leflunomide has been researched along with Necrosis in 3 studies
Leflunomide: An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.
leflunomide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 73-year-old woman had been taking leflunomide for psoriatic arthritis for one year and subsequently, developed three abdominal ulcerations and necrosis of one hallux." | 7.74 | [Leflunomide-induced skin necrosis]. ( Delaporte, E; Delesalle, F; Gautier, S; Gros, C, 2008) |
| "Primary rat hepatocytes were exposed to the bile acid glycochenodeoxycholic acid (GCDCA), the superoxide anion donor menadione, or tumor necrosis factor (TNF) alpha in combination with actinomycin D." | 3.74 | The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis. ( Buist-Homan, M; Faber, KN; Kalsbeek, AJ; Moshage, H; Vrenken, TE, 2008) |
| "A 73-year-old woman had been taking leflunomide for psoriatic arthritis for one year and subsequently, developed three abdominal ulcerations and necrosis of one hallux." | 3.74 | [Leflunomide-induced skin necrosis]. ( Delaporte, E; Delesalle, F; Gautier, S; Gros, C, 2008) |
| "Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that is safe at therapeutic doses but which can precipitate liver injury at high doses." | 1.34 | Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury. ( Boelsterli, UA; Goh, CW; Latchoumycandane, C; Ong, MM, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vrenken, TE | 1 |
| Buist-Homan, M | 1 |
| Kalsbeek, AJ | 1 |
| Faber, KN | 1 |
| Moshage, H | 1 |
| Latchoumycandane, C | 1 |
| Goh, CW | 1 |
| Ong, MM | 1 |
| Boelsterli, UA | 1 |
| Gros, C | 1 |
| Delesalle, F | 1 |
| Gautier, S | 1 |
| Delaporte, E | 1 |
3 other studies available for leflunomide and Necrosis
| Article | Year |
|---|---|
The active metabolite of leflunomide, A77 1726, protects rat hepatocytes against bile acid-induced apoptosis.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Bile Acids and Salts | 2008 |
Mitochondrial protection by the JNK inhibitor leflunomide rescues mice from acetaminophen-induced liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Apoptosis; bcl-X Protein; Enzyme Inhibitors; Immun | 2007 |
[Leflunomide-induced skin necrosis].
Topics: Abdomen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Psoriatic; Female; Follow-Up Stud | 2008 |