Proteins > 5-hydroxytryptamine receptor 7
Page last updated: 2024-08-07 16:31:53
5-hydroxytryptamine receptor 7
A 5-hydroxytryptamine receptor 7 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P34969]
Synonyms
5-HT-7;
5-HT7;
5-HT-X;
Serotonin receptor 7
Research
Bioassay Publications (148)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (0.68) | 18.7374 |
| 1990's | 1 (0.68) | 18.2507 |
| 2000's | 40 (27.03) | 29.6817 |
| 2010's | 81 (54.73) | 24.3611 |
| 2020's | 25 (16.89) | 2.80 |
Compounds (117)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tryptamine | Homo sapiens (human) | Ki | 0.1585 | 1 | 1 |
| 8-hydroxy-2-(di-n-propylamino)tetralin | Homo sapiens (human) | Ki | 0.3554 | 6 | 6 |
| 1-(1-naphthyl)piperazine | Homo sapiens (human) | Ki | 0.0830 | 1 | 1 |
| 1-(3-chlorophenyl)piperazine | Homo sapiens (human) | Ki | 0.2335 | 2 | 2 |
| 2-methyl-5-ht | Homo sapiens (human) | Ki | 1.2580 | 1 | 1 |
| 5-carboxamidotryptamine | Homo sapiens (human) | Ki | 0.0017 | 8 | 8 |
| methylbufotenin | Homo sapiens (human) | Ki | 0.0300 | 1 | 1 |
| 5-methoxytryptamine | Homo sapiens (human) | Ki | 0.0035 | 2 | 2 |
| dan 2163 | Homo sapiens (human) | Ki | 0.0183 | 2 | 2 |
| amoxapine | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| buspirone | Homo sapiens (human) | Ki | 0.4260 | 2 | 2 |
| chlorpromazine | Homo sapiens (human) | Ki | 0.1142 | 5 | 7 |
| cisapride | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| cyproheptadine | Homo sapiens (human) | Ki | 0.0880 | 2 | 2 |
| haloperidol | Homo sapiens (human) | Ki | 0.7366 | 3 | 4 |
| imipramine | Homo sapiens (human) | Ki | 3.7300 | 1 | 3 |
| ketanserin | Homo sapiens (human) | Ki | 1.2965 | 2 | 2 |
| methiothepin | Homo sapiens (human) | IC50 | 0.0075 | 5 | 5 |
| methiothepin | Homo sapiens (human) | Ki | 0.0017 | 9 | 9 |
| mianserin | Homo sapiens (human) | IC50 | 0.1148 | 1 | 1 |
| mianserin | Homo sapiens (human) | Ki | 2.7097 | 3 | 3 |
| mirtazapine | Homo sapiens (human) | Ki | 0.2650 | 1 | 1 |
| nan 190 | Homo sapiens (human) | Ki | 0.0438 | 2 | 2 |
| ondansetron | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| perphenazine | Homo sapiens (human) | Ki | 0.0230 | 1 | 1 |
| propranolol | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| quetiapine | Homo sapiens (human) | Ki | 0.0631 | 1 | 1 |
| quipazine | Homo sapiens (human) | Ki | 3.0330 | 1 | 1 |
| risperidone | Homo sapiens (human) | Ki | 0.0019 | 3 | 3 |
| ritanserin | Homo sapiens (human) | Ki | 0.0304 | 2 | 2 |
| spiperone | Homo sapiens (human) | Ki | 0.0900 | 5 | 5 |
| sulpiride | Homo sapiens (human) | Ki | 3.0000 | 1 | 1 |
| sumatriptan | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| thioridazine | Homo sapiens (human) | Ki | 0.1255 | 2 | 2 |
| n-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-n-(2-pyridinyl)cyclohexanecarboxamide | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| lysergic acid diethylamide | Homo sapiens (human) | Ki | 0.0065 | 2 | 2 |
| indopan | Homo sapiens (human) | Ki | 0.1027 | 1 | 2 |
| dibenzepin | Homo sapiens (human) | Ki | 12.3000 | 1 | 1 |
| 2-bromolysergic acid diethylamide | Homo sapiens (human) | Ki | 0.0239 | 3 | 3 |
| azaperone | Homo sapiens (human) | Ki | 0.1177 | 2 | 4 |
| n-methyllaurotetanine | Homo sapiens (human) | Ki | 0.0200 | 1 | 1 |
| glaucine | Homo sapiens (human) | Ki | 0.0430 | 1 | 1 |
| molindone | Homo sapiens (human) | Ki | 0.2650 | 1 | 1 |
| pizotyline | Homo sapiens (human) | Ki | 0.0250 | 1 | 1 |
| metergoline | Homo sapiens (human) | Ki | 0.0063 | 3 | 3 |
| penfluridol | Homo sapiens (human) | Ki | 0.2800 | 1 | 1 |
| butaclamol | Homo sapiens (human) | Ki | 0.0631 | 1 | 1 |
| ipsapirone | Homo sapiens (human) | Ki | 1.4060 | 1 | 1 |
| aripiprazole | Homo sapiens (human) | Ki | 0.0235 | 8 | 8 |
| ziprasidone | Homo sapiens (human) | Ki | 0.0053 | 3 | 3 |
| baicalin | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| ch 29717 | Homo sapiens (human) | Ki | 0.0180 | 1 | 1 |
| mesulergine | Homo sapiens (human) | IC50 | 0.2050 | 2 | 2 |
| mesulergine | Homo sapiens (human) | Ki | 0.0079 | 1 | 1 |
| way 100635 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| gr 127935 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| pramipexole | Homo sapiens (human) | Ki | 1.1880 | 1 | 1 |
| tamsulosin | Homo sapiens (human) | Ki | 0.0840 | 1 | 1 |
| harmalan | Homo sapiens (human) | Ki | 0.2800 | 1 | 1 |
| n-demethyllysergic acid diethylamide | Homo sapiens (human) | IC50 | 0.1430 | 1 | 1 |
| 5-hydroxy-2-n,n-dipropylaminotetralin | Homo sapiens (human) | Ki | 0.4660 | 1 | 1 |
| nantenine, (+-)-isomer | Homo sapiens (human) | Ki | 0.0670 | 1 | 1 |
| scutellarin | Homo sapiens (human) | IC50 | 63.4000 | 1 | 1 |
| latrepirdine | Homo sapiens (human) | Ki | 0.0080 | 3 | 3 |
| lurasidone | Homo sapiens (human) | IC50 | 0.0157 | 1 | 1 |
| lurasidone | Homo sapiens (human) | Ki | 0.0005 | 2 | 2 |
| sorafenib | Homo sapiens (human) | Ki | 7.0710 | 1 | 1 |
| 1-methyl-6-methoxy-dihydro-beta-carboline | Homo sapiens (human) | Ki | 2.9600 | 1 | 1 |
| 5-hydroxytryptophan | Homo sapiens (human) | Ki | 0.0021 | 1 | 1 |
| sb 243213 | Homo sapiens (human) | IC50 | 1.0000 | 1 | 1 |
| hydroxyphenethylferulate | Homo sapiens (human) | IC50 | 47.6000 | 1 | 1 |
| butylidenephthalide | Homo sapiens (human) | IC50 | 126.6000 | 1 | 1 |
| 3,4,5-trimethoxycinnamic acid | Homo sapiens (human) | IC50 | 10.0000 | 2 | 4 |
| mitragynine | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| paynantheine | Homo sapiens (human) | Ki | 0.8700 | 1 | 1 |
| mm 77 | Homo sapiens (human) | Ki | 0.0900 | 1 | 1 |
| harmine | Homo sapiens (human) | Ki | 5.5000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 350.0000 | 1 | 1 |
| wogonin | Homo sapiens (human) | IC50 | 350.0000 | 1 | 1 |
| ly 344864 | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| l 745870 | Homo sapiens (human) | Ki | 0.2263 | 1 | 1 |
| sb 258719 | Homo sapiens (human) | Ki | 0.0317 | 9 | 9 |
| sb 271046 | Homo sapiens (human) | Ki | 1.4147 | 3 | 3 |
| 1-methyl-d-lysergic acid butanolamide | Homo sapiens (human) | Ki | 0.0460 | 2 | 2 |
| 8-hydroxy-2-(di-n-propylamino)tetralin, (r)-isomer | Homo sapiens (human) | Ki | 0.0480 | 1 | 1 |
| sb 269970 | Homo sapiens (human) | IC50 | 0.0019 | 5 | 9 |
| sb 269970 | Homo sapiens (human) | Ki | 0.0009 | 22 | 26 |
| vilazodone | Homo sapiens (human) | Ki | 3.9000 | 1 | 1 |
| 2-ethyl-5-methoxy-n,n-dimethyltryptamine | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| 2-ethyl-5-methoxy-n,n-dimethyltryptamine | Homo sapiens (human) | Ki | 0.3000 | 1 | 1 |
| 5-methoxy-2-phenyl-n,n-dimethyltryptamine | Homo sapiens (human) | Ki | 0.1550 | 1 | 1 |
| ms-245 | Homo sapiens (human) | Ki | 1.2500 | 2 | 2 |
| n-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| 4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| sb258741 | Homo sapiens (human) | Ki | 0.0031 | 5 | 5 |
| slv 313 | Homo sapiens (human) | Ki | 0.0631 | 1 | 1 |
| st 1936 | Homo sapiens (human) | Ki | 0.2900 | 1 | 1 |
| 4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| vortioxetine | Homo sapiens (human) | Ki | 0.0246 | 5 | 5 |
| sb-656104-a | Homo sapiens (human) | Ki | 0.0023 | 4 | 4 |
| 5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| way 181187 | Homo sapiens (human) | Ki | 0.4850 | 2 | 4 |
| sb-649915 | Homo sapiens (human) | Ki | 0.1995 | 1 | 1 |
| way-208466 | Homo sapiens (human) | IC50 | 4.7640 | 1 | 1 |
| meridianin a | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| cariprazine | Homo sapiens (human) | Ki | 0.1110 | 1 | 1 |
| barettin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| sb 742457 | Homo sapiens (human) | Ki | 14.2300 | 2 | 2 |
| naluzotan | Homo sapiens (human) | Ki | 0.7000 | 1 | 1 |
| col-144 | Homo sapiens (human) | Ki | 0.5900 | 1 | 1 |
| td-5108 | Homo sapiens (human) | Ki | 0.1000 | 1 | 1 |
| brexpiprazole | Homo sapiens (human) | Ki | 0.0037 | 1 | 1 |
| 4-(4-chlorophenyl)sulfonyl-5-(3,4-dihydro-1H-isoquinolin-2-yl)-2-ethylsulfonylthiazole | Homo sapiens (human) | Ki | 15.7700 | 1 | 1 |
| mitragynine | Homo sapiens (human) | Ki | 1.6000 | 1 | 1 |
| a 803467 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| sp 203 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| lu ae58054 | Homo sapiens (human) | Ki | 8.6350 | 1 | 1 |
| e-55888 | Homo sapiens (human) | Ki | 0.0021 | 5 | 6 |
| n-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide | Homo sapiens (human) | Ki | 0.0088 | 7 | 7 |
| n,n-diallyl-5-methoxytryptamine | Homo sapiens (human) | Ki | 0.0410 | 2 | 3 |
| clozapine | Homo sapiens (human) | Ki | 0.3338 | 28 | 33 |
| olanzapine | Homo sapiens (human) | Ki | 0.2089 | 4 | 4 |
| tegaserod | Homo sapiens (human) | Ki | 0.1000 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| methiothepin | Homo sapiens (human) | Kb | 0.0001 | 2 | 2 |
| metergoline | Homo sapiens (human) | Activity | 0.0180 | 1 | 1 |
| mesulergine | Homo sapiens (human) | Kb | 0.0110 | 1 | 1 |
| mesulergine | Homo sapiens (human) | Kbapp | 0.0160 | 1 | 1 |
| sb 269970 | Homo sapiens (human) | Kb | 0.0006 | 4 | 4 |
Structure-activity relationships of serotonin 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HTBioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016
Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 25, Issue:7, 2015
Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.Journal of medicinal chemistry, , Dec-16, Volume: 47, Issue:26, 2004
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
[no title available]European journal of medicinal chemistry, , May-05, Volume: 235, 2022
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Privileged scaffold-based design to identify a novel drug-like 5-HTEuropean journal of medicinal chemistry, , Aug-01, Volume: 199, 2020
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
Structure-Activity Relationships and Therapeutic Potentials of 5-HTJournal of medicinal chemistry, , 10-11, Volume: 61, Issue:19, 2018
Development of 3,4-dihydroisoquinolin-1(2H)-one derivatives for the Positron Emission Tomography (PET) imaging of σ₂ receptors.European journal of medicinal chemistry, , Volume: 69, 2013
Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.Journal of medicinal chemistry, , Dec-16, Volume: 47, Issue:26, 2004
A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp.Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
2a-[4-(Tetrahydropyridoindol-2-yl)butyl]tetrahydrobenzindole derivatives: new selective antagonists of the 5-hydroxytryptamine7 receptor.Journal of medicinal chemistry, , May-23, Volume: 45, Issue:11, 2002
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues.Journal of medicinal chemistry, , Volume: 21, Issue:8, 1978
Structure-activity relationships of serotonin 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins.ACS chemical biology, , 09-15, Volume: 12, Issue:9, 2017
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.Bioorganic & medicinal chemistry, , May-01, Volume: 21, Issue:9, 2013
CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs.Bioorganic & medicinal chemistry, , Oct-01, Volume: 19, Issue:19, 2011
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
Structure-activity relationships of serotonin 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
[no title available]Journal of medicinal chemistry, , 09-09, Volume: 64, Issue:17, 2021
Multifunctional 6-fluoro-3-[3-(pyrrolidin-1-yl)propyl]-1,2-benzoxazoles targeting behavioral and psychological symptoms of dementia (BPSD).European journal of medicinal chemistry, , Apr-01, Volume: 191, 2020
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 207, 2020
[no title available]Bioorganic & medicinal chemistry letters, , 12-01, Volume: 29, Issue:23, 2019
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.Bioorganic & medicinal chemistry, , 09-15, Volume: 27, Issue:18, 2019
Structure-activity relationships of serotonin 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
[no title available]Bioorganic & medicinal chemistry letters, , 06-15, Volume: 28, Issue:11, 2018
Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity.Journal of medicinal chemistry, , 09-14, Volume: 60, Issue:17, 2017
Design, synthesis, and anticonvulsant activity of some derivatives of xanthone with aminoalkanol moieties.Chemical biology & drug design, , Volume: 89, Issue:3, 2017
Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.European journal of medicinal chemistry, , Apr-13, Volume: 112, 2016
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.Journal of medicinal chemistry, , Jun-12, Volume: 57, Issue:11, 2014
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists.European journal of medicinal chemistry, , Volume: 56, 2012
Novel quinazolinone derivatives as 5-HT7 receptor ligands.Bioorganic & medicinal chemistry, , Mar-01, Volume: 16, Issue:5, 2008
Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro.Journal of natural products, , Volume: 69, Issue:3, 2006
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Synthesis and structure-activity relationship of 2-(aminoalkyl)-2,3,3a,8-tetrahydrodibenzo[c,f]isoxazolo[2,3-a]azepine derivatives: a novel series of 5-HT(2A/2C) receptor antagonists. Part 1.Bioorganic & medicinal chemistry letters, , Jan-21, Volume: 12, Issue:2, 2002
Novel DEuropean journal of medicinal chemistry, , Mar-15, Volume: 232, 2022
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Structure-activity relationships of serotonin 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Antitubercular polyhalogenated phenothiazines and phenoselenazine with reduced binding to CNS receptors.European journal of medicinal chemistry, , Sep-01, Volume: 201, 2020
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
A novel ergot alkaloid as a 5-HT(1A) inhibitor produced by Dicyma sp.Journal of medicinal chemistry, , Nov-20, Volume: 46, Issue:24, 2003
Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).Journal of medicinal chemistry, , Sep-12, Volume: 45, Issue:19, 2002
Structure-activity relationships of serotonin 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Structure-activity relationships of serotonin 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates.Bioorganic & medicinal chemistry, , Nov-15, Volume: 18, Issue:22, 2010
The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 20, Issue:8, 2010
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Novel DEuropean journal of medicinal chemistry, , Mar-15, Volume: 232, 2022
A study of the structure-affinity relationship in SYA16263; is a DBioorganic & medicinal chemistry, , 01-15, Volume: 30, 2021
New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263.European journal of medicinal chemistry, , Mar-15, Volume: 214, 2021
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT₁A/5-HT₂A/5-HT₇ and dopamine D₂/D₃ receptors.European journal of medicinal chemistry, , Volume: 60, 2013
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Polypharmacology - foe or friend?Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
Towards the development of 5-HT₇ ligands combining serotonin-like and arylpiperazine moieties.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
The extracellular entrance provides selectivity to serotonin 5-HT7 receptor antagonists with antidepressant-like behavior in vivo.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Chemical update on the potential for serotonin 5-HTBioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists.European journal of medicinal chemistry, , Volume: 45, Issue:2, 2010
Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 20, Issue:1, 2010
New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263.European journal of medicinal chemistry, , Mar-15, Volume: 214, 2021
[no title available]Bioorganic & medicinal chemistry, , 05-15, Volume: 28, Issue:10, 2020
[no title available]European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.European journal of medicinal chemistry, , Jul-01, Volume: 173, 2019
Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents.Journal of enzyme inhibition and medicinal chemistry, , Volume: 25, Issue:1, 2010
Activity of Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
Activity of Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
Structure-activity relationships of serotonin 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Structure-Activity Relationships and Therapeutic Potentials of 5-HTJournal of medicinal chemistry, , 10-11, Volume: 61, Issue:19, 2018
Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.Bioorganic & medicinal chemistry, , May-01, Volume: 21, Issue:9, 2013
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-02, Volume: 12, Issue:17, 2002
First pharmacophoric hypothesis for 5-HT7 antagonism.Bioorganic & medicinal chemistry letters, , May-15, Volume: 10, Issue:10, 2000
(R)-3,N-dimethyl-N-[1-methyl-3-(4-methyl-piperidin-1-yl) propyl]benzenesulfonamide: the first selective 5-HT7 receptor antagonist.Journal of medicinal chemistry, , Feb-26, Volume: 41, Issue:5, 1998
Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HTEuropean journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 18, Issue:2, 2008
Bicyclic piperazinylbenzenesulphonamides are potent and selective 5-HT6 receptor antagonists.Bioorganic & medicinal chemistry letters, , May-20, Volume: 12, Issue:10, 2002
Discovery of G Protein-Biased Antagonists against 5-HTJournal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
[no title available]European journal of medicinal chemistry, , Sep-01, Volume: 201, 2020
Structure-activity relationships of serotonin 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Novel multitarget 5-arylidenehydantoins with arylpiperazinealkyl fragment: Pharmacological evaluation and investigation of cytotoxicity and metabolic stability.Bioorganic & medicinal chemistry, , 09-15, Volume: 27, Issue:18, 2019
[1]Benzothieno[3,2-d]pyrimidine derivatives as ligands for the serotonergic 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
[no title available]Bioorganic & medicinal chemistry letters, , 06-15, Volume: 28, Issue:11, 2018
Structure-Activity Relationships and Therapeutic Potentials of 5-HTJournal of medicinal chemistry, , 10-11, Volume: 61, Issue:19, 2018
[no title available]Journal of medicinal chemistry, , 08-23, Volume: 61, Issue:16, 2018
New N- and O-arylpiperazinylalkyl pyrimidines and 2-methylquinazolines derivatives as 5-HTBioorganic & medicinal chemistry, , 02-01, Volume: 25, Issue:3, 2017
Design and synthesis of new homo and hetero bis-piperazinyl-1-propanone derivatives as 5-HT7R selective ligands over 5-HT1AR.Bioorganic & medicinal chemistry letters, , 08-15, Volume: 26, Issue:16, 2016
5-HT7 receptor modulators: Amino groups attached to biphenyl scaffold determine functional activity.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Novel N-acyl-carbazole derivatives as 5-HT7R antagonists.European journal of medicinal chemistry, , Mar-03, Volume: 110, 2016
Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors.Bioorganic & medicinal chemistry, , 11-15, Volume: 24, Issue:22, 2016
Synthesis and binding properties of new long-chain 4-substituted piperazine derivatives as 5-HT₁A and 5-HT₇ receptor ligands.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 25, Issue:7, 2015
Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression.Bioorganic & medicinal chemistry, , Sep-01, Volume: 22, Issue:17, 2014
Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT(7) and 5-HT(1A) receptor ligands.European journal of medicinal chemistry, , Oct-06, Volume: 85, 2014
Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.Journal of medicinal chemistry, , Jun-12, Volume: 57, Issue:11, 2014
Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.Bioorganic & medicinal chemistry, , May-01, Volume: 21, Issue:9, 2013
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists.European journal of medicinal chemistry, , Volume: 56, 2012
Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT(7) antagonists.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Synthesis and biological evaluation of potential 5-HT(7) receptor PET radiotracers.European journal of medicinal chemistry, , Volume: 46, Issue:8, 2011
Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands.Bioorganic & medicinal chemistry, , Nov-15, Volume: 19, Issue:22, 2011
Sulfonamides with the N-alkyl-N'-dialkylguanidine moiety as 5-HT7 receptor ligands.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 19, Issue:16, 2009
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
1-(Bicyclopiperazinyl)ethylindoles and 1-(homopiperazinyl)ethyl-indoles as highly selective and potent 5-HT(7) receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-02, Volume: 12, Issue:17, 2002
A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).Journal of medicinal chemistry, , Feb-10, Volume: 43, Issue:3, 2000
2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 15, Issue:19, 2005
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.Journal of medicinal chemistry, , Mar-09, Volume: 43, Issue:5, 2000
N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.Journal of medicinal chemistry, , Nov-08, Volume: 44, Issue:23, 2001
N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists.Bioorganic & medicinal chemistry letters, , Oct-16, Volume: 10, Issue:20, 2000
Structure-activity relationships of serotonin 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Structure-Activity Relationships and Therapeutic Potentials of 5-HTJournal of medicinal chemistry, , 10-11, Volume: 61, Issue:19, 2018
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).Journal of medicinal chemistry, , Feb-10, Volume: 43, Issue:3, 2000
Chemical update on the potential for serotonin 5-HTBioorganic & medicinal chemistry letters, , 10-01, Volume: 49, 2021
[no title available]Bioorganic & medicinal chemistry letters, , 12-01, Volume: 29, Issue:23, 2019
[no title available]Bioorganic & medicinal chemistry letters, , 12-15, Volume: 29, Issue:24, 2019
[no title available]European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
[no title available]Bioorganic & medicinal chemistry letters, , 12-15, Volume: 27, Issue:24, 2017
Spiro[pyrrolidine-3,3'-oxindoles] as 5-HTBioorganic & medicinal chemistry letters, , 08-01, Volume: 28, Issue:14, 2018
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists.European journal of medicinal chemistry, , Volume: 56, 2012
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.Bioorganic & medicinal chemistry letters, , Nov-18, Volume: 12, Issue:22, 2002
Activity of Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
Positron Emission Tomography (PET) Imaging Tracers for Serotonin Receptors.Journal of medicinal chemistry, , 08-25, Volume: 65, Issue:16, 2022
Discovery of G Protein-Biased Ligands against 5-HTJournal of medicinal chemistry, , 06-10, Volume: 64, Issue:11, 2021
Structure-activity relationships of serotonin 5-HTEuropean journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Search for a 5-CT alternative. MedChemComm, , Nov-01, Volume: 9, Issue:11, 2018
Structure-Activity Relationships and Therapeutic Potentials of 5-HTJournal of medicinal chemistry, , 10-11, Volume: 61, Issue:19, 2018
Search for a 5-CT alternative. MedChemComm, , Nov-01, Volume: 9, Issue:11, 2018
Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study.European journal of medicinal chemistry, , Sep-14, Volume: 120, 2016
Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT(7) and 5-HT(1A) receptor ligands.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 23, Issue:22, 2013
Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.Journal of medicinal chemistry, , Jul-26, Volume: 55, Issue:14, 2012
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists.European journal of medicinal chemistry, , Volume: 56, 2012
Receptor binding profiles and quantitative structure-affinity relationships of some 5-substituted-N,N-diallyltryptamines.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging 'Novel Psychoactive Drugs'.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 23, Issue:11, 2013
Novel DEuropean journal of medicinal chemistry, , Mar-15, Volume: 232, 2022
[no title available]European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Structural manipulation of aporphines via C10 nitrogenation leads to the identification of new 5-HTBioorganic & medicinal chemistry, , 08-01, Volume: 28, Issue:15, 2020
[no title available]European journal of medicinal chemistry, , Sep-01, Volume: 201, 2020
[no title available]European journal of medicinal chemistry, , May-15, Volume: 170, 2019
Synthesis and computer-aided SAR studies for derivatives of phenoxyalkyl-1,3,5-triazine as the new potent ligands for serotonin receptors 5-HTEuropean journal of medicinal chemistry, , Sep-15, Volume: 178, 2019
2-Aminoimidazole-based antagonists of the 5-HTEuropean journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HTEuropean journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HTEuropean journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
[no title available]MedChemComm, , Jun-01, Volume: 9, Issue:6, 2018
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
Computer-aided insights into receptor-ligand interaction for novel 5-arylhydantoin derivatives as serotonin 5-HTEuropean journal of medicinal chemistry, , Mar-10, Volume: 147, 2018
[no title available]ACS medicinal chemistry letters, , Apr-13, Volume: 8, Issue:4, 2017
Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.European journal of medicinal chemistry, , Apr-13, Volume: 112, 2016
Synthesis and evaluation of antidepressant-like activity of some 4-substituted 1-(2-methoxyphenyl)piperazine derivatives.Chemical biology & drug design, , Volume: 85, Issue:3, 2015
Antidepressant- and anxiolytic-like activity of 7-phenylpiperazinylalkyl-1,3-dimethyl-purine-2,6-dione derivatives with diversified 5-HT₁A receptor functional profile.Bioorganic & medicinal chemistry, , Jan-01, Volume: 23, Issue:1, 2015
Semisynthetic Studies on and Biological Evaluation of N-Methyllaurotetanine Analogues as Ligands for 5-HT Receptors.Journal of natural products, , Apr-24, Volume: 78, Issue:4, 2015
Solid-Supported Synthesis and 5-HT7 /5-HT1A Receptor Affinity of Arylpiperazinylbutyl Derivatives of 4,5-dihydro-1,2,4-triazine-6-(1H)-one.Chemical biology & drug design, , Volume: 86, Issue:4, 2015
SAR-studies on the importance of aromatic ring topologies in search for selective 5-HT(7) receptor ligands among phenylpiperazine hydantoin derivatives.European journal of medicinal chemistry, , May-06, Volume: 78, 2014
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 24, Issue:2, 2014
Synthesis and evaluation of pharmacological properties of some new xanthone derivatives with piperazine moiety.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 23, Issue:15, 2013
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists.European journal of medicinal chemistry, , Volume: 56, 2012
The development and validation of a novel virtual screening cascade protocol to identify potential serotonin 5-HT(7)R antagonists.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 20, Issue:8, 2010
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.Journal of medicinal chemistry, , Dec-18, Volume: 46, Issue:26, 2003
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).Journal of medicinal chemistry, , Jul-03, Volume: 46, Issue:14, 2003
2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors.Journal of medicinal chemistry, , Mar-09, Volume: 43, Issue:5, 2000
[no title available]European journal of medicinal chemistry, , Feb-10, Volume: 145, 2018
The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HT₇ receptor antagonists.European journal of medicinal chemistry, , Volume: 56, 2012
Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs.Journal of medicinal chemistry, , Oct-18, Volume: 50, Issue:21, 2007
Discovery of new tetracyclic tetrahydrofuran derivatives as potential broad-spectrum psychotropic agents.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Enables
This protein enables 3 target(s):
| Target | Category | Definition |
|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| G protein-coupled serotonin receptor activity | molecular function | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:ai] |
| neurotransmitter receptor activity | molecular function | Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| trans-Golgi network membrane | cellular component | The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. [GOC:mah] |
| synapse | cellular component | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|
| dendrite | cellular component | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|
| smooth muscle contraction | biological process | A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732] |
| circadian rhythm | biological process | Any biological process in an organism that recurs with a regularity of approximately 24 hours. [GOC:bf, GOC:go_curators] |
| blood circulation | biological process | The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. [GOC:mtg_heart, ISBN:0192800825] |
| vasoconstriction | biological process | A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure. [GOC:pr, ISBN:0192800752] |
| G protein-coupled serotonin receptor signaling pathway | biological process | The series of molecular signals generated as a consequence of a G protein-coupled serotonin receptor binding to one of its physiological ligands. [GOC:mah] |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |