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Neurotensin receptor type 2
A neurotensin receptor type 2 that is encoded in the genome of rat. [OMA:Q63384, PRO:DNx]
Synonyms
NT-R-2;
NTR2;
High-affinity levocabastine-sensitive neurotensin receptor
Research
Bioassay Publications (3)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| levocabastine | Rattus norvegicus (Norway rat) | Ki | 0.0330 | 1 | 1 |
| sr 48692 | Rattus norvegicus (Norway rat) | Ki | 0.0620 | 1 | 1 |
| sr 142948 | Rattus norvegicus (Norway rat) | Ki | 0.0063 | 3 | 3 |
| sr 48527 | Rattus norvegicus (Norway rat) | Ki | 0.6440 | 1 | 1 |
| neurotensin | Rattus norvegicus (Norway rat) | IC50 | 0.0582 | 3 | 3 |
| neurotensin | Rattus norvegicus (Norway rat) | Ki | 0.0226 | 3 | 3 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| levocabastine | Rattus norvegicus (Norway rat) | EC50 | 0.0280 | 1 | 1 |
| sr 48692 | Rattus norvegicus (Norway rat) | EC50 | 0.1200 | 1 | 1 |
| sr 142948 | Rattus norvegicus (Norway rat) | EC50 | 0.0200 | 3 | 3 |
| sr 48527 | Rattus norvegicus (Norway rat) | EC50 | 0.2170 | 1 | 1 |
| neurotensin | Rattus norvegicus (Norway rat) | EC50 | 0.1000 | 1 | 1 |
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 25, Issue:2, 2015
Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.Journal of medicinal chemistry, , Jun-26, Volume: 57, Issue:12, 2014
Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 25, Issue:2, 2015
Identification of N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine (NTRC-824), a neurotensin-like nonpeptide compound selective for the neurotensin receptor type 2.Journal of medicinal chemistry, , Sep-11, Volume: 57, Issue:17, 2014
Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound.Journal of medicinal chemistry, , Jun-26, Volume: 57, Issue:12, 2014