Page last updated: 2024-12-05

1,3,5-tribromobenzene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 1,3,5-Tribromobenzene: A Building Block for Research

**1,3,5-tribromobenzene** is an organic compound with the formula C6H3Br3. It is a white solid at room temperature with a characteristic odor. Its structure consists of a benzene ring with three bromine atoms attached at the 1st, 3rd, and 5th positions.

**Why is it important for research?**

1,3,5-tribromobenzene serves as a **versatile building block** in various fields of research, including:

* **Organic synthesis:** It is a precursor for synthesizing various organic compounds. Its highly reactive bromine atoms can be substituted with other functional groups through nucleophilic aromatic substitution reactions, allowing for the creation of a wide array of new molecules.
* **Materials science:** It plays a role in the development of new materials with tailored properties. Its rigid structure and the presence of bromine atoms can contribute to the formation of crystalline materials with specific optical or electronic properties.
* **Medicinal chemistry:** 1,3,5-tribromobenzene can be used as a starting material in the synthesis of potential drug candidates. The bromine atoms can be modified to create new compounds with desired biological activities.
* **Analytical chemistry:** It is used as a reference standard in analytical techniques like gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC).
* **Environmental chemistry:** It can be used as a model compound for studying the fate and transport of brominated organic pollutants in the environment.

**Specific examples of its applications:**

* **Synthesis of polybrominated diphenyl ethers (PBDEs):** These compounds are widely used as flame retardants, but some are considered environmentally hazardous. Studying the synthesis of PBDEs from 1,3,5-tribromobenzene can provide insights into their environmental impact.
* **Development of new materials with photoluminescent properties:** Researchers have used 1,3,5-tribromobenzene to synthesize materials exhibiting photoluminescence, potentially useful in optical devices and sensors.
* **Synthesis of novel drugs for treating cancer:** 1,3,5-tribromobenzene has been incorporated into the synthesis of several potential anticancer drugs, demonstrating its potential in the fight against cancer.

In conclusion, 1,3,5-tribromobenzene is an essential reagent for research in various fields, serving as a versatile building block for synthesizing new molecules with potentially valuable applications in organic synthesis, materials science, medicinal chemistry, and environmental chemistry.

Cross-References

ID SourceID
PubMed CID12279
SCHEMBL ID24617
MeSH IDM0155943

Synonyms (37)

Synonym
o3td0u1oaq ,
unii-o3td0u1oaq
AKOS009031625
EN300-20007
1,3,5-tribromo-benzene
1,3,5-tribromobenzene
benzene, 1,3,5-tribromo-
inchi=1/c6h3br3/c7-4-1-5(8)3-6(9)2-4/h1-3
1,5-tribromobenzene
benzene,3,5-tribromo-
nsc62439
626-39-1
nsc-62439
ai3-15483
einecs 210-947-3
nsc 62439
1,3,5-tribromobenzene, 98%
NCIOPEN2_008123
T0347
A833903
AM20061088
CX1334
SCHEMBL24617
1,3,5-tribromobezene
tox21_303951
dtxcid0030879
dtxsid3052307 ,
NCGC00357185-01
cas-626-39-1
W-104975
1,3,5-tribromobenzene, purum, >=98.0% (at)
mfcd00000080
GS-3046
1,3,5-tribromobenzene; nsc 62439
SY006267
Q27285289
CS-0019382
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLI family zinc finger 3Homo sapiens (human)Potency0.24340.000714.592883.7951AID1259369
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency30.37750.000657.913322,387.1992AID1259377; AID1259378
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 40.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index40.98 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.54 (4.65)
Search Engine Demand Index56.46 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (40.98)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]