Proteins > Sodium- and chloride-dependent GABA transporter 3
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Sodium- and chloride-dependent GABA transporter 3
A sodium- and chloride-dependent GABA transporter 3 that is encoded in the genome of mouse. [OMA:P31650, PRO:DNx]
Synonyms
GAT-3;
Sodium- and chloride-dependent GABA transporter 4;
GAT-4;
Solute carrier family 6 member 11
Research
Bioassay Publications (17)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 14 (82.35) | 24.3611 |
| 2020's | 2 (11.76) | 2.80 |
Compounds (21)
Drugs with Inhibition Measurements
Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.European journal of medicinal chemistry, , Feb-15, Volume: 188, 2020
Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors.Bioorganic & medicinal chemistry, , Jun-01, Volume: 21, Issue:11, 2013
Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.European journal of medicinal chemistry, , Volume: 46, Issue:5, 2011
Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.European journal of medicinal chemistry, , Feb-15, Volume: 188, 2020
Synthesis of N-substituted acyclic β-amino acids and their investigation as GABA uptake inhibitors.European journal of medicinal chemistry, , Volume: 65, 2013
Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.European journal of medicinal chemistry, , Volume: 46, Issue:5, 2011
Synthesis of 4-substituted nipecotic acid derivatives and their evaluation as potential GABA uptake inhibitors.Bioorganic & medicinal chemistry, , May-01, Volume: 24, Issue:9, 2016
Synthesis of N-substituted acyclic β-amino acids and their investigation as GABA uptake inhibitors.European journal of medicinal chemistry, , Volume: 65, 2013
Synthesis and evaluation of N-substituted nipecotic acid derivatives with an unsymmetrical bis-aromatic residue attached to a vinyl ether spacer as potential GABA uptake inhibitors.Bioorganic & medicinal chemistry, , Jun-01, Volume: 21, Issue:11, 2013
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.European journal of medicinal chemistry, , Volume: 43, Issue:11, 2008
Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.European journal of medicinal chemistry, , Feb-15, Volume: 188, 2020
Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.European journal of medicinal chemistry, , Volume: 43, Issue:11, 2008
Structure activity relationship of selective GABA uptake inhibitors.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.Journal of medicinal chemistry, , Mar-14, Volume: 56, Issue:5, 2013
Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.Journal of medicinal chemistry, , Mar-14, Volume: 56, Issue:5, 2013
Synthesis of N-substituted acyclic β-amino acids and their investigation as GABA uptake inhibitors.European journal of medicinal chemistry, , Volume: 65, 2013
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.European journal of medicinal chemistry, , Volume: 43, Issue:11, 2008
Structure-Activity Relationship, Pharmacological Characterization, and Molecular Modeling of Noncompetitive Inhibitors of the Betaine/γ-Aminobutyric Acid Transporter 1 (BGT1).Journal of medicinal chemistry, , 11-09, Volume: 60, Issue:21, 2017
Structure activity relationship of selective GABA uptake inhibitors.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Aminomethyltetrazoles as potential inhibitors of the γ-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation.Bioorganic & medicinal chemistry, , Nov-01, Volume: 19, Issue:21, 2011
Development of tricyclic N-benzyl-4-hydroxybutanamide derivatives as inhibitors of GABA transporters mGAT1-4 with anticonvulsant, antinociceptive, and antidepressant activity.European journal of medicinal chemistry, , Oct-05, Volume: 221, 2021
Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice.European journal of medicinal chemistry, , Feb-15, Volume: 188, 2020
Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4.Bioorganic & medicinal chemistry, , 01-01, Volume: 27, Issue:1, 2019
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a cis-alkene spacer as GABA uptake inhibitors.Bioorganic & medicinal chemistry, , 03-01, Volume: 27, Issue:5, 2019
Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors.Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro[4.5]decanes.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Structure activity relationship of selective GABA uptake inhibitors.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-yl-acetic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 23, Issue:6, 2015
Synthesis, biological evaluation and structure-activity relationship of new GABA uptake inhibitors, derivatives of 4-aminobutanamides.European journal of medicinal chemistry, , Aug-18, Volume: 83, 2014
Synthesis of N-substituted acyclic β-amino acids and their investigation as GABA uptake inhibitors.European journal of medicinal chemistry, , Volume: 65, 2013
Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.European journal of medicinal chemistry, , Volume: 46, Issue:5, 2011
Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4.European journal of medicinal chemistry, , Volume: 43, Issue:11, 2008