Proteins > Amine oxidase [flavin-containing] A
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Amine oxidase [flavin-containing] A
An amine oxidase [flavin-containing] A that is encoded in the genome of rat. [PRO:DNx]
Synonyms
EC 1.4.3.4;
Monoamine oxidase type A;
MAO-A
Research
Bioassay Publications (47)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (4.26) | 18.7374 |
| 1990's | 7 (14.89) | 18.2507 |
| 2000's | 12 (25.53) | 29.6817 |
| 2010's | 24 (51.06) | 24.3611 |
| 2020's | 2 (4.26) | 2.80 |
Compounds (52)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease.Chemical biology & drug design, , Volume: 88, Issue:6, 2016
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's diJournal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 09-15, Volume: 26, Issue:17, 2018
Discovery, biological evaluation, and structure-activity and -selectivity relationships of 6'-substituted (E)-2-(benzofuran-3(2H)-ylidene)-N-methylacetamides, a novel class of potent and selective monoamine oxidase inhibitors.Journal of medicinal chemistry, , Mar-28, Volume: 56, Issue:6, 2013
Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.Bioorganic & medicinal chemistry, , Feb-15, Volume: 18, Issue:4, 2010
Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
[no title available]Journal of natural products, , 04-26, Volume: 82, Issue:4, 2019
α-Ketoamino acid ester derivatives as promising MAO inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 25, Issue:1, 2015
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.Bioorganic & medicinal chemistry, , Sep-01, Volume: 15, Issue:17, 2007
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
A new therapeutic approach in Alzheimer disease: some novel pyrazole derivatives as dual MAO-B inhibitors and antiinflammatory analgesics.Bioorganic & medicinal chemistry, , Sep-01, Volume: 15, Issue:17, 2007
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 21, Issue:7, 2011
Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Synthesis and selective monoamine oxidase B-inhibiting properties of 1-methyl-1,2,3,6-tetrahydropyrid-4-yl carbamate derivatives: potential prodrugs of (R)- and (S)-nordeprenyl.Journal of medicinal chemistry, , Nov-22, Volume: 39, Issue:24, 1996
5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3H)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type B inhibitors.Journal of medicinal chemistry, , Apr-30, Volume: 36, Issue:9, 1993
Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors.Journal of medicinal chemistry, , Oct-02, Volume: 35, Issue:20, 1992
Enzyme-activated irreversible inhibitors of monoamine oxidase: phenylallylamine structure-activity relationships.Journal of medicinal chemistry, , Volume: 28, Issue:2, 1985
Synthesis and monoamine oxidase inhibitory activities of alpha-allenic amines in vivo and in vitro. Different activities of two enantiomeric allenes.Journal of medicinal chemistry, , Volume: 26, Issue:7, 1983
Benzyloxynitrostyrene analogues - A novel class of selective and highly potent inhibitors of monoamine oxidase B.European journal of medicinal chemistry, , Jan-05, Volume: 125, 2017
Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors.Journal of medicinal chemistry, , Jun-30, Volume: 48, Issue:13, 2005
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Selective and potent monoamine oxidase type B inhibitors: 2-substituted 5-aryltetrazole derivatives.Journal of medicinal chemistry, , Nov-24, Volume: 38, Issue:24, 1995
Selective inhibitors of monoamine oxidase (MAO). 5. 1-Substituted phenoxathiin inhibitors containing no nitrogen that inhibit MAO A by binding it to a hydrophobic site.Journal of medicinal chemistry, , Jun-04, Volume: 41, Issue:12, 1998
A selective, reversible, competitive inhibitor of monoamine oxidase A containing no nitrogen, with negligible potentiation of tyramine-induced blood pressure rise.Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Discovery of 3, 6-disubstituted isobenzofuran-1(3H)-ones as novel inhibitors of monoamine oxidases.Bioorganic & medicinal chemistry letters, , 07-01, Volume: 67, 2022
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.Journal of medicinal chemistry, , Oct-04, Volume: 50, Issue:20, 2007
2-Benzylidene-1-indanone derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 26, Issue:19, 2016
Selected furanochalcones as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 23, Issue:17, 2013
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase.Bioorganic & medicinal chemistry, , 09-15, Volume: 26, Issue:17, 2018
Reversible and irreversible small molecule inhibitors of monoamine oxidase B (MAO-B) investigated by biophysical techniques.Bioorganic & medicinal chemistry, , Feb-15, Volume: 23, Issue:4, 2015
Novel arylalkenylpropargylamines as neuroprotective, potent, and selective monoamine oxidase B inhibitors for the treatment of Parkinson's disease.Journal of medicinal chemistry, , Feb-12, Volume: 58, Issue:3, 2015
Acetylene Group, Friend or Foe in Medicinal Chemistry.Journal of medicinal chemistry, , 06-11, Volume: 63, Issue:11, 2020
Indazole- and indole-5-carboxamides: selective and reversible monoamine oxidase B inhibitors with subnanomolar potency.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
Molecular determinants of MAO selectivity in a series of indolylmethylamine derivatives: biological activities, 3D-QSAR/CoMFA analysis, and computational simulation of ligand recognition.Journal of medicinal chemistry, , May-04, Volume: 43, Issue:9, 2000
Multi-target design strategies for the improved treatment of Alzheimer's disease.European journal of medicinal chemistry, , Aug-15, Volume: 176, 2019
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's diJournal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011