| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
aminolevulinic acid
Aminolevulinic Acid: A compound produced from succinyl-CoA and GLYCINE as an intermediate in heme synthesis. It is used as a PHOTOCHEMOTHERAPY for actinic KERATOSIS.. 5-aminolevulinic acid : The simplest delta-amino acid in which the hydrogens at the gamma position are replaced by an oxo group. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used (in the form of the hydrochloride salt)in combination with blue light illumination for the treatment of minimally to moderately thick actinic keratosis of the face or scalp. | 1.96 | 1 | 0 | 4-oxo monocarboxylic acid;
amino acid zwitterion;
delta-amino acid | antineoplastic agent;
dermatologic drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite;
prodrug;
Saccharomyces cerevisiae metabolite |
benzene
[no description available] | 2.46 | 2 | 0 | aromatic annulene;
benzenes;
volatile organic compound | carcinogenic agent;
environmental contaminant;
non-polar solvent |
hexachlorocyclohexane
Lindane: An organochlorine insecticide made up of greater than 99% gamma-Hexachlorocyclohexane. It has been used as a pediculicide and scabicide, and shown to cause cancer.. beta-hexachlorocyclohexane : The beta-isomer of hexachlorocyclohexane. | 2.11 | 1 | 0 | chlorocyclohexane | |
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond. | 7.07 | 1 | 0 | elemental hydrogen;
elemental molecule;
gas molecular entity | antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite |
phthalic acid
phthalic acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7178. phthalic acid : A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions. | 2.13 | 1 | 0 | benzenedicarboxylic acid | human xenobiotic metabolite |
toluene
methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups. | 3.88 | 11 | 0 | methylbenzene;
toluenes;
volatile organic compound | cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent |
2,4,6-tribromophenol
[no description available] | 2.03 | 1 | 0 | bromophenol | environmental contaminant;
fungicide;
marine metabolite |
ddt
1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane: structure in first source | 2.52 | 2 | 0 | benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide | bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant |
endosulfan
Endosulfan: A polychlorinated compound used for controlling a variety of insects. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its mode of action involves repetitive nerve-discharges positively correlated to increase in temperature. This compound is extremely toxic to most fish. (From Comp Biochem Physiol (C) 1993 Jul;105(3):347-61). endosulfan : A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10. | 2.11 | 1 | 0 | cyclic sulfite ester;
cyclodiene organochlorine insecticide | acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant |
phencyclidine
Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects. | 4.37 | 5 | 0 | benzenes;
piperidines | anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug |
tetrabromobisphenol a
tetrabromobisphenol A: a brominated flame retardant. 3,3',5,5'-tetrabromobisphenol A : A bromobisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups and the phenyl rings are substituted by bromo groups at positions 2, 2', 6 and 6'. It is a brominated flame retardant. | 3.59 | 2 | 0 | brominated flame retardant;
bromobisphenol | |
2,3,4,5,6-pentabromotoluene
[no description available] | 3.71 | 9 | 0 | | |
2-chlorotoluene
2-chlorotoluene: RN given refers to parent cpd | 2.13 | 1 | 0 | | |
1,4-dibromobenzene
[no description available] | 1.99 | 1 | 0 | dibromobenzene | |
4-xylene
p-xylene : A xylene with methyl groups at positions 1 and 4. | 2.11 | 1 | 0 | xylene | |
hexachlorobenzene
Hexachlorobenzene: An agricultural fungicide and seed treatment agent.. hexachlorobenzene : A member of the class of chlorobenzenes that is benzene in which all of the hydrogens are replaced by chlorines. An agricultural fungicide introduced in the mid-1940s and formerly used as a seed treatment, its use has been banned since 1984 under the Stockholm Convention on Persistent Organic Pollutants. | 4.51 | 7 | 0 | aromatic fungicide;
chlorobenzenes | antifungal agrochemical;
carcinogenic agent;
persistent organic pollutant |
hexafluorobenzene
[no description available] | 7.67 | 3 | 0 | fluorobenzenes;
fluorocarbon | NMR chemical shift reference compound |
dihydrotestosterone
Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5. | 2.03 | 1 | 0 | 17beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite |
2,3,4,5,6-pentachloroaniline
[no description available] | 2.13 | 1 | 0 | | |
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form. | 2.1 | 1 | 0 | dialdehyde | biomarker |
1,2-dibromobenzene
dibromobenzene : Any member of the class of bromobenzenes that consists of a benzene or a substituted benzene ring carrying two bromo groups at unspecified positions. | 1.99 | 1 | 0 | dibromobenzene | |
1,2,4-tribromobenzene
[no description available] | 1.99 | 1 | 0 | | |
1,3,5-tribromobenzene
[no description available] | 1.99 | 1 | 0 | | |
decabromobiphenyl ether
decabromobiphenyl ether: a flame retardant. decabromodiphenyl ether : A polybromodiphenyl ether that is diphenyl ether in which all of the hydrogens have been replaced by bromines. | 3.05 | 4 | 0 | polybromodiphenyl ether | neurotoxin |
octachloronaphthalene
Perna: A genus of freshwater mussel in the family MYTILIDAE, class BIVALVIA. It is found in tropical and warm temperate coastal waters. Most species have green in their shells. | 1.98 | 1 | 0 | | |
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane: a flame retardant and androgen receptor agonist; structure in first source | 2.44 | 2 | 0 | | |
rhodium
Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45. | 7.51 | 2 | 0 | cobalt group element atom | |
bromine
Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested. | 2.69 | 3 | 0 | diatomic bromine | |
dechlorane plus
dechlorane plus: a flame retardant; structure in first source | 2.17 | 1 | 0 | | |
tris(2,3-dibromopropyl)phosphate
tris(2,3-dibromopropyl)phosphate: flame retardant | 2.1 | 1 | 0 | trialkyl phosphate | |
alkenes
[no description available] | 2.07 | 1 | 0 | | |
dechlorane 602
dechlorane 602: structure in first source | 2.11 | 1 | 0 | | |
2,4,5,2',4',5'-hexachlorobiphenyl
[no description available] | 1.98 | 1 | 0 | hexachlorobiphenyl | |
1,2-bis(2,4,6-tribromophenoxy)ethane
1,2-bis(2,4,6-tribromophenoxy)ethane: structure given in first source | 4.1 | 4 | 0 | | |
2,2',4,4'-tetrabromodiphenyl ether
[no description available] | 2.78 | 3 | 0 | aromatic ether;
organobromine compound | |
beta-bromostyrene
[no description available] | 2.03 | 1 | 0 | | |
decabromodiphenyl ethane
decabromodiphenyl ethane: structure in first source | 5.31 | 9 | 0 | | |
tribromodiphenyl ether 28
4-bromophenyl 2,4-dibromophenyl ether : A polybromodiphenyl ether that is diphenyl ether in which the hydrogens at the 2, 4, and 4' positions have been replaced by bromines. | 2.48 | 2 | 0 | polybromodiphenyl ether | |
bde 183
2,2',3,4,4',5',6-heptabromodiphenyl ether: a polybrominated diphenyl ether compound | 2.03 | 1 | 0 | aromatic ether;
organobromine compound | |
2-ethylhexyl 2,3,4,5-tetrabromobenzoate
2-ethylhexyl 2,3,4,5-tetrabromobenzoate: structure in first source | 2.53 | 2 | 0 | | |
2,3-dibromopropyl-2,4,6-tribromophenyl ether
2,3-dibromopropyl-2,4,6-tribromophenyl ether: brominated flame retardant; structure in first source | 2.79 | 3 | 0 | | |