Proteins > Poly [ADP-ribose] polymerase 1
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Poly [ADP-ribose] polymerase 1

A poly [ADP-ribose] polymerase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09874]

Synonyms

PARP-1;
EC 2.4.2.30;
ADP-ribosyltransferase diphtheria toxin-like 1;
ARTD1;
DNA ADP-ribosyltransferase PARP1;
2.4.2.-;
NAD(+) ADP-ribosyltransferase 1;
ADPRT 1;
Poly[ADP-ribose] synthase 1;
Protein poly-ADP-ribosyltran

Research

Bioassay Publications (119)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's23 (19.33)29.6817
2010's65 (54.62)24.3611
2020's31 (26.05)2.80

Compounds (53)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
niacinamideHomo sapiens (human)IC50187.007067
1,5-dihydroxyisoquinolineHomo sapiens (human)IC500.329323
3-aminobenzamideHomo sapiens (human)IC5020.49151416
3-aminobenzamideHomo sapiens (human)Ki3.575044
4-amino-1,8-naphthalimideHomo sapiens (human)IC500.065034
phenanthridoneHomo sapiens (human)IC500.344578
5-aminoisoquinolinoneHomo sapiens (human)IC501.233657
benzamideHomo sapiens (human)IC5015.800033
pj-34Homo sapiens (human)IC500.10961317
1-hydroxyphthalazineHomo sapiens (human)IC5012.000011
chlorthenoxazinHomo sapiens (human)IC508.500011
isocarbostyrilHomo sapiens (human)IC503.504522
flavoneHomo sapiens (human)IC501.390212
2,4(1h,3h)-quinazolinedioneHomo sapiens (human)IC508.100011
4-hydroxybenzamideHomo sapiens (human)IC50280.000011
naphthalimidesHomo sapiens (human)IC501.400011
4-fluorobenzamideHomo sapiens (human)IC50200.000011
5-iodo-6-amino-1,2-benzopyroneHomo sapiens (human)IC5013.147012
alantolactoneHomo sapiens (human)IC5010.000011
4-aminobenzamideHomo sapiens (human)IC501,800.000011
4-MethoxybenzamideHomo sapiens (human)IC5057.000011
3-methoxybenzamideHomo sapiens (human)IC5017.000011
3',4'-dihydroxyflavoneHomo sapiens (human)IC501.279512
3,4-dihydro-5-methyl-1(2h)-isoquinolinoneHomo sapiens (human)IC500.246733
3,4-dihydro-5-methyl-1(2h)-isoquinolinoneHomo sapiens (human)Ki0.070011
1-oxo-1,2,3,4-tetrahydroisoquinolineHomo sapiens (human)IC50100.000011
cyclo(alanylalanyl)Homo sapiens (human)IC50900.000011
N-[4-[[[4-(4-methoxyphenyl)-4-oxanyl]methylamino]-oxomethyl]phenyl]-2-furancarboxamideHomo sapiens (human)IC501.800011
ha 1100Homo sapiens (human)IC5027.000011
apigeninHomo sapiens (human)IC50100.000011
luteolinHomo sapiens (human)IC504.232912
amentoflavoneHomo sapiens (human)IC500.102333
3',4',7-trihydroxyflavoneHomo sapiens (human)IC507.542912
adenosine diphosphate (hydroxymethyl)pyrrolidinediolHomo sapiens (human)IC501,000.000011
ag 14361Homo sapiens (human)Ki0.005811
gpi 6150Homo sapiens (human)IC500.134512
rucaparibHomo sapiens (human)IC500.06591619
rucaparibHomo sapiens (human)Ki0.001455
3,4-dihydro-5-(4-(1-piperidinyl)butoxy)-1(2h)-isoquinolinoneHomo sapiens (human)IC503.245834
veliparibHomo sapiens (human)IC505.60742024
veliparibHomo sapiens (human)Ki0.004644
olaparibHomo sapiens (human)IC500.17416568
olaparibHomo sapiens (human)Ki0.000811
niraparibHomo sapiens (human)IC500.003222
niraparibHomo sapiens (human)IC500.02781517
niraparibHomo sapiens (human)Ki0.003211
cep 26401Homo sapiens (human)IC5030.000011
iwr-1 endoHomo sapiens (human)IC5055.612544
nms-p118Homo sapiens (human)IC500.059522
g007-lkHomo sapiens (human)IC50100.000022
nu 1025Homo sapiens (human)Ki0.050022
2-methyl-4(3h)-quinazolinoneHomo sapiens (human)IC503.405022
4-hydroxyquinazolineHomo sapiens (human)IC5012.528445
1,4-Dihydrothieno[3,2-d]pyrimidin-4-oneHomo sapiens (human)IC5014.000011
xav939Homo sapiens (human)IC502.99251517
2-(4-methoxyphenyl)-1H-quinazolin-4-oneHomo sapiens (human)IC501.099333
bmn 673Homo sapiens (human)IC500.002399
bmn 673Homo sapiens (human)Ki0.001033
me0328Homo sapiens (human)IC504.297534
nvp-tnks656Homo sapiens (human)IC5019.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
pj-34Homo sapiens (human)EC500.020011
pj-34Homo sapiens (human)Kd0.110011
rucaparibHomo sapiens (human)EC500.010822
rucaparibHomo sapiens (human)Kd0.003211
veliparibHomo sapiens (human)EC5027.235066
veliparibHomo sapiens (human)Kd0.002322
olaparibHomo sapiens (human)EC502.680466
olaparibHomo sapiens (human)Kd1.327844
niraparibHomo sapiens (human)EC500.024022
niraparibHomo sapiens (human)EC507.802044
niraparibHomo sapiens (human)Kd0.001011
nms-p118Homo sapiens (human)Kd0.015933
xav939Homo sapiens (human)Kd0.620011
bmn 673Homo sapiens (human)EC500.002733
bmn 673Homo sapiens (human)Kd0.001111

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
niraparibHomo sapiens (human)EC900.220011
niraparibHomo sapiens (human)EC900.045011
niraparibHomo sapiens (human)IC900.049333

Enables

This protein enables 30 target(s):

TargetCategoryDefinition
DNA bindingmolecular functionAny molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
chromatin bindingmolecular functionBinding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
damaged DNA bindingmolecular functionBinding to damaged DNA. [GOC:jl]
RNA bindingmolecular functionBinding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
NAD+ ADP-ribosyltransferase activitymolecular functionCatalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor. [EC:2.4.2.30]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
nucleotidyltransferase activitymolecular functionCatalysis of the transfer of a nucleotidyl group to a reactant. [ISBN:0198506732]
enzyme bindingmolecular functionBinding to an enzyme, a protein with catalytic activity. [GOC:jl]
protein kinase bindingmolecular functionBinding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
nuclear estrogen receptor bindingmolecular functionBinding to a nuclear estrogen receptor. [GOC:ai]
nucleosome bindingmolecular functionBinding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. [GOC:mah]
ubiquitin protein ligase bindingmolecular functionBinding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]
protein homodimerization activitymolecular functionBinding to an identical protein to form a homodimer. [GOC:jl]
histone deacetylase bindingmolecular functionBinding to histone deacetylase. [GOC:jl]
NAD bindingmolecular functionBinding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai]
RNA polymerase II-specific DNA-binding transcription factor bindingmolecular functionBinding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw]
R-SMAD bindingmolecular functionBinding to a receptor-regulated SMAD signaling protein. [GOC:BHF, GOC:vk, PMID:19114992]
NAD DNA ADP-ribosyltransferase activitymolecular functionCatalysis of the transfer of the ADP-ribose group of NAD+ to a residue in double-stranded DNA. [PMID:27471034, PMID:29361132, PMID:29520010]
transcription regulator activator activitymolecular functionA molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification. [PMID:9597751]
NAD+-protein-serine ADP-ribosyltransferase activitymolecular functionCatalysis of the reaction: L-seryl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-seryl-[protein]. [PMID:32028527, PMID:33186521, RHEA:58232]
NAD+- protein-aspartate ADP-ribosyltransferase activitymolecular functionCatalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide. [PMID:19764761, PMID:25043379, RHEA:54424]
NAD+-protein-glutamate ADP-ribosyltransferase activitymolecular functionCatalysis of the reaction: L-glutamyl-[protein] + NAD+ = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide. [PMID:19764761, PMID:25043379, RHEA:58224]
NAD+-protein-tyrosine ADP-ribosyltransferase activitymolecular functionCatalysis of the reaction: L-tyrosyl-[protein] + NAD+ = H+ + nicotinamide + O-(ADP-D-ribosyl)-L-tyrosyl-[protein]. [PMID:29954836, PMID:30257210, RHEA:58236]
NAD+-protein-histidine ADP-ribosyltransferase activitymolecular functionCatalysis of the reaction: L-histidyl-[protein] + NAD+ = H+ + Nt-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide. [PMID:35393539]
NAD+-histone H2BS6 serine ADP-ribosyltransferase activitymolecular functionCatalysis of the transfer of ADP-ribose groups to the serine-6 or an equivalent residue of the N-terminal tail of histone H2B. [PMID:34874266]
NAD+-histone H3S10 serine ADP-ribosyltransferase activitymolecular functionCatalysis of the transfer of ADP-ribose groups to the serine-10 or an equivalent residue of the N-terminal tail of histone H3. [PMID:34874266]
NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activitymolecular functionCatalysis of the transfer of ADP-ribose groups to the glutamate-35 residue of the N-terminal tail of histone H2B (or an equivalent residue). [PMID:32822587]
NAD+-protein ADP-ribosyltransferase activitymolecular functionCatalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. [PMID:1899243]

Located In

This protein is located in 10 target(s):

TargetCategoryDefinition
chromosome, telomeric regioncellular componentThe end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres). [GOC:elh]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nuclear envelopecellular componentThe double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
nucleoluscellular componentA small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]
mitochondrioncellular componentA semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
nuclear bodycellular componentExtra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]
site of double-strand breakcellular componentA region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]
site of DNA damagecellular componentA region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:pg]

Active In

This protein is active in 6 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
site of double-strand breakcellular componentA region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:bf, GOC:mah, GOC:vw, PMID:20096808, PMID:21035408]
nuclear replication forkcellular componentThe Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes. [GOC:jl, GOC:mtg_sensu]
site of DNA damagecellular componentA region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:pg]
nucleoluscellular componentA small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome. [ISBN:0198506732]

Part Of

This protein is part of 4 target(s):

TargetCategoryDefinition
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
transcription regulator complexcellular componentA protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. [GOC:jl]
protein-containing complexcellular componentA stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]
protein-DNA complexcellular componentA macromolecular complex containing both protein and DNA molecules. [GOC:mah]

Involved In

This protein is involved in 50 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
telomere maintenancebiological processAny process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences. [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831]
DNA repairbiological processThe process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [PMID:11563486]
double-strand break repairbiological processThe repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. [GOC:elh]
transcription by RNA polymerase IIbiological processThe synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
apoptotic processbiological processA programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
DNA damage responsebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. [GOC:go_curators]
transforming growth factor beta receptor signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:BHF, GOC:mah, GOC:signaling]
response to gamma radiationbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum. [GOC:tair_curators]
positive regulation of cardiac muscle hypertrophybiological processAny process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division. [GOC:BHF, GOC:dph, GOC:tb]
carbohydrate biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [ISBN:0198506732]
protein autoprocessingbiological processProcessing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein. [GOC:ai, PMID:9335337]
signal transduction involved in regulation of gene expressionbiological processAny process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another. [GOC:mtg_signal]
macrophage differentiationbiological processThe process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. [GOC:add, ISBN:0781735149]
DNA ADP-ribosylationbiological processThe covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA. [PMID:11592983, PMID:27471034, PMID:29361132, PMID:29520010]
positive regulation of DNA-templated transcription, elongationbiological processAny process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase. [GOC:mah, GOC:txnOH]
cellular response to insulin stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
positive regulation of intracellular estrogen receptor signaling pathwaybiological processAny process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway. [GOC:mah]
negative regulation of transcription elongation by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH]
cellular response to UVbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:mah]
positive regulation of canonical NF-kappaB signal transductionbiological processAny process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
innate immune responsebiological processInnate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
regulation of circadian sleep/wake cycle, non-REM sleepbiological processAny process that modulates the frequency, rate or extent of non-rapid eye movement sleep. [GOC:go_curators]
negative regulation of innate immune responsebiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the innate immune response. [GOC:go_curators]
negative regulation of DNA-templated transcriptionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
decidualizationbiological processThe cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta. [ISBN:0721662544, PMID:11133685]
regulation of catalytic activitybiological processAny process that modulates the activity of an enzyme. [GOC:ai, GOC:ebc, GOC:vw]
positive regulation of mitochondrial depolarizationbiological processAny process that activates, maintains or increases the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive. [GOC:ai]
positive regulation of SMAD protein signal transductionbiological processAny process that increases the rate, frequency or extent of SMAD protein signal transduction. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of necroptotic processbiological processAny process that increases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
protein poly-ADP-ribosylationbiological processThe transfer of multiple ADP-ribose residues from NAD to a protein amino acid, forming a poly(ADP-ribose) chain. [GOC:BHF, GOC:mah, GOC:rl, PMID:25043379]
protein auto-ADP-ribosylationbiological processThe ADP-ribosylation by a protein of one or more of its own amino acid residues, or residues on an identical protein. [GOC:BHF, GOC:rl]
protein localization to chromatinbiological processAny process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into chromatin. [GOC:mah]
cellular response to zinc ionbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. [GOC:mah]
replication fork reversalbiological processReplication fork processing that involves the unwinding of blocked forks to form four-stranded structures resembling Holliday junctions, which are subsequently resolved. [PMID:19406929]
negative regulation of cGAS/STING signaling pathwaybiological processAny process that stops, prevents or reduces the frequency, rate or extent of cGAS/STING signaling pathway. [PMID:29875158]
positive regulation of protein localization to nucleusbiological processAny process that activates or increases the frequency, rate or extent of protein localization to nucleus. [GOC:TermGenie]
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathwaybiological processAny process that modulates the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie]
positive regulation of single strand break repairbiological processAny process that activates or increases the frequency, rate or extent of single strand break repair. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17395247]
response to aldosteronebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldosterone stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:17644563]
negative regulation of adipose tissue developmentbiological processAny process that stops, prevents or reduces the frequency, rate or extent of adipose tissue development. [GO_REF:0000058, GOC:TermGenie, PMID:23081848]
negative regulation of telomere maintenance via telomere lengtheningbiological processAny process that stops, prevents or reduces the frequency, rate or extent of telomere maintenance via telomere lengthening. [GO_REF:0000058, GOC:BHF, GOC:BHF_telomere, GOC:nc, GOC:TermGenie, PMID:23959892]
cellular response to amyloid-betabiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
positive regulation of myofibroblast differentiationbiological processAny process that activates or increases the frequency, rate or extent of myofibroblast differentiation. [GO_REF:0000058, GOC:BHF, GOC:BHF_miRNA, GOC:rph, GOC:TermGenie, PMID:20533548]
regulation of base-excision repairbiological processAny process that modulates the frequency, rate or extent of base-excision repair. [GO_REF:0000058, GOC:ah, GOC:TermGenie, PMID:18973764]
positive regulation of double-strand break repair via homologous recombinationbiological processAny process that activates or increases the frequency, rate or extent of double-strand break repair via homologous recombination. [GO_REF:0000058, GOC:TermGenie, PMID:12023299]
cellular response to nerve growth factor stimulusbiological processA process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus. [PMID:22399805, Wikipedia:Nerve_growth_factor]
ATP generation from poly-ADP-D-ribosebiological processThe process of generating ATP in the nucleus from poly-ADP-D-ribose. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. [PMID:27257257]
negative regulation of ATP biosynthetic processbiological processAny process that stops, prevents or reduces the frequency, rate or extent of ATP biosynthetic process. [GOC:obol]