Neuropeptide Y receptor type 1

A neuropeptide Y receptor type 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P25929]

Synonyms

NPY1-R

Research

Bioassay Publications (21)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (9.52)	18.2507
2000's	9 (42.86)	29.6817
2010's	9 (42.86)	24.3611
2020's	1 (4.76)	2.80

Compounds (10)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
benextramine	Homo sapiens (human)	Ki	1.8000	1	1
bibp 3226	Homo sapiens (human)	IC50	0.0091	6	6
bibp 3226	Homo sapiens (human)	Ki	0.1956	12	12
cgp 71683 a	Homo sapiens (human)	IC50	8.3700	1	1
4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride	Homo sapiens (human)	Ki	1.0000	1	1
bms 193885	Homo sapiens (human)	IC50	0.0042	1	1
bms 193885	Homo sapiens (human)	Ki	0.0033	1	1
neuropeptide y (24-36) amide, n-acetyl-(leu(28,31))-	Homo sapiens (human)	Ki	0.2100	2	2
neuropeptide y	Homo sapiens (human)	IC50	0.0014	3	3
neuropeptide y	Homo sapiens (human)	Ki	0.0048	4	4
bombesin	Homo sapiens (human)	IC50	0.0047	1	1
lu aa33810	Homo sapiens (human)	IC50	1.0000	1	1
nitd 609	Homo sapiens (human)	IC50	10.0000	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bibp 3226	Homo sapiens (human)	Kd	0.0021	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
bibp 3226	Homo sapiens (human)	Kb	0.0015	4	4
bms 193885	Homo sapiens (human)	Kb	0.0045	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
peptide YY receptor activity	molecular function	Combining with gut peptide YY to initiate a change in cell activity. [PMID:9315606]
pancreatic polypeptide receptor activity	molecular function	Combining with pancreatic polypeptide PP to initiate a change in cell activity. [PMID:9315606]
neuropeptide Y receptor activity	molecular function	Combining with neuropeptide Y to initiate a change in cell activity. [PMID:9315606]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
neuropeptide receptor activity	molecular function	Combining with a neuropeptide to initiate a change in cell activity. [GOC:ai]
neuropeptide binding	molecular function	Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]

Involved In

This protein is involved in 10 target(s):

Target	Category	Definition
outflow tract morphogenesis	biological process	The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries. [GOC:mtg_heart, UBERON:0004145]
glucose metabolic process	biological process	The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. [ISBN:0198506732]
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194]
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
neuropeptide signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]
locomotory behavior	biological process	The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions. [GOC:dph]
feeding behavior	biological process	Behavior associated with the intake of food. [GOC:mah]
regulation of blood pressure	biological process	Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
sensory perception of pain	biological process	The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process. [GOC:curators]
regulation of multicellular organism growth	biological process	Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. [GOC:dph, GOC:ems, GOC:tb]