Sodium/nucleoside cotransporter 2

A sodium/nucleoside cotransporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O43868]

Synonyms

Concentrative nucleoside transporter 2;
CNT 2;
hCNT2;
Na(+)/nucleoside cotransporter 2;
Sodium-coupled nucleoside transporter 2;
Sodium/purine nucleoside co-transporter;
SPNT;
Solute carrier family 28 member 2

Research

Bioassay Publications (3)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (33.33)	29.6817
2010's	2 (66.67)	24.3611
2020's	0 (0.00)	2.80

Compounds (6)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
floxuridine	Homo sapiens (human)	IC50	1,000.0000	1	1
uridine	Homo sapiens (human)	IC50	32.0000	1	1
uridine	Homo sapiens (human)	Ki	31.0000	1	1
phlorhizin	Homo sapiens (human)	IC50	550.0000	2	2
adenosine	Homo sapiens (human)	IC50	5.5000	1	1
adenosine	Homo sapiens (human)	Ki	5.3000	1	1
tecadenoson	Homo sapiens (human)	IC50	239.0000	1	1
tecadenoson	Homo sapiens (human)	Ki	231.0000	1	1
7,8,3'-trihydroxyflavone	Homo sapiens (human)	IC50	1,000.0000	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
neurotransmitter transmembrane transporter activity	molecular function	Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai, ISBN:0198506732]
purine nucleobase transmembrane transporter activity	molecular function	Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. [ISBN:0198506732]
nucleoside:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in). [GOC:ai]
purine nucleoside transmembrane transporter activity	molecular function	Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other. [GOC:ai]
uridine transmembrane transporter activity	molecular function	Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other. [GOC:go_curators]
pyrimidine- and adenosine-specific:sodium symporter activity	molecular function	Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenosine)(out) + Na+(out) = (pyrimidine nucleoside or adenosine)(in) + Na+(in). [TC:2.A.41.2.3]
azole transmembrane transporter activity	molecular function	Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other. [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
vesicle membrane	cellular component	The lipid bilayer surrounding any membrane-bounded vesicle in the cell. [GOC:mah, GOC:vesicle]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
apicolateral plasma membrane	cellular component	The apical end of the lateral plasma membrane of epithelial cells. [GOC:hb]
coated vesicle	cellular component	Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins. [ISBN:0815316194]
brush border membrane	cellular component	The portion of the plasma membrane surrounding the brush border. [GOC:mah]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 15 target(s):

Target	Category	Definition
nucleobase-containing compound metabolic process	biological process	Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. [GOC:ai]
xenobiotic metabolic process	biological process	The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc]
neurotransmitter transport	biological process	The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai]
xenobiotic transmembrane transport	biological process	The process in which a xenobiotic, a compound foreign to the organim exposed to it, is transported across a membrane. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:ai, GOC:bf, GOC:krc]
pyrimidine nucleobase transport	biological process	The directed movement of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
purine nucleoside transmembrane transport	biological process	The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar. [GOC:ai, GOC:vw]
uridine transmembrane transport	biological process	The directed movement of uridine, uracil riboside, across a lipid bilayer, by means of some agent such as a transporter or pore. [GOC:go_curators]
adenosine transport	biological process	The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:mah]
inosine transport	biological process	The directed movement of the purine ribonucleoside inosine, also known as hypoxanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [PMID:19135251]
azole transmembrane transport	biological process	The directed movement of azoles, heterocyclic compounds found in many biologically important substances, across a lipid bilayer, across a membrane. [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]
pyrimidine-containing compound transmembrane transport	biological process	The process in which a pyrimidine-containing compound is transported across a membrane. A pyrimidine-containing compound is any compound that contains pyrimidine or a formal derivative thereof. [GOC:mah]
transport across blood-brain barrier	biological process	The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008]
nucleoside transmembrane transport	biological process	The directed movement of nucleoside across a membrane. [GOC:pr, GOC:TermGenie]
purine nucleobase transmembrane transport	biological process	The process in which a purine nucleobase is transported across a membrane. [GO_REF:0000069, GOC:TermGenie]
retina homeostasis	biological process	A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function. [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178]