A protein that is a translation product of any of the following genes in human
Bcl2-L-2;
Apoptosis regulator Bcl-W
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 12 (80.00) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| gossypol | Homo sapiens (human) | Ki | 17.7000 | 1 | 1 |
| epigallocatechin gallate | Homo sapiens (human) | IC50 | 2.3300 | 1 | 1 |
| chelerythrine chloride | Homo sapiens (human) | Ki | 106.0000 | 1 | 1 |
| blastmycin | Homo sapiens (human) | Ki | 127.0000 | 1 | 1 |
| apogossypol | Homo sapiens (human) | Ki | 2.1000 | 1 | 1 |
| umi-77 | Homo sapiens (human) | Ki | 8.1900 | 1 | 1 |
| abt-737 | Homo sapiens (human) | IC50 | 1.4573 | 4 | 7 |
| abt-737 | Homo sapiens (human) | Ki | 0.0578 | 5 | 5 |
| navitoclax | Homo sapiens (human) | IC50 | 0.0700 | 1 | 1 |
| navitoclax | Homo sapiens (human) | Ki | 0.2450 | 1 | 1 |
| abt-199 | Homo sapiens (human) | Ki | 0.2450 | 2 | 2 |
| a-1155463 | Homo sapiens (human) | Ki | 0.0190 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| protein-containing complex binding | molecular function | Binding to a macromolecular complex. [GOC:jl] |
| disordered domain specific binding | molecular function | Binding to a disordered domain of a protein. [GOC:gg, PMID:11746698] |
| BH domain binding | molecular function | Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial outer membrane | cellular component | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| Bcl-2 family protein complex | cellular component | A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. [GOC:so, PMID:14634621] |
This protein is involved in 14 target(s):
| Target | Category | Definition |
|---|---|---|
| response to ischemia | biological process | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply. [GOC:hjd] |
| spermatogenesis | biological process | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821] |
| negative regulation of mitochondrial membrane permeability | biological process | Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane. [PMID:10781072] |
| regulation of apoptotic process | biological process | Any process that modulates the occurrence or rate of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| negative regulation of apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| Sertoli cell proliferation | biological process | The multiplication or reproduction of Sertoli cells, resulting in the expansion of the Sertoli cell population. A Sertoli cell is a supporting cell projecting inward from the basement membrane of seminiferous tubules. [GOC:dph] |
| cellular response to estradiol stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah] |
| negative regulation of release of cytochrome c from mitochondria | biological process | Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb] |
| cellular response to amyloid-beta | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824] |
| cellular response to glycine | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glycine stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18984164] |
| extrinsic apoptotic signaling pathway in absence of ligand | biological process | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705] |
| release of cytochrome c from mitochondria | biological process | The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217] |
| intrinsic apoptotic signaling pathway in response to DNA damage | biological process | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. [GOC:go_curators, GOC:mtg_apoptosis] |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | biological process | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] |