Page last updated: 2024-08-07 10:17:35
7,8-dihydro-8-oxoguanine triphosphatase
An oxidized purine nucleoside triphosphate hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36639]
Synonyms
EC 3.6.1.55;
2-hydroxy-dATP diphosphatase;
3.6.1.56;
8-oxo-dGTPase;
Nucleoside diphosphate-linked moiety X motif 1;
Nudix motif 1
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
Compounds (19)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| kinetin | Homo sapiens (human) | IC50 | 24.5000 | 1 | 2 |
| 7-azaindole | Homo sapiens (human) | IC50 | 132.0000 | 1 | 1 |
| 2-aminobenzimidazole | Homo sapiens (human) | IC50 | 44.0000 | 1 | 1 |
| imiquimod | Homo sapiens (human) | IC50 | 0.6460 | 1 | 1 |
| 1h-imidazo(4,5-b)pyridine | Homo sapiens (human) | IC50 | 123.0000 | 1 | 1 |
| resiquimod | Homo sapiens (human) | IC50 | 2.0560 | 1 | 1 |
| 4-methyl-2-quinazolinamine | Homo sapiens (human) | IC50 | 5.6000 | 1 | 1 |
| 8-deoxygartanin | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| zeatin | Homo sapiens (human) | IC50 | 18.0000 | 1 | 2 |
| mangostin | Homo sapiens (human) | IC50 | 0.4700 | 1 | 1 |
| norathyriol | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| gamma-mangostin | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| 1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| sch 51344 | Homo sapiens (human) | IC50 | 0.4137 | 3 | 3 |
| 3,4,5,6-tetrahydroxyxanthone | Homo sapiens (human) | IC50 | 57.0000 | 1 | 1 |
| sm360320 | Homo sapiens (human) | IC50 | 2.8090 | 1 | 1 |
| 3-isomangostin | Homo sapiens (human) | IC50 | 0.0520 | 1 | 1 |
| garcinone c | Homo sapiens (human) | IC50 | 2.7000 | 1 | 1 |
| ent-crizotinib | Homo sapiens (human) | IC50 | 0.5289 | 7 | 7 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 7-azaindole | Homo sapiens (human) | Kd | 96.0000 | 1 | 1 |
| 2-aminobenzimidazole | Homo sapiens (human) | Kd | 18.0000 | 1 | 1 |
| ent-crizotinib | Homo sapiens (human) | EC50 | 3.6000 | 1 | 1 |
| ent-crizotinib | Homo sapiens (human) | Kd | 0.0390 | 1 | 1 |
Enables
This protein enables 12 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | molecular function | Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. [PMID:15878881, RHEA:60032] |
| dATP diphosphatase activity | molecular function | Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate. [GOC:pde, PMID:11139615, RHEA:28334] |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | molecular function | Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. [GOC:jl] |
| snoRNA binding | molecular function | Binding to a small nucleolar RNA. [GOC:mah] |
| 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity | molecular function | Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. [PMID:17804481, PMID:7782328, PMID:7859359, RHEA:31575] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| ATP diphosphatase activity | molecular function | Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate. [RHEA:14245] |
| 2-hydroxy-ATP hydrolase activity | molecular function | Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate. [PMID:11139615, RHEA:67392] |
| 2-hydroxy-dATP hydrolase activity | molecular function | Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate. [PMID:11139615, RHEA:31583] |
| N6-methyl-(d)ATP hydrolase activity | molecular function | Catalysis of the reaction N6-methyl-(d)ATP + H2O = N6-methyl-(d)AMP + diphosphate + H+. [PMID:32144205] |
| O6-methyl-dGTP hydrolase activity | molecular function | Catalysis of the reaction O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+. [PMID:30304478, RHEA:67600] |
Located In
This protein is located in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| acrosomal vesicle | cellular component | A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. [ISBN:0124325653, ISBN:0198506732] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| nuclear membrane | cellular component | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| purine nucleoside catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:go_curators] |
| DNA repair | biological process | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486] |
| response to oxidative stress | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731] |
| male gonad development | biological process | The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid] |
| DNA protection | biological process | Any process in which DNA is protected from damage by, for example, oxidative stress. [GOC:jl] |
| response to cadmium ion | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. [GOC:ai] |