2015 |
Dual antiplatelet therapy for PCI: Are we tailored to all?
Topics: Aspirin; Female; Humans; Male; Myocardium; Necrosis; Percutaneous Coronary Intervention; Platelet Ag | 2015 |
Treatment of Hyaluronic Acid Filler-Induced Impending Necrosis With Hyaluronidase: Consensus Recommendations.
Topics: Aspirin; Dermal Fillers; Humans; Hyaluronic Acid; Hyaluronoglucosaminidase; Massage; Necrosis; Nitro | 2015 |
Effects of aspirin-triggered resolvin D1 on peripheral blood mononuclear cells from patients with Chagas' heart disease.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Count; Cell Proliferation; | 2016 |
Provoking conditions, management and outcomes of type 2 myocardial infarction and myocardial necrosis.
Topics: Aged; Aged, 80 and over; Aspirin; Electrocardiography; Female; Hospital Mortality; Humans; Hydroxyme | 2016 |
Aspirin Protects against Acinar Cells Necrosis in Severe Acute Pancreatitis in Mice.
Topics: Acinar Cells; Animals; Apoptosis; Aspirin; bcl-2-Associated X Protein; Caspase 3; Cell Nucleus; Down | 2016 |
NO-donating aspirin inhibits angiogenesis by suppressing VEGF expression in HT-29 human colon cancer mouse xenografts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colonic Neoplasms; HT29 Cells; Humans; Im | 2008 |
Nitric oxide-donating aspirin inhibits the growth of pancreatic cancer cells through redox-dependent signaling.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Line, Tumor; Cell Proliferation; C | 2009 |
Livedoid vasculopathy with underlying subcutaneous necrotizing venulitis in an asymptomatic hepatitis B virus carrier: is livedoid vasculopathy a true nonvasculitic disorder?
Topics: Administration, Oral; Adult; Alprostadil; Aspirin; Biopsy; Carrier State; Combined Modality Therapy; | 2009 |
The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Angina, Unstable; Aspirin; Comorbidity; Drug Resistance; Electrocardi | 2009 |
Vascular perfusion abnormalities in infants with spinal muscular atrophy.
Topics: Anti-Infective Agents, Local; Anticoagulants; Aspirin; Diosmin; Female; Fingers; Heparin; Humans; In | 2009 |
Platelet-bound P-selectin expression in patients with coronary artery disease: impact on clinical presentation and myocardial necrosis, and effect of diabetes mellitus and anti-platelet medication.
Topics: Acute Coronary Syndrome; Angina Pectoris; Aspirin; Biomarkers; Blood Platelets; Clopidogrel; Coronar | 2010 |
[Pseudoneoplastic regeneration of the stomach. Histopathology and differential diagnosis].
Topics: Aspirin; Carcinoma; Diagnosis, Differential; Gastritis; Helicobacter Infections; Humans; Intestinal | 2010 |
ANCA-positive necrotizing vasculitis and thrombotic vasculopathy induced by levamisole-adulterated cocaine: a distinctive clinicopathologic presentation.
Topics: Adrenal Cortex Hormones; Antibodies, Antineutrophil Cytoplasmic; Aspirin; Biopsy, Needle; Cocaine-Re | 2011 |
Management of impending necrosis associated with soft tissue filler injections.
Topics: Adult; Antacids; Aspirin; Cosmetic Techniques; Durapatite; Female; Humans; Hyaluronic Acid; Hyaluron | 2011 |
Extensive skin necrosis induced by low-molecular-weight heparin in a patient with systemic lupus erythematosus and antiphospholipid syndrome.
Topics: Antiphospholipid Syndrome; Aspirin; Drug Eruptions; Drug Therapy, Combination; Enoxaparin; Female; F | 2012 |
Intestinal ischaemia and mesenteric necrosis in a heavy smoker.
Topics: Abdominal Pain; Aspirin; Diarrhea; Humans; Jejunal Diseases; Male; Mesenteric Arteries; Middle Aged; | 2013 |
Effects of aspirin on mesenteric lymph nodes of rabbits as basis for its use on lymph nodes metastases.
Topics: Animals; Antineoplastic Agents; Apoptosis; Aspirin; Drug Screening Assays, Antitumor; Germinal Cente | 2012 |
Can the diagnosis of NSAID-induced or Hp-associated gastric ulceration be predicted from histology?
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biopsy; Comorbidity; Diagnosis, Differential | 2002 |
Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Edema; Esters; Gastric Mucosa; Humans; Hy | 2003 |
Effect of D-003 on isoproterenol-induced myocardial necrosis in rats.
Topics: Animals; Aspirin; Disease Models, Animal; Fatty Acids; Isoproterenol; Male; Myocardial Infarction; M | 2003 |
Platelet function predicts myocardial damage in patients with acute myocardial infarction.
Topics: Abciximab; Adenosine Diphosphate; Aged; Antibodies, Monoclonal; Anticoagulants; Aspirin; Cardiovascu | 2004 |
Is aspirin resistance or female gender associated with a high incidence of myonecrosis after nonurgent percutaneous coronary intervention?
Topics: Angioplasty, Balloon, Coronary; Aspirin; Drug Resistance; Female; Fibrinolytic Agents; Humans; Incid | 2005 |
Reversible ischaemia after raising a radial forearm flap with ulceration of three fingers in a cigarette smoker.
Topics: Anticoagulants; Aspirin; Carcinoma, Squamous Cell; Fascia; Fibrinolytic Agents; Fingers; Forearm; He | 2006 |
Phosphatidylcholine-associated nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit DNA synthesis and the growth of colon cancer cells in vitro.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Line, Tumor; Cell Proliferation; C | 2006 |
Partial inhibition of platelet thromboxane A2 synthesis by aspirin is associated with myonecrosis in patients with ST-segment elevation myocardial infarction.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Blood Platelets; Case-Control Studies; Drug Resistance; Fem | 2007 |
Platelet activation and myocardial necrosis in patients undergoing radiofrequency and cryoablation of isthmus-dependent atrial flutter.
Topics: Anticoagulants; Aspirin; Atrial Flutter; Biomarkers; Catheter Ablation; Chi-Square Distribution; Cry | 2007 |
Generalized vasculitic exanthem following Loxosceles reclusa envenomation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cryotherapy; Dapsone; Drug Therapy, Combi | 2007 |
Measuring aspirin resistance, clopidogrel responsiveness, and postprocedural markers of myonecrosis in patients undergoing percutaneous coronary intervention.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Angioplasty, Balloon, Coronary; Aspirin; Biomarkers; | 2007 |
Cannabis arteritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arteritis; Aspirin; Early Diagnosis; Female; Humans; Mariju | 2008 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis.
Topics: Animals; Aspirin; Body Weight; Creatine Kinase; Cyclic AMP; Heart; Isoproterenol; Male; Myocardial I | 1981 |
The role of metabolic activation of analgesics and non-steroidal anti-inflammatory drugs in the development of renal papillary necrosis and upper urothelial carcinoma.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Aspirin; B | 1984 |
Acetyl salicylic acid-induced gastric mucosal lesions: no role of gastric glutathione.
Topics: Animals; Aspirin; Cysteine; Gastric Acid; Gastric Mucosa; Glutathione; Liver; Male; Necrosis; Rats; | 1984 |
Increase in pepsin content in gastric mucosa during the course of aspirin- and taurocholate-induced gastric ulceration in rats.
Topics: Animals; Aspirin; Diffusion; Gastric Mucosa; Hydrogen-Ion Concentration; Male; Necrosis; Pepsin A; P | 1980 |
Prevention of chemically induced myocardial damage & concomitant changes in fibrinolytic system by acetyl salicylic acid in rats.
Topics: Animals; Aspirin; Female; Fibrinolysis; Heart; Male; Myocardium; Necrosis; Rats | 1980 |
[Cerebral space-occupying lesion in thrombocytosis].
Topics: Adult; Aspirin; Bleeding Time; Cerebral Veins; Combined Modality Therapy; Humans; Intracranial Embol | 1995 |
Effect of dissolution profile and (-)-alpha-bisabolol on the gastrotoxicity of acetylsalicylic acid.
Topics: Animals; Aspirin; Chemistry, Pharmaceutical; Gastric Mucosa; Male; Monocyclic Sesquiterpenes; Necros | 1995 |
Effect of policosanol on isoprenaline-induced myocardial necrosis in rats.
Topics: Administration, Oral; Animals; Aspirin; Fatty Alcohols; Glycosaminoglycans; Heart; Isoproterenol; Ma | 1994 |
[Anticardiolipin syndrome with only skin involvement].
Topics: Adult; Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Arm; Aspirin; Azathioprine; Combined | 1994 |
[Use of necrectomy in the treatment of suppurative infective wounds].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anti-Infective Agents; Aspirin; Child; Child, P | 1994 |
Esophageal necrosis in the Stevens-Johnson syndrome.
Topics: Adult; Aspirin; Epithelium; Esophagus; Humans; Male; Mucous Membrane; Necrosis; Stevens-Johnson Synd | 1993 |
Gastric adaptation to injury by repeated doses of aspirin strengthens mucosal defence against subsequent exposure to various strong irritants in rats.
Topics: Adaptation, Physiological; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Tolerance | 1995 |
Edmund Prince Fowler Award Thesis. Evaluation of random skin flap survival in a porcine model.
Topics: Animals; Antioxidants; Aspirin; Dinoprostone; Dose-Response Relationship, Drug; Erythrocyte Deformab | 1996 |
Intimal injury in a transiently occluded coronary artery increases myocardial necrosis. Effect of aspirin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bleeding Time; Blood Cell Count; Coronary | 1996 |
Synthesis and anti-inflammatory properties of 8-(3-dimethylaminopropionyl)-1,6-benzodioxocane.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bri | 1995 |
Apoptosis induction and inhibition of colon-26 tumour growth and angiogenesis: findings on COX-1 and COX-2 inhibitors in vitro & in vivo and topical diclofenac in hyaluronan.
Topics: Administration, Topical; Animals; Apoptosis; Aspirin; Cell Division; Cell Survival; Colonic Neoplasm | 1997 |
Aspirin toxicity for human colonic tumor cells results from necrosis and is accompanied by cell cycle arrest.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Aspirin; Cell Cycle; Cell Division; Colonic Neoplasms; | 1998 |
Efficacy of pentoxifylline with aspirin in the treatment of frostbite in rats.
Topics: Animals; Aspirin; Cold Temperature; Drug Therapy, Combination; Female; Frostbite; Male; Necrosis; Pe | 1998 |
Effect of a novel tetrapeptide derivative in a model of isoproterenol induced myocardial necrosis.
Topics: Adrenergic beta-Agonists; Animals; Aspirin; Body Weight; Creatine Kinase; Disease Models, Animal; Fe | 1998 |
Noninvasive measurements of infarct size after thrombolysis with a necrosis-avid MRI contrast agent.
Topics: Animals; Aspirin; Contrast Media; Coronary Thrombosis; Dogs; Drug Therapy, Combination; Heparin; Ima | 1999 |
Craniofacial pain followed by scalp necrosis and stroke. An unusual presentation of the primary antiphospholipid syndrome.
Topics: Aged; Antibodies, Antiphospholipid; Anticoagulants; Antiphospholipid Syndrome; Aspirin; Autoimmune D | 1999 |
Effects of hemoglobin-based oxygen-carrying solutions in anesthetized rats with acute ischemic renal failure.
Topics: Acute Kidney Injury; Animals; Aspirin; Blood Pressure; Glomerular Filtration Rate; Heart Rate; Hemog | 2000 |
NSAIDs induce both necrosis and apoptosis in guinea pig gastric mucosal cells in primary culture.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspiri | 2001 |
Experimental myocardial necrosis in rats: role of arjunolic acid on platelet aggregation, coagulation and antioxidant status.
Topics: Animals; Antioxidants; Aspirin; Blood Coagulation; Electrocardiography; Female; Humans; Hydrogen Per | 2001 |
Antiphospholipid antibody syndrome.
Topics: Antibodies, Anticardiolipin; Antiphospholipid Syndrome; Aspirin; Child, Preschool; Fibrinolytic Agen | 2001 |
Studies on the signal cascade mechanism mediating the cardioprotective actions of bradykinin.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aspirin; Bradykinin; Female; Heart Ventricles; Li | 2002 |
Analgesic nephropathy.
Topics: Acidosis; Analgesics, Opioid; Aspirin; Australia; Dehydration; Health Education; Humans; Kidney Dise | 1976 |
Action of gold thioglucose on pericapillary structures in the ventromedial hypothalamus.
Topics: Animals; Aspirin; Aurothioglucose; Blood-Brain Barrier; Brain Edema; Dose-Response Relationship, Dru | 1979 |
[Side effects of drug for thromboembolism prophylaxis. Results from the University Women's Clinic Freiburg/Br].
Topics: Adult; Anaphylaxis; Anticoagulants; Aspirin; Dextrans; Female; Hemorrhage; Heparin; Humans; Necrosis | 1979 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 23--1977.
Topics: Acetaminophen; Acute Disease; Adolescent; Arthritis, Juvenile; Aspirin; Brain Death; Brain Edema; Ch | 1977 |
Effects of acetylsalicylic acid, dipyridamole, and hydrocortisone on epinephrine-induced myocardial injury in dogs.
Topics: Acute Disease; Animals; Aspartate Aminotransferases; Aspirin; Calcium; Calcium Chloride; Cardiomyopa | 1976 |
The effect of a potent inhibitor of platelet aggregation, BL-3459, on adrenaline-induced myocardial necrosis in beagle dogs.
Topics: Animals; Aspirin; Blood Pressure; Disease Models, Animal; Dogs; Epinephrine; Female; Imidazoles; Mal | 1976 |
[Prevention of digestive complications of aspirin].
Topics: Animals; Aspirin; Gastric Mucosa; Gastritis; Gastrointestinal Hemorrhage; Humans; Necrosis; Rats; So | 1975 |
Granulomatous panniculitis in erythema nodosum.
Topics: Adult; Aged; Aspirin; Caseins; Erythema Induratum; Erythema Nodosum; Female; Follow-Up Studies; Gran | 1975 |
[The thrombosis of superficial venous system].
Topics: Aged; Aspirin; Coumarins; Female; Humans; Male; Microcirculation; Middle Aged; Necrosis; Phlebograph | 1975 |
[The effect of acetylsalicylic acid on the development of infarct-like myocardial necroses experimentally induced in rats by a single administration of novodrin (isopropylnoreadrenaline)].
Topics: Animals; Aspirin; Male; Myocardial Infarction; Necrosis; Norepinephrine; Rats | 1975 |
Transforming growth factor alpha protection against drug-induced injury to the rat gastric mucosa in vivo.
Topics: Animals; Aspirin; Dinoprostone; Ethanol; Ethylmaleimide; Gastric Mucins; Gastric Mucosa; Image Proce | 1992 |
Thromboxane plasma level in kappa-carrageenin-induced acronecrosis of the tail in rats.
Topics: Animals; Aspirin; Carrageenan; Chlorpromazine; Dexamethasone; Heparin; Imidazoles; Naphthalenes; Nec | 1991 |
Acetaminophen hepatotoxicity: is there a role for prostaglandin synthesis?
Topics: Acetaminophen; Animals; Aspirin; Chemical and Drug Induced Liver Injury; Glutathione; Hexobarbital; | 1990 |
Protection of irradiated parotid by prostaglandin synthesis inhibitors.
Topics: Amylases; Animals; Aspirin; Female; Indomethacin; Necrosis; Parotid Gland; Prostaglandin Antagonists | 1986 |
Gastric epithelial mucus--a densitometric histochemical study of aspirin-induced damage in the rat.
Topics: Animals; Aspirin; Densitometry; Gastric Mucins; Gastric Mucosa; Histocytochemistry; Male; Mucus; Nec | 1985 |
Effects of inhibitors of arachidonic acid metabolism on Paf-induced gastric mucosal necrosis and haemoconcentration.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic | 1986 |
Lack of cytoprotection by acetaminophen against ethanol-, HCl.ethanol- and HCl.aspirin-induced gastric mucosal lesions in rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetaminophen; Animals; Aspirin; Ethanol; Gastric Mucosa; Hydrochlor | 1987 |
Rare adverse reactions to nonsteroidal antiinflammatory drugs.
Topics: Anti-Inflammatory Agents; Aspirin; Asthma; Biomechanical Phenomena; Bone Diseases; Drug Hypersensiti | 1985 |
Analgesic nephropathy. A clinicopathologic study using electron microscopy.
Topics: Adult; Aspirin; Autopsy; Bacterial Infections; Basement Membrane; Beta-Globulins; Biopsy; Collagen; | 1971 |
[Periarteritis nodosa and colonic perforation].
Topics: Aged; Amputation, Surgical; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Autopsy; Colon | 1974 |
Experimental digital replantation after prolonged cooling.
Topics: Animals; Arteries; Aspirin; Autopsy; Cold Temperature; Dipyridamole; Fingers; Graft Rejection; Haplo | 1974 |
Chondrolysis of the hip.
Topics: Adolescent; Arthroplasty; Aspirin; Cartilage Diseases; Child; Epiphyses, Slipped; Exercise Therapy; | 1974 |
Protection against epinephrine-induced myocardial necrosis by drugs that inhibit platelet aggregation.
Topics: Animals; Arteriosclerosis; Aspirin; Catecholamines; Dipyridamole; Dogs; Epinephrine; Heart; Myocardi | 1972 |
Clinical and therapeutical problems concerning postthrombotic indurations.
Topics: Ascorbic Acid; Aspirin; Atrophy; Auscultation; Cellulitis; Drug Combinations; Edema; Humans; Leg Ulc | 1972 |
[Fatal diffuse rhabdomyolysis during salicylate and nifuroxazide poisoning].
Topics: Adolescent; Amylases; Aspirin; Autopsy; Biopsy; Creatine Kinase; Fructose-Bisphosphate Aldolase; Hum | 1972 |
Aspirin: intestinal damage in rats.
Topics: Animals; Aspirin; Azo Compounds; Food Deprivation; Ileum; Intestinal Diseases; Intestinal Mucosa; In | 1970 |
[Acute anuric renal insufficiency with necrosing arteriolitis. Etiologic problems].
Topics: Acute Kidney Injury; Adult; Anemia, Hemolytic; Angioedema; Anuria; Arteritis; Arthritis; Aspirin; Dr | 1968 |