Proteins > Endothelin receptor type B
Page last updated: 2024-08-07 16:10:08

Endothelin receptor type B

An endothelin receptor type B that is encoded in the genome of rat. [OMA:P21451, PRO:DNx]

Synonyms

ET-B;
ET-BR;
Endothelin receptor non-selective type

Research

Bioassay Publications (7)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (42.86)18.2507
2000's2 (28.57)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80

Compounds (230)

Drugs with Potency Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
amlexanoxRattus norvegicus (Norway rat)Potency7.079510
anisindioneRattus norvegicus (Norway rat)Potency17.782810
6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diolRattus norvegicus (Norway rat)Potency3.162310
ebselenRattus norvegicus (Norway rat)Potency22.387210
indoprofenRattus norvegicus (Norway rat)Potency15.848910
leflunomideRattus norvegicus (Norway rat)Potency17.782810
thiabendazoleRattus norvegicus (Norway rat)Potency31.622810
quinophthaloneRattus norvegicus (Norway rat)Potency14.125410
dehydrothio-4-toluidineRattus norvegicus (Norway rat)Potency12.589310
indirubinRattus norvegicus (Norway rat)Potency17.782810
hematoxylinRattus norvegicus (Norway rat)Potency8.912510
4-(benzoylamino)-2-hydroxybenzoic acidRattus norvegicus (Norway rat)Potency17.782810
2-phenylbenzimidazoleRattus norvegicus (Norway rat)Potency12.589310
2,5-diphenyloxazoleRattus norvegicus (Norway rat)Potency11.220210
drometrizoleRattus norvegicus (Norway rat)Potency19.952610
2-(alpha-thenoylamino)-2-nitro-5-thiazoleRattus norvegicus (Norway rat)Potency14.125410
1,6-bismaleimidohexaneRattus norvegicus (Norway rat)Potency8.912510
diacereinRattus norvegicus (Norway rat)Potency31.622810
n-(cyclohexylthio)phthalimideRattus norvegicus (Norway rat)Potency14.125410
k 308Rattus norvegicus (Norway rat)Potency15.848910
nitazoxanideRattus norvegicus (Norway rat)Potency12.589310
xanthyletineRattus norvegicus (Norway rat)Potency25.118910
pifexoleRattus norvegicus (Norway rat)Potency14.125410
2-(2'-pyridyl)benzimidazoleRattus norvegicus (Norway rat)Potency15.848910
methyl fluorone blackRattus norvegicus (Norway rat)Potency35.481310
4-(2-thiazolylazo)resorcinolRattus norvegicus (Norway rat)Potency25.118910
3,5-di-tert-butyl-1,2-benzoquinoneRattus norvegicus (Norway rat)Potency14.125410
witisolRattus norvegicus (Norway rat)Potency15.848910
1,4-di(2'-thienyl)-1,4-butadioneRattus norvegicus (Norway rat)Potency19.952610
2-phenyl-1,2-benzisothiazol-3-(2h)-oneRattus norvegicus (Norway rat)Potency39.810710
N-(4-methoxyphenyl)carbamic acid propan-2-yl esterRattus norvegicus (Norway rat)Potency15.848910
1-Anilino-9,10-dioxo-2-anthroic acidRattus norvegicus (Norway rat)Potency25.118910
gossypol acetic acidRattus norvegicus (Norway rat)Potency0.794310
2-pyridin-4-yl-1,3-benzothiazoleRattus norvegicus (Norway rat)Potency15.848910
2-[(6-butoxy-3-pyridinyl)amino]-4-chlorobenzoic acidRattus norvegicus (Norway rat)Potency28.183810
2-hydroxyestradiolRattus norvegicus (Norway rat)Potency0.562310
nsc228155Rattus norvegicus (Norway rat)Potency35.481310
DubamineRattus norvegicus (Norway rat)Potency15.848910
4,5,7-trihydroxy-9,10-dioxo-2-anthracenecarboxylic acidRattus norvegicus (Norway rat)Potency17.782810
(R)-norlaudanosolineRattus norvegicus (Norway rat)Potency0.501210
resveratrolRattus norvegicus (Norway rat)Potency17.782810
3-(3,5-dimethyl-1-pyrazolyl)-1,2-benzothiazole 1,1-dioxideRattus norvegicus (Norway rat)Potency12.589310
chalconeRattus norvegicus (Norway rat)Potency15.848910
7-methoxyisoflavoneRattus norvegicus (Norway rat)Potency15.848910
2'-hydroxychalconeRattus norvegicus (Norway rat)Potency31.622810
3-methyl-4-(7-methyl-2-indolizinyl)-1,2,5-oxadiazoleRattus norvegicus (Norway rat)Potency25.118910
N,N-dimethyl-6-phenyl-3-pyridazinamineRattus norvegicus (Norway rat)Potency25.118910
3-(3,5-dimethoxyphenyl)-4-prop-2-enyl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency28.183810
3-(3-benzoyl-6-chloro-4,5-dihydroxy-7-benzofuranyl)pentane-2,4-dioneRattus norvegicus (Norway rat)Potency11.220210
4-cyclohexyl-3-[(3-methylphenoxy)methyl]-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency17.782810
acetic acid (11-oxo-6H-benzo[c][1]benzoxepin-2-yl) esterRattus norvegicus (Norway rat)Potency35.481310
4-cyclohexyl-3-(3-pyridinyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency8.912510
4-cyclohexyl-3-(4-methoxyphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency4.466810
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2,5-dimethyl-3-furamideRattus norvegicus (Norway rat)Potency15.848910
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-hydroxy-3-pyrazolecarboxylic acid ethyl esterRattus norvegicus (Norway rat)Potency28.183810
2-[(3-methyl-2-thiophenyl)methylidene]indene-1,3-dioneRattus norvegicus (Norway rat)Potency14.125410
2-(thiophen-2-ylmethylidene)indene-1,3-dioneRattus norvegicus (Norway rat)Potency14.125410
krm iiiRattus norvegicus (Norway rat)Potency15.848910
2-(4-hydroxyanilino)-1,4-naphthoquinoneRattus norvegicus (Norway rat)Potency7.943310
4-[2-(1-methyl-2-benzimidazolyl)ethyl]anilineRattus norvegicus (Norway rat)Potency25.118910
4-(2,5-dimethylphenyl)-3-pyridin-4-yl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency19.952610
nsc185058Rattus norvegicus (Norway rat)Potency13.427010
2-(4-fluorophenyl)-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidineRattus norvegicus (Norway rat)Potency25.118910
3-[(4-methylphenoxy)methyl]-4-phenyl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency31.622810
1-(4,5-dihydrothiazol-2-yl)-3-phenylureaRattus norvegicus (Norway rat)Potency25.118910
3-(2,3-dimethyl-1H-indol-5-yl)-4-prop-2-enyl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency11.220210
3-(3-nitrophenyl)-4-(phenylmethyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency22.387210
N-(2-fluoro-5-methylphenyl)-3-phenylpropanamideRattus norvegicus (Norway rat)Potency19.952610
4-[[(4-acetyloxy-3-methoxyphenyl)-oxomethyl]amino]benzoic acidRattus norvegicus (Norway rat)Potency25.118910
acetic acid [4-[(4-hydroxyanilino)-oxomethyl]-2-methoxyphenyl] esterRattus norvegicus (Norway rat)Potency28.183810
3-bromo-N-(2-furanylmethyl)benzamideRattus norvegicus (Norway rat)Potency15.848910
N-(cyclopentylideneamino)-4,5,6,7-tetrahydro-1H-indazole-3-carboxamideRattus norvegicus (Norway rat)Potency28.183810
4-(3-chlorophenyl)-3-methyl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency31.622810
2-methyl-N-(2-naphthalenyl)-3-furancarboxamideRattus norvegicus (Norway rat)Potency17.782810
2-(ethylthio)-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-oneRattus norvegicus (Norway rat)Potency15.848910
3-(2-furanyl)-4-(2-methylphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency22.387210
N-(1,3-benzodioxol-5-yl)-5-methyl-2-furancarboxamideRattus norvegicus (Norway rat)Potency17.782810
3-(1,3-dimethyl-4-pyrazolyl)-4-(2-methoxyphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency22.387210
4-(2-methylphenyl)-3-(5-methyl-3-thiophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency10.000010
3-(4-ethyl-5-methyl-3-thiophenyl)-4-(phenylmethyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency25.118910
4-(3-methylphenyl)-3-(5-propyl-3-thiophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency31.622810
3-(1,3-benzodioxol-5-yl)-4-(2,5-dimethylphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency3.981110
3-(1-benzothiophen-3-yl)-4-(2-methylphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency14.125410
4-(3-methylphenyl)-3-(5-propan-2-yl-3-thiophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency10.000010
3-(4,5-dimethyl-3-thiophenyl)-4-(2-methylphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency7.943310
3-(2-methyl-3-furanyl)-4-(2-methylphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency28.183810
4-(phenylmethyl)-3-(5-propyl-3-thiophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency25.118910
4-methoxy-2-[3-(4-methoxyphenyl)-5-methyl-1H-pyrazol-4-yl]phenolRattus norvegicus (Norway rat)Potency28.183810
5-(1-methyl-2-benzimidazolyl)-2-thiophenecarboxaldehydeRattus norvegicus (Norway rat)Potency25.118910
N-(2-fluorophenyl)-3-phenylpropanamideRattus norvegicus (Norway rat)Potency25.118910
benzoic acid (2-oxo-2-thiophen-2-ylethyl) esterRattus norvegicus (Norway rat)Potency15.848910
4-sulfanylidene-1,6,7,8,9,10-hexahydropyrimido[3,4]pyrrolo[3,5-a]azepine-11-carbonitrileRattus norvegicus (Norway rat)Potency22.387210
2-[[anilino(oxo)methyl]amino]-N-(2-furanylmethyl)benzamideRattus norvegicus (Norway rat)Potency31.622810
4-[methyl(methylsulfonyl)amino]-N-(2-phenylethyl)benzamideRattus norvegicus (Norway rat)Potency11.220210
4-phenacyloxybenzoic acid methyl esterRattus norvegicus (Norway rat)Potency12.589310
3-(4-ethoxyphenyl)-4-(phenylmethyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency31.622810
N-(4,5-dihydrothiazol-2-yl)-2-(2-methylphenoxy)acetamideRattus norvegicus (Norway rat)Potency31.622810
3-[4-(2-methylphenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]-1H-pyridazin-6-oneRattus norvegicus (Norway rat)Potency39.810710
3-[5-(2-furanyl)-1H-pyrazol-3-yl]-4-(2-methoxyphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency3.548110
4-(4-chlorophenyl)-3-(2-phenylethyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency19.952610
N-(4-methoxyphenyl)-2-(methylthio)benzamideRattus norvegicus (Norway rat)Potency28.183810
4-phenyl-3-(thiophen-2-ylmethyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency10.000010
4-(2-methylphenyl)-3-pyridin-4-yl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency31.622810
3-[[(3-acetylanilino)-oxomethyl]amino]-2-thiophenecarboxylic acid methyl esterRattus norvegicus (Norway rat)Potency15.848910
6-hydroxy-2-(4-nitrophenyl)-3,1-benzoxazin-4-oneRattus norvegicus (Norway rat)Potency14.125410
umi-77Rattus norvegicus (Norway rat)Potency3.548110
N-(5-chloro-2-pyridinyl)-2-ethyl-3-pyrazolecarboxamideRattus norvegicus (Norway rat)Potency28.183810
1-[4-[3-[5-(2-furanyl)-1H-pyrazol-3-yl]-5-sulfanylidene-1H-1,2,4-triazol-4-yl]phenyl]ethanoneRattus norvegicus (Norway rat)Potency12.589310
N-(3-methoxyphenyl)-4-(1-oxopropylamino)benzamideRattus norvegicus (Norway rat)Potency19.952610
3-[[1-oxo-2-[(4,6,9-trimethyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)thio]ethyl]amino]benzoic acidRattus norvegicus (Norway rat)Potency31.622810
N-[5-(4-methoxyphenyl)-1,3,4-thiadiazol-2-yl]-5-methyl-3-isoxazolecarboxamideRattus norvegicus (Norway rat)Potency15.848910
N-(1,3-benzodioxol-5-yl)-2-[[4-(4-methylphenyl)-5-thiophen-2-yl-1,2,4-triazol-3-yl]thio]acetamideRattus norvegicus (Norway rat)Potency39.810710
4-(2-chlorophenyl)-3-(5-methyl-3-phenyl-4-isoxazolyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency17.782810
3-[(1,3-benzothiazol-2-ylthio)methyl]-4-cyclohexyl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency11.220210
4-methyl-2-(4-nitrophenyl)-5-thiazolecarboxylic acidRattus norvegicus (Norway rat)Potency15.848910
3-phenyl-2H-1,4-benzoxazineRattus norvegicus (Norway rat)Potency8.912510
2-(6-chloro-3-pyridinyl)-1H-benzimidazoleRattus norvegicus (Norway rat)Potency25.118910
4-butyl-3-(5-ethyl-3-thiophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency14.125410
4-butyl-3-(5-propan-2-yl-3-thiophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency31.622810
4-butyl-3-(3-methyl-2-thiophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency31.622810
1-[[4-[(3,4-dichlorophenyl)thio]-3-pyridinyl]sulfonyl]-3-propylureaRattus norvegicus (Norway rat)Potency25.118910
4-(2-bromo-4-methylphenyl)-3-[5-(2-furanyl)-1H-pyrazol-3-yl]-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency22.387210
4-(2,5-dimethoxyphenyl)-3-[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency14.125410
4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(3,4-dimethoxyphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency8.912510
3-(1,3-benzodioxol-5-yl)-4-(3-chloro-4-fluorophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency14.125410
2-[[4-(2-chlorophenyl)-5-sulfanylidene-1H-1,2,4-triazol-3-yl]methyl]-1-phthalazinoneRattus norvegicus (Norway rat)Potency25.118910
4-(phenylmethyl)-3-[2-(4-propoxyphenyl)ethyl]-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency19.952610
4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(4-methoxyphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency3.162310
3,4,5-trimethoxy-N-[[2-(4-morpholinyl)anilino]-sulfanylidenemethyl]benzamideRattus norvegicus (Norway rat)Potency8.912510
4-(2,5-dimethoxyphenyl)-3-(3-phenyl-1H-pyrazol-5-yl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency10.000010
3-(4-bromophenyl)-4-(4-methoxyphenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency10.000010
N-[(tert-butylamino)-oxomethyl]-2-[4-(4-hydroxyphenyl)-1-piperazinyl]acetamideRattus norvegicus (Norway rat)Potency12.589310
N-(3,4-dihydro-2H-pyrrol-5-yl)-5-phenyl-1,3,4-oxadiazol-2-amineRattus norvegicus (Norway rat)Potency19.952610
5-(3,4-dimethoxyphenyl)-3-(4-methoxyphenyl)-1H-imidazole-2-thioneRattus norvegicus (Norway rat)Potency7.943310
5-(3,4-dimethoxyphenyl)-3-(4-ethoxyphenyl)-1H-imidazole-2-thioneRattus norvegicus (Norway rat)Potency2.818410
N-[5-(2-methylpropyl)-1,3,4-thiadiazol-2-yl]-4-nitrobenzenesulfonamideRattus norvegicus (Norway rat)Potency28.183810
2,5-dimethoxybenzenesulfonic acid (1,3-dioxo-2-isoindolyl) esterRattus norvegicus (Norway rat)Potency31.622810
4-butyl-3-(phenylmethyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency12.589310
1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)ethanoneRattus norvegicus (Norway rat)Potency28.183810
1-(2-chlorophenyl)-2-(3,5-dimethyl-4-nitro-1-pyrazolyl)ethanoneRattus norvegicus (Norway rat)Potency17.782810
2-chloro-3-pyridinecarboxylic acid [2-(4-fluorophenyl)-2-oxoethyl] esterRattus norvegicus (Norway rat)Potency25.118910
3-(1,3-benzodioxol-5-yl)-4-phenyl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency7.079510
7-methyl-N-[4-(4-morpholinyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxamideRattus norvegicus (Norway rat)Potency28.183810
3-methoxy-N-(4-methyl-2-thiazolyl)benzamideRattus norvegicus (Norway rat)Potency15.848910
3-[[(2,4-dichlorophenyl)methylthio]methyl]-4-propan-2-yl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency28.183810
2-[3-(4-pyridyl)-1H-1,2,4-triazol-5-yl]pyridineRattus norvegicus (Norway rat)Potency15.848910
N-[(2-hydroxyphenyl)-oxomethyl]-2,3-dihydrobenzofuran-5-carboxamideRattus norvegicus (Norway rat)Potency17.782810
4-(2-furanylmethyl)-3-[(3-methoxyphenyl)methyl]-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency11.220210
3-[4-(4-chlorophenyl)-1-piperazinyl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dioneRattus norvegicus (Norway rat)Potency35.481310
3-(4-methoxyphenyl)-3-(4-methylphenyl)sulfonyl-1-phenyl-1-propanoneRattus norvegicus (Norway rat)Potency15.848910
2-(3,4-dimethylphenyl)-5-ethyl-5-phenyl-1,2,4-triazolidine-3-thioneRattus norvegicus (Norway rat)Potency39.810710
4-(1-phenylethyl)-3-pyridin-4-yl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency31.622810
4-[1-(4-fluorophenyl)ethyl]-3-thiophen-2-yl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency25.118910
3-(benzenesulfonyl)-3-(4-methoxyphenyl)-1-phenyl-1-propanoneRattus norvegicus (Norway rat)Potency15.848910
2-quinolinecarboxylic acid (1-oxo-1-phenylpropan-2-yl) esterRattus norvegicus (Norway rat)Potency31.622810
yl-109Rattus norvegicus (Norway rat)Potency28.183810
4-[4-[[1-(2-methylbutan-2-yl)-5-tetrazolyl]-(6-quinolinyl)methyl]-1-piperazinyl]phenolRattus norvegicus (Norway rat)Potency25.118910
4-[4-[(1-tert-butyl-5-tetrazolyl)-pyridin-4-ylmethyl]-1-piperazinyl]phenolRattus norvegicus (Norway rat)Potency31.622810
3-(4-bromophenyl)-4-(2-furanylmethyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency22.387210
4-[[(3-methoxyphenyl)-oxomethyl]amino]benzoic acidRattus norvegicus (Norway rat)Potency25.118910
4-butyl-3-(4-chloro-1,5-dimethyl-3-pyrazolyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency12.589310
3-(6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-4-prop-2-enyl-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency25.118910
4-butyl-3-(6-methyl-4,5,6,7-tetrahydro-1-benzothiophen-3-yl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency17.782810
N-cycloheptyl-4-(2-oxolanylmethoxy)benzamideRattus norvegicus (Norway rat)Potency19.952610
2-[(4-amino-7-tert-butyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)thio]acetic acidRattus norvegicus (Norway rat)Potency25.118910
3-nitro-N-(2-phenylethyl)-2-pyridinamineRattus norvegicus (Norway rat)Potency14.125410
4-(2-methylcyclohexyl)-3-(3-pyridinyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency19.952610
2-[2-[5-amino-4-(3-thiophenyl)-1-pyrazolyl]-4-phenyl-5-thiazolyl]acetic acidRattus norvegicus (Norway rat)Potency39.810710
4-[[(2-methyl-5-nitro-1H-imidazol-4-yl)thio]methyl]-2-nitrophenolRattus norvegicus (Norway rat)Potency15.848910
3,5-bis(4-methoxyphenyl)-1H-imidazole-2-thioneRattus norvegicus (Norway rat)Potency1.412510
4-(1-phenylethyl)-3-(5-propyl-3-thiophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency22.387210
2-methoxy-N-(5-phenyl-1,2,4-thiadiazol-3-yl)benzamideRattus norvegicus (Norway rat)Potency28.183810
2-[[2-(3,4-dimethoxyanilino)-2-oxoethyl]thio]-3-pyridinecarboxylic acid propan-2-yl esterRattus norvegicus (Norway rat)Potency35.481310
3-(4-chloro-1,5-dimethyl-3-pyrazolyl)-4-(4-fluorophenyl)-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency39.810710
2-(2-fluoroanilino)-3-pyridinecarboxylic acid [2-[(1,1-dioxo-3-thiolanyl)-methylamino]-2-oxoethyl] esterRattus norvegicus (Norway rat)Potency17.782810
N,N,4-trimethyl-2-[[(5-methyl-2-furanyl)-oxomethyl]amino]-5-thiazolecarboxamideRattus norvegicus (Norway rat)Potency22.387210
4-(4-chlorophenyl)-3-[2-(4-methylphenyl)cyclopropyl]-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency35.481310
4-(4-chlorophenyl)-3-phenyl-1H-imidazole-2-thioneRattus norvegicus (Norway rat)Potency2.511910
4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[[2-(2-pyridinyl)-1-benzimidazolyl]methyl]-1H-1,2,4-triazole-5-thioneRattus norvegicus (Norway rat)Potency14.125410
3-(2-methoxyphenyl)-4-phenyl-1H-imidazole-2-thioneRattus norvegicus (Norway rat)Potency11.220210
4-(4-methylphenyl)-3-phenyl-1H-imidazole-2-thioneRattus norvegicus (Norway rat)Potency11.220210
2-cyano-N'-[2,6-dinitro-4-(trifluoromethyl)phenyl]acetohydrazideRattus norvegicus (Norway rat)Potency25.118910
3-(4-methyl-1,3-dioxan-2-yl)-1-benzopyran-4-oneRattus norvegicus (Norway rat)Potency22.387210
N-[bis(methylthio)methylideneamino]-4-hydroxybenzamideRattus norvegicus (Norway rat)Potency31.622810
chrysoeriolRattus norvegicus (Norway rat)Potency15.848910
4-hydroxyestradiolRattus norvegicus (Norway rat)Potency1.000010
4-hydroxychalconeRattus norvegicus (Norway rat)Potency12.589310
3-(prop-2-enylthio)-[1,2,4]triazino[5,6-d][3,1]benzoxazepineRattus norvegicus (Norway rat)Potency25.118910
5,7-dihydroxy-4',6-dimethoxyflavoneRattus norvegicus (Norway rat)Potency7.943310
erbstatinRattus norvegicus (Norway rat)Potency4.466810
2'-hydroxy-4-methoxychalconeRattus norvegicus (Norway rat)Potency25.118910
(2e)-3-phenyl-1-(2,3,4,5-tetrahydro-1,6-benzodioxocin-8-yl)prop-2-en-1-oneRattus norvegicus (Norway rat)Potency28.183810
styrylquinolineRattus norvegicus (Norway rat)Potency12.589310
7-hydroxyisoflavoneRattus norvegicus (Norway rat)Potency12.589310
dithiazanine iodideRattus norvegicus (Norway rat)Potency22.387210
quinaldine redRattus norvegicus (Norway rat)Potency15.848910
2',3,4-trihydroxychalconeRattus norvegicus (Norway rat)Potency11.220210
chloride of pseudoisocyanineRattus norvegicus (Norway rat)Potency14.125410
alpha-(p-Methoxyphenyl)-2-pyridineacrylonitrileRattus norvegicus (Norway rat)Potency8.912510
Adenosine 5'-monophosphate monohydrateRattus norvegicus (Norway rat)Potency10.000010
1-(3-methoxyphenyl)-3-[2-(methylthio)phenyl]ureaRattus norvegicus (Norway rat)Potency22.387210
altenusinRattus norvegicus (Norway rat)Potency2.818410
hydralazine 4-anisaldehyde hydrazoneRattus norvegicus (Norway rat)Potency11.220210
lissamine rhodamine bRattus norvegicus (Norway rat)Potency15.848910
N-[3-[butyl(ethyl)amino]propyl]-2-[6-(4-morpholinylsulfonyl)-3-oxo-1,4-benzothiazin-4-yl]acetamideRattus norvegicus (Norway rat)Potency17.782810
5-methyl-5-pentyl-2-phenyl-1,2,4-triazolidine-3-thioneRattus norvegicus (Norway rat)Potency3.981110
1-(1,4-dioxan-2-yl)-N-[[3-(diphenylmethyl)-1,2,4-oxadiazol-5-yl]methyl]-N-methylmethanamineRattus norvegicus (Norway rat)Potency14.125410
acid blue 129Rattus norvegicus (Norway rat)Potency14.125410
LSM-16789Rattus norvegicus (Norway rat)Potency22.387210

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
cyproheptadineRattus norvegicus (Norway rat)Ki0.050111
mianserinRattus norvegicus (Norway rat)Ki0.063111
ritanserinRattus norvegicus (Norway rat)Ki0.015811
spiperoneRattus norvegicus (Norway rat)Ki0.020011
2-bromolysergic acid diethylamideRattus norvegicus (Norway rat)Ki0.010011
metergolineRattus norvegicus (Norway rat)Ki0.006311
butaclamolRattus norvegicus (Norway rat)Ki0.063111
mesulergineRattus norvegicus (Norway rat)Ki0.007911
bosentan anhydrousRattus norvegicus (Norway rat)IC500.095011
ro 46-2005Rattus norvegicus (Norway rat)IC501.000011
pd 142893Rattus norvegicus (Norway rat)IC503.950022
endothelin (16-21)Rattus norvegicus (Norway rat)IC5050.000011
atrasentanRattus norvegicus (Norway rat)IC500.000011
lu 135252Rattus norvegicus (Norway rat)Ki0.371011
1-methyl-d-lysergic acid butanolamideRattus norvegicus (Norway rat)Ki0.012611
lu 208075Rattus norvegicus (Norway rat)IC500.195011
zibotentanRattus norvegicus (Norway rat)IC500.100011
macitentanRattus norvegicus (Norway rat)IC500.391011
act-132577Rattus norvegicus (Norway rat)IC500.987011
endothelinsRattus norvegicus (Norway rat)IC500.001611
clozapineRattus norvegicus (Norway rat)Ki0.012611

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
lu 208075Rattus norvegicus (Norway rat)Kd1.212822