pentobarbital has been researched along with Necrosis in 28 studies
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prior administration of aminoacetonitrile (AAN) or imidazole but not isoxazole to rats, was able partially to prevent thioacetamide (TAC)-induced liver necrosis at 24 h." | 7.66 | Prevention of thioacetamide-induced liver necrosis by prior aminoacetonitrile or imidazole administration. ( Castro, JA; De Fenos, OM; De Ferreyra, EC, 1982) |
| " Pentobarbital given from start of overt seizures (30 to 60 mg/kg, IP, thrice daily) was able to stop convulsions and to antagonize processes involved in ischemia-induced neuronal death of CA1 hippocampus." | 3.69 | Neurologic and cytologic outcome following repeated ischemia. Effect of pentobarbital. ( Bralet, J; Marie, C; Mossiat, C, 1994) |
| "Prior administration of aminoacetonitrile (AAN) or imidazole but not isoxazole to rats, was able partially to prevent thioacetamide (TAC)-induced liver necrosis at 24 h." | 3.66 | Prevention of thioacetamide-induced liver necrosis by prior aminoacetonitrile or imidazole administration. ( Castro, JA; De Fenos, OM; De Ferreyra, EC, 1982) |
| "Pentobarbital sleeping time was significantly increased over that of corn oil control groups in rats but decreased in mice." | 1.27 | Rat hepatic mitochondria are more sensitive to allyl alcohol than are those of mice. ( Jacobs, JM; Roebuck, BD; Rutkowski, JV; Smith, RP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (67.86) | 18.7374 |
| 1990's | 5 (17.86) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 2 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kalaskar, MG | 1 |
| Surana, SJ | 1 |
| Krysl, D | 1 |
| Deykun, K | 1 |
| Lambert, L | 1 |
| Pokorny, J | 1 |
| Mares, J | 1 |
| Oliveira, FA | 1 |
| Chaves, MH | 1 |
| Almeida, FR | 1 |
| Lima, RC | 1 |
| Silva, RM | 1 |
| Maia, JL | 1 |
| Brito, GA | 1 |
| Santos, FA | 1 |
| Rao, VS | 1 |
| De Ferreyra, EC | 2 |
| De Fenos, OM | 3 |
| Castro, JA | 4 |
| Wright, NG | 1 |
| Minto, AW | 1 |
| Nash, AS | 1 |
| Kondziolka, D | 1 |
| Somaza, S | 1 |
| Flickinger, JC | 1 |
| Claassen, D | 1 |
| Lunsford, LD | 1 |
| Marie, C | 1 |
| Mossiat, C | 1 |
| Bralet, J | 1 |
| Magloczky, Z | 1 |
| Freund, TF | 1 |
| Koechel, DA | 1 |
| Krejci, ME | 1 |
| Ridgewell, RE | 1 |
| Kimbro, JR | 1 |
| Kelly, PJ | 1 |
| Drummond, JC | 1 |
| Cole, DJ | 1 |
| Patel, PM | 1 |
| Hendry, JH | 1 |
| Herman, EH | 1 |
| Balazs, T | 1 |
| Young, R | 1 |
| Earl, FL | 1 |
| Krop, S | 1 |
| Ferrans, VJ | 1 |
| Shuster, L | 1 |
| Quimby, F | 1 |
| Bates, A | 1 |
| Thompson, ML | 1 |
| Ferreyra, EC | 1 |
| de Castro, CR | 1 |
| Diaz Gómez, MI | 1 |
| Gram, TE | 1 |
| Reagan, RL | 1 |
| Guarino, AM | 1 |
| Zhang, ZL | 1 |
| Wen, QZ | 1 |
| Liu, CX | 1 |
| Jacobs, JM | 1 |
| Rutkowski, JV | 1 |
| Roebuck, BD | 1 |
| Smith, RP | 1 |
| Wagner, KR | 1 |
| Ting, P | 1 |
| Westfall, MV | 1 |
| Yamaguchi, S | 1 |
| Bacher, JD | 1 |
| Myers, RE | 1 |
| Nishie, K | 1 |
| Norred, WP | 1 |
| Pensabene, JW | 1 |
| Meltzer, HY | 1 |
| Clasen, RA | 1 |
| Pandolfi, S | 1 |
| Casey, D | 1 |
| Koff, RS | 1 |
| Davidson, LJ | 1 |
| Gordon, G | 1 |
| Sabesin, SM | 1 |
| Gilbert, EF | 1 |
| Da Silva, A | 1 |
| Cignoli, EV | 1 |
| Wheatley, DN | 1 |
| Klatte, EC | 1 |
| Brooks, AL | 1 |
| Rhamy, RK | 1 |
| Leavell, UW | 1 |
| Syrkin, AB | 1 |
| Plotnikov, NP | 1 |
| Zaĭtseva, LA | 1 |
| Bodiagin, DA | 1 |
28 other studies available for pentobarbital and Necrosis
| Article | Year |
|---|---|
Free radical scavenging and hepatoprotective potential of Ficus microcarpa L. fil. bark extracts.
Topics: Animals; Biphenyl Compounds; Carbon Tetrachloride; Ficus; Free Radical Scavengers; Liver; Male; Mice | 2011 |
Perifocal and remote blood-brain barrier disruption in cortical photothrombotic ischemic lesion and its modulation by the choice of anesthesia.
Topics: Adrenergic alpha-2 Receptor Agonists; Anesthetics; Animals; Blood-Brain Barrier; Brain Ischemia; Exc | 2012 |
Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Bur | 2005 |
Prevention of thioacetamide-induced liver necrosis by prior aminoacetonitrile or imidazole administration.
Topics: Acetamides; Acetonitriles; Aminoacetonitrile; Animals; Chemical and Drug Induced Liver Injury; Imida | 1982 |
Necrotising glomerulopathy in cats euthanased with ketamine hydrochloride and sodium pentobarbitone.
Topics: Animals; Cat Diseases; Cats; Ketamine; Kidney Diseases; Kidney Glomerulus; Necrosis; Pentobarbital | 1982 |
Effect of different chemicals on thioacetamine-induced liver necrosis.
Topics: Acetamides; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme System; Liver; | 1980 |
Cerebral radioprotective effects of high-dose pentobarbital evaluated in an animal radiosurgery model.
Topics: Animals; Brain; Necrosis; Pentobarbital; Radiation Injuries, Experimental; Radiation-Protective Agen | 1994 |
Neurologic and cytologic outcome following repeated ischemia. Effect of pentobarbital.
Topics: Animals; Blood Glucose; Body Temperature; Brain; Cerebrovascular Circulation; Hippocampus; Ischemic | 1994 |
Selective neuronal death in the contralateral hippocampus following unilateral kainate injections into the CA3 subfield.
Topics: Anesthetics; Animals; Biomarkers; Calbindin 2; Cell Death; Chloral Hydrate; Disease Models, Animal; | 1993 |
S-(1,2-dichlorovinyl)-3-mercaptopropionic acid effects on renal function and ultrastructure in pentobarbital-anesthetized dogs: site-specific toxicity and evidence for its toxification via the pathway responsible for beta-oxidation of fatty acids.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, | 1993 |
Isoflurane and pentobarbital reduce AMPA toxicity in vivo in the rat cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Inhalation; Animals; Blood Pr | 2000 |
Radionecrosis of normal tissue: studies on mouse tails.
Topics: Anesthetics; Animals; Dose-Response Relationship, Radiation; Female; Mice; Necrosis; Oxygen; Pentoba | 1978 |
Acute cardiomyopathy induced by the vasodilating antihypertensive agent minoxidil.
Topics: Anesthesia; Animals; Arteritis; Cardiomyopathies; Coronary Vessels; Dogs; Hemorrhage; Hypotension; M | 1979 |
Liver damage from cocaine in mice.
Topics: Animals; Aspartate Aminotransferases; Cocaine; Dose-Response Relationship, Drug; Drug Interactions; | 1977 |
Studies on the role of protein syntheis in cell injury by toxic agents: I. Effect of cycloheximide administration on several factors modulating carbon tetrachloride-induced liver necrosis.
Topics: Animals; Body Temperature; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cycloheximi | 1977 |
Hepatoprotective effects of astraglus root.
Topics: Alanine Transaminase; Animals; Astragalus propinquus; Drugs, Chinese Herbal; Female; Liver; Liver Di | 1990 |
Rat hepatic mitochondria are more sensitive to allyl alcohol than are those of mice.
Topics: 1-Propanol; Alanine Transaminase; Animals; Drug Resistance; Hepatitis, Alcoholic; Mice; Mitochondria | 1987 |
Brain metabolic correlates of hypoxic-ischemic cerebral necrosis in mid-gestational sheep fetuses: significance of hypotension.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Energy Metabolism; Female; Fetal Diseases; Hypotensi | 1986 |
Effect of short-term administration of N-nitroso compounds on liver histology and on pentobarbital-induced sleeping time in mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum; Lipid Metabolism; Liver; Liv | 1974 |
Muscle toxicity produced by phencyclidine and restraint stress.
Topics: Animals; Cold Temperature; Creatine Kinase; Dose-Response Relationship, Drug; Electroshock; Fructose | 1972 |
Furosemide and pentobarbital in cryogenic cerebral injury and edema.
Topics: Animals; Brain; Brain Edema; Cerebral Hemorrhage; Drug Synergism; Erythrocytes; Freezing; Furosemide | 1974 |
D-galactosamine hepatotoxicity. 3. Normoactive smooth endoplasmic reticulum and modification by phenobarbital.
Topics: Animals; Cytochrome c Group; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Endoplasmic Reti | 1973 |
Henoch-Schöenlein purpura. Report of a fatal case with gastrointestinal hemorrhage and necrosis.
Topics: Adolescent; Chlorpheniramine; Dexamethasone; Diphenhydramine; Gastrointestinal Diseases; Gastrointes | 1966 |
Effect of inhibitors of drug metabolizing enzymes on carbon tetrachloride hepatotoxicity.
Topics: Aminopyrine; Animals; Biotransformation; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemi | 1971 |
Prevention of the adrenocorticolytic actions of 7,12-dimethylbenz[a]anthracene and 7-hydroxymethyl-12-methylbenz[a]anthracene by beta-diethylaminoethyldiphenyl-n-propyl acetate (SKF 525-A).
Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Drug Synergism; Ethionine; Female; Injections, Intraper | 1968 |
Toxicity of intra-arterial barbiturates and tranquilizing drugs.
Topics: Acute Kidney Injury; Animals; Calcinosis; Humans; Hydroxyzine; Injections, Intra-Arterial; Necrosis; | 1969 |
Sweat gland necrosis in barbiturate poisoning.
Topics: Adult; Fever; Humans; Male; Necrosis; Pentobarbital; Sweat Glands | 1969 |
[Pharmacological properties of 20 antibiotic isolated from Aspergillus fumigatus].
Topics: Adrenal Glands; Animals; Antibiotics, Antineoplastic; Aspergillus; Behavior, Animal; Blood Pressure; | 1969 |