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Tubulin alpha-1A chain
[no definition available]
Synonyms
Alpha-tubulin 1;
Tubulin alpha-1 chain
Research
Bioassay Publications (74)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (2.70) | 18.7374 |
| 1990's | 5 (6.76) | 18.2507 |
| 2000's | 21 (28.38) | 29.6817 |
| 2010's | 38 (51.35) | 24.3611 |
| 2020's | 8 (10.81) | 2.80 |
Compounds (37)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Synthesis, tubulin binding, antineoplastic evaluation, and structure-activity relationship of oncodazole analogues.Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
[no title available]European journal of medicinal chemistry, , May-05, Volume: 235, 2022
Design, synthesis, and bioevaluation of imidazo [1,2-a] pyrazine derivatives as tubulin polymerization inhibitors with potent anticancer activities.Bioorganic & medicinal chemistry, , 12-15, Volume: 76, 2022
Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors.Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities.European journal of medicinal chemistry, , Aug-05, Volume: 238, 2022
Isoxazole derivatives as anticancer agent: A review on synthetic strategies, mechanism of action and SAR studies.European journal of medicinal chemistry, , Oct-05, Volume: 221, 2021
Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.Journal of medicinal chemistry, , 01-23, Volume: 63, Issue:2, 2020
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.European journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents.European journal of medicinal chemistry, , Dec-15, Volume: 184, 2019
Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents.European journal of medicinal chemistry, , Apr-13, Volume: 112, 2016
Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
New Colchicine-Derived Triazoles and Their Influence on Cytotoxicity and Microtubule Morphology.ACS medicinal chemistry letters, , Feb-11, Volume: 7, Issue:2, 2016
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer.Journal of medicinal chemistry, , Dec-10, Volume: 58, Issue:23, 2015
Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties.Journal of medicinal chemistry, , Dec-27, Volume: 55, Issue:24, 2012
Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis and biological evaluation of 2,4,5-substituted pyrimidines as a new class of tubulin polymerization inhibitors.Journal of medicinal chemistry, , May-12, Volume: 54, Issue:9, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.Bioorganic & medicinal chemistry letters, , Nov-04, Volume: 12, Issue:21, 2002
Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
Antitumor agents. 199. Three-dimensional quantitative structure-activity relationship study of the colchicine binding site ligands using comparative molecular field analysis.Journal of medicinal chemistry, , Jan-27, Volume: 43, Issue:2, 2000
Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 8, Issue:15, 1998
Structure--antitubulin activity relationship in steganacin congeners and analogues. Inhibition of tubulin polymerization in vitro by (+/-)-isodeoxypodophyllotoxin.Journal of medicinal chemistry, , Volume: 23, Issue:5, 1980
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Inhibitors of tubulin assembly identified through screening a compound library.Chemical biology & drug design, , Volume: 72, Issue:6, 2008
Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.Bioorganic & medicinal chemistry, , May-15, Volume: 16, Issue:10, 2008
Structure-activity relationship studies on a novel class of antiproliferative agents derived from Lavendustin A. Part I: Ring A modifications.Bioorganic & medicinal chemistry, , Aug-15, Volume: 16, Issue:16, 2008
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 15, Issue:24, 2005
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
Structure--antitubulin activity relationship in steganacin congeners and analogues. Inhibition of tubulin polymerization in vitro by (+/-)-isodeoxypodophyllotoxin.Journal of medicinal chemistry, , Volume: 23, Issue:5, 1980
4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent. From discovery to initial validation in an in vivo metastasis model.European journal of medicinal chemistry, , Aug-28, Volume: 101, 2015
Synthesis and biological evaluation of tubulysin D analogs related to stereoisomers of tubuvaline.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity.Bioorganic & medicinal chemistry letters, , Nov-04, Volume: 12, Issue:21, 2002
Synthesis and Biological Evaluation of a Biotinylated Paclitaxel With an Extra-Long Chain Spacer Arm.ACS medicinal chemistry letters, , Sep-13, Volume: 3, Issue:9, 2012
Synthesis and NMR-driven conformational analysis of taxol analogues conformationally constrained on the C13 side chain.Journal of medicinal chemistry, , May-10, Volume: 44, Issue:10, 2001
Synthesis and biological evaluation of novel 9-functional heterocyclic coupled 7-deoxy-9-dihydropaclitaxel analogue.Bioorganic & medicinal chemistry letters, , Mar-06, Volume: 10, Issue:5, 2000
Structure-activity studies of antitumor taxanes: synthesis of novel C-13 side chain homologated taxol and taxotere analogs.Journal of medicinal chemistry, , Sep-02, Volume: 37, Issue:18, 1994
Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
Novel sulfonate derivatives: potent antimitotic agents.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
[no title available]European journal of medicinal chemistry, , May-05, Volume: 235, 2022
Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors.Bioorganic & medicinal chemistry, , 11-01, Volume: 73, 2022
Design, synthesis and biological evaluation of combretastatin A-4 sulfamate derivatives as potential anti-cancer agents.RSC medicinal chemistry, , Aug-18, Volume: 12, Issue:8, 2021
Design and synthesis of (2-(phenylamino)thieno[3,2-d]pyrimidin-4-yl)(3,4,5-trimethoxyphenyl)methanone analogues as potent anti-tubulin polymerization agents.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Discovery of Novel Quinoline-Chalcone Derivatives as Potent Antitumor Agents with Microtubule Polymerization Inhibitory Activity.Journal of medicinal chemistry, , 01-24, Volume: 62, Issue:2, 2019
Design, synthesis, and biological evaluation of 1-substituted -2-aryl imidazoles targeting tubulin polymerization as potential anticancer agents.European journal of medicinal chemistry, , Dec-15, Volume: 184, 2019
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
[no title available]European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
[no title available]European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents.European journal of medicinal chemistry, , Feb-01, Volume: 163, 2019
Potent combretastatin A-4 analogs containing 1,2,4-triazole: Synthesis, antiproliferative, anti-tubulin activity, and docking study.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Design and synthesis of cis-restricted benzimidazole and benzothiazole mimics of combretastatin A-4 as antimitotic agents with apoptosis inducing ability.Bioorganic & medicinal chemistry letters, , 09-15, Volume: 26, Issue:18, 2016
Design, synthesis of phenstatin/isocombretastatin-oxindole conjugates as antimitotic agents.Bioorganic & medicinal chemistry, , Apr-15, Volume: 24, Issue:8, 2016
Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.Bioorganic & medicinal chemistry, , Jul-15, Volume: 22, Issue:14, 2014
Design and synthesis of silicon-containing tubulin polymerization inhibitors: replacement of the ethylene moiety of combretastatin A-4 with a silicon linker.Bioorganic & medicinal chemistry, , Dec-01, Volume: 21, Issue:23, 2013
Structure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.Journal of medicinal chemistry, , Sep-12, Volume: 56, Issue:17, 2013
Novel cyanocombretastatins as potent tubulin polymerisation inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 22, Issue:21, 2012
Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis.Journal of medicinal chemistry, , Mar-08, Volume: 55, Issue:5, 2012
Synthesis and biological evaluation of 1-benzylidene-3,4-dihydronaphthalen-2-one as a new class of microtubule-targeting agents.Journal of medicinal chemistry, , Jun-28, Volume: 55, Issue:12, 2012
Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.Bioorganic & medicinal chemistry, , Jan-01, Volume: 20, Issue:1, 2012
Synthesis and biological evaluation of phenstatin metabolites.Bioorganic & medicinal chemistry, , Oct-15, Volume: 19, Issue:20, 2011
1,2,3-triazole analogs of combretastatin A-4 as potential microtubule-binding agents.Bioorganic & medicinal chemistry, , Sep-15, Volume: 18, Issue:18, 2010
1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin.Bioorganic & medicinal chemistry, , May-01, Volume: 16, Issue:9, 2008
Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.Bioorganic & medicinal chemistry letters, , Apr-09, Volume: 11, Issue:7, 2001
Antitumor Agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
The synthesis and tubulin binding activity of thiophene-based analogues of combretastatin A-4.Bioorganic & medicinal chemistry letters, , Sep-03, Volume: 11, Issue:17, 2001
Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Synthesis and biological evaluation of dihydrobenzofuran lignans and related compounds as potential antitumor agents that inhibit tubulin polymerization.Journal of medicinal chemistry, , Dec-30, Volume: 42, Issue:26, 1999
Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.Bioorganic & medicinal chemistry letters, , Aug-04, Volume: 8, Issue:15, 1998
N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Jun-23, Volume: 54, Issue:12, 2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization.Bioorganic & medicinal chemistry, , Jul-15, Volume: 19, Issue:14, 2011
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.European journal of medicinal chemistry, , Volume: 45, Issue:8, 2010
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Mar-12, Volume: 52, Issue:5, 2009
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Nov-29, Volume: 50, Issue:24, 2007
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Dec-28, Volume: 49, Issue:26, 2006
Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1.Bioorganic & medicinal chemistry, , Jan-01, Volume: 20, Issue:1, 2012
Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug.Journal of medicinal chemistry, , Jul-13, Volume: 43, Issue:14, 2000
Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.ACS medicinal chemistry letters, , Oct-09, Volume: 5, Issue:10, 2014
Synthesis and structure-activity relationship study of antimicrotubule agents phenylahistin derivatives with a didehydropiperazine-2,5-dione structure.Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
Tubulin photoaffinity labeling study with a plinabulin chemical probe possessing a biotin tag at the oxazole.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Anti-microtubule 'plinabulin' chemical probe KPU-244-B3 labeled both alpha- and beta-tubulin.Bioorganic & medicinal chemistry, , May-01, Volume: 18, Issue:9, 2010