7,8-dihydro-8-oxoguanine triphosphatase

An oxidized purine nucleoside triphosphate hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36639]

Synonyms

EC 3.6.1.55;
2-hydroxy-dATP diphosphatase;
3.6.1.56;
8-oxo-dGTPase;
Nucleoside diphosphate-linked moiety X motif 1;
Nudix motif 1

Research

Bioassay Publications (8)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	7 (87.50)	24.3611
2020's	1 (12.50)	2.80

Compounds (19)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
kinetin	Homo sapiens (human)	IC50	24.5000	1	2
7-azaindole	Homo sapiens (human)	IC50	132.0000	1	1
2-aminobenzimidazole	Homo sapiens (human)	IC50	44.0000	1	1
imiquimod	Homo sapiens (human)	IC50	0.6460	1	1
1h-imidazo(4,5-b)pyridine	Homo sapiens (human)	IC50	123.0000	1	1
resiquimod	Homo sapiens (human)	IC50	2.0560	1	1
4-methyl-2-quinazolinamine	Homo sapiens (human)	IC50	5.6000	1	1
8-deoxygartanin	Homo sapiens (human)	IC50	20.0000	1	1
zeatin	Homo sapiens (human)	IC50	18.0000	1	2
mangostin	Homo sapiens (human)	IC50	0.4700	1	1
norathyriol	Homo sapiens (human)	IC50	100.0000	1	1
gamma-mangostin	Homo sapiens (human)	IC50	2.0000	1	1
1,3,7-trihydroxy-2-(3-methylbut-2-enyl)-xanthone	Homo sapiens (human)	IC50	1.7000	1	1
sch 51344	Homo sapiens (human)	IC50	0.4137	3	3
3,4,5,6-tetrahydroxyxanthone	Homo sapiens (human)	IC50	57.0000	1	1
sm360320	Homo sapiens (human)	IC50	2.8090	1	1
3-isomangostin	Homo sapiens (human)	IC50	0.0520	1	1
garcinone c	Homo sapiens (human)	IC50	2.7000	1	1
ent-crizotinib	Homo sapiens (human)	IC50	0.5289	7	7

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
7-azaindole	Homo sapiens (human)	Kd	96.0000	1	1
2-aminobenzimidazole	Homo sapiens (human)	Kd	18.0000	1	1
ent-crizotinib	Homo sapiens (human)	EC50	3.6000	1	1
ent-crizotinib	Homo sapiens (human)	Kd	0.0390	1	1

Enables

This protein enables 12 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity	molecular function	Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. [PMID:15878881, RHEA:60032]
dATP diphosphatase activity	molecular function	Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate. [GOC:pde, PMID:11139615, RHEA:28334]
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	molecular function	Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. [GOC:jl]
snoRNA binding	molecular function	Binding to a small nucleolar RNA. [GOC:mah]
8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity	molecular function	Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA. [PMID:17804481, PMID:7782328, PMID:7859359, RHEA:31575]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
ATP diphosphatase activity	molecular function	Catalysis of the reaction: ATP + H2O = AMP + H+ + diphosphate. [RHEA:14245]
2-hydroxy-ATP hydrolase activity	molecular function	Catalysis of the reaction: 2-hydroxy-ATP + H2O = 2-hydroxy-AMP + H+ + diphosphate. [PMID:11139615, RHEA:67392]
2-hydroxy-dATP hydrolase activity	molecular function	Catalysis of the reaction: 2-hydroxy-dATP + H2O = 2-hydroxy-dAMP + H+ + diphosphate. [PMID:11139615, RHEA:31583]
N6-methyl-(d)ATP hydrolase activity	molecular function	Catalysis of the reaction N6-methyl-(d)ATP + H2O = N6-methyl-(d)AMP + diphosphate + H+. [PMID:32144205]
O6-methyl-dGTP hydrolase activity	molecular function	Catalysis of the reaction O6-methyl-dGTP + H2O = O6-methyl-dGMP + diphosphate + H+. [PMID:30304478, RHEA:67600]

Located In

This protein is located in 8 target(s):

Target	Category	Definition
acrosomal vesicle	cellular component	A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome. [ISBN:0124325653, ISBN:0198506732]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial matrix	cellular component	The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nuclear membrane	cellular component	Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 6 target(s):

Target	Category	Definition
purine nucleoside catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). [GOC:go_curators]
DNA repair	biological process	The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]
response to oxidative stress	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:jl, PMID:12115731]
male gonad development	biological process	The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure. [GOC:jid]
DNA protection	biological process	Any process in which DNA is protected from damage by, for example, oxidative stress. [GOC:jl]
response to cadmium ion	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. [GOC:ai]