Page last updated: 2024-09-23

oxazolidin-2-one

Description

Oxazolidinones: Derivatives of oxazolidin-2-one. They represent an important class of synthetic antibiotic agents. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

oxazolidin-2-one : An oxazolidinone that is 1,3-oxazolidine with an oxo substituent at position 2. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

oxazolidinone : An oxazolidine containing one or more oxo groups. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID73949
CHEMBL ID1867161
CHEBI ID1237
MeSH IDM0249955

Synonyms (60)

Synonym
carbamic acid, .gamma.-lactone
oxazolidin-2-one
nsc-38240
nsc38240
2-oxazolidone
1,3-oxazolidin-2-one
nsc35382
nsc-35382
wln: t5mvotj
oxazolidone
einecs 207-840-9
ai3-38980
nsc 35382
brn 0106251
carbamic acid, (2-hydroxyethyl)-, gamma-lactone
oxazolidinone
inchi=1/c3h5no2/c5-3-4-1-2-6-3/h1-2h2,(h,4,5
oxazolidine,2-one
497-25-6
2-oxazolidinone
C06695
2-oxazolidinone, 98%
smr000857362
MLS001335929
MLS001335930
O0188
AKOS000119963
51667-26-6
A827830
2h-oxazol-2-id-4-one;oxazolidin-2-one
CHEBI:1237 ,
HMS2231L03
4-27-00-02516 (beilstein handbook reference)
z4d49w92pp ,
unii-z4d49w92pp
oxazolidinones
FT-0613254
hydroxy-oxazoline
2-oxo-1,3-oxazolidine
oxazolodinone
oxazolidine-2-one
W-106010
CHEMBL1867161
carbamic acid, (2-hydroxyethyl)-, .gamma.-lactone
2-oxazolidine
2-oxotetrahydro-1,3-oxazole
mfcd00005268
DTXSID2074326
CS-W007548
2-oxazolidinon
F0001-1296
SY003480
Q425555
hydroxyoxazoline
STL183293
STR03231
AMY39498
C93484
EN300-19697
Z104474784

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
oxazolidinoneAn oxazolidine containing one or more oxo groups.
carbamate esterAny ester of carbamic acid or its N-substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency112.20200.354828.065989.1251AID504847
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency35.48130.050127.073689.1251AID588590
gemininHomo sapiens (human)Potency0.23440.004611.374133.4983AID624296; AID624297
VprHuman immunodeficiency virus 1Potency0.89131.584919.626463.0957AID651644
Rap guanine nucleotide exchange factor 4Homo sapiens (human)Potency39.81073.981146.7448112.2020AID720708
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (10)

Processvia Protein(s)Taxonomy
adaptive immune responseRap guanine nucleotide exchange factor 4Homo sapiens (human)
G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayRap guanine nucleotide exchange factor 4Homo sapiens (human)
calcium-ion regulated exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of exocytosisRap guanine nucleotide exchange factor 4Homo sapiens (human)
insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
positive regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of synaptic vesicle cycleRap guanine nucleotide exchange factor 4Homo sapiens (human)
Ras protein signal transductionRap guanine nucleotide exchange factor 4Homo sapiens (human)
regulation of insulin secretionRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
guanyl-nucleotide exchange factor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
cAMP bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
protein-macromolecule adaptor activityRap guanine nucleotide exchange factor 4Homo sapiens (human)
small GTPase bindingRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
cytosolRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
hippocampal mossy fiber to CA3 synapseRap guanine nucleotide exchange factor 4Homo sapiens (human)
plasma membraneRap guanine nucleotide exchange factor 4Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4,186)

TimeframeStudies, This Drug (%)All Drugs %
pre-1990212 (5.06)18.7374
1990's218 (5.21)18.2507
2000's1775 (42.40)29.6817
2010's1718 (41.04)24.3611
2020's263 (6.28)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials347 (7.93%)5.53%
Reviews542 (12.39%)6.00%
Case Studies563 (12.87%)4.05%
Observational9 (0.21%)0.25%
Other2,915 (66.61%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Safety/Toxicity (111)

ArticleYear
Efficacy and safety of intranasal agents for the acute treatment of migraine: a systematic review and network meta-analysis.
The journal of headache and pain, Sep-18, Volume: 24, Issue: 1
2023
Prolonged use of linezolid in bone and joint infections: a retrospective analysis of adverse effects.
The Journal of antimicrobial chemotherapy, 11-06, Volume: 78, Issue: 11
2023
A phase IIb, open-label, randomized controlled dose ranging multi-centre trial to evaluate the safety, tolerability, pharmacokinetics and exposure-response relationship of different doses of delpazolid in combination with bedaquiline delamanid moxifloxaci
Trials, Jun-06, Volume: 24, Issue: 1
2023
Real-world evaluation of linezolid-associated serotonin toxicity with and without concurrent serotonergic agents.
International journal of antimicrobial agents, Volume: 62, Issue: 1
2023
Efficacy and safety of tedizolid for the treatment of ventilated gram-positive hospital-acquired or ventilator-associated bacterial pneumonia in Japanese patients: Results from a subgroup analysis of a phase 3, randomized, double-blind study comparing ted
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Volume: 28, Issue: 9
2022
Single Ascending-Dose Study To Evaluate the Safety, Tolerability, and Pharmacokinetics of Sutezolid in Healthy Adult Subjects.
Antimicrobial agents and chemotherapy, 04-19, Volume: 66, Issue: 4
2022
A Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections.
The Journal of antimicrobial chemotherapy, 05-29, Volume: 77, Issue: 6
2022
Long-term safety and efficacy of anacetrapib in patients with atherosclerotic vascular disease.
European heart journal, 04-06, Volume: 43, Issue: 14
2022
Serious adverse events with tedizolid and linezolid: pharmacovigilance insights through the FDA adverse event reporting system.
Expert opinion on drug safety, Volume: 20, Issue: 11
2021
Hematological side effect analysis of linezolid in MDR-TB patients with individual therapy.
Journal of basic and clinical physiology and pharmacology, Jun-25, Volume: 32, Issue: 4
2021
Long term safety, tolerability, and efficacy of intracutaneous zolmitriptan (M207) in the acute treatment of migraine.
The journal of headache and pain, May-17, Volume: 22, Issue: 1
2021
Residues and dietary intake risk assessments of clomazone, fomesafen, haloxyfop-methyl and its metabolite haloxyfop in spring soybean field ecosystem.
Food chemistry, Oct-30, Volume: 360
2021
Neuropsychiatric toxicity and cycloserine concentrations during treatment for multidrug-resistant tuberculosis.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Volume: 105
2021
Safety and Efficacy of Oral and/or Intravenous Tedizolid Phosphate From a Randomized Phase 3 Trial in Adolescents With Acute Bacterial Skin and Skin Structure Infections.
The Pediatric infectious disease journal, 03-01, Volume: 40, Issue: 3
2021
Safety and Tolerability of More than Six Days of Tedizolid Treatment.
Antimicrobial agents and chemotherapy, 06-23, Volume: 64, Issue: 7
2020
Multiple-dose Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Oral LCB01-0371 in Healthy Male Volunteers.
Clinical therapeutics, Volume: 40, Issue: 12
2018
The effect and safety of anacetrapib in the treatment of dyslipidemia: a systematic review and meta-analysis.
Postgraduate medicine, Volume: 130, Issue: 1
2018
Safety, tolerability and pharmacokinetics of 21 day multiple oral administration of a new oxazolidinone antibiotic, LCB01-0371, in healthy male subjects.
The Journal of antimicrobial chemotherapy, Jan-01, Volume: 73, Issue: 1
2018
Randomized, double-blind, placebo-controlled, parallel-group, multi-center study of the safety and efficacy of ADAM zolmitriptan for the acute treatment of migraine.
Cephalalgia : an international journal of headache, Volume: 38, Issue: 2
2018
Single- and Multiple-Dose Study To Determine the Safety, Tolerability, Pharmacokinetics, and Food Effect of Oral MRX-I versus Linezolid in Healthy Adult Subjects.
Antimicrobial agents and chemotherapy, Volume: 61, Issue: 4
2017
Modulating Mineralocorticoid Receptor with Non-steroidal Antagonists. New Opportunities for the Development of Potent and Selective Ligands without Off-Target Side Effects.
Journal of medicinal chemistry, 04-13, Volume: 60, Issue: 7
2017
[Clinical efficacy and safety of vancomycin compared with linezolid for the treatment of neonatal gram-positive bacterial sepsis].
Zhonghua er ke za zhi = Chinese journal of pediatrics, Volume: 54, Issue: 9
2016
Can herbicide safeners allow selective control of weedy rice infesting rice crops?
Pest management science, Volume: 73, Issue: 1
2017
Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib in Japanese patients with heterozygous familial hypercholesterolemia.
Atherosclerosis, Volume: 249
2016
Drug-drug interactions and safety of linezolid, tedizolid, and other oxazolidinones.
Expert opinion on drug metabolism & toxicology, Volume: 11, Issue: 12
2015
Efficacy and safety of World Health Organization group 5 drugs for multidrug-resistant tuberculosis treatment.
The European respiratory journal, Volume: 46, Issue: 5
2015
Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies.
Journal of medicinal chemistry, Aug-27, Volume: 58, Issue: 16
2015
Safety, tolerability, and efficacy of GSK1322322 in the treatment of acute bacterial skin and skin structure infections.
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 11
2014
Lipids, safety parameters, and drug concentrations after an additional 2 years of treatment with anacetrapib in the DEFINE study.
Journal of cardiovascular pharmacology and therapeutics, Volume: 19, Issue: 6
2014
Efficacy and safety of linezolid for the treatment of infections in children: a meta-analysis.
European journal of pediatrics, Volume: 173, Issue: 9
2014
New potent antibacterial oxazolidinone (MRX-I) with an improved class safety profile.
Journal of medicinal chemistry, Jun-12, Volume: 57, Issue: 11
2014
Efficacy, safety, and tolerability of telcagepant in the treatment of acute migraine: a meta-analysis.
Pain practice : the official journal of World Institute of Pain, Volume: 15, Issue: 2
2015
Evaluation of lipids, drug concentration, and safety parameters following cessation of treatment with the cholesteryl ester transfer protein inhibitor anacetrapib in patients with or at high risk for coronary heart disease.
The American journal of cardiology, Jan-01, Volume: 113, Issue: 1
2014
Cadazolid, a novel antibiotic with potent activity against Clostridium difficile: safety, tolerability and pharmacokinetics in healthy subjects following single and multiple oral doses.
The Journal of antimicrobial chemotherapy, Volume: 69, Issue: 3
2014
Comparative evaluation of serotonin toxicity among veterans affairs patients receiving linezolid and vancomycin.
Antimicrobial agents and chemotherapy, Volume: 57, Issue: 12
2013
Impact of weight on treatment efficacy and safety in complicated skin and skin structure infections and nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus.
Clinical therapeutics, Volume: 35, Issue: 10
2013
Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib in Japanese patients with dyslipidemia.
Atherosclerosis, Volume: 230, Issue: 1
2013
Photocatalytic degradation of the herbicide clomazone in natural water using TiO2: kinetics, mechanism, and toxicity of degradation products.
Chemosphere, Volume: 93, Issue: 1
2013
Safety of cycloserine and terizidone for the treatment of drug-resistant tuberculosis: a meta-analysis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, Volume: 17, Issue: 10
2013
Systematic identification of proteins that elicit drug side effects.
Molecular systems biology, Volume: 9
2013
Linezolid plasma concentrations and occurrence of drug-related haematological toxicity in patients with gram-positive infections.
International journal of antimicrobial agents, Volume: 41, Issue: 6
2013
The efficacy and safety of linezolid and glycopeptides in the treatment of Staphylococcus aureus infections.
PloS one, Volume: 8, Issue: 3
2013
Clinical relevance of linezolid-associated serotonin toxicity.
The Annals of pharmacotherapy, Volume: 47, Issue: 3
2013
Safety of inhibition of cholesteryl ester transfer protein with anacetrapib: the DEFINE study.
Expert review of cardiovascular therapy, Volume: 10, Issue: 8
2012
Safety of CETP inhibition.
Current opinion in lipidology, Volume: 23, Issue: 6
2012
Efficacy and safety of meropenem-clavulanate added to linezolid-containing regimens in the treatment of MDR-/XDR-TB.
The European respiratory journal, Volume: 41, Issue: 6
2013
A reduced linezolid dosage maintains favorable efficacy with minimal hematologic toxicity in a methicillin-resistant Staphylococcus aureus-infected patient with renal insufficiency.
Scandinavian journal of infectious diseases, Volume: 45, Issue: 1
2013
A randomized, evaluator-blind, phase 2 study comparing the safety and efficacy of omadacycline to those of linezolid for treatment of complicated skin and skin structure infections.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 11
2012
Adverse effects of antimicrobials via predictable or idiosyncratic inhibition of host mitochondrial components.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 8
2012
Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients.
The Journal of antimicrobial chemotherapy, Volume: 67, Issue: 8
2012
Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis.
The European respiratory journal, Volume: 40, Issue: 6
2012
Safety and efficacy of linezolid in 16 infants and children in Japan.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Volume: 18, Issue: 4
2012
The safety and efficacy of linezolid and daptomycin as an additive in Optisol-GS against methicillin-resistant Staphylococcus aureus.
Cornea, Volume: 31, Issue: 5
2012
Immediate hematological toxicity of linezolid in healthy volunteers with different body weight: a phase I clinical trial.
The Journal of antibiotics, Volume: 65, Issue: 4
2012
Comparison of serotonin toxicity with concomitant use of either linezolid or comparators and serotonergic agents: an analysis of Phase III and IV randomized clinical trial data.
The Journal of antimicrobial chemotherapy, Volume: 67, Issue: 2
2012
Efficacy and safety of linezolid in the treatment of extensively drug-resistant tuberculosis.
Japanese journal of infectious diseases, Volume: 64, Issue: 6
2011
Efficacy and safety after cessation of treatment with the cholesteryl ester transfer protein inhibitor anacetrapib (MK-0859) in patients with primary hypercholesterolemia or mixed hyperlipidemia.
American heart journal, Volume: 162, Issue: 4
2011
Linezolid: an effective, safe and cheap drug for patients failing multidrug-resistant tuberculosis treatment in India.
The European respiratory journal, Volume: 39, Issue: 4
2012
Randomized, double-blind, phase II, multicenter study evaluating the safety/tolerability and efficacy of JNJ-Q2, a novel fluoroquinolone, compared with linezolid for treatment of acute bacterial skin and skin structure infection.
Antimicrobial agents and chemotherapy, Volume: 55, Issue: 12
2011
Potential for linezolid-related blindness: a review of spontaneous adverse event reports.
Pharmacotherapy, Volume: 31, Issue: 6
2011
A randomized, double-blind phase 2 study comparing the efficacy and safety of an oral fusidic acid loading-dose regimen to oral linezolid for the treatment of acute bacterial skin and skin structure infections.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Volume: 52 Suppl 7
2011
Linezolid: safety and efficacy in special populations.
The Journal of antimicrobial chemotherapy, Volume: 66 Suppl 4
2011
Population pharmacokinetic and pharmacodynamic analysis of linezolid and a hematologic side effect, thrombocytopenia, in Japanese patients.
Antimicrobial agents and chemotherapy, Volume: 55, Issue: 5
2011
Efficacy and safety of linezolid in liver transplant patients.
Transplant infectious disease : an official journal of the Transplantation Society, Volume: 13, Issue: 4
2011
Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections.
Antimicrobial agents and chemotherapy, Volume: 55, Issue: 2
2011
Safety of anacetrapib in patients with or at high risk for coronary heart disease.
The New England journal of medicine, Dec-16, Volume: 363, Issue: 25
2010
Biomarker-assisted dose selection for safety and efficacy in early development of PNU-100480 for tuberculosis.
Antimicrobial agents and chemotherapy, Volume: 55, Issue: 2
2011
Sustained pain freedom and no adverse events as an endpoint in clinical trials of acute migraine treatments: application to patient-level data from a trial of the CGRP receptor antagonist, telcagepant, and zolmitriptan.
Cephalalgia : an international journal of headache, Volume: 31, Issue: 3
2011
Efficacy and safety of linezolid versus vancomycin for the treatment of complicated skin and soft-tissue infections proven to be caused by methicillin-resistant Staphylococcus aureus.
American journal of surgery, Volume: 199, Issue: 6
2010
Efficacy and safety of linezolid in immunocompromised children with cancer.
Pediatrics international : official journal of the Japan Pediatric Society, Volume: 52, Issue: 5
2010
The safety of intraocular linezolid in rabbits.
Investigative ophthalmology & visual science, Volume: 51, Issue: 6
2010
Linezolid: a review of safety and tolerability.
The Journal of infection, Volume: 59 Suppl 1
2009
Hematologic safety profile of linezolid in the early periengraftment period after allogeneic stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, Volume: 15, Issue: 10
2009
Pure red cell precursor toxicity by linezolid in a pediatric case.
Journal of pediatric hematology/oncology, Volume: 31, Issue: 9
2009
Update on the safety of linezolid.
Expert opinion on drug safety, Volume: 8, Issue: 4
2009
A retrospective TBNET assessment of linezolid safety, tolerability and efficacy in multidrug-resistant tuberculosis.
The European respiratory journal, Volume: 34, Issue: 2
2009
Serotonin toxicity as a consequence of linezolid use in revision hip arthroplasty.
Orthopedics, Volume: 31, Issue: 11
2008
Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients.
American heart journal, Volume: 157, Issue: 2
2009
Toxicity of extended courses of linezolid: results of an Infectious Diseases Society of America Emerging Infections Network survey.
Diagnostic microbiology and infectious disease, Volume: 62, Issue: 4
2008
Efficacy and safety of tigecycline compared with vancomycin or linezolid for treatment of serious infections with methicillin-resistant Staphylococcus aureus or vancomycin-resistant enterococci: a Phase 3, multicentre, double-blind, randomized study.
The Journal of antimicrobial chemotherapy, Volume: 62 Suppl 1
2008
[Adverse effect optic neuropathy].
Medizinische Monatsschrift fur Pharmazeuten, Volume: 31, Issue: 6
2008
Larger vancomycin doses (at least four grams per day) are associated with an increased incidence of nephrotoxicity.
Antimicrobial agents and chemotherapy, Volume: 52, Issue: 4
2008
Meta-analysis of the efficacy and safety of zolmitriptan in the acute treatment of migraine.
Headache, Volume: 48, Issue: 2
2008
The role of vitamin B6 in the prevention of haematological toxic effects of linezolid in patients with cancer.
The Journal of antimicrobial chemotherapy, Volume: 61, Issue: 2
2008
Linezolid: effectiveness and safety for approved and off-label indications.
Expert opinion on pharmacotherapy, Volume: 8, Issue: 14
2007
[Toxicity of recent and less recent drugs on the optic nerve. Does Viagra cause blindness?].
Bulletin de la Societe belge d'ophtalmologie, Issue: 304
2007
Efficacy and safety of linezolid for Gram-positive orthopedic infections: a prospective case series.
Diagnostic microbiology and infectious disease, Volume: 59, Issue: 2
2007
Comparative study of the effects of pyridoxine, rifampin, and renal function on hematological adverse events induced by linezolid.
Antimicrobial agents and chemotherapy, Volume: 51, Issue: 7
2007
Tongue discoloration in an elderly kidney transplant recipient: Treatment-related adverse event?
The American journal of geriatric pharmacotherapy, Volume: 4, Issue: 3
2006
Bell's palsy associated with linezolid therapy: case report and review of neuropathic adverse events.
Pharmacotherapy, Volume: 26, Issue: 8
2006
Serotonin toxicity associated with the use of linezolid: a review of postmarketing data.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Jun-01, Volume: 42, Issue: 11
2006
Efficacy and safety of linezolid compared with vancomycin in a randomized, double-blind study of febrile neutropenic patients with cancer.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Mar-01, Volume: 42, Issue: 5
2006
The effectiveness and safety of oral linezolid for the primary and secondary treatment of osteomyelitis.
Journal of chemotherapy (Florence, Italy), Volume: 17, Issue: 6
2005
Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited.
Internal medicine journal, Volume: 35, Issue: 10
2005
Possibly linezolid-induced peripheral and central neurotoxicity: report of four cases.
Infection, Volume: 33, Issue: 3
2005
Efficacy and safety of linezolid in multidrug resistant tuberculosis (MDR-TB)--a report of ten cases.
The Journal of infection, Volume: 52, Issue: 2
2006
Serotonin toxicity associated with concomitant use of linezolid.
The Annals of pharmacotherapy, Volume: 39, Issue: 5
2005
Zolmitriptan nasal spray exhibits good long-term safety and tolerability in migraine: results of the INDEX trial.
Headache, Volume: 45, Issue: 1
2005
The safety and efficacy of linezolid in orthopaedic practice for the treatment of infection due to antibiotic-resistant organisms.
Expert opinion on drug safety, Volume: 3, Issue: 5
2004
Safety and tolerability of linezolid in children.
The Pediatric infectious disease journal, Volume: 22, Issue: 9 Suppl
2003
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Long-term Use (16)

ArticleYear
The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection.
Microbiology spectrum, 10-26, Volume: 10, Issue: 5
2022
Synergistic effect of serotonin 1A and serotonin 1B/D receptor agonists in the treatment of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats.
Experimental neurology, Volume: 358
2022
Long-term use of tedizolid for pulmonary nocardiosis.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Volume: 28, Issue: 8
2022
Long-term use of liposomal nebulized amikacin and tedizolid for the treatment of disseminated nocardiosis after allogeneic hematopoietic stem cell transplantation.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Volume: 40, Issue: 9
2021
Safety, tolerability and pharmacokinetics of 21 day multiple oral administration of a new oxazolidinone antibiotic, LCB01-0371, in healthy male subjects.
The Journal of antimicrobial chemotherapy, Jan-01, Volume: 73, Issue: 1
2018
Chronic Administration of Anacetrapib Is Associated With Accumulation in Adipose and Slow Elimination.
Clinical pharmacology and therapeutics, Volume: 102, Issue: 5
2017
Pharmacological issues of linezolid: an updated critical review.
Clinical pharmacokinetics, Volume: 49, Issue: 7
2010
Linezolid-associated optic neuropathy in a patient with ocular sarcoidosis.
Japanese journal of ophthalmology, Volume: 53, Issue: 4
2009
Linezolid for the treatment of patients with [corrected] mycobacterial infections [corrected] a systematic review.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, Volume: 11, Issue: 6
2007
[Linezolid in the treatment of antibiotic-resistant gram-positive infections of the musculoskeletal system].
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca, Volume: 73, Issue: 5
2006
Efficacy and tolerability of daily-half dose linezolid in patients with intractable multidrug-resistant tuberculosis.
The Journal of antimicrobial chemotherapy, Volume: 58, Issue: 3
2006
Successful treatment of chronic bone and joint infections with oral linezolid.
Clinical orthopaedics and related research, Issue: 427
2004
Peripheral neuropathy associated with prolonged use of linezolid.
The Lancet. Infectious diseases, Volume: 4, Issue: 8
2004
Effects of acute or chronic administration of anti-migraine drugs sumatriptan and zolmitriptan on serotonin synthesis in the rat brain.
Cephalalgia : an international journal of headache, Volume: 24, Issue: 1
2004
Tolerability and consistency of effect of zolmitriptan nasal spray in a long-term migraine treatment trial.
CNS drugs, Volume: 17, Issue: 11
2003
Pharmacokinetic and pharmacodynamic interaction between toloxatone, a new reversible monoamine oxidase-A inhibitor, and oral tyramine in healthy subjects.
Clinical pharmacology and therapeutics, Volume: 52, Issue: 4
1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (197)

ArticleYear
A pharmacokinetic-pharmacodynamic (PKPD) model-based analysis of tedizolid against enterococci using the hollow-fibre infection model.
The Journal of antimicrobial chemotherapy, 08-25, Volume: 77, Issue: 9
2022
Single Ascending-Dose Study To Evaluate the Safety, Tolerability, and Pharmacokinetics of Sutezolid in Healthy Adult Subjects.
Antimicrobial agents and chemotherapy, 04-19, Volume: 66, Issue: 4
2022
Pharmacokinetics and Pharmacodynamics of Tedizolid.
Clinical pharmacokinetics, Volume: 61, Issue: 4
2022
Population Pharmacokinetics, Exposure-Response, and Probability of Target Attainment Analyses for Tedizolid in Adolescent Patients with Acute Bacterial Skin and Skin Structure Infections.
Antimicrobial agents and chemotherapy, 11-17, Volume: 65, Issue: 12
2021
Quality by Design Approach for Preparation of Zolmitriptan/Chitosan Nanostructured Lipid Carrier Particles - Formulation and Pharmacodynamic Assessment.
International journal of nanomedicine, Volume: 15
2020
Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics.
Journal of medicinal chemistry, 11-12, Volume: 63, Issue: 21
2020
Pharmacokinetics of tedizolid, sutezolid, and sutezolid-M1 in non-human primates.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Aug-01, Volume: 151
2020
Population Pharmacokinetics Study of Contezolid (MRX-I), a Novel Oxazolidinone Antibacterial Agent, in Chinese Patients.
Clinical therapeutics, Volume: 42, Issue: 5
2020
Pharmacokinetic study and brain tissue analysis of Zolmitriptan loaded chitosan nanoparticles in rats by LC-MS method.
International journal of biological macromolecules, Jan-01, Volume: 142
2020
Metabolic profiles and pharmacokinetics of goitrin in rats through liquid chromatography combined with electrospray ionization-tandem mass spectrometry.
Biomedical chromatography : BMC, Volume: 33, Issue: 10
2019
Tolerability and Pharmacokinetics of Contezolid at Therapeutic and Supratherapeutic Doses in Healthy Chinese Subjects, and Assessment of Contezolid Dosing Regimens Based on Pharmacokinetic/Pharmacodynamic Analysis.
Clinical therapeutics, Volume: 41, Issue: 6
2019
Chiral separation and thermodynamic investigation of WCK 3023: A novel oxazolidinone antibacterial agent, application to pre-clinical pharmacokinetic study.
Biomedical chromatography : BMC, Volume: 33, Issue: 9
2019
Multiple-dose Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Oral LCB01-0371 in Healthy Male Volunteers.
Clinical therapeutics, Volume: 40, Issue: 12
2018
Pharmacokinetics and Pharmacodynamics of Anacetrapib in Black and White Healthy Subjects.
Journal of clinical pharmacology, Volume: 58, Issue: 12
2018
Pharmacokinetics and Skin Tolerability of Intracutaneous Zolmitriptan Delivery in Swine Using Adhesive Dermally Applied Microarray.
Journal of pharmaceutical sciences, Volume: 107, Issue: 8
2018
In vivo efficacy and pharmacokinetics of bi-aryl oxazolidinone RBx 11760 loaded polylactic acid-polyethylene glycol nanoparticles in mouse hematogenous bronchopneumonia and rat groin abscess caused by Staphylococcus aureus.
Nanomedicine : nanotechnology, biology, and medicine, Volume: 14, Issue: 4
2018
Non-clinical pharmacokinetic profiles of rovatirelin, an orally available thyrotropin-releasing hormone analogue.
Xenobiotica; the fate of foreign compounds in biological systems, Volume: 49, Issue: 1
2019
Steady state pharmacokinetics of cycloserine in patients on terizidone for multidrug-resistant tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 01-01, Volume: 22, Issue: 1
2018
Safety, tolerability and pharmacokinetics of 21 day multiple oral administration of a new oxazolidinone antibiotic, LCB01-0371, in healthy male subjects.
The Journal of antimicrobial chemotherapy, Jan-01, Volume: 73, Issue: 1
2018
Clinical Pharmacokinetics and Pharmacodynamics of Oxazolidinones.
Clinical pharmacokinetics, Volume: 57, Issue: 5
2018
Pharmacokinetics and Pharmacodynamics of Anacetrapib Following Single Doses in Healthy, Young Japanese and White Male Subjects.
Journal of clinical pharmacology, Volume: 58, Issue: 2
2018
Improving the pharmacokinetics and tissue distribution of pyrinezolid by self-assembled polymeric micelles.
Colloids and surfaces. B, Biointerfaces, Aug-01, Volume: 156
2017
Single- and Multiple-Dose Study To Determine the Safety, Tolerability, Pharmacokinetics, and Food Effect of Oral MRX-I versus Linezolid in Healthy Adult Subjects.
Antimicrobial agents and chemotherapy, Volume: 61, Issue: 4
2017
Exploring the pharmacodynamic interactions between tedizolid and other orally bioavailable antimicrobials against Staphylococcus aureus and Staphylococcus epidermidis.
The Journal of antimicrobial chemotherapy, 05-01, Volume: 72, Issue: 5
2017
Pharmacokinetic drug evaluation of anacetrapib for the treatment of dyslipidemia.
Expert opinion on drug metabolism & toxicology, Volume: 13, Issue: 2
2017
Pharmacokinetics of Tedizolid in Morbidly Obese and Covariate-Matched Nonobese Adults.
Antimicrobial agents and chemotherapy, Volume: 60, Issue: 8
2016
Cholesteryl Ester Transfer Protein Inhibition With Anacetrapib Decreases Fractional Clearance Rates of High-Density Lipoprotein Apolipoprotein A-I and Plasma Cholesteryl Ester Transfer Protein.
Arteriosclerosis, thrombosis, and vascular biology, Volume: 36, Issue: 5
2016
Intranasal Pharmacokinetic Data for Triptans Such as Sumatriptan and Zolmitriptan Can Render Area Under the Curve (AUC) Predictions for the Oral Route: Strategy Development and Application.
Journal of pain & palliative care pharmacotherapy, Volume: 30, Issue: 1
2016
Simultaneous determination of tedizolid and linezolid in rat plasma by ultra performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Feb-01, Volume: 1011
2016
Pharmacokinetic/pharmacodynamic research on three different infusion time regimens of linezolid in healthy Chinese volunteers.
International journal of clinical pharmacology and therapeutics, Volume: 53, Issue: 9
2015
Tedizolid Adsorption and Transmembrane Clearance during in vitro Continuous Renal Replacement Therapy.
Blood purification, Volume: 40, Issue: 1
2015
Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects.
The Journal of clinical investigation, Volume: 125, Issue: 6
2015
Assessment of the persistence of anacetrapib and evacetrapib concentrations using two pharmacokinetic modeling approaches.
Journal of clinical pharmacology, Volume: 55, Issue: 7
2015
Concentration-response studies and modelling of the pharmacodynamics of linezolid: Staphylococcus aureus versus Enterococcus faecium.
International journal of antimicrobial agents, Volume: 45, Issue: 1
2015
Nonclinical and pharmacokinetic assessments to evaluate the potential of tedizolid and linezolid to affect mitochondrial function.
Antimicrobial agents and chemotherapy, Volume: 59, Issue: 1
2015
Linezolid dosage in pediatric patients based on pharmacokinetics and pharmacodynamics.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Volume: 21, Issue: 1
2015
Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation.
The Journal of antimicrobial chemotherapy, Volume: 70, Issue: 1
2015
Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor.
Journal of medicinal chemistry, Sep-25, Volume: 57, Issue: 18
2014
Tedizolid population pharmacokinetics, exposure response, and target attainment.
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 11
2014
Pharmacokinetics of tedizolid in subjects with renal or hepatic impairment.
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 11
2014
Analysis of thrombocytopenic effects and population pharmacokinetics of linezolid: a dosage strategy according to the trough concentration target and renal function in adult patients.
International journal of antimicrobial agents, Volume: 44, Issue: 3
2014
Single-dose linezolid pharmacokinetics in critically ill patients with impaired renal function especially chronic hemodialysis patients.
Biopharmaceutics & drug disposition, Volume: 35, Issue: 7
2014
Activity of daptomycin or linezolid in combination with rifampin or gentamicin against biofilm-forming Enterococcus faecalis or E. faecium in an in vitro pharmacodynamic model using simulated endocardial vegetations and an in vivo survival assay using Gal
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 8
2014
Pharmacokinetic and pharmacodynamic evaluation of AZD5847 in a mouse model of tuberculosis.
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 7
2014
Influence of renal and hepatic impairment on the pharmacokinetics of anacetrapib.
Journal of clinical pharmacology, Volume: 54, Issue: 11
2014
Population pharmacokinetic/pharmacodynamic analysis of the bactericidal activities of sutezolid (PNU-100480) and its major metabolite against intracellular Mycobacterium tuberculosis in ex vivo whole-blood cultures of patients with pulmonary tuberculosis.
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 6
2014
Target site pharmacokinetics of linezolid after single and multiple doses in diabetic patients with soft tissue infection.
Journal of clinical pharmacology, Volume: 54, Issue: 9
2014
Potent fluorinated agelastatin analogues for chronic lymphocytic leukemia: design, synthesis, and pharmacokinetic studies.
Journal of medicinal chemistry, Jun-26, Volume: 57, Issue: 12
2014
Developments in the pharmacokinetic/pharmacodynamic index of linezolid: a step toward dose optimization using Monte Carlo simulation in critically ill patients.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Volume: 22
2014
The emergence of linezolid resistance among Enterococci in intestinal microbiota of treated patients is unrelated to individual pharmacokinetic characteristics.
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 5
2014
Clinical population pharmacokinetics and toxicodynamics of linezolid.
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 4
2014
Monte Carlo simulation analysis of ceftobiprole, dalbavancin, daptomycin, tigecycline, linezolid and vancomycin pharmacodynamics against intensive care unit-isolated methicillin-resistant Staphylococcus aureus.
Clinical and experimental pharmacology & physiology, Volume: 41, Issue: 6
2014
Cadazolid, a novel antibiotic with potent activity against Clostridium difficile: safety, tolerability and pharmacokinetics in healthy subjects following single and multiple oral doses.
The Journal of antimicrobial chemotherapy, Volume: 69, Issue: 3
2014
Simultaneous quantification of linezolid, tinidazole, norfloxacin, moxifloxacin, levofloxacin, and gatifloxacin in human plasma for therapeutic drug monitoring and pharmacokinetic studies in human volunteers.
Therapeutic drug monitoring, Volume: 35, Issue: 6
2013
Population pharmacokinetic analysis of linezolid in low body weight patients with renal dysfunction.
Journal of clinical pharmacology, Volume: 53, Issue: 9
2013
Pharmacokinetics and relative bioavailability evaluation of linezolid suspension and tablet formulations.
Drug research, Volume: 63, Issue: 9
2013
Influence of the MBC/MIC ratio on the antibacterial activity of vancomycin versus linezolid against methicillin-resistant Staphylococcus aureus isolates in a pharmacodynamic model simulating serum and soft tissue interstitial fluid concentrations reported
The Journal of antimicrobial chemotherapy, Volume: 68, Issue: 10
2013
Effects of Rifampin, a potent inducer of drug-metabolizing enzymes and an inhibitor of OATP1B1/3 transport, on the single dose pharmacokinetics of anacetrapib.
Journal of clinical pharmacology, Volume: 53, Issue: 7
2013
Pharmacokinetics, pharmacodynamics and efficacy of novel FabI inhibitor AFN-1252 against MSSA and MRSA in the murine thigh infection model.
Journal of chemotherapy (Florence, Italy), Volume: 25, Issue: 1
2013
Weight-adjusted versus fixed dose of linezolid for Chinese healthy volunteers of higher and lower body weight: a Phase I pharmacokinetic and pharmacodynamic study.
Expert opinion on investigational drugs, Volume: 22, Issue: 3
2013
Pharmacokinetics of intravenous linezolid in moderately to morbidly obese adults.
Antimicrobial agents and chemotherapy, Volume: 57, Issue: 3
2013
Comparative pharmacodynamics of the new oxazolidinone tedizolid phosphate and linezolid in a neutropenic murine Staphylococcus aureus pneumonia model.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 11
2012
Pharmacokinetic evaluation of zolmitriptan for the treatment of migraines.
Expert opinion on drug metabolism & toxicology, Volume: 8, Issue: 8
2012
Quantitative determination of zolmitriptan in rat blood and cerebrospinal fluid by reversed phase HPLC-ESI-MS/MS analysis: application to in vivo preclinical pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Jul-15, Volume: 901
2012
Efficacy of linezolid versus a pharmacodynamically optimized vancomycin therapy in an experimental pneumonia model caused by methicillin-resistant Staphylococcus aureus.
The Journal of antimicrobial chemotherapy, Volume: 67, Issue: 8
2012
Evaluation of standard- and high-dose daptomycin versus linezolid against vancomycin-resistant Enterococcus isolates in an in vitro pharmacokinetic/pharmacodynamic model with simulated endocardial vegetations.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 6
2012
Pharmacokinetics and pulmonary disposition of tedizolid and linezolid in a murine pneumonia model under variable conditions.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 6
2012
Pharmacokinetic-pharmacodynamic evaluation of daptomycin, tigecycline, and linezolid versus vancomycin for the treatment of MRSA infections in four western European countries.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Volume: 31, Issue: 9
2012
Alveolar diffusion and pharmacokinetics of linezolid administered in continuous infusion to critically ill patients with ventilator-associated pneumonia.
The Journal of antimicrobial chemotherapy, Volume: 67, Issue: 5
2012
Evaluation of the pharmacokinetics of linezolid in an obese Japanese patient.
Scandinavian journal of infectious diseases, Volume: 44, Issue: 8
2012
Lack of a meaningful effect of anacetrapib on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.
British journal of clinical pharmacology, Volume: 74, Issue: 1
2012
Impact of spores on the comparative efficacies of five antibiotics for treatment of Bacillus anthracis in an in vitro hollow fiber pharmacodynamic model.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 3
2012
Differential effects of linezolid and ciprofloxacin on toxin production by Bacillus anthracis in an in vitro pharmacodynamic system.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 1
2012
Lack of an effect of anacetrapib on the pharmacokinetics of digoxin in healthy subjects.
Biopharmaceutics & drug disposition, Volume: 32, Issue: 9
2011
In vitro pharmacokinetic/pharmacodynamic activity of NXL103 versus clindamycin and linezolid against clinical Staphylococcus aureus and Streptococcus pyogenes isolates.
International journal of antimicrobial agents, Volume: 38, Issue: 4
2011
The antistaphylococcal pharmacodynamics of linezolid alone and in combination with doxycycline in an in vitro dynamic model.
Journal of chemotherapy (Florence, Italy), Volume: 23, Issue: 3
2011
Clinical pharmacokinetic/pharmacodynamic profile of linezolid in severely ill intensive care unit patients.
International journal of antimicrobial agents, Volume: 38, Issue: 4
2011
Determination of tissue penetration and pharmacokinetics of linezolid in patients with diabetic foot infections using in vivo microdialysis.
Antimicrobial agents and chemotherapy, Volume: 55, Issue: 9
2011
Influence of linezolid clearance on the induction of thrombocytopenia and reduction of hemoglobin.
The American journal of the medical sciences, Volume: 342, Issue: 6
2011
Linezolid in the central nervous system: comparison between cerebrospinal fluid and plasma pharmacokinetics.
Scandinavian journal of infectious diseases, Volume: 43, Issue: 9
2011
Linezolid pharmacokinetics and pharmacodynamics in clinical treatment.
The Journal of antimicrobial chemotherapy, Volume: 66 Suppl 4
2011
Pharmacokinetics of intravenous and oral linezolid in adults with cystic fibrosis.
Antimicrobial agents and chemotherapy, Volume: 55, Issue: 7
2011
In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model.
Antimicrobial agents and chemotherapy, Volume: 55, Issue: 7
2011
Population pharmacokinetic and pharmacodynamic analysis of linezolid and a hematologic side effect, thrombocytopenia, in Japanese patients.
Antimicrobial agents and chemotherapy, Volume: 55, Issue: 5
2011
Pharmacokinetics of diphenylboroxazolidones of L-α-amino acids with activity on the CNS: quantification in rat DBS by UPLC-MS/MS.
Bioanalysis, Volume: 3, Issue: 4
2011
Comparison of the pharmacokinetic properties of vancomycin, linezolid, tigecyclin, and daptomycin.
European journal of medical research, Nov-30, Volume: 15, Issue: 12
2010
Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections.
Antimicrobial agents and chemotherapy, Volume: 55, Issue: 2
2011
Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers.
The Journal of infectious diseases, Sep-01, Volume: 202, Issue: 5
2010
Comparison of the pharmacokinetics of two dosage regimens of linezolid in multidrug-resistant and extensively drug-resistant tuberculosis patients.
Clinical pharmacokinetics, Volume: 49, Issue: 8
2010
Pharmacokinetics and distribution of linezolid in cerebrospinal fluid in children and adolescents.
The Pediatric infectious disease journal, Volume: 29, Issue: 9
2010
Unexpected effect of rifampin on the pharmacokinetics of linezolid: in silico and in vitro approaches to explain its mechanism.
Journal of clinical pharmacology, Volume: 51, Issue: 2
2011
Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype.
Antimicrobial agents and chemotherapy, Volume: 54, Issue: 4
2010
Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 38, Issue: 3
2010
Pharmacokinetics of linezolid in septic patients with and without extended dialysis.
European journal of clinical pharmacology, Volume: 66, Issue: 3
2010
[Pharmacokinetic evaluation of linezolid in patients with major thermal injuries].
Pathologie-biologie, Volume: 58, Issue: 2
2010
Single-dose pharmacokinetics and pharmacodynamics of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects.
British journal of clinical pharmacology, Volume: 68, Issue: 4
2009
Pharmacokinetic-pharmacodynamic modeling of the in vitro activities of oxazolidinone antimicrobial agents against methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy, Volume: 53, Issue: 12
2009
Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell lines.
The Journal of antimicrobial chemotherapy, Volume: 64, Issue: 5
2009
Evaluating aztreonam and ceftazidime pharmacodynamics with Escherichia coli in combination with daptomycin, linezolid, or vancomycin in an in vitro pharmacodynamic model.
Antimicrobial agents and chemotherapy, Volume: 53, Issue: 10
2009
Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis.
Antimicrobial agents and chemotherapy, Volume: 53, Issue: 9
2009
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (115)

ArticleYear
The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection.
Microbiology spectrum, 10-26, Volume: 10, Issue: 5
2022
Evaluation of Brain Targeting Potential of Zolmitriptan Mucoadhesive Nanoparticles for Intranasal Drug Delivery.
Pharmaceutical nanotechnology, Volume: 10, Issue: 2
2022
Simultaneous determination of a novel oxazolidinone anti-tuberculosis OTB-658 and its metabolites in monkey blood by LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Mar-15, Volume: 1167
2021
Design, Synthesis, and Pharmacological Characterization of a Neutral, Non-Prodrug Thrombin Inhibitor with Good Oral Pharmacokinetics.
Journal of medicinal chemistry, 11-12, Volume: 63, Issue: 21
2020
Evidence Associated with the Use of Oxazolidinones for the Treatment of Skin and Skin Structure Infections: A Retrospective Study.
Acta medica portuguesa, Jun-28, Volume: 32, Issue: 6
2019
Effect of Amorphous Nanoparticle Size on Bioavailability of Anacetrapib in Dogs.
Journal of pharmaceutical sciences, Volume: 108, Issue: 9
2019
Development of a Clinically Relevant Dissolution Method for Metaxalone Immediate Release Formulations Based on an IVIVC Model.
Pharmaceutical research, Jun-22, Volume: 35, Issue: 8
2018
Pharmacokinetics and Skin Tolerability of Intracutaneous Zolmitriptan Delivery in Swine Using Adhesive Dermally Applied Microarray.
Journal of pharmaceutical sciences, Volume: 107, Issue: 8
2018
Non-clinical pharmacokinetic profiles of rovatirelin, an orally available thyrotropin-releasing hormone analogue.
Xenobiotica; the fate of foreign compounds in biological systems, Volume: 49, Issue: 1
2019
Development of zolmitriptan transfersomes by Box-Behnken design for nasal delivery: in vitro and in vivo evaluation.
Drug development and industrial pharmacy, Volume: 44, Issue: 3
2018
Clinical Pharmacokinetics and Pharmacodynamics of Oxazolidinones.
Clinical pharmacokinetics, Volume: 57, Issue: 5
2018
Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available Δ-5 Desaturase (D5D) Inhibitors.
Journal of medicinal chemistry, 11-09, Volume: 60, Issue: 21
2017
Brain targeting efficiency of antimigrain drug loaded mucoadhesive intranasal nanoemulsion.
International journal of pharmaceutics, Aug-30, Volume: 529, Issue: 1-2
2017
Improving the pharmacokinetics and tissue distribution of pyrinezolid by self-assembled polymeric micelles.
Colloids and surfaces. B, Biointerfaces, Aug-01, Volume: 156
2017
Single- and Multiple-Dose Study To Determine the Safety, Tolerability, Pharmacokinetics, and Food Effect of Oral MRX-I versus Linezolid in Healthy Adult Subjects.
Antimicrobial agents and chemotherapy, Volume: 61, Issue: 4
2017
Exploring the pharmacodynamic interactions between tedizolid and other orally bioavailable antimicrobials against Staphylococcus aureus and Staphylococcus epidermidis.
The Journal of antimicrobial chemotherapy, 05-01, Volume: 72, Issue: 5
2017
Intranasal Eutectic Powder of Zolmitriptan with Enhanced Bioavailability in the Rat Brain.
Molecular pharmaceutics, 09-06, Volume: 13, Issue: 9
2016
Trans-nasal zolmitriptan novasomes: in-vitro preparation, optimization and in-vivo evaluation of brain targeting efficiency.
Drug delivery, Volume: 23, Issue: 9
2016
Quantitation of anacetrapib, stable-isotope labeled-anacetrapib (microdose), and four metabolites in human plasma using liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Feb-01, Volume: 1011
2016
Poloxamer 407-based intranasal thermoreversible gel of zolmitriptan-loaded nanoethosomes: formulation, optimization, evaluation and permeation studies.
Journal of liposome research, Volume: 26, Issue: 4
2016
Oxazolidinones as Anti-tubercular Agents: Discovery, Development and Future Perspectives.
Current medicinal chemistry, Volume: 22, Issue: 38
2015
Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies.
Journal of medicinal chemistry, Aug-27, Volume: 58, Issue: 16
2015
Drug in Adhesive Patch of Zolmitriptan: Formulation and In vitro /In vivo Correlation.
AAPS PharmSciTech, Volume: 16, Issue: 6
2015
Optimization of combinational intranasal drug delivery system for the management of migraine by using statistical design.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Apr-05, Volume: 70
2015
[Therapeutic Drug Monitoring of antiinfectives in intensive care medicine].
Deutsche medizinische Wochenschrift (1946), Volume: 139, Issue: 38
2014
Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor.
Journal of medicinal chemistry, Sep-25, Volume: 57, Issue: 18
2014
Tedizolid population pharmacokinetics, exposure response, and target attainment.
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 11
2014
Clinical experience with linezolid for the treatment of orthopaedic implant infections.
The Journal of antimicrobial chemotherapy, Volume: 69 Suppl 1
2014
European perspective and update on the management of complicated skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus after more than 10 years of experience with linezolid.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Volume: 20 Suppl 4
2014
Synthesis of stable isotope labeled anacetrapib, its major metabolites and [(14) C]anacetrapib.
Journal of labelled compounds & radiopharmaceuticals, Volume: 56, Issue: 12
2013
Pharmacokinetics and relative bioavailability evaluation of linezolid suspension and tablet formulations.
Drug research, Volume: 63, Issue: 9
2013
Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.
Journal of medicinal chemistry, Jun-13, Volume: 56, Issue: 11
2013
Linezolid in late-chronic prosthetic joint infection caused by gram-positive bacteria.
Diagnostic microbiology and infectious disease, Volume: 76, Issue: 1
2013
Oral bioavailability of linezolid before and after Roux-en-Y gastric bypass surgery: is dose modification necessary in obese subjects?
The Journal of antimicrobial chemotherapy, Volume: 68, Issue: 3
2013
Decreased serum linezolid concentrations in two patients receiving linezolid and rifampicin due to bone infections.
Scandinavian journal of infectious diseases, Volume: 44, Issue: 7
2012
Tedizolid (TR-701): a new oxazolidinone with enhanced potency.
Expert opinion on investigational drugs, Volume: 21, Issue: 4
2012
Fast relief from migraine attacks using fast-disintegrating sublingual zolmitriptan tablets.
Drug development and industrial pharmacy, Volume: 38, Issue: 6
2012
Design, synthesis, and structure-activity relationship studies of highly potent novel benzoxazinyl-oxazolidinone antibacterial agents.
Journal of medicinal chemistry, Nov-10, Volume: 54, Issue: 21
2011
A randomized, double-blind phase 2 study comparing the efficacy and safety of an oral fusidic acid loading-dose regimen to oral linezolid for the treatment of acute bacterial skin and skin structure infections.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Volume: 52 Suppl 7
2011
Linezolid pharmacokinetics and pharmacodynamics in clinical treatment.
The Journal of antimicrobial chemotherapy, Volume: 66 Suppl 4
2011
Pharmacokinetics of intravenous and oral linezolid in adults with cystic fibrosis.
Antimicrobial agents and chemotherapy, Volume: 55, Issue: 7
2011
Model-based development of anacetrapib, a novel cholesteryl ester transfer protein inhibitor.
The AAPS journal, Volume: 13, Issue: 2
2011
Comparison of the pharmacokinetic properties of vancomycin, linezolid, tigecyclin, and daptomycin.
European journal of medical research, Nov-30, Volume: 15, Issue: 12
2010
[Linezolide in paediatrics].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, Volume: 17 Suppl 4
2010
Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers.
The Journal of infectious diseases, Sep-01, Volume: 202, Issue: 5
2010
Preclinical and clinical evidence for the collaborative transport and renal secretion of an oxazolidinone antibiotic by organic anion transporter 3 (OAT3/SLC22A8) and multidrug and toxin extrusion protein 1 (MATE1/SLC47A1).
The Journal of pharmacology and experimental therapeutics, Sep-01, Volume: 334, Issue: 3
2010
Pharmacokinetics, metabolism, and excretion of anacetrapib, a novel inhibitor of the cholesteryl ester transfer protein, in rats and rhesus monkeys.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 38, Issue: 3
2010
Linezolid: a review of safety and tolerability.
The Journal of infection, Volume: 59 Suppl 1
2009
Population pharmacokinetics of linezolid in adults with pulmonary tuberculosis.
Antimicrobial agents and chemotherapy, Volume: 53, Issue: 9
2009
Application of affinity selection/mass spectrometry to determine the structural isomer of parnafungins responsible for binding polyadenosine polymerase.
Journal of the American Chemical Society, Dec-10, Volume: 130, Issue: 49
2008
Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial.
Lancet (London, England), Dec-20, Volume: 372, Issue: 9656
2008
Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.
Bioorganic & medicinal chemistry letters, Dec-01, Volume: 18, Issue: 23
2008
Linezolid in children: recent patents and advances.
Recent patents on anti-infective drug discovery, Volume: 2, Issue: 1
2007
Burned rice straw reduces the availability of clomazone to barnyardgrass.
The Science of the total environment, Mar-25, Volume: 392, Issue: 2-3
2008
Experience with linezolid therapy in children with osteoarticular infections.
The Pediatric infectious disease journal, Volume: 26, Issue: 11
2007
Synthesis and biological evaluation of new N-linked 5-triazolylmethyl oxazolidinones.
European journal of medicinal chemistry, Volume: 43, Issue: 8
2008
Does linezolid inhibit its own metabolism? Population pharmacokinetics as a tool to explain the observed nonlinearity in both healthy volunteers and septic patients.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 35, Issue: 10
2007
Efficacy and safety of linezolid for Gram-positive orthopedic infections: a prospective case series.
Diagnostic microbiology and infectious disease, Volume: 59, Issue: 2
2007
[Linezolid--novel antibiotic for the treatment of gram-positive bacterial infections].
Wiadomosci lekarskie (Warsaw, Poland : 1960), Volume: 59, Issue: 9-10
2006
[Linezolid in the treatment of antibiotic-resistant gram-positive infections of the musculoskeletal system].
Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca, Volume: 73, Issue: 5
2006
Efficacy of linezolid versus vancomycin in the treatment of methicillin-resistant Staphylococcus aureus discitis: a controlled animal model.
Spine, Oct-15, Volume: 31, Issue: 22
2006
Treatment of post-traumatic hand Staphylococcus aureus osteomyelitis with oral linezolid.
Journal of chemotherapy (Florence, Italy), Volume: 18, Issue: 4
2006
Quantification of metaxalone in human plasma by liquid chromatography coupled to tandem mass spectrometry.
Journal of analytical toxicology, Volume: 30, Issue: 4
2006
Effectiveness of linezolid and imipenem association in the treatment of severe community-acquired pneumonia in children: two case reports.
Scandinavian journal of infectious diseases, Volume: 38, Issue: 5
2006
Management of infections of osteoarticular prosthesis.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Volume: 12 Suppl 3
2006
Early experience with linezolid for infections in orthopaedics.
Injury, Volume: 37, Issue: 9
2006
In vitro activity of linezolid and other antibiotics against Gram-positive bacteria from the major teaching hospitals in Kuwait.
Journal of chemotherapy (Florence, Italy), Volume: 17, Issue: 6
2005
Linezolid: a pharmacoeconomic review of its use in serious Gram-positive infections.
PharmacoEconomics, Volume: 23, Issue: 9
2005
Oxazolidinones--a new class of broad-spectrum chemotherapeutics.
Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina, Volume: 59, Issue: 2
2004
Absolute bioavailability and pharmacokinetics of linezolid in hospitalized patients given enteral feedings.
Antimicrobial agents and chemotherapy, Volume: 49, Issue: 9
2005
Role of linezolid in the treatment of orthopedic infections.
Expert review of anti-infective therapy, Volume: 3, Issue: 3
2005
Pharmacokinetics and pharmacodynamics of linezolid in obese patients with cellulitis.
The Annals of pharmacotherapy, Volume: 39, Issue: 3
2005
Quantification of zolmitriptan in plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Dec-25, Volume: 813, Issue: 1-2
2004
A review of linezolid: the first oxazolidinone antibiotic.
Expert review of anti-infective therapy, Volume: 2, Issue: 1
2004
[Linezolid, an agent from a new class of antibiotics].
Nederlands tijdschrift voor geneeskunde, Aug-07, Volume: 148, Issue: 32
2004
The safety and efficacy of linezolid in orthopaedic practice for the treatment of infection due to antibiotic-resistant organisms.
Expert opinion on drug safety, Volume: 3, Issue: 5
2004
[The role of linezolid in the therapy of infections caused by multiresistant gram-positive cocci].
Le infezioni in medicina, Volume: 12, Issue: 1
2004
Intranasal medications for the treatment of migraine and cluster headache.
CNS drugs, Volume: 18, Issue: 10
2004
Similar hematologic effects of long-term linezolid and vancomycin therapy in a prospective observational study of patients with orthopedic infections.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Apr-15, Volume: 38, Issue: 8
2004
4,5-Disubstituted-1,3-oxazolidin-2-imine derivatives: a new class of orally bioavailable nitric oxide synthase inhibitor.
Bioorganic & medicinal chemistry letters, Jan-19, Volume: 14, Issue: 2
2004
Treatment of gram-positive surgical sepsis: role of the oxazolidinones.
Journal of chemotherapy (Florence, Italy), Volume: 15, Issue: 4
2003
Predicting oral absorption of drugs: a case study with a novel class of antimicrobial agents.
Pharmaceutical research, Volume: 20, Issue: 8
2003
Worldwide assessment of linezolid's clinical safety and tolerability: comparator-controlled phase III studies.
Antimicrobial agents and chemotherapy, Volume: 47, Issue: 6
2003
Pharmacokinetic and pharmacodynamic profile of linezolid in healthy volunteers and patients with Gram-positive infections.
The Journal of antimicrobial chemotherapy, Volume: 51 Suppl 2
2003
Quinupristin-dalfopristin and linezolid: evidence and opinion.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Feb-15, Volume: 36, Issue: 4
2003
Linezolid: an oxazolidinone antimicrobial agent.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, Dec-15, Volume: 59, Issue: 24
2002
The discovery of linezolid, the first oxazolidinone antibacterial agent.
Current drug targets. Infectious disorders, Volume: 1, Issue: 2
2001
[Antimicrobial and clinical effect of linezolid (ZYVOX), new class of synthetic antibacterial drug].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Volume: 120, Issue: 4
2002
Pharmacokinetics, toxicokinetics, distribution, metabolism and excretion of linezolid in mouse, rat and dog.
Xenobiotica; the fate of foreign compounds in biological systems, Volume: 32, Issue: 10
2002
Linezolid: its role in the treatment of gram-positive, drug-resistant bacterial infections.
American family physician, Feb-15, Volume: 65, Issue: 4
2002
Oxazolidinone antibiotics.
Lancet (London, England), Dec-08, Volume: 358, Issue: 9297
2001
Linezolid absolute bioavailability and the effect of food on oral bioavailability.
Biopharmaceutics & drug disposition, Volume: 22, Issue: 3
2001
The oxazolidinones as a new family of antimicrobial agent.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, Volume: 7 Suppl 4
2001
Linezolid--a review of the first oxazolidinone.
Expert opinion on pharmacotherapy, Volume: 2, Issue: 2
2001
[Emergency treatment of migraine attacks with particular reference to agonists of 5-HT1B/1D receptor].
Neurologia i neurochirurgia polska, Volume: 32 Suppl 6
1999
Oxazolidinones: a review.
Drugs, Volume: 59, Issue: 1
2000
[Clinical efficacy of zolmitriptan in migraine].
Neurologia (Barcelona, Spain), Volume: 13 Suppl 2
1998
[Mechanism of action of zolmitriptan].
Neurologia (Barcelona, Spain), Volume: 13 Suppl 2
1998
The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers.
British journal of clinical pharmacology, Volume: 46, Issue: 5
1998
The novel anti-migraine compound zolmitriptan (Zomig 311C90) has no clinically significant interactions with paracetamol or metoclopramide.
European journal of clinical pharmacology, Volume: 53, Issue: 3-4
1997
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (293)

ArticleYear
Efficacy and safety of intranasal agents for the acute treatment of migraine: a systematic review and network meta-analysis.
The journal of headache and pain, Sep-18, Volume: 24, Issue: 1
2023
A phase IIb, open-label, randomized controlled dose ranging multi-centre trial to evaluate the safety, tolerability, pharmacokinetics and exposure-response relationship of different doses of delpazolid in combination with bedaquiline delamanid moxifloxaci
Trials, Jun-06, Volume: 24, Issue: 1
2023
The Novel Oxazolidinone TBI-223 Is Effective in Three Preclinical Mouse Models of Methicillin-Resistant Staphylococcus aureus Infection.
Microbiology spectrum, 10-26, Volume: 10, Issue: 5
2022
Clinical Pharmacology and Utility of Contezolid in Chinese Patients with Complicated Skin and Soft-Tissue Infections.
Antimicrobial agents and chemotherapy, 06-21, Volume: 66, Issue: 6
2022
Pharmacokinetics and Pharmacodynamics of Tedizolid.
Clinical pharmacokinetics, Volume: 61, Issue: 4
2022
Therapeutic drug monitoring of linezolid: HPLC-based assays for routine quantification of linezolid in human serum and cerebrospinal fluid.
European journal of hospital pharmacy : science and practice, Volume: 30, Issue: 6
2023
Thorough QT Study To Evaluate the Effect of Zoliflodacin, a Novel Therapeutic for Gonorrhea, on Cardiac Repolarization in Healthy Adults.
Antimicrobial agents and chemotherapy, 11-17, Volume: 65, Issue: 12
2021
Negative cross-resistance to clomazone in imazethapyr-resistant Echinochloa crus-galli caused by increased metabolization.
Pesticide biochemistry and physiology, Volume: 178
2021
Influence of the quality of capsule shell on the non-invasive monitoring of medicines using Terizidone as an example.
Journal of pharmaceutical and biomedical analysis, Sep-10, Volume: 204
2021
Evaluation of the Anti-Mycobacterial Activity of Newly Synthesized (S)-N-(3-(2-Fluoro-4'-(2-Amino-4-Thiazolyl)Biphenyl-4-Yl)-2-Oxo-1,3-Oxazolidie-5-Ylmethyl) Acetamide Derivative in Vitro and in Mycobacterium marinum-Infected Zebrafish.
Japanese journal of infectious diseases, May-24, Volume: 74, Issue: 3
2021
Population Pharmacokinetics Study of Contezolid (MRX-I), a Novel Oxazolidinone Antibacterial Agent, in Chinese Patients.
Clinical therapeutics, Volume: 42, Issue: 5
2020
Neuropeptide S Displays as a Key Neuromodulator in Olfactory Spatial Memory.
Chemical senses, 04-17, Volume: 45, Issue: 3
2020
Tolerability and Pharmacokinetics of Contezolid at Therapeutic and Supratherapeutic Doses in Healthy Chinese Subjects, and Assessment of Contezolid Dosing Regimens Based on Pharmacokinetic/Pharmacodynamic Analysis.
Clinical therapeutics, Volume: 41, Issue: 6
2019
The Sterilizing Effect of Intermittent Tedizolid for Pulmonary Tuberculosis.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 11-28, Volume: 67, Issue: suppl_3
2018
Multiple-dose Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Oral LCB01-0371 in Healthy Male Volunteers.
Clinical therapeutics, Volume: 40, Issue: 12
2018
An evaluation of tedizolid for the treatment of MRSA infections.
Expert opinion on pharmacotherapy, Volume: 19, Issue: 13
2018
Clomazone influence soil microbial community and soil nitrogen cycling.
The Science of the total environment, Dec-10, Volume: 644
2018
Steady state pharmacokinetics of cycloserine in patients on terizidone for multidrug-resistant tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 01-01, Volume: 22, Issue: 1
2018
Safety, tolerability and pharmacokinetics of 21 day multiple oral administration of a new oxazolidinone antibiotic, LCB01-0371, in healthy male subjects.
The Journal of antimicrobial chemotherapy, Jan-01, Volume: 73, Issue: 1
2018
Clinical Pharmacokinetics and Pharmacodynamics of Oxazolidinones.
Clinical pharmacokinetics, Volume: 57, Issue: 5
2018
Pharmacokinetics and Pharmacodynamics of Anacetrapib Following Single Doses in Healthy, Young Japanese and White Male Subjects.
Journal of clinical pharmacology, Volume: 58, Issue: 2
2018
Preclinical Evidence That 5-HT1B Receptor Agonists Show Promise as Medications for Psychostimulant Use Disorders.
The international journal of neuropsychopharmacology, 08-01, Volume: 20, Issue: 8
2017
Chronic Administration of Anacetrapib Is Associated With Accumulation in Adipose and Slow Elimination.
Clinical pharmacology and therapeutics, Volume: 102, Issue: 5
2017
Exploring the pharmacodynamic interactions between tedizolid and other orally bioavailable antimicrobials against Staphylococcus aureus and Staphylococcus epidermidis.
The Journal of antimicrobial chemotherapy, 05-01, Volume: 72, Issue: 5
2017
Pharmacokinetic drug evaluation of anacetrapib for the treatment of dyslipidemia.
Expert opinion on drug metabolism & toxicology, Volume: 13, Issue: 2
2017
Drug monitoring and individual dose optimization of antimicrobial drugs: oxazolidinones.
Expert opinion on drug metabolism & toxicology, Volume: 12, Issue: 5
2016
Quantitation of anacetrapib, stable-isotope labeled-anacetrapib (microdose), and four metabolites in human plasma using liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Feb-01, Volume: 1011
2016
Poloxamer 407-based intranasal thermoreversible gel of zolmitriptan-loaded nanoethosomes: formulation, optimization, evaluation and permeation studies.
Journal of liposome research, Volume: 26, Issue: 4
2016
Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 44, Issue: 3
2016
New treatment options for infections caused by increasingly antimicrobial-resistant Neisseria gonorrhoeae.
Expert review of anti-infective therapy, Volume: 14, Issue: 2
2016
Minimal systemic and high faecal exposure to cadazolid in patients with severe Clostridium difficile infection.
International journal of antimicrobial agents, Volume: 46, Issue: 5
2015
Multicenter, Double-Blind, Randomized, Phase 2 Study Evaluating the Novel Antibiotic Cadazolid in Patients with Clostridium difficile Infection.
Antimicrobial agents and chemotherapy, Volume: 59, Issue: 10
2015
Pharmacokinetic/pharmacodynamic research on three different infusion time regimens of linezolid in healthy Chinese volunteers.
International journal of clinical pharmacology and therapeutics, Volume: 53, Issue: 9
2015
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.
Scientific reports, Jul-14, Volume: 5
2015
Thinking outside the "bug": a unique assay to measure intracellular drug penetration in gram-negative bacteria.
Analytical chemistry, Apr-07, Volume: 87, Issue: 7
2015
Treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus in a renal dysfunction patient undergoing adjustments to the linezolid dose.
Internal medicine (Tokyo, Japan), Volume: 54, Issue: 2
2015
Therapeutic drug monitoring: linezolid too?
Critical care (London, England), Sep-15, Volume: 18, Issue: 5
2014
In vitro resistance studies with bacteria that exhibit low mutation frequencies: prediction of "antimutant" linezolid concentrations using a mixed inoculum containing both susceptible and resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy, Volume: 59, Issue: 2
2015
Linezolid in the treatment of disseminated nontuberculous mycobacterial infection in anti-interferon-gamma autoantibody-positive patients.
The Southeast Asian journal of tropical medicine and public health, Volume: 45, Issue: 5
2014
Nonclinical and pharmacokinetic assessments to evaluate the potential of tedizolid and linezolid to affect mitochondrial function.
Antimicrobial agents and chemotherapy, Volume: 59, Issue: 1
2015
Optimizing therapy for vancomycin-resistant enterococcal bacteremia in children.
Current opinion in infectious diseases, Volume: 27, Issue: 6
2014
Linezolid dosage in pediatric patients based on pharmacokinetics and pharmacodynamics.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Volume: 21, Issue: 1
2015
Kinetics and thermodynamics of the sorption of furaltadone from aqueous solutions on magnetic multi-walled carbon nanotubes.
Water science and technology : a journal of the International Association on Water Pollution Research, Volume: 70, Issue: 6
2014
Colistin and anti-Gram-positive bacterial agents against Acinetobacter baumannii.
Revista da Sociedade Brasileira de Medicina Tropical, Volume: 47, Issue: 4
2014
Plasma and cerebrospinal fluid concentrations of linezolid in neurosurgical critically ill patients with proven or suspected central nervous system infections.
International journal of antimicrobial agents, Volume: 44, Issue: 5
2014
[Therapeutic Drug Monitoring of antiinfectives in intensive care medicine].
Deutsche medizinische Wochenschrift (1946), Volume: 139, Issue: 38
2014
Pharmacokinetic/pharmacodynamic evaluation of linezolid in hospitalized paediatric patients: a step toward dose optimization by means of therapeutic drug monitoring and Monte Carlo simulation.
The Journal of antimicrobial chemotherapy, Volume: 70, Issue: 1
2015
Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin.
European heart journal, Jan-01, Volume: 36, Issue: 1
2015
Analysis of thrombocytopenic effects and population pharmacokinetics of linezolid: a dosage strategy according to the trough concentration target and renal function in adult patients.
International journal of antimicrobial agents, Volume: 44, Issue: 3
2014
Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study.
Critical care (London, England), Jul-10, Volume: 18, Issue: 4
2014
High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug-resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea.
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 9
2014
Once-weekly dalbavancin versus daily conventional therapy for skin infection.
The New England journal of medicine, Jun-05, Volume: 370, Issue: 23
2014
Totally drug-resistant tuberculosis and adjunct therapies.
Journal of internal medicine, Volume: 277, Issue: 4
2015
Serotonin syndrome associated with metaxalone overdose.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, Volume: 10, Issue: 4
2014
Tedizolid: a new oxazolidinone antimicrobial.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, Apr-15, Volume: 71, Issue: 8
2014
Population pharmacokinetic/pharmacodynamic analysis of the bactericidal activities of sutezolid (PNU-100480) and its major metabolite against intracellular Mycobacterium tuberculosis in ex vivo whole-blood cultures of patients with pulmonary tuberculosis.
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 6
2014
Developments in the pharmacokinetic/pharmacodynamic index of linezolid: a step toward dose optimization using Monte Carlo simulation in critically ill patients.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Volume: 22
2014
Comparative effectiveness of linezolid and vancomycin among a national veterans affairs cohort with methicillin-resistant Staphylococcus aureus pneumonia.
Pharmacotherapy, Volume: 34, Issue: 5
2014
[The extraction technology of epigoitri from isatidis radix by supercritical CO2 fluid].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, Volume: 36, Issue: 7
2013
Duel-acting subcutaneous microemulsion formulation for improved migraine treatment with zolmitriptan and diclofenac: formulation and in vitro-in vivo characterization.
The AAPS journal, Volume: 16, Issue: 2
2014
Evaluation of lipids, drug concentration, and safety parameters following cessation of treatment with the cholesteryl ester transfer protein inhibitor anacetrapib in patients with or at high risk for coronary heart disease.
The American journal of cardiology, Jan-01, Volume: 113, Issue: 1
2014
Formulation and evaluation of chitosan-chondroitin sulphate based nasal inserts for zolmitriptan.
BioMed research international, Volume: 2013
2013
In vitro activity of cadazolid against clinically relevant Clostridium difficile isolates and in an in vitro gut model of C. difficile infection.
The Journal of antimicrobial chemotherapy, Volume: 69, Issue: 3
2014
Impact of weight on treatment efficacy and safety in complicated skin and skin structure infections and nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus.
Clinical therapeutics, Volume: 35, Issue: 10
2013
Plasma exposure of free linezolid and its ratio to minimum inhibitory concentration varies in critically ill patients.
International journal of antimicrobial agents, Volume: 42, Issue: 4
2013
A rapid and sensitive HPLC assay of some concomitant anti-migraine drugs.
Journal of chromatographic science, Volume: 52, Issue: 7
2014
Linezolid decreases susceptibility to secondary bacterial pneumonia postinfluenza infection in mice through its effects on IFN-γ.
Journal of immunology (Baltimore, Md. : 1950), Aug-15, Volume: 191, Issue: 4
2013
Pharmacokinetics and relative bioavailability evaluation of linezolid suspension and tablet formulations.
Drug research, Volume: 63, Issue: 9
2013
Spectrofluorimetric determination of terbinafine hydrochloride and linezolid in their dosage forms and human plasma.
Journal of fluorescence, Volume: 23, Issue: 5
2013
The efficacy of triptans in childhood and adolescence migraine.
Current pain and headache reports, Volume: 17, Issue: 7
2013
Subtherapeutic linezolid concentrations in a patient with morbid obesity and methicillin-resistant Staphylococcus aureus pneumonia: case report and review of the literature.
The Annals of pharmacotherapy, Volume: 47, Issue: 6
2013
Vancomycin versus linezolid in the treatment of methicillin-resistant Staphylococcus aureus meningitis.
Surgical infections, Volume: 14, Issue: 4
2013
Effects of Rifampin, a potent inducer of drug-metabolizing enzymes and an inhibitor of OATP1B1/3 transport, on the single dose pharmacokinetics of anacetrapib.
Journal of clinical pharmacology, Volume: 53, Issue: 7
2013
Can intermittent dosing optimize prolonged linezolid treatment of difficult multidrug-resistant tuberculosis?
Antimicrobial agents and chemotherapy, Volume: 57, Issue: 7
2013
High plasma linezolid concentration and impaired renal function affect development of linezolid-induced thrombocytopenia.
The Journal of antimicrobial chemotherapy, Volume: 68, Issue: 9
2013
Serotonergic and adrenergic drug interactions associated with linezolid: a critical review and practical management approach.
The Annals of pharmacotherapy, Volume: 47, Issue: 4
2013
Quantifying subpopulation synergy for antibiotic combinations via mechanism-based modeling and a sequential dosing design.
Antimicrobial agents and chemotherapy, Volume: 57, Issue: 5
2013
A PET study with [11C]AZ10419369 to determine brain 5-HT1B receptor occupancy of zolmitriptan in healthy male volunteers.
Cephalalgia : an international journal of headache, Volume: 33, Issue: 10
2013
Weight-adjusted versus fixed dose of linezolid for Chinese healthy volunteers of higher and lower body weight: a Phase I pharmacokinetic and pharmacodynamic study.
Expert opinion on investigational drugs, Volume: 22, Issue: 3
2013
Inoculum effects of ceftobiprole, daptomycin, linezolid, and vancomycin with Staphylococcus aureus and Streptococcus pneumoniae at inocula of 10(5) and 10(7) CFU injected into opposite thighs of neutropenic mice.
Antimicrobial agents and chemotherapy, Volume: 57, Issue: 3
2013
Pharmacokinetics of intravenous linezolid in moderately to morbidly obese adults.
Antimicrobial agents and chemotherapy, Volume: 57, Issue: 3
2013
Vancomycin versus linezolid in the treatment of methicillin-resistant Staphylococcus aureus meningitis in an experimental rabbit model.
Medical science monitor : international medical journal of experimental and clinical research, Volume: 18, Issue: 11
2012
Linezolid-containing regimens for the treatment of drug-resistant tuberculosis in South African children.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, Volume: 16, Issue: 12
2012
Efficacy and safety of meropenem-clavulanate added to linezolid-containing regimens in the treatment of MDR-/XDR-TB.
The European respiratory journal, Volume: 41, Issue: 6
2013
A reduced linezolid dosage maintains favorable efficacy with minimal hematologic toxicity in a methicillin-resistant Staphylococcus aureus-infected patient with renal insufficiency.
Scandinavian journal of infectious diseases, Volume: 45, Issue: 1
2013
Comparative pharmacodynamics of the new oxazolidinone tedizolid phosphate and linezolid in a neutropenic murine Staphylococcus aureus pneumonia model.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 11
2012
Does resistance in severe infections caused by methicillin-resistant Staphylococcus aureus give you the 'creeps'?
Current opinion in critical care, Volume: 18, Issue: 5
2012
Clinical efficacy of oral linezolid compared with intravenous vancomycin for the treatment of methicillin-resistant Staphylococcus aureus-complicated skin and soft tissue infections: a retrospective, propensity score-matched, case-control analysis.
Clinical therapeutics, Volume: 34, Issue: 8
2012
Metaxalone estimation in biological matrix using high-throughput LC-MS/MS bioanalytical method.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Aug-01, Volume: 902
2012
Treatment of methicillin-resistant Staphylococcus aureus ventilator-associated pneumonia with high-dose vancomycin or linezolid.
The journal of trauma and acute care surgery, Volume: 72, Issue: 6
2012
In vitro activity and microbiological efficacy of tedizolid (TR-700) against Gram-positive clinical isolates from a phase 2 study of oral tedizolid phosphate (TR-701) in patients with complicated skin and skin structure infections.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 9
2012
Elimination of teicoplanin by adsorption to the filter membrane during haemodiafiltration: screening experiments for linezolid, teicoplanin and vancomycin followed by in vitro haemodiafiltration models for teicoplanin.
Anaesthesia and intensive care, Volume: 40, Issue: 3
2012
Therapeutic drug monitoring may improve safety outcomes of long-term treatment with linezolid in adult patients.
The Journal of antimicrobial chemotherapy, Volume: 67, Issue: 8
2012
Efficacy of linezolid versus a pharmacodynamically optimized vancomycin therapy in an experimental pneumonia model caused by methicillin-resistant Staphylococcus aureus.
The Journal of antimicrobial chemotherapy, Volume: 67, Issue: 8
2012
Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis.
The European respiratory journal, Volume: 40, Issue: 6
2012
Evaluation of standard- and high-dose daptomycin versus linezolid against vancomycin-resistant Enterococcus isolates in an in vitro pharmacokinetic/pharmacodynamic model with simulated endocardial vegetations.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 6
2012
Scaling adult doses of antifungal and antibacterial agents to children.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 6
2012
Comparative in vivo efficacies of epithelial lining fluid exposures of tedizolid, linezolid, and vancomycin for methicillin-resistant Staphylococcus aureus in a mouse pneumonia model.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 5
2012
Pulmonary disposition of tedizolid following administration of once-daily oral 200-milligram tedizolid phosphate in healthy adult volunteers.
Antimicrobial agents and chemotherapy, Volume: 56, Issue: 5
2012
Tedizolid (TR-701): a new oxazolidinone with enhanced potency.
Expert opinion on investigational drugs, Volume: 21, Issue: 4
2012
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (39)

ArticleYear
A phase IIb, open-label, randomized controlled dose ranging multi-centre trial to evaluate the safety, tolerability, pharmacokinetics and exposure-response relationship of different doses of delpazolid in combination with bedaquiline delamanid moxifloxaci
Trials, Jun-06, Volume: 24, Issue: 1
2023
In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae.
The Journal of antimicrobial chemotherapy, 12-01, Volume: 74, Issue: 12
2019
Oxazolidinones Can Replace Clarithromycin in Combination with Rifampin in a Mouse Model of Buruli Ulcer.
Antimicrobial agents and chemotherapy, Volume: 63, Issue: 3
2019
Drug-drug interactions and safety of linezolid, tedizolid, and other oxazolidinones.
Expert opinion on drug metabolism & toxicology, Volume: 11, Issue: 12
2015
Potential drug interaction between warfarin and linezolid.
Internal medicine (Tokyo, Japan), Volume: 54, Issue: 5
2015
Activity of daptomycin or linezolid in combination with rifampin or gentamicin against biofilm-forming Enterococcus faecalis or E. faecium in an in vitro pharmacodynamic model using simulated endocardial vegetations and an in vivo survival assay using Gal
Antimicrobial agents and chemotherapy, Volume: 58, Issue: 8
2014
In vitro activity of fosfomycin in combination with linezolid against clinical isolates of methicillin-resistant Staphylococcus aureus.
The Journal of antibiotics, Volume: 67, Issue: 5
2014
Secretory ranalexin produced in recombinant Pichia pastoris exhibits additive or synergistic bactericidal activity when used in combination with polymyxin B or linezolid against multi-drug resistant bacteria.
Biotechnology journal, Volume: 9, Issue: 1
2014
Antimicrobial activity of linezolid combined with minocycline against vancomycin-resistant Enterococci.
Chinese medical journal, Volume: 126, Issue: 14
2013
Serotonergic and adrenergic drug interactions associated with linezolid: a critical review and practical management approach.
The Annals of pharmacotherapy, Volume: 47, Issue: 4
2013
Probable drug-drug interaction leading to serotonin syndrome in a patient treated with concomitant buspirone and linezolid in the setting of therapeutic hypothermia.
Journal of clinical pharmacy and therapeutics, Volume: 37, Issue: 5
2012
Effectiveness of ciprofloxacin or linezolid in combination with rifampicin against Enterococcus faecalis in biofilms.
The Journal of antimicrobial chemotherapy, Volume: 67, Issue: 2
2012
Linezolid combined with trimethoprim-sulfamethoxazole therapy for the treatment of disseminated nocardiosis.
Journal of medical microbiology, Volume: 60, Issue: Pt 7
2011
Efficacy of usual and high doses of daptomycin in combination with rifampin versus alternative therapies in experimental foreign-body infection by methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy, Volume: 54, Issue: 12
2010
Efficacy of fosfomycin and its combination with linezolid, vancomycin and imipenem in an experimental peritonitis model caused by a Staphylococcus aureus strain with reduced susceptibility to vancomycin.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Volume: 30, Issue: 1
2011
In vitro evaluation of ceftaroline alone and in combination with tobramycin against hospital-acquired meticillin-resistant Staphylococcus aureus (HA-MRSA) isolates.
International journal of antimicrobial agents, Volume: 35, Issue: 6
2010
[Effect of linezolid in combination with isoniazid and rifampicin against multidrug resistant Mycobacterium tuberculosis clinical isolates].
Mikrobiyoloji bulteni, Volume: 43, Issue: 2
2009
Evaluating aztreonam and ceftazidime pharmacodynamics with Escherichia coli in combination with daptomycin, linezolid, or vancomycin in an in vitro pharmacodynamic model.
Antimicrobial agents and chemotherapy, Volume: 53, Issue: 10
2009
Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib as monotherapy and coadministered with atorvastatin in dyslipidemic patients.
American heart journal, Volume: 157, Issue: 2
2009
Linezolid alone or combined with rifampin against methicillin-resistant Staphylococcus aureus in experimental foreign-body infection.
Antimicrobial agents and chemotherapy, Volume: 53, Issue: 3
2009
Efficacy of linezolid alone and in combination with rifampin in staphylococcal experimental foreign-body infection.
The Journal of infection, Volume: 57, Issue: 3
2008
Assessment by time-kill methodology of the synergistic effects of oritavancin in combination with other antimicrobial agents against Staphylococcus aureus.
Antimicrobial agents and chemotherapy, Volume: 52, Issue: 10
2008
Linezolid alone and in combination with rifampicin prevents experimental vascular graft infection due to methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis.
The Journal of surgical research, May-15, Volume: 139, Issue: 2
2007
In vitro activity of linezolid in combination with doxycycline, fosfomycin, levofloxacin, rifampicin and vancomycin against methicillin-susceptible Staphylococcus aureus.
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, Volume: 19, Issue: 3
2006
Enhanced activity of rifalazil in combination with levofloxacin, linezolid, or mupirocin against Staphylococcus aureus in vitro.
The Journal of antibiotics, Volume: 59, Issue: 5
2006
In vitro and in vivo assessment of linezolid combined with ertapenem: a highly synergistic combination against methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy, Volume: 50, Issue: 7
2006
Drug interactions between linezolid and selective serotonin reuptake inhibitors: case report involving sertraline and review of the literature.
Pharmacotherapy, Volume: 26, Issue: 2
2006
In vitro and in vivo synergistic activities of linezolid combined with subinhibitory concentrations of imipenem against methicillin-resistant Staphylococcus aureus.
Antimicrobial agents and chemotherapy, Volume: 49, Issue: 1
2005
Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model.
Antimicrobial agents and chemotherapy, Volume: 48, Issue: 12
2004
In vivo efficacy of linezolid in combination with gentamicin for the treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus.
International journal of antimicrobial agents, Volume: 24, Issue: 4
2004
Prophylactic efficacy of linezolid alone or combined with levofloxacin and vancomycin in a rat subcutaneous pouch model of graft infection caused by Staphylococcus epidermidis with intermediate resistance to glycopeptides.
The Journal of antimicrobial chemotherapy, Volume: 52, Issue: 4
2003
In vitro activities of linezolid combined with other antimicrobial agents against Staphylococci, Enterococci, Pneumococci, and selected gram-negative organisms.
Antimicrobial agents and chemotherapy, Volume: 47, Issue: 6
2003
In vitro activity of linezolid alone and in combination with gentamicin, vancomycin or rifampicin against methicillin-resistant Staphylococcus aureus by time-kill curve methods.
The Journal of antimicrobial chemotherapy, Volume: 51, Issue: 4
2003
In vitro bactericidal activities of linezolid in combination with vancomycin, gentamicin, ciprofloxacin, fusidic acid, and rifampin against Staphylococcus aureus.
Antimicrobial agents and chemotherapy, Volume: 47, Issue: 1
2003
AZD2563, a new oxazolidinone: bactericidal activity and synergy studies combined with gentamicin or vancomycin against staphylococci and streptococcal strains.
Diagnostic microbiology and infectious disease, Volume: 43, Issue: 1
2002
Effects of the antimigraine compound zolmitriptan ('Zomig') on psychomotor performance alone and in combination with diazepam in healthy volunteers.
Cephalalgia : an international journal of headache, Volume: 18, Issue: 7
1998
Potential drug interactions with the novel antimigraine compound zolmitriptan (Zomig, 311C90).
Cephalalgia : an international journal of headache, Volume: 17 Suppl 18
1997
Peripheral vascular effects and pharmacokinetics of the antimigraine compound, zolmitriptan, in combination with oral ergotamine in healthy volunteers.
Cephalalgia : an international journal of headache, Volume: 17, Issue: 6
1997
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]