Page last updated: 2024-12-05

idoxuridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID5905
CHEMBL ID788
CHEBI ID147675
SCHEMBL ID3683
SCHEMBL ID15850897
MeSH IDM0010989

Synonyms (152)

Synonym
MLS002154175
smr001233472
allergan 211
idur
5-iudr
skf 14287
5-iodouracil deoxyriboside
idoxuridin
joddeoxiuridin
5-iododeoxyuridine
5iudr
sk&f 14287
2'-deoxy-5-iodouridine
iodoxuridine
nsc-39661
idurd
SMP2_000072
cas-54-42-2
NCGC00016243-01
PRESTWICK3_000018
NCGC00179673-01
BPBIO1_000061
5-iodo-2'-deoxyuridine ,
virudox
1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-iodo-pyrimidine-2,4-dione
idoxuridine ,
5idu
stoxil
kerecid
herplex
5-i-2'-durd
iudr
iduridin
54-42-2
IDU ,
idoxene
id2 ,
1-beta-d-2'-deoxyribofuranosyl-5-iodouracil
iododeoxyridine
1-(2-deoxy-beta-d-ribofuranosyl)-5-iodouracil
(+)-5-iodo-2'-deoxyuridine
DB00249
1beta-d-2'-deoxyribofuranosyl-5-iodouracil
idoxuridine (jp17/usp/inn)
D00342
herplex (tn)
dendrid (tn)
iduoculos
einecs 200-207-8
allergan 201
ccris 2827
c9h11in2o5
iododeoxyuridine
uracil, 5-iodo-1-(2-deoxy-beta-d-ribofuranosyl)-
ai3-50861
idossuridina [dcit]
sk&f-14287
antizona
brn 0030397
heratil
idoxuridinum [inn-latin]
idoxuridina [inn-spanish]
BSPBIO_000055
5-iodo-2'-deoxyuridine, >=99% (hplc)
5 iododeoxyuridine
5 iodo 2' deoxyuridine
HMS2090M10
allergan-211
CHEMBL788
CHEBI:147675 ,
idoxuridina
idoxuridinum
I0258
1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
HMS2095C17
tox21_110324
dtxsid2045238 ,
dtxcid0025238
1-(2-deoxy-ss -d-ribofuranosyl)-5-iodouracil
herpes-gel
AKOS015920431
HMS2230E10
bdbm50370388
lgp81v5245 ,
hsdb 7479
idossuridina
unii-lgp81v5245
idoxuridine [usan:usp:inn:ban:jan]
4-24-00-01235 (beilstein handbook reference)
idoxuridine [vandf]
idoxuridine [inn]
idoxuridine [hsdb]
idoxuridine [orange book]
idoxuridine [jan]
allergan211
2'-desoxy-5-iodouridine
idoxuridine [who-dd]
idoxuridinum [who-ip latin]
idoxuridine [usp impurity]
idoxuridine [mi]
idoxuridine [usp monograph]
idoxuridine [mart.]
idoxuridine [ep monograph]
idoxuridine [who-ip]
idoxuridine [usp-rs]
EPITOPE ID:138107
S1883
1-((2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1h,3h)-dione
5-iodo-2-deoxyuridine
CCG-220018
HY-B0307
5-iodo-2'deoxyuridine
5-iodo-deoxyuridine
XQFRJNBWHJMXHO-RRKCRQDMSA-N
SCHEMBL3683
tox21_110324_1
NCGC00179673-03
J-700180
SCHEMBL15850897
(+)-5-iodo-2-deoxyuridine
1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dione
5-iodo-2 inverted exclamation marka-deoxyuridine
AC-8219
SR-05000001510-4
sr-05000001510
idoxuridine, united states pharmacopeia (usp) reference standard
idoxuridine, european pharmacopoeia (ep) reference standard
SR-05000001510-1
SR-05000001510-3
J-009907
HMS3712C17
SW198484-2
Q409765
AS-13469
BRD-K76634210-001-14-7
5-iudr; idu; idurd; idoxuridine
BCP29428
NCGC00179673-05
idoxuridine 100 microg/ml in acetonitrile
BP-58646
d06bb01
idoxurudine
j05ab02
s01ad01
idoxuridine (usp monograph)
idoxuridinum (inn-latin)
idoxuridina (inn-spanish)
idoxuridine (usp-rs)
idoxuridine (usp impurity)
idoxuridine (usan:usp:inn:ban:jan)
idoxuridine (mart.)
idoxuridine (ep monograph)

Research Excerpts

Effects

Idoxuridine has been used for many years in the treatment of herpex simplex infections of the eye. It has also been used to treat herpes simplex virus and aphthous stomatitis.

ExcerptReferenceRelevance
"Idoxuridine has been used for many years in the treatment of herpex simplex infections of the eye. "( Allergic contact dermatitis caused by idoxuridine. Patterns of cross reactivity with other pyrimidine analogues.
Amon, RB; Hanifin, JM; Lis, AW, 1975
)
1.97
"Idoxuridine has been used for herpes simplex virus, and corticosteroids and antibiotics have been used for aphthous stomatitis."( Iontophoresis treatment.
Lekas, MD,
)
0.85
"Both idoxuridine and acyclovir have been investigated in placebo-controlled double-blind studies."( Management of varicella zoster infections in immunocompetent hosts.
Peterslund, NA, 1988
)
0.73

Treatment

Idoxuridine is useful in treatment of herpetic keratitis. Treatment caused significant toxic changes in the regenerating epithelium clinically and histologically.

ExcerptReferenceRelevance
"Idoxuridine treatment failures were found in 11 cases of herpetic superficial keratitis."( [Ocular herpes simplex in children (author's transl)].
Chastel, C; Colin, J; Le Grignou, A; Le Grignou, M; Renard, G, 1982
)
0.99
"Idoxuridine treatment caused significant toxic changes in the regenerating epithelium clinically and histologically with a significant delay in epithelial wound healing in comparison to control or aciclovir treated eyes."( Aciclovir and corneal wound healing.
Lass, JH; Park, NH; Pavan-Langston, D, 1979
)
0.98
"Idoxuridine is useful in treatment of herpetic keratitis."( Viral chemotherapy.
Williams, BB, 1977
)
0.98

Toxicity

ExcerptReferenceRelevance
" As expected, 125I (LD50: 45 rad; D0: 74 rad) proved much more toxic to CHO cells than either 3H (LD50: 380 rad; D0: 250 rad) or external X-irradiation (LD50: 330 rad; D0: 230 rad)."( Biological toxicity of Auger emitters: molecular fragmentation versus electron irradiation.
Hofer, KG; Keough, G; Smith, JM, 1978
)
0.26
" In in vitro cytotoxicity experiments with fibroblasts (V-79 Chinese hamster cell line), no toxic effects were observed with SB-73 concentrations (120 micrograms/ml) having antiviral activity."( Comparison of the antiviral activity and toxicity of a protein magnesium ammonium phospholinoleate anhydride polymer with other antiviral drugs.
Da-Silva-Nunes, O; Durán, N; Haun, M; Mazetto, MN; Pereira-da-Silva, L; Pisani, FJ; Pisani, R; Souza-Brito, AR, 1990
)
0.28
" However it acts toxically on tumor cells though it is not toxic for intact cells so that its action is different as compared to that of cytotoxic agents."( [Toxicity of para-aminobenzhydrazide and its influence on nucleic acid biosynthesis in cultures of normal and tumor cells].
Filov, VA; Onishchuk, FD; Tret'iakov, AV, 1989
)
0.28
"The present paper reviews the adverse side effects caused by topically applied antiviral agents in herpetic keratitis."( [Adverse side effects caused by topically applied antiviral agents in herpetic keratitis].
Chen, CW, 1989
)
0.28
"The toxic effects of the short-lived (T 1/2 = 13."( Radiotoxicity of 5-[123I]iodo-2'-deoxyuridine in V79 cells: a comparison with 5-[125I]iodo-2'-deoxyuridine.
Adelstein, SJ; Baranowska-Kortylewicz, J; Kassis, AI; Makrigiorgos, GM; McElvany, KD; Sastry, KS; Welch, MJ, 1989
)
0.28
" It is concluded that in situ evaluation of tumour activity loss rates in carcinoma EO 771 is not disturbed by toxic effects of I-UdR or 125I-UdR within the dose limits mentioned."( Evaluation of radio- and chemotoxic effects of 125I-UdR on tumour growth and host survival.
Feinendegen, LE; Mühlensiepen, H; Porschen, R; Porschen, W, 1985
)
0.27
" FUdR was found to be chemically toxic in itself to 2 canine tissue culture lines at doses used in the literature to increase 125IUdR uptake."( The toxicity of fluorodeoxyuridine when used to increase the uptake of 125I-iododeoxyuridine into tissue culture cells in vitro.
Holmes, JM, 1983
)
0.27
" Saline or diphtheria toxin (DT), which is selectively toxic to human cells compared to those of mice, was injected, and the loss of 125I from the animals was monitored daily with a whole-body gamma scintillation detector."( Correlation of cytotoxicity with elimination of iodine-125 from nude mice inoculated with prelabeled human melanoma cells.
Giovanella, BC; Lockshin, A; Mendoza, JT; Quian, C; Stehlin, JS; Vardeman, DM, 1984
)
0.27
" Toward this goal, we have performed preclinical and clinical studies, using various routes of administration, to detect adverse changes in normal tissues in both humans and animals."( Radiolabeled iododeoxyuridine: safety evaluation.
Augustine, SC; Baranowska-Kortylewicz, J; Chiou, RK; Cohen, SM; Dalrymple, GV; Harrison, KA; Holdeman, KP; Leichner, PK; Lieberman, RP; Schneiderman, MH; Sharp, JG; Taylor, RJ; Tempero, MA, 1996
)
0.29
"To date, no evidence of adverse effects on normal tissue or alteration of hematologic or metabolic indices have been seen in pigs or humans."( Radiolabeled iododeoxyuridine: safety evaluation.
Augustine, SC; Baranowska-Kortylewicz, J; Chiou, RK; Cohen, SM; Dalrymple, GV; Harrison, KA; Holdeman, KP; Leichner, PK; Lieberman, RP; Schneiderman, MH; Sharp, JG; Taylor, RJ; Tempero, MA, 1996
)
0.29
" No adverse systemic effects were identified."( On the safety of 5-[125I]iodo-2'-deoxyuridine--Preclinical evaluation in swine.
Baranowska-Kortylewicz, J; Clausen, SR; Cohen, SM; Dalrymple, GV; Harrison, KA; Helseth, L; Hoffman, D; Holdeman, KP; Lai, J; Lieberman, RP; Schneiderman, GS; Schneiderman, MH; Sharp, JG, 1996
)
0.29
"The toxic effects of DNA-incorporated 5-[(125)I]iodo-2'-deoxyuridine ((125)IdUrd) were assessed by the colony-forming assay with cells incubated in medium containing serum and/or dimethyl sulphoxide (DMSO)."( Chemical modification of 5-[125I]iodo-2'-deoxyuridine toxicity in mammalian cells in vitro.
Adelstein, SJ; Kassis, AI; Walicka, MA, 2001
)
0.31
" An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems."( Developing structure-activity relationships for the prediction of hepatotoxicity.
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010
)
0.36

Pharmacokinetics

ExcerptReferenceRelevance
" Administration of different amounts of IL-2 in vivo to 2 patients with melanoma revealed that the initial level of IL-2 in the circulation was related to the dose given and had a half-life of approximately 22."( Clearance rates and systemic effects of intravenously administered interleukin 2 (IL-2) containing preparations in human subjects.
Bindon, C; Czerniecki, M; Edwards, A; Harris, R; Hersey, P; McCarthy, WH; Ruell, P, 1983
)
0.27
" This paper describes a new approach, based upon pharmacokinetic clearance of radioactivity from the tumor, with which to quantify the fraction of [125I]IUdR incorporated within the DNA of tumor cells."( Pharmacokinetics and dosimetry of iodine-125-IUdR in the treatment of colorectal cancer metastatic to liver.
Daghighian, F; Finn, R; Humm, JL; Izzo, J; Kemeny, N; Larson, SM; Macapinlac, HA; Zhang, J, 1996
)
0.29
"The objective of this study was to determine the physiochemical, biochemical and pharmacokinetic properties of 5-iodo-3'-O-nitro-2'-deoxyuridine (INUdR), a novel prodrug releasing both nitric oxide (NO) and 5-iodo-2'-deoxyuridine."( Biochemical and pharmacokinetic evaluation of a novel pyrimidine nucleoside nitric oxide donor as a potential anticancer/antiviral agent.
Khalili, P; Knaus, EE; Naimi, E; Sun, WY; Wiebe, LI, 2003
)
0.32
"A toxicology and pharmacokinetic study of orally administered (po) IPdR (5-3iodo-2-pyrimidinone-2'deoxyribose, NSC-726188) was performed in Fischer-344 rats using a once daily (qd) x 28 days dosing schedule as proposed for an initial phase I clinical trial of IPdR as a radiosensitizer."( Toxicology and pharmacokinetic study of orally administered 5-iodo-2-pyrimidinone-2'deoxyribose (IPdR) x 28 days in Fischer-344 rats: impact on the initial clinical phase I trial design of IPdR-mediated radiosensitization.
Burback, B; Hong, S; Johnson, JP; Kinsella, MT; Kinsella, TJ; Tosca, PJ, 2008
)
0.35
" These toxicology and pharmacokinetic data were used when considering the design of our initial phase I trial of po IPdR as a clinical radiosensitizer."( Toxicology and pharmacokinetic study of orally administered 5-iodo-2-pyrimidinone-2'deoxyribose (IPdR) x 28 days in Fischer-344 rats: impact on the initial clinical phase I trial design of IPdR-mediated radiosensitization.
Burback, B; Hong, S; Johnson, JP; Kinsella, MT; Kinsella, TJ; Tosca, PJ, 2008
)
0.35

Compound-Compound Interactions

ExcerptReferenceRelevance
" Continuous intraarterial infusion of IUdR was combined with irradiation to maximize drug concentration in tumor and reduce potential systemic toxicity."( Intraarterial iododeoxyuridine infusion combined with irradiation. A pilot study.
Ansfield, FJ; Stephenson, JA; Vermund, H; Wiley, AL; Wirtanen, GW, 1990
)
0.28
"The sensitivity of varicella zoster virus (VZV) strain Ellen to acyclovir in combination with other antiherpetic agents in vitro has been examined by the plaque-reduction and infectious center assay methods."( Effect of acyclovir combined with other antiherpetic agents on varicella zoster virus in vitro.
Biron, KK; Elion, GB, 1982
)
0.26
" These mt-QSARs offer also a good opportunity to construct drug-drug Complex Networks (CNs) that can be used to explore large and complex drug-viral species databases."( Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
Chou, KC; González-Díaz, H; Martinez de la Vega, O; Prado-Prado, FJ; Ubeira, FM; Uriarte, E, 2009
)
0.35

Bioavailability

ExcerptReferenceRelevance
" The data also indicate that some factors may act specifically on BP synthesis, without affecting IGF synthesis, and in this way play a role in regulating the bioavailability of the IGFs."( FGFs stimulate IGF binding protein synthesis without affecting IGF synthesis in rat astroblasts in primary culture.
Binoux, M; Janet, T; Labourdette, G; Loret, C; Schneid, H, 1991
)
0.28
"The mechanism of transport of desciclovir (DCV)--a structural analogue and prodrug of acyclovir (ACV) which provides an improved oral bioavailability of ACV--was investigated in human erythrocytes with a "papaverine-stop" assay."( Desciclovir permeation of the human erythrocyte membrane by nonfacilitated diffusion.
Domin, BA; Mahony, WB; Zimmerman, TP, 1991
)
0.28
" In conclusion, the bioavailability of 5-iodo 2'-deoxyuridine 5'-monophosphate to the parenchymal liver cell is dramatically enhanced as a result of the conjugation of the anti-viral drugs to lactosylated poly-L-lysine."( Specific targeting of the antiviral drug 5-iodo 2'-deoxyuridine to the parenchymal liver cell using lactosylated poly-L-lysine.
Beuting, DM; Biessen, EA; Bijsterbosch, MK; Van Berkel, TJ; Vietsch, H, 1994
)
0.29
"89 l/kg) and high oral bioavailability (F=0."( Biochemical and pharmacokinetic evaluation of a novel pyrimidine nucleoside nitric oxide donor as a potential anticancer/antiviral agent.
Khalili, P; Knaus, EE; Naimi, E; Sun, WY; Wiebe, LI, 2003
)
0.32
" This work led us to propose a model in which the human DNA helicase RECQ1 acts as a governor of the single-stranded DNA binding protein RPA and regulates its bioavailability for DNA synthesis."( Single-Molecule DNA Fiber Analyses to Characterize Replication Fork Dynamics in Living Cells.
Banerjee, T; Brosh, RM; Datta, A; Dhar, S, 2019
)
0.51
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51

Dosage Studied

ExcerptRelevanceReference
" The validity of therapy with either of these drugs in generalized herpetic infections is questioned because activity was minimal against the infecting agent even when the dosage of the drug was sufficient to produce serious defects in certain developing tissues."( Experimental infection with herpes simplex virus type 2 in newborn rats: Effects of treatment with iododeoxyuridine and cytosine arabinoside.
Hatch, LA; Percy, DH, 1975
)
0.25
" The mortality rate from viral infection was significantly reduced (greater than or equal to 30%) by the following treatment regimens: cytosine arabinoside, adenine arabinoside, iododeoxyuridine, and ribavirin, administered daily for seven consecutive days starting immediately after inoculation of virus, at dosage levels of 4-20 mg/kg, 20-100mg/kg, 100mg/kg, and 20-100 mg/kg, respectively; and chlorite-oxidized oxyamylose, polyriboinosinic-polyribocytidylic acid, and mouse interferon, administered 24 hr before viral challenge, as single doses of 100-500 mg/kg, 20mg/kg, and 10(7)-10(8) international reference units/kg respectively."( Intranasal challenge of mice with herpes simplex virus: an experimental model for evaluation of the efficacy of antiviral drugs.
De Clercq, E; Luczak, M, 1976
)
0.26
" Dose-response studies showed that the level of viral induction by UV was dependent upon cellular UV exposure."( Ultraviolet radiation induction of endogenous murine type C virus.
Brewer, PP; Hellman, KB, 1979
)
0.26
" The dosage of irradiation required to introduce DNA strand breakage in IdUrd-substituted virions was equivalent to that employed to affect greater than 99% loss of infectious virus activity in both control and IdUrd-containing virions."( Effect of ultraviolet light on DNA structure in 5-iodo-2'-deoxyuridine-substituted HSV-1 DNA.
Marongiu, ME; Prusoff, WH; Wood, TG, 1991
)
0.28
" Dose-response curves comparing both X rays and neutrons in the same cell line with the same IdUrd replacement showed a similar radiation enhancement for IdUrd incorporation."( Halogenated pyrimidines as radiosensitizers for high-LET radiation.
Atcher, RW; DeGraff, WG; Grdina, DJ; Mitchell, JB; Moore, M; Russo, A, 1989
)
0.28
" We also studied the relationship between the clinical efficacy of different dosing frequencies and the amount of IDU in the stratum corneum."( Measurement of the stratum corneum drug reservoir to predict the therapeutic efficacy of topical iododeoxyuridine for herpes simplex virus infection.
McKeough, MB; Sheth, NV; Spruance, SL, 1987
)
0.27
" Regardless of the distribution of decay events, all treatment groups exhibited identical dose-response curves (D0: 101 125I decays/cell)."( Cell lethality after selective irradiation of the DNA replication fork.
Hofer, KG; Warters, RL, 1985
)
0.27
" When the dosage of halogenated nucleosides reached 500 mg/kg, satisfactory differential sister chromatid staining of bone marrow cells was obtained."( An improved method for the analysis of sister-chromatid exchange in vivo.
Long, JB; Ou, BX, 1985
)
0.27
"55 micrograms I-UdR/mouse, radiotoxicity of 125I-UdR on tumour growth (up to 17 days after implantation), tracer incorporation, whole-body and tumour retention (up to 12 days after 125I-UdR injection) could be excluded up to a dosage of 50 microCi 125I-UdR/mouse."( Evaluation of radio- and chemotoxic effects of 125I-UdR on tumour growth and host survival.
Feinendegen, LE; Mühlensiepen, H; Porschen, R; Porschen, W, 1985
)
0.27
" This method was applied to the study of the hormone-sensitivity of breast tumours, some of which showed a dose-response to 17 beta-estradiol."( Quantitative organ culture: an approach to prediction of tumour response.
Krishnaswamy, A; Masters, JR; O'Donoghue, EP; Rigby, CC, 1980
)
0.26
" Low dose and either continuous infusion or repetitive dosing of leucovorin, as well as the effect of treatment sequence and intervals between drugs, require additional investigation."( Preclinical and clinical aspects of biomodulation of 5-fluorouracil.
Allegra, CJ; Grogan, L; Sotos, GA, 1994
)
0.29
"In the analysis of the effects of radiation or drugs on clonogenic survival data of mammalian cells, it is often advantageous to compare entire dose-response curves generated under different experimental conditions rather than to conduct single-dose comparisons."( Global comparison of radiation and chemotherapy dose-response curves with a test for interaction.
Kinsella, TJ; Kunugi, KA; Lindstrom, MJ, 1993
)
0.29
"It can be concluded that the linear-quadratic analysis of dose-response relationships offers insights into the correlation between cell survival and induction of exchanges in non-sensitized and radiosensitized cells."( Correlation between cell reproductive death and chromosome aberrations assessed by FISH for low and high doses of radiation and sensitization by iodo-deoxyuridine in human SW-1573 cells.
Barendsen, GW; Darroudi, F; Franken, NA; Kipp, JB; Ludwików, G; Ruurs, P; van Bree, C, 1999
)
0.3
" administered 5-iodo2-pyrimidinone-2'-deoxyribose (IPdR) given daily for 14 days as a prodrug for 5-iodo-2'-deoxyuridine (IUdR)-mediated tumor radiosensitization, we determined the systemic toxicities and the percentage IUdR-DNA incorporation in normal athymic mouse tissues and a human glioblastoma xenograft (U251) after this dosing schedule of IPdR."( Preclinical toxicity and efficacy study of a 14-day schedule of oral 5-iodo-2-pyrimidinone-2'-deoxyribose as a prodrug for 5-iodo-2'-deoxyuridine radiosensitization in U251 human glioblastoma xenografts.
Davis, TW; Kinsella, TJ; Kunugi, KA; Sands, H; Schupp, J; Vielhuber, KA, 2000
)
0.31
" For the IPdR systemic toxicity and toxicology study, twenty-four male or female ferrets were randomly assigned to four IPdR dosage groups receiving 0, 15, 150, and 1500 mg/kg/day by oral gavage x 14 days prior to sacrifice on study day 15."( Preclinical study of the systemic toxicity and pharmacokinetics of 5-iodo-2-deoxypyrimidinone-2'-deoxyribose as a radiosensitizing prodrug in two, non-rodent animal species: implications for phase I study design.
Balis, F; Barnett, J; Berry, SE; Davis, TW; Hwang, HS; Kinsella, TJ; Sands, H; Schupp, JE; Warren, K, 2000
)
0.31
" These included collection of individual, rather than pooled, animal response data; the inclusion of a concurrent positive control; and consideration of dose-response information and statistical analyses."( ICCVAM evaluation of the murine local lymph node assay. Conclusions and recommendations of an independent scientific peer review panel.
Dean, JH; Hattan, DG; Sailstad, DM; Stokes, WS; Tice, RR; Twerdok, LE, 2001
)
0.31
" However, the optimal duration and dosage of antiviral prevention have yet to be defined."( [The latest in herpes simplex keratitis therapy].
Labetoulle, M, 2004
)
0.32
" The purpose of this study is to measure the effect of different drug dosing schedules on tumor radiosensitization and therapeutic index in human glioblastoma xenografts."( Schedule-dependent drug effects of oral 5-iodo-2-pyrimidinone-2'-deoxyribose as an in vivo radiosensitizer in U251 human glioblastoma xenografts.
Kinsella, TJ; Radivoyevitch, T; Schupp, JE; Seo, Y; Yan, T, 2005
)
0.33
"Ready dosage form (eye drops) prepared on the basis of recombinant alpha2-IFN exhibits high activity towards herpes simplex type 1 virus in vitro."( Combined antiherpetic effect of complex preparation "Viferon-eye drops" and modified nucleosides.
Andronova, VL; Galegov, GA; Malinovskaya, VV; Vyzhlova, EN, 2006
)
0.33
"A toxicology and pharmacokinetic study of orally administered (po) IPdR (5-3iodo-2-pyrimidinone-2'deoxyribose, NSC-726188) was performed in Fischer-344 rats using a once daily (qd) x 28 days dosing schedule as proposed for an initial phase I clinical trial of IPdR as a radiosensitizer."( Toxicology and pharmacokinetic study of orally administered 5-iodo-2-pyrimidinone-2'deoxyribose (IPdR) x 28 days in Fischer-344 rats: impact on the initial clinical phase I trial design of IPdR-mediated radiosensitization.
Burback, B; Hong, S; Johnson, JP; Kinsella, MT; Kinsella, TJ; Tosca, PJ, 2008
)
0.35
" Animals were monitored for clinical signs during and following treatment with full necropsy of one-half of each dosage group at day 29 and 57."( Toxicology and pharmacokinetic study of orally administered 5-iodo-2-pyrimidinone-2'deoxyribose (IPdR) x 28 days in Fischer-344 rats: impact on the initial clinical phase I trial design of IPdR-mediated radiosensitization.
Burback, B; Hong, S; Johnson, JP; Kinsella, MT; Kinsella, TJ; Tosca, PJ, 2008
)
0.35
" Cells exposed to media from [131I]MIBG- or [131I]IUdR-treated cells demonstrated a dose-response relationship with respect to clonogenic cell death."( Radiation quality-dependent bystander effects elicited by targeted radionuclides.
Boyd, M; Mairs, RJ; McCluskey, AG; Sorensen, A, 2008
)
0.35
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
antiviral drugA substance used in the prophylaxis or therapy of virus diseases.
DNA synthesis inhibitorAny substance that inhibits the synthesis of DNA.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
pyrimidine 2'-deoxyribonucleoside
organoiodine compoundAn organoiodine compound is a compound containing at least one carbon-iodine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (21)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency44.66840.003245.467312,589.2998AID2517
TDP1 proteinHomo sapiens (human)Potency2.37560.000811.382244.6684AID686978; AID686979
AR proteinHomo sapiens (human)Potency11.73110.000221.22318,912.5098AID743035; AID743063
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency9.71880.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency33.49150.000417.946075.1148AID1346784
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency3.08350.003041.611522,387.1992AID1159552; AID1159555
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency9.92420.001530.607315,848.9004AID1224841; AID1259401
estrogen nuclear receptor alphaHomo sapiens (human)Potency9.71980.000229.305416,493.5996AID743075; AID743080; AID743091
67.9K proteinVaccinia virusPotency0.50120.00018.4406100.0000AID720580
importin subunit beta-1 isoform 1Homo sapiens (human)Potency125.89205.804836.130665.1308AID540263
snurportin-1Homo sapiens (human)Potency125.89205.804836.130665.1308AID540263
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.12510.050127.073689.1251AID588590
gemininHomo sapiens (human)Potency0.60570.004611.374133.4983AID624296; AID624297
VprHuman immunodeficiency virus 1Potency12.58931.584919.626463.0957AID651644
TAR DNA-binding protein 43Homo sapiens (human)Potency0.89131.778316.208135.4813AID652104
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency12.74480.011917.942071.5630AID651632
Ataxin-2Homo sapiens (human)Potency12.74480.011912.222168.7989AID651632
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thymidine kinase Macacine alphaherpesvirus 1IC50 (µMol)1.50000.15002.57504.2000AID326127
Thymidine kinase, cytosolicHomo sapiens (human)Ki0.09000.09001.52137.0000AID210688
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Thymidine phosphorylaseHomo sapiens (human)Km157.00000.16000.16000.1600AID211066
Thymidine kinaseVaccinia virus WRKm31.00004.30004.30004.3000AID324741
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (53)

Processvia Protein(s)Taxonomy
nucleobase-containing compound metabolic processThymidine kinase, cytosolicHomo sapiens (human)
deoxyribonucleoside monophosphate biosynthetic processThymidine kinase, cytosolicHomo sapiens (human)
thymidine metabolic processThymidine kinase, cytosolicHomo sapiens (human)
thymidine biosynthetic processThymidine kinase, cytosolicHomo sapiens (human)
protein homotetramerizationThymidine kinase, cytosolicHomo sapiens (human)
DNA synthesis involved in mitotic DNA replicationThymidine kinase, cytosolicHomo sapiens (human)
mitochondrial genome maintenanceThymidine phosphorylaseHomo sapiens (human)
angiogenesisThymidine phosphorylaseHomo sapiens (human)
pyrimidine nucleobase metabolic processThymidine phosphorylaseHomo sapiens (human)
pyrimidine nucleoside metabolic processThymidine phosphorylaseHomo sapiens (human)
chemotaxisThymidine phosphorylaseHomo sapiens (human)
signal transductionThymidine phosphorylaseHomo sapiens (human)
cell differentiationThymidine phosphorylaseHomo sapiens (human)
regulation of myelinationThymidine phosphorylaseHomo sapiens (human)
dTMP catabolic processThymidine phosphorylaseHomo sapiens (human)
regulation of transmission of nerve impulseThymidine phosphorylaseHomo sapiens (human)
regulation of gastric motilityThymidine phosphorylaseHomo sapiens (human)
negative regulation of protein phosphorylationTAR DNA-binding protein 43Homo sapiens (human)
mRNA processingTAR DNA-binding protein 43Homo sapiens (human)
RNA splicingTAR DNA-binding protein 43Homo sapiens (human)
negative regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
regulation of protein stabilityTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of insulin secretionTAR DNA-binding protein 43Homo sapiens (human)
response to endoplasmic reticulum stressTAR DNA-binding protein 43Homo sapiens (human)
positive regulation of protein import into nucleusTAR DNA-binding protein 43Homo sapiens (human)
regulation of circadian rhythmTAR DNA-binding protein 43Homo sapiens (human)
regulation of apoptotic processTAR DNA-binding protein 43Homo sapiens (human)
negative regulation by host of viral transcriptionTAR DNA-binding protein 43Homo sapiens (human)
rhythmic processTAR DNA-binding protein 43Homo sapiens (human)
regulation of cell cycleTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA destabilizationTAR DNA-binding protein 43Homo sapiens (human)
3'-UTR-mediated mRNA stabilizationTAR DNA-binding protein 43Homo sapiens (human)
nuclear inner membrane organizationTAR DNA-binding protein 43Homo sapiens (human)
amyloid fibril formationTAR DNA-binding protein 43Homo sapiens (human)
regulation of gene expressionTAR DNA-binding protein 43Homo sapiens (human)
cell population proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of B cell proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
nuclear DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
signal transduction in response to DNA damageATPase family AAA domain-containing protein 5Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
isotype switchingATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of isotype switching to IgG isotypesATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloadingATPase family AAA domain-containing protein 5Homo sapiens (human)
regulation of mitotic cell cycle phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of cell cycle G2/M phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of receptor internalizationAtaxin-2Homo sapiens (human)
regulation of translationAtaxin-2Homo sapiens (human)
RNA metabolic processAtaxin-2Homo sapiens (human)
P-body assemblyAtaxin-2Homo sapiens (human)
stress granule assemblyAtaxin-2Homo sapiens (human)
RNA transportAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (21)

Processvia Protein(s)Taxonomy
thymidine kinase activityThymidine kinase, cytosolicHomo sapiens (human)
protein bindingThymidine kinase, cytosolicHomo sapiens (human)
ATP bindingThymidine kinase, cytosolicHomo sapiens (human)
zinc ion bindingThymidine kinase, cytosolicHomo sapiens (human)
identical protein bindingThymidine kinase, cytosolicHomo sapiens (human)
1,4-alpha-oligoglucan phosphorylase activityThymidine phosphorylaseHomo sapiens (human)
protein bindingThymidine phosphorylaseHomo sapiens (human)
growth factor activityThymidine phosphorylaseHomo sapiens (human)
thymidine phosphorylase activityThymidine phosphorylaseHomo sapiens (human)
protein homodimerization activityThymidine phosphorylaseHomo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
double-stranded DNA bindingTAR DNA-binding protein 43Homo sapiens (human)
RNA bindingTAR DNA-binding protein 43Homo sapiens (human)
mRNA 3'-UTR bindingTAR DNA-binding protein 43Homo sapiens (human)
protein bindingTAR DNA-binding protein 43Homo sapiens (human)
lipid bindingTAR DNA-binding protein 43Homo sapiens (human)
identical protein bindingTAR DNA-binding protein 43Homo sapiens (human)
pre-mRNA intronic bindingTAR DNA-binding protein 43Homo sapiens (human)
molecular condensate scaffold activityTAR DNA-binding protein 43Homo sapiens (human)
protein bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP hydrolysis activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloader activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
RNA bindingAtaxin-2Homo sapiens (human)
epidermal growth factor receptor bindingAtaxin-2Homo sapiens (human)
protein bindingAtaxin-2Homo sapiens (human)
mRNA bindingAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (17)

Processvia Protein(s)Taxonomy
nucleusThymidine kinase, cytosolicHomo sapiens (human)
cytosolThymidine kinase, cytosolicHomo sapiens (human)
cytosolThymidine phosphorylaseHomo sapiens (human)
cytosolThymidine phosphorylaseHomo sapiens (human)
intracellular non-membrane-bounded organelleTAR DNA-binding protein 43Homo sapiens (human)
nucleusTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
perichromatin fibrilsTAR DNA-binding protein 43Homo sapiens (human)
mitochondrionTAR DNA-binding protein 43Homo sapiens (human)
cytoplasmic stress granuleTAR DNA-binding protein 43Homo sapiens (human)
nuclear speckTAR DNA-binding protein 43Homo sapiens (human)
interchromatin granuleTAR DNA-binding protein 43Homo sapiens (human)
nucleoplasmTAR DNA-binding protein 43Homo sapiens (human)
chromatinTAR DNA-binding protein 43Homo sapiens (human)
Elg1 RFC-like complexATPase family AAA domain-containing protein 5Homo sapiens (human)
nucleusATPase family AAA domain-containing protein 5Homo sapiens (human)
cytoplasmAtaxin-2Homo sapiens (human)
Golgi apparatusAtaxin-2Homo sapiens (human)
trans-Golgi networkAtaxin-2Homo sapiens (human)
cytosolAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
membraneAtaxin-2Homo sapiens (human)
perinuclear region of cytoplasmAtaxin-2Homo sapiens (human)
ribonucleoprotein complexAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (400)

Assay IDTitleYearJournalArticle
AID1294502Cytotoxicity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by MTS assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
AID87323Antiherpes activity was tested as percent of control of plaque-formation against HSV-2 (CEU-G) virus by 100 uM of the compound1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID156700Antiviral activity against HSV-1 (KOS) in Primary Rabbit Kidney (PRK) cells1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID217419Proliferation of Vero cells by propagation on day 4 by measuring optical density (absorbance) at 100 ug/mL1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID326134Antiviral activity against Herpes B virus 24105 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID625282Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID220992Evaluation of antitumor activity against thymidine kinase deficient Raji cell line1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID1124512Inhibition of thymidine kinase in BHK21 (C13) cells using [14C]thymidine at 0.19 mM after 10 mins by liquid scintillation spectrometer analysis relative to control in presence of Mg2+1979Journal of medicinal chemistry, Jun, Volume: 22, Issue:6
Design of species- or isozyme-specific enzyme inhibitors. 1. Effect of thymidine substituents on affinity for the thymidine site of hamster cytoplasmic thymidine kinase.
AID85567Concentration required to inhibit HSV type 1 strain 377 induced cytopathogenic affects by 50%1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
AID625290Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID167909Minimal inhibitory concentration against vesicular stomatitis virus-induced cytopathogenicity by 50% in rabbit kidney cell cultures1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.
AID87829Minimum inhibitory concentration (MIC) required to reduce HSV-2 strain (Lyons) induced cytopathogenicity in primary rabbit kidney cell cultures1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID625283Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1123149Antiviral activity against HSV1 2931 infected in African green monkey Vero cells assessed as inhibition of virus replication at 10 ug/ml after 24 hrs relative to control1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.
AID161452Antiviral activity against B2006 strain of thymidine kinase deficient (TK-) herpes simplex virus-1 in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID324743Activity of human thymidine kinase 1 assessed as ATP utilization by luciferase-based assay2007Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
AID93930Minimum inhibitory concentration (MIC) required to inhibit proliferation of murine leukemia L1210 (TK-)1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID221339Evaluation for antitumor activity against human lymphoblast Raji cells1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID1372793Antiviral activity against HSV1 MP infected in African green monkey Vero cells assessed as inhibition of plaque formation after 48 hrs2018Bioorganic & medicinal chemistry, 01-15, Volume: 26, Issue:2
An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold.
AID1079937Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source]
AID1123150Antiviral activity against HSV1 2931 infected in African green monkey Vero cells assessed as inhibition of virus replication at 100 ug/ml after 24 hrs relative to control1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.
AID87321Antiherpes activity was tested as percent of control of plaque-formation against HSV-2 (333) virus by 100 uM of the compound1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID210722Inhibition constant was measured against Thymidine kinase1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID67595In vitro cell cytotoxicity against EMT-6 cell lines2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
AID84418Compound was tested for antiviral activity against herpes simplex virus( HSV-1-KOS) strain in primary rabbit kidney cells1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID1124513Inhibition of human mitochondrial thymidine kinase using [14C]thymidine at 0.19 mM after 10 mins by liquid scintillation spectrometer analysis relative to control in presence of Mg2+1979Journal of medicinal chemistry, Jun, Volume: 22, Issue:6
Design of species- or isozyme-specific enzyme inhibitors. 1. Effect of thymidine substituents on affinity for the thymidine site of hamster cytoplasmic thymidine kinase.
AID625289Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID167908Minimal inhibitory concentration against vaccinia virus-induced cytopathogenicity by 50% in rabbit kidney cell cultures1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.
AID85559Concentration required to reduce the number of viral plaques in vivo cell monolayers of herpes simplex virus type 1.1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2'-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides.
AID96826Inhibitory concentration required to reduce [3H-methyl]-dThd C incorporation into cellular DNA by 50% in Murine Leukemia L1210 cells1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID1135905Antiviral activity against Vesicular stomatitis virus infected in rabbit primary kidney cells assessed as inhibition of viral cytopathogenicity after 2 days1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Antiviral activity of aliphatic nucleoside analogues: structure-function relationship.
AID87326Binding affinity against HSV-2(333)1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID542149Antiviral activity against thymidine kinase deficient Cowpox virus harboring TK:GFP lacZ infected in HFF after 48 hrs by beta-galactosidase assay2009Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
AID324742Ratio of Vmax to Km for Vaccinia virus WR thymidine kinase2007Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
AID63767The minimum inhibitory concentration was measured on E6SM cells against Vesicular stomatitis virus1994Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID232840Ratio of Vmax to that of dThd (Vmax = 0.14)1980Journal of medicinal chemistry, Aug, Volume: 23, Issue:8
Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines.
AID112441Inhibitory activity against incorporation of deoxy-[methyl.3H-]-thymidine (dThd) into the DNA of murine leukemia L1210 cell cultures1983Journal of medicinal chemistry, May, Volume: 26, Issue:5
Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID165524Concentration of compound required to inhibit [methyl-3H]dThd incorporation into host cell DNA by 50% in primary rabbit kidney cell cultures1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID98532Evaluation of cytostatic activity by using antitumor assays against murine leukemia L1210 cells1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID96825Inhibitory concentration required to reduce [14C-2]-dUrd incorporation into cellular DNA by 50% in Murine Leukemia L1210 cells1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID217888Antiviral activity against HSV-1 (Brand) in Vero cells1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID84604Concentration required to reduce cytopathogenicity of Herpes simplex virus type 2 (strain G) by 50% in primary rabbit kidney (PRK) cells1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID217674Inhibitory concentration against VZV strain YS in human embryonic lung (HEL) cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID167906Minimal inhibitory concentration against HSV-2 (G)-induced cytopathogenicity by 50% in rabbit kidney cell cultures1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.
AID85432Inhibition constant against HSV-1 TK2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID85378Inhibitory concentration against HSV type 2 strain 196 in human embryonic skin muscle (ESM) fibroblast cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID63754Tested for the minimum inhibitory concentration required to reduce vaccinia virus(VV) induced cytopathogenicity by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID84420Compound was tested for antiviral activity against herpes simplex virus( HSV-1-McIntyre) strain in primary rabbit kidney cells1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID87968Minimum inhibitory concentration causing 25% inhibition cytopathic effect induced by Herpes simplex virus(HSV) -1 (thymidine kinase deficient) in HEp-2 cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID1079943Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source]
AID98529Evaluation of antitumor activity against mutant murine leukemia L1210 cells1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID85556Antiviral activity against various strains of Herpes Simplex virus type I1982Journal of medicinal chemistry, Nov, Volume: 25, Issue:11
Synthesis and antiviral properties of some 2'-deoxy-5-(fluoroalkenyl)uridines.
AID167903Minimal inhibitory concentration against HSV-1 (KOS)-induced cytopathogenicity by 50% in rabbit kidney cell cultures1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.
AID218244Antiherpes activity was measured in a plaque reduction assay in Vero cells, against HSV-2 strain 186.1990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofu
AID84966Minimum inhibitory concentration (MIC50) in Herpes simplex virus type-2 (HSV-2) using MS strain.1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Carbocyclic analogues of 5-substituted uracil nucleosides: synthesis and antiviral activity.
AID1123151Cytotoxicity against mouse L5178Y cells assessed as growth inhibition after 96 hrs1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.
AID63763The minimum inhibitory concentration was measured on E6SM cells against Herpes simplex virus type 2 (Lyons strain)1994Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID1135473Antiviral activity against Herpes simplex virus 2 Curtis assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID1123153Antiviral activity against HSV1 2931 infected in African green monkey Vero cells assessed as inhibition of virus replication at 0.1 ug/ml after 24 hrs relative to control1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.
AID83146Antiviral activity against VZV (Ellen) in human lung fibroblast (HLF-1) cells1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID156514Concentration required to inhibit incorporation of [Me-3H]-dThd into DNA of primary rabbit kidney (PRK) cells by 50%1981Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.
AID563784Antiviral activity against HSV2 harboring frameshift mutation in TK infected in HFF after 3 days by plaque reduction assay2009Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12
Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.
AID85091Antiviral activity against herpes simplex virus(2) strain MS expressed as virus rating1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Carbocyclic analogues of 5-substituted uracil nucleosides: synthesis and antiviral activity.
AID87971Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by herpes simplex virus (HSV)-1 (K979) in vero cells.1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID87823Minimum inhibitory concentration required to reduce HSV-2 (196) strain-induced cytopathogenicity in primary rabbit kidney cell cultures1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID88276In vitro antiviral activity by means of plaque-inhibition assay with monolayers of Vero cells infected with the MP strain of herpes simplex virus-1 (HSV-1)1984Journal of medicinal chemistry, Aug, Volume: 27, Issue:8
Pyrazolo[4,3-d]pyrimidine nucleosides. Synthesis and antiviral activity of 1-beta-D-ribofuranosyl-3-methyl-6-substituted-7H-pyrazolo[4,3-d]pyr imi din-7-ones.
AID268228Cytotoxicity against HFF cells by neutral red uptake assay2006Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.
AID227702Ratio of ID50 for dThd or dUrd incorporation to ID50 for HSV-1, HSV-2 or VV(whatever was lowest)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID218243Antiherpes activity was measured in a plaque reduction assay in Vero cells, against HSV-1 strain KOS.1990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofu
AID94495In vitro cell cytotoxicity against KBALB-STK cell lines expressed in HSV-1 TK2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
AID326137Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID99532In vitro growth inhibition of L5178Y-Parental murine leukemia cells by incorporation of [14C]-Thd.2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID543560Antiviral activity against J2R gene deficient Vaccinia virus harboring VVTK::luc infected in HFF assessed as reduction of plaque formation after 3 days2009Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
AID161453Antiviral activity against F strain of herpes simplex virus-1 in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID167907Minimal inhibitory concentration against HSV-2 (Lyons)-induced cytopathogenicity by 50% in rabbit kidney cell cultures1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.
AID326131Activity of Herpes B virus recombinant thymidine kinase at 100 uM2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID63758The minimum inhibitory concentration was measured against Herpes simplex virus type 1 (KOS strain) on E6SM cells1994Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID217932Minimum inhibitory concentration (MIC) required to reduce vesicular stomatis virus induced cytopathogenicity in primary rabbit kidney cell cultures1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID63751Tested for the minimum inhibitory concentration required to reduce thymidine kinase deficient herpes simplex virus type 1 (TK- HSV-1) strain B2006 induced cytopathogenicity by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID84071Compound was evaluated for antiviral activity against HSV-1(TK-, strain B2006)1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID542154Antiviral activity against Vaccinia virus WR infected in HFF assessed as inhibition of DNA synthesis after 24 hrs by PCR analysis2009Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
AID161460Antiviral activity against Vesicular stomatitis virus in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID87510Minimum inhibitory concentration (MIC) required to reduce HSV-1 strain McIntyre induced cytopathogenicity in primary rabbit kidney cell cultures1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID209539Inhibitory concentration against TK-VZV strain YS-R in human embryonic lung (HEL) cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID2907In vitro cell cytotoxicity was determined against 143B cell line2004Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
AID1131481Antiviral activity against HSV1 CL101 infected in African green monkey Vero cells assessed as plaque forming unit at 50 uM after 40 hrs relative to control1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID1135814Dissociation constant, pKa of the compound1978Journal of medicinal chemistry, Nov, Volume: 21, Issue:11
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
AID156527Concentration required to reduce HSV-2 induced cytopathogenicity by 50% in primary rabbit kidney (PRK) cells; 0.2-0.41981Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.
AID87503Minimum inhibitory concentration required to reduce HSV-1 (F) strain-induced cytopathogenicity in primary rabbit kidney cell cultures1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID63621Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-2) strain 196 induced cytopathogenicity by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID83902Minimum inhibitory concentration (MIC50) in Herpes simplex virus type-1 (HSV-1) using 377 strain.1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Carbocyclic analogues of 5-substituted uracil nucleosides: synthesis and antiviral activity.
AID563782Antiviral activity against 4'-thioIDU-resistant HSV2 infected in HFF after 3 days by plaque reduction assay2009Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12
Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.
AID86208Proliferation of Hep-2 cells by propagation on day 4 by measuring optical density (absorbance) at 30 ug/mL1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID85427Antiviral activity against herpes simplex virus type I was measured at 5 uM concentration.1980Journal of medicinal chemistry, Feb, Volume: 23, Issue:2
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
AID1123152Antiviral activity against HSV1 2931 infected in African green monkey Vero cells assessed as inhibition of virus replication at 0.01 ug/ml after 24 hrs relative to control1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.
AID563744Antiviral activity against HSV2 MS infected in HFF after 3 days by plaque reduction assay2009Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12
Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.
AID1135480Antiviral activity against Vaccinia virus infected in primary rabbit kidney cells assessed as inhibition of virus-induced cytopathogenicity1977Journal of medicinal chemistry, Jul, Volume: 20, Issue:7
Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.
AID1135479Antiviral activity against Herpes simplex virus 1 infected in human skin fibroblasts assessed as inhibition of virus-induced cytopathogenicity1977Journal of medicinal chemistry, Jul, Volume: 20, Issue:7
Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.
AID625288Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079938Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source]
AID86215Antiviral activity against HSV-1 (Brand) in human epithelial (Hep-2) cells1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID85379Inhibitory concentration against HSV type 2 strain G in human embryonic skin muscle (ESM) fibroblast cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID87508Evaluation of antiviral activity against Herpes simplex virus type 1 (HSV-1) strain McIntyre1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID63625Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-2) strain Lyons induced cytopathogenicity by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID625284Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID210869Inhibitory activity against thymidine kinase (TK) from L1210 cells1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
Synthesis and biological activity of various 3'-azido and 3'-amino analogues of 5-substituted pyrimidine deoxyribonucleosides.
AID1146019Antiviral activity against Herpes simplex virus 2 Curtis assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID146667Minimum inhibitory concentration (MIC) required to inhibit proliferation of Novikoff rat hepatoma1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID563783Selectivity ratio of EC50 for 4'-thioIDU-resistant HSV2 infected in HFF to EC50 for HSV2 MS infected in HFF2009Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12
Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.
AID167910Minimal inhibitory concentration required to cause a microscopically detectable alteration of normal cell morphology of rabbit kidney cell culture1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.
AID217420Proliferation of Vero cells by propagation on day 4 by measuring optical density (absorbance) at 30 ug/mL1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID42137Inhibition of cellular DNA synthesis in BSCL cells at the dose of 0.8 ug/mL.1983Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
Antiviral compounds. 1. Structure-activity relationship of some antiviral enediones derived from aldehydo sugars.
AID155218Antiherpes activity was tested as percent of control of plaque-formation against PFAr virus by 100 uM of the compound1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID167137Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-2 (G)1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID84756In vitro antiviral activity in secondary cultures of rabbit kidney cells infected with HSV type 2 strain MS1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
AID268225Antiviral activity against TK+ cowpox virus delta crmA in HFF cells2006Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.
AID82894Tested for the 50% inhibitory concentration required to reduce TK+ Varicella-Zoster virus (TK+ VZV) strain YS plaque formation by 50%1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID218237Cytotoxic effect on Vero cells was determined in mock infected cell monolayers incubated with the compound for 48 hr at 37 degree celsius.1990Journal of medicinal chemistry, Jan, Volume: 33, Issue:1
Fluoro carbocyclic nucleosides: synthesis and antiviral activity of 2'- and 6'-fluoro carbocyclic pyrimidine nucleosides including carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-methyluracil and carbocyclic 1-(2-deoxy-2-fluoro-beta-D-arabinofu
AID87830Minimum inhibitory concentration (MIC) required to reduce HSV-2 strain G induced cytopathogenicity in primary rabbit kidney cell cultures1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID63623Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-2) strain G induced cytopathogenicity by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID165527Concentration required to reduce Herpes simplex virus type 2 induced cytopathogenicity in primary rabbit kidney (PRK) cell cultures1983Journal of medicinal chemistry, May, Volume: 26, Issue:5
Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID1135598Antiviral activity against Herpes simplex virus 1 KOS infected in human skin fibroblasts primed with interferon and superinduced with cyclohexamide and actinomycin D assessed as inhibition of virus-induced cytopathogenicity1978Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.
AID1146018Antiviral activity against Herpes simplex virus 1 Sheely assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID87970Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus-1 (K979) in HEp-2 cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID409954Inhibition of mouse brain MAOA2008Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
AID165552Tested for its antimetabolic activity by measuring the concentration required for [2-14C]- Urd incorporation into host cell DNA by 50%1980Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition.
AID1079949Proposed mechanism(s) of liver damage. [column 'MEC' in source]
AID217829Concentration required to reduce cytopathogenicity of vaccinia virus by 50% in primary rabbit kidney (PRK) cells1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID167905Minimal inhibitory concentration against HSV-2 (196)-induced cytopathogenicity by 50% in rabbit kidney cell cultures1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.
AID2909In vitro cell cytotoxicity against 143B-LTK cell lines expressed in HSV-1 TK2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
AID161451Antiviral activity against 196 strain of herpes simplex virus-2 in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID324735Cytotoxicity against HFF cells after 7 days by CellTiter-Glo assay2007Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
AID625281Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1294506Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by MTS assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
AID156701Antiviral activity against HSV-2 (G) in Primary Rabbit Kidney (PRK) cells1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID625286Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID87827Evaluation of antiviral activity against Herpes simplex virus type 2 (HSV-2) strain G1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID165523Concentration of compound required to inhibit [1',2'-3H]dUrd incorporation into host cell DNA by 50% in primary rabbit kidney cell cultures1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID165558Tested for its antiviral activity in primary rabbit kidney (PRK) cell cultures inoculated with vaccinia virus1980Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition.
AID84609Concentration required to inhibit HSV type 2 strain MS induced cytopathogenic affects by 50%1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
AID63759The minimum inhibitory concentration was measured on E6SM cells against Herpes simplex virus type 1 (F strain)1994Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID167140Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against Vesicular stomatitis virus1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID221302Compound was tested for antiviral activity against herpes simplex Vassicular stomatitis in primary rabbit kidney cells1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID63617Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-1) strain KOS induced cytopathogenicity by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID156516Concentration required to reduce HSV-1 induced cytopathogenicity by 50% in primary rabbit kidney (PRK) cells1981Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.
AID86209Proliferation of Hep-2 cells by propagation on day 4 by measuring optical density (absorbance) at 330 ug/mL1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID63615Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-1) strain F induced cytopathogenicity by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID2911In vitro cell cytotoxicity was determined against 143B-LTK cell line2004Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
AID1131493Cytotoxicity against mouse S180 cells at 50 uM after 18 to 42 hrs relative to control1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID217807Minimum inhibitory concentration required to reduce vaccinia virus-induced cytopathogenicity in primary rabbit kidney cell cultures1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID210687Catalytic turnover constant of compound against HSV-1 thymidine kinase; ND denotes not determined2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID1079944Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source]
AID543558Antiviral activity against cidofovir-resistant Vaccinia virus 15A harboring DNA polymerase E9L mutant infected in HFF assessed as reduction of plaque formation after 3 days2009Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
AID86216Antiviral activity against HSV-2 (K979) in human epithelial (Hep-2) cells1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID1079939Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source]
AID217982Compound was evaluated for antiviral activity against vaccinia1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID1123146Cytotoxicity against mouse P815 cells assessed as growth inhibition after 96 hrs1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.
AID268226Antiviral activity against cowpox virus in HFF cells by plaque reduction assay2006Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.
AID161459Antiviral activity against Vaccinia virus in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID1079931Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source]
AID156400Concentration required to inhibit incorporation of [1,'2'-3H]dUrd into DNA of primary rabbit kidney (PRK) cells by 50%1981Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.
AID85419Compound was tested for antiviral activity against herpes simplex virus( HSV-2-G) strain in primary rabbit kidney cells1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID1135481Antiviral activity against Herpes simplex virus 1 infected in primary rabbit kidney cells assessed as inhibition of virus-induced cytopathogenicity1977Journal of medicinal chemistry, Jul, Volume: 20, Issue:7
Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.
AID209532Inhibitory concentration against TK-HSV type 1 strain B2006 in human embryonic skin muscle (ESM) fibroblast cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID2904In vitro cell cytotoxicity against 143-B cell lines (Human osteosarcoma cell line)2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
AID324744Ratio of Vmax to Km for human thymidine kinase 12007Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
AID87500Percent inhibition of herpes simplex type-1 virus at the concentration of 50 uM1980Journal of medicinal chemistry, Dec, Volume: 23, Issue:12
Synthesis and biological activities of chloroethylurea, methylurea, and nitrosourea analogues of N-deacetylmethylthiocolchicine.
AID1123148Antiviral activity against HSV1 2931 infected in African green monkey Vero cells assessed as inhibition of virus replication at 1 ug/ml after 24 hrs relative to control1979Journal of medicinal chemistry, Jan, Volume: 22, Issue:1
Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides.
AID56582Inhibitory activity against deoxycytidine kinase from L1210 cells1983Journal of medicinal chemistry, Dec, Volume: 26, Issue:12
Synthesis and biological activity of various 3'-azido and 3'-amino analogues of 5-substituted pyrimidine deoxyribonucleosides.
AID161450Minimum cytotoxic concentration required to cause a microscopically detectable alteration of rabbit kidney cell morphology1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID324732Antiviral activity against TK- Cowpox virus TK:GFP lacZ in HFF cells after 48 hrs by beta-galactosidase assay2007Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
AID156686Inhibitory concentration required to reduce incorporation of 2-deoxyuridine (dUrd) into DNA of Primary Rabbit kidney (PRK) cell cultures1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID165543Inhibitory activity against incorporation of deoxy-[methyl.3H-]-thymidine (dThd) into the DNA of uninfected primary rabbit kidney (PRK) cell cultures1983Journal of medicinal chemistry, May, Volume: 26, Issue:5
Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID30871Antiherpes activity was tested as percent of control of plaque-formation against ACG (S1) virus by 100 uM of the compound1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID127888Effect on the survival rate of mouse infected with herpes genitalis (HSV-2) administered intravaginally at 2% dosage twice in a day1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiherpetic activity of some 4-[(aryloxy)alkyl]pyrazoles.
AID161456Antiviral activity against Lyons strain of herpes simplex virus-2 in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID156399Compound was evaluated for antiviral activity in rabbit kidney cells infected with vaccinia virus1981Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.
AID84417Compound was tested for antiviral activity against herpes simplex virus( HSV-1-F) strain in primary rabbit kidney cells1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID165557Tested for its antiviral activity in primary rabbit kidney (PRK) cell cultures inoculated with herpes simplex type 2 virus; range 0.2-0.41980Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition.
AID63760The minimum inhibitory concentration was measured on E6SM cells against Herpes simplex virus type 1 (McIntyre strain)1994Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID1135483Dissociation constant, pKa of the compound by spectrophotometric analysis1977Journal of medicinal chemistry, Jul, Volume: 20, Issue:7
Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.
AID167136Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-2 (196)1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID87509Minimum inhibitory concentration (MIC) required to reduce HSV-1 strain (F) induced cytopathogenicity in primary rabbit kidney cell cultures1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID167134Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-1 (F)1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID81757Minimum toxic effect against HEp-2 cells.1985Journal of medicinal chemistry, Nov, Volume: 28, Issue:11
5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID87826Evaluation of antiviral activity against Herpes simplex virus type 2 (HSV-2) strain 196.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID625287Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID324731Antiviral activity against Cowpox virus Brighton in HFF cells after 1 hr by plaque reduction assay2007Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
AID1135600Cytotoxicity against mouse L cells assessed as suppression of replication1978Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.
AID83020Tested for the inhibitory concentration required to reduce cytomegalovirus (CMV) strain AD-169 plaque formation by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID625291Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID167902Minimal inhibitory concentration against HSV-1 (F)-induced cytopathogenicity by 50% in rabbit kidney cell cultures1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.
AID209538Inhibitory concentration against TK-VZV strain 07-1 in human embryonic lung (HEL) cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID87196Antiherpes activity was tested as percent of control of plaque-formation against HSV-1 (KOS) virus by 100 uM of the compound1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID1131485Cytotoxicity against African green monkey Vero cells at 50 uM after 3 days by haemocytometry1978Journal of medicinal chemistry, Jan, Volume: 21, Issue:1
A novel synthesis and biological activity of several 5-halo-5'-amino analogues of deoxyribopyrimidine nucleosides.
AID84953Compound was evaluated for antiviral activity against HSV-2(strain G)1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID127889Effect on the survival rate of mouse infected with herpes genitalis (HSV-2) administered intravaginally at 5% dosage twice in a day1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiherpetic activity of some 4-[(aryloxy)alkyl]pyrazoles.
AID85372Inhibitory concentration against HSV type 1 strain F in human embryonic skin muscle (ESM) fibroblast cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID156685Inhibitory concentration required to reduce incorporation of 2-deoxythymidine (dThd) into DNA of Primary Rabbit kidney (PRK) cell cultures1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID85373Inhibitory concentration against HSV type 1 strain KOS in human embryonic skin muscle (ESM) fibroblast cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID85558Concentration required to reduce cytopathogenicity of Herpes simplex virus type 1 (strain KOS) by 50% in primary rabbit kidney (PRK) cells1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID87969Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus-1 (Brand) in vero cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID63764The minimum inhibitory concentration was measured on E6SM cells against TK+/TK-Herpes simplex virus type 1 (VMW1837 strain)1994Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID87505Minimum inhibitory concentration required to reduce HSV-1 (McIntyre) strain-induced cytopathogenicity in primary rabbit kidney cell cultures1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID83893Minimum inhibitory concentration against HSV-1.1985Journal of medicinal chemistry, Nov, Volume: 28, Issue:11
5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID99530In vitro growth inhibition of L5178Y-Parental murine leukemia cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID324734Ratio of EC50 for TK- Cowpox virus TK:GFP lacZ in HFF cells to EC50 for TK+ Cowpox virus delta crmA in HFF cells2007Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
AID1135478Antiviral activity against Vaccinia virus infected in human skin fibroblasts assessed as inhibition of virus-induced cytopathogenicity1977Journal of medicinal chemistry, Jul, Volume: 20, Issue:7
Improved synthesis and in vitro antiviral activities of 5-cyanouridine and 5-cyano-2'-deoxyuridine.
AID94494In vitro cell cytotoxicity was determined against KBALB cell line2004Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
AID1135597Antiviral activity against Herpes simplex virus 1 KOS infected in primary rabbit kidney cells assessed as inhibition of virus-induced cytopathogenicity1978Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.
AID67597In vitro cell cytotoxicity was determined against EMT-6 cell line2004Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
AID87639Minimum inhibitory concentration (MIC) required to reduce thymidine kinase deficient HSV-1 induced cytopathogenicity in primary rabbit kidney cell cultures1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID217488Inhibitory concentration against VV in human embryonic skin muscle (ESM) fibroblast cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID588209Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset2010Chemical research in toxicology, Jul-19, Volume: 23, Issue:7
Developing structure-activity relationships for the prediction of hepatotoxicity.
AID1294503Cytotoxicity against human A549 cells assessed as reduction in cell viability after 72 hrs by MTS assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
AID1079932Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source]
AID167133Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-1 ((KOS)1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID84061Antiviral activity against herpes simplex virus(1) strain 377, expressed as virus rating1983Journal of medicinal chemistry, Feb, Volume: 26, Issue:2
Carbocyclic analogues of 5-substituted uracil nucleosides: synthesis and antiviral activity.
AID625279Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID94497In vitro cell cytotoxicity was determined against KBALB-STK cell line2004Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.
AID543559Antiviral activity against ST-246-resistant Vaccinia virus VV911 harboring DNA polymerase E13L mutant infected in HFF assessed as reduction of plaque formation after 3 days2009Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
AID268224Antiviral activity against vaccinia virus in HFF cells by plaque reduction assay2006Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.
AID268227Antiviral activity against TK- cowpox virus TK:GFP lacZ in HFF cells2006Journal of medicinal chemistry, Jul-13, Volume: 49, Issue:14
Toward orthopoxvirus countermeasures: a novel heteromorphic nucleoside of unusual structure.
AID218132Evaluation of antiviral activity against Vaccinia virus1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID1135906Antiviral activity against Vaccinia virus infected in rabbit primary kidney cells assessed as inhibition of viral cytopathogenicity after 3 days1979Journal of medicinal chemistry, May, Volume: 22, Issue:5
Antiviral activity of aliphatic nucleoside analogues: structure-function relationship.
AID210688Binding affinity constant against HSV-1 thymidine kinase2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID165528Concentration required to reduce Vaccinia virus induced cytopathogenicity in primary rabbit kidney (PRK) cell cultures1983Journal of medicinal chemistry, May, Volume: 26, Issue:5
Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID542155Ratio of EC50 for thymidine kinase deficient Cowpox virus harboring TK:GFP lacZ to EC50 for thymidine kinase positive Cowpox virus harboring deltacrmA lacZ2009Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
AID1124514Inhibition of human cytoplasmic thymidine kinase using [14C]thymidine at 0.19 mM after 10 mins by liquid scintillation spectrometer analysis relative to control in presence of Mg2+1979Journal of medicinal chemistry, Jun, Volume: 22, Issue:6
Design of species- or isozyme-specific enzyme inhibitors. 1. Effect of thymidine substituents on affinity for the thymidine site of hamster cytoplasmic thymidine kinase.
AID63761The minimum inhibitory concentration was measured on E6SM cells against Herpes simplex virus type 2 (196 strain)1994Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID324741Activity of Vaccinia virus WR thymidine kinase assessed as ATP utilization by luciferase-based assay2007Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
AID326138Cytotoxicity against african green monkey Vero cells after 2 days2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID1079948Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source]
AID165542Inhibitory activity against incorporation of deoxy-[1',2'-3H]uridine (dUrd) into the DNA of uninfected primary rabbit kidney (PRK) cell cultures1983Journal of medicinal chemistry, May, Volume: 26, Issue:5
Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID542150Antiviral activity against thymidine kinase positive Cowpox virus harboring deltacrmA lacZ infected in HFF after 48 hrs by beta-galactosidase assay2009Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
AID87327Relative phosphorylation rate against HSV-2(333)1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID87999Minimum inhibitory concentration causing 25% inhibition cytopathic effect induced by Herpes simplex virus(HSV) -2 (thymidine kinase deficient) in vero cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID94492In vitro cell cytotoxicity against KBALB cell line (transformed fibroblast sarcoma cell line)2003Journal of medicinal chemistry, Mar-13, Volume: 46, Issue:6
Synthesis of 3'- and 5'-nitrooxy pyrimidine nucleoside nitrate esters: "nitric oxide donor" agents for evaluation as anticancer and antiviral agents.
AID217673Inhibitory concentration against VZV strain OKA in human embryonic lung (HEL) cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID138120Effect on the survival rate of mouse infected with herpes genitalis (HSV-2) administered intravaginally at 2% dosage twice in a day1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiherpetic activity of some 4-[(aryloxy)alkyl]pyrazoles.
AID85701In vitro antiviral activity in secondary cultures of rabbit kidney cells infected with HSV type 1 strain 3771984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Synthesis and antiviral activity of carbocyclic analogues of 2'-deoxyribofuranosides of 2-amino-6-substituted-purines and of 2-amino-6-substituted-8-azapurines.
AID99533In vitro growth inhibition of FdUrd resistant L5178Y-Resistant murine leukemia cells2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID167135Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-1 (McIntyre)1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID85418Compound was tested for antiviral activity against herpes simplex virus( HSV-2-196 strain in primary rabbit kidney cells1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID1079942Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source]
AID63766The minimum inhibitory concentration was measured on E6SM cells against Vaccinia virus1994Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID86207Proliferation of Hep-2 cells by propagation on day 4 by measuring optical density (absorbance) at 100 ug/mL1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID87206Binding affinity against HSV-1(KOS)1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID83023Tested for the inhibitory concentration required to reduce thymidine kinase deficient Varicella-Zoster virus (TK- VZV) strain 07/1 plaque formation by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID28488Catalytic rate constant was determined; ND: Not determined2003Journal of medicinal chemistry, Nov-06, Volume: 46, Issue:23
Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine.
AID139991Inhibition constant for influx competition with [6-3H]thymidine in mouse erythrocytes1989Journal of medicinal chemistry, Jun, Volume: 32, Issue:6
Synthesis and tumor uptake of 5-82Br- and 5-131I-labeled 5-halo-1-(2-fluoro-2-deoxy-beta-D-ribofuranosyl)uracils.
AID85420Compound was tested for antiviral activity against herpes simplex virus( HSV-2-lyons) strain in primary rabbit kidney cells1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID84605Concentration required to reduce the number of viral plaques in vivo cell monolayers of herpes simplex virus type 2.1989Journal of medicinal chemistry, Feb, Volume: 32, Issue:2
Synthesis and antiviral activity of phosphonoacetic and phosphonoformic acid esters of 5-bromo-2'-deoxyuridine and related pyrimidine nucleosides and acyclonucleosides.
AID167904Minimal inhibitory concentration against HSV-1 (McIntyre)-induced cytopathogenicity by 50% in rabbit kidney cell cultures1987Journal of medicinal chemistry, Feb, Volume: 30, Issue:2
5-Quinone derivatives of 2'-deoxyuridine 5'-phosphate: inhibition and inactivation of thymidylate synthase, antitumor cell, and antiviral studies.
AID63762The minimum inhibitory concentration was measured on E6SM cells against Herpes simplex virus type 2 (G strain)1994Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID99531In vitro growth inhibition of L5178Y-Parental murine leukemia cells by incorporation of [14C]Leu.2000Journal of medicinal chemistry, Nov-30, Volume: 43, Issue:24
5-Substituted N(4)-hydroxy-2'-deoxycytidines and their 5'-monophosphates: synthesis, conformation, interaction with tumor thymidylate synthase, and in vitro antitumor activity.
AID83024Tested for the inhibitory concentration required to reduce thymidine kinase deficient Varicella-Zoster virus (TK- VZV) strain YS/R plaque formation by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID87504Minimum inhibitory concentration required to reduce HSV-1 (KOS) strain-induced cytopathogenicity in primary rabbit kidney cell cultures1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID87319Relative phosphorylation rate against HSV-1(KOS)1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID112423Concentration required to reduce leukemia L1210 cell growth in mice1983Journal of medicinal chemistry, May, Volume: 26, Issue:5
Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID83022Tested for the inhibitory concentration required to reduce cytomegalovirus (CMV) strain Davis plaque formation by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID218134Minimum inhibitory concentration (MIC) required to reduce vaccinia virus induced cytopathogenicity in primary rabbit kidney cell cultures1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID1079946Presence of at least one case with successful reintroduction. [column 'REINT' in source]
AID66000Tested for the minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology in human embryonic skin muscle (E6SM) fibroblast cell cultures.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID1079941Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source]
AID217889Antiviral activity against HSV-2 (K979) in Vero cells1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID326136Antiviral activity against Herpes B virus E90-136 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID392536Antiviral activity against Vaccinia virus2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID87847Minimum inhibitory concentration causing 25% inhibition cytopathic effect induced by Herpes simplex virus-1 (Brand) in HEp-2 cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID84072Compound was evaluated for antiviral activity against HSV-1(strain KOS)1984Journal of medicinal chemistry, Mar, Volume: 27, Issue:3
Synthesis of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine and related analogues: potent and unusually selective antiviral activity of (E)-5-(3,3,3-trifluoro-1-propenyl)-2'-deoxyuridine against herpes simplex virus type 1.
AID324733Antiviral activity against TK+ Cowpox virus Delta crmA in HFF cells after 48 hrs by beta-galactosidase assay2007Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
AID1135595Antiviral activity against Vaccinia virus infected in primary rabbit kidney cells assessed as inhibition of virus-induced cytopathogenicity1978Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.
AID87824Minimum inhibitory concentration required to reduce HSV-2 (G) strain-induced cytopathogenicity in primary rabbit kidney cell cultures1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID1135807Antiviral activity against HSV1 CL101 infected in African green monkey Vero cells assessed as inhibition of plaque formation at 50 uM after 40 hrs relative to control1978Journal of medicinal chemistry, Nov, Volume: 21, Issue:11
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
AID1079933Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is
AID1135812Antimicrobial activity against Streptococcus faecium assessed as growth inhibition at 400 uM after 15 to 17 hrs by turbidity assay in presence of 4.53 nM folic acid1978Journal of medicinal chemistry, Nov, Volume: 21, Issue:11
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
AID165553Tested for its antimetabolic activity by measuring the concentration required for [Me-3H] dThd incorporation into host cell DNA by 50%1980Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition.
AID1135596Antiviral activity against Vaccinia virus infected in human skin fibroblasts primed with interferon and superinduced with cyclohexamide and actinomycin D assessed as inhibition of virus-induced cytopathogenicity1978Journal of medicinal chemistry, Feb, Volume: 21, Issue:2
5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.
AID409956Inhibition of mouse brain MAOB2008Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
AID517844Antiviral activity against HBV assessed as inhibition of viral DNA replication relative to control2010Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19
Antiviral activity of various 1-(2'-deoxy-β-D-lyxofuranosyl), 1-(2'-fluoro-β-D-xylofuranosyl), 1-(3'-fluoro-β-D-arabinofuranosyl), and 2'-fluoro-2',3'-didehydro-2',3'-dideoxyribose pyrimidine nucleoside analogues against duck hepatitis B virus (DHBV) and
AID1294505Cytotoxicity against human Ramos cells assessed as reduction in cell viability after 72 hrs by MTS assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
AID63619Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (HSV-1) strain McIntyre induced cytopathogenicity by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID1079935Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source]
AID625280Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1135472Antiviral activity against Herpes simplex virus 1 Sheely assessed as inhibition of virus-induced cytopathic effect at 37 degC after 72 hrs by two-fold dilution method1977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Antiviral activity of some beta-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses.
AID81193Inhibitory concentration required to inhibit cell growth by 50% in human embryonic lung (HEL) cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID87193Antiherpes activity was tested as percent of control of plaque-formation against HSV-1 (CL101) virus by 100 uM of the compound1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID63755Tested for the minimum inhibitory concentration required to reduce vesicular stomatitis virus(VSV) induced cytopathogenicity by 50%1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID1135817Retention time of the compound by liquid chromatography1978Journal of medicinal chemistry, Nov, Volume: 21, Issue:11
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
AID1079934Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source]
AID156531Concentration required to reduce TK-HSV-1 (B2006) induced cytopathogenicity by 50% in primary rabbit kidney (PRK) cells1981Journal of medicinal chemistry, Apr, Volume: 24, Issue:4
Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.
AID43637Antiherpes activity was tested as percent of control of plaque-formation against BVdUr virus by 100 uM of the compound1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID326127Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID1135815Competitive inhibition of HSV-1 pyrimidine deoxythymidine kinase using 2-[14C]deoxythymidine as substrate1978Journal of medicinal chemistry, Nov, Volume: 21, Issue:11
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
AID211066Michaelis-Menten constant (Km) against horse liver thymidine phosphorylase1980Journal of medicinal chemistry, Aug, Volume: 23, Issue:8
Thymidine phosphorylase. Substrate specificity for 5-substituted 2'-deoxyuridines.
AID625292Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID217421Proliferation of Vero cells by propagation on day 4 by measuring optical density (absorbance) at 330 ug/mL1987Journal of medicinal chemistry, Jul, Volume: 30, Issue:7
2'-Fluorinated arabinonucleosides of 5-(2-haloalkyl)uracil: synthesis and antiviral activity.
AID326135Antiviral activity against Herpes B virus 32425 infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs2007Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
AID1135811Antimicrobial activity against Streptococcus faecium assessed as growth inhibition at 400 uM after 15 to 17 hrs by turbidity assay in presence of 7 uM deoxythymidine1978Journal of medicinal chemistry, Nov, Volume: 21, Issue:11
Synthesis and biological activities of some uronic acids, uronates, uronamides, and urononitriles of pyrimidine nucleosides.
AID85386Inhibition of viral DNA synthesis in HSV-1 virus at the dose of 0.8 ug/mL.1983Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
Antiviral compounds. 1. Structure-activity relationship of some antiviral enediones derived from aldehydo sugars.
AID165554Tested for its antiviral activity in primary rabbit kidney (PRK) cell cultures inoculated with herpes simplex type 1 virus1980Journal of medicinal chemistry, Mar, Volume: 23, Issue:3
Synthesis of 5-[(methylthio)methyl]-2'-deoxyuridine, the corresponding sulfoxide and sulfone, and their 5'-phosphates: antiviral effects and thymidylate synthetase inhibition.
AID165526Concentration required to reduce Herpes simplex virus type 1 induced cytopathogenicity in primary rabbit kidney (PRK) cell cultures1983Journal of medicinal chemistry, May, Volume: 26, Issue:5
Nucleic acid related compounds. 40. Synthesis and biological activities of 5-alkynyluracil nucleosides.
AID217971Compound was tested for antiviral activity against Vaccinia virus in primary rabbit kidney cells1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID87507Evaluation of antiviral activity against Herpes simplex virus type 1 (HSV-1) strain KOS.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID85380Inhibitory concentration against HSV type 2 strain Lyons in human embryonic skin muscle (ESM) fibroblast cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID1079936Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source]
AID82551Tested for the cytotoxic concentration, required to reduce cell growth by 50% in human embryonic lung (HEL) cells.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID167138Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against HSV-2 (Lycons)1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID87511Minimum inhibitory concentration (MIC) required to reduce Herpes simplex virus (HSV-1) KOS strain induced cytopathogenicity in primary rabbit kidney cell cultures1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID30874Antiherpes activity was tested as percent of control of plaque-formation against ACG (Tr7) virus by 100 uM of the compound1985Journal of medicinal chemistry, Jul, Volume: 28, Issue:7
Synthesis and biological activities of 2-pyrimidinone nucleosides. 2. 5-Halo-2-pyrimidinone 2'-deoxyribonucleosides.
AID87821Antiviral activity expressed as minimum HSV-2 (Lyons) strain-induced cytopathogenicity in primary rabbit kidney cell cultures1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID222316Minimum inhibitory concentration (MIC) required to inhibit proliferation of human lymphoblast Raji1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID392504Antiviral activity against Cowpox virus2009Bioorganic & medicinal chemistry, Jan-15, Volume: 17, Issue:2
Unified QSAR approach to antimicrobials. 4. Multi-target QSAR modeling and comparative multi-distance study of the giant components of antiviral drug-drug complex networks.
AID84415Compound was tested for antiviral activity against herpes simplex virus (thymidine kinase deficient herpes simplex virus ( HSV-1 (B2006) in primary rabbit kidney cells1987Journal of medicinal chemistry, Aug, Volume: 30, Issue:8
Synthesis and biological activity of 5-(2,2-difluorovinyl)-2'-deoxyuridine.
AID303431Metabolic stability in mouse liver microsomes after 30 min2007Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
Synthesis and evaluation of cis-1-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-5-[(124)I]iodouracil: a new potential PET imaging agent for HSV1-tk expression.
AID161458Antiviral activity against VMW 1837 strain of thymidine kinase deficient (TK-) herpes simplex virus-1 in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID87828Evaluation of antiviral activity against Herpes simplex virus type 2 (HSV-2) strain Lyons1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID162825Kinetic inhibition constant against herpes simplex virus type I pyrimidine deoxyribonucleoside kinase was measured1980Journal of medicinal chemistry, Feb, Volume: 23, Issue:2
Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues.
AID82895Tested for the inhibitory concentration required to reduce TK+ Varicella-Zoster virus (TK+ VZV) strain OKA plaque formation by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID216247Minimum inhibitory concentration required to reduce vesicular stomatis virus-induced cytopathogenicity in primary rabbit kidney cell cultures1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine.
AID167150Minimum cytotoxic concentration causing toxic effects on uninfected cells in rabbit1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID517842Cytotoxicity against HuH7 cells2010Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19
Antiviral activity of various 1-(2'-deoxy-β-D-lyxofuranosyl), 1-(2'-fluoro-β-D-xylofuranosyl), 1-(3'-fluoro-β-D-arabinofuranosyl), and 2'-fluoro-2',3'-didehydro-2',3'-dideoxyribose pyrimidine nucleoside analogues against duck hepatitis B virus (DHBV) and
AID1079947Comments (NB not yet translated). [column 'COMMENTAIRES' in source]
AID625285Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID517843Antiviral activity against DHBV infected in duck hepatocytes assessed as inhibition of viral DNA replication relative to control2010Journal of medicinal chemistry, Oct-14, Volume: 53, Issue:19
Antiviral activity of various 1-(2'-deoxy-β-D-lyxofuranosyl), 1-(2'-fluoro-β-D-xylofuranosyl), 1-(3'-fluoro-β-D-arabinofuranosyl), and 2'-fluoro-2',3'-didehydro-2',3'-dideoxyribose pyrimidine nucleoside analogues against duck hepatitis B virus (DHBV) and
AID542166Antiviral activity against Vaccinia virus WR infected in HFF assessed as reduction of plaque formation after 3 days2009Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
Activities of certain 5-substituted 4'-thiopyrimidine nucleosides against orthopoxvirus infections.
AID217483Inhibitory concentration against VSV in human embryonic skin muscle (ESM) fibroblast cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID216388Concentration required to reduce cytopathogenicity of Vesicular stomatitis virus by 50% in primary rabbit kidney (PRK) cells1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID161454Antiviral activity against G strain of herpes simplex virus-2 in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID96829Inhibitory concentration required to reduce cell growth of Murine Leukemia L1210 cells1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Nucleic acid related compounds. 47. Synthesis and biological activities of pyrimidine and purine "acyclic" nucleoside analogues.
AID303432Metabolic stability in mouse serum after 6 hrs2007Journal of medicinal chemistry, Nov-29, Volume: 50, Issue:24
Synthesis and evaluation of cis-1-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-5-[(124)I]iodouracil: a new potential PET imaging agent for HSV1-tk expression.
AID138121Effect on the survival rate of mouse infected with herpes genitalis (HSV-2) administered intravaginally at 5% dosage twice in a day1981Journal of medicinal chemistry, Jun, Volume: 24, Issue:6
Synthesis and antiherpetic activity of some 4-[(aryloxy)alkyl]pyrazoles.
AID280941Cytotoxicity against mouse L1210/0 cells after 48 hrs2007Journal of medicinal chemistry, Apr-05, Volume: 50, Issue:7
Probing the anticancer activity of nucleoside analogues: a QSAR model approach using an internally consistent training set.
AID1079940Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source]
AID161455Antiviral activity against KOS strain of herpes simplex virus-1 in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID87974Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus(HSV) -1 (thymidine kinase deficient) in vero cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID87506Evaluation of antiviral activity against Herpes simplex virus type 1 (HSV-1) strain F1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID161457Antiviral activity against McIntyre strain of herpes simplex virus-1 in primary rabbit kidney cell cultures1989Journal of medicinal chemistry, Aug, Volume: 32, Issue:8
Synthesis and antiviral activity of the enantiomeric forms of carba-5-iodo-2'-deoxyuridine and carba-(E)-5-(2-bromovinyl)-2'-deoxyuridine.
AID84961Minimum inhibitory concentration against HSV-2.1985Journal of medicinal chemistry, Nov, Volume: 28, Issue:11
5-(Haloalkyl)-2'-deoxyuridines: a novel type of potent antiviral nucleoside analogue.
AID85374Inhibitory concentration against HSV type 1 strain Mc Intyre in human embryonic skin muscle (ESM) fibroblast cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID63746Tested for the minimum inhibitory concentration required to reduce herpes simplex virus type 1 (TK- / TK+ HSV-1) strain VMW-1837 induced cytopathogenicity by 50%.1995Journal of medicinal chemistry, Mar-03, Volume: 38, Issue:5
Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides.
AID63768The minimum inhibitory concentration was measured on E6SM cells for morphological alteration1994Journal of medicinal chemistry, Sep-16, Volume: 37, Issue:19
Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.
AID88114Minimum inhibitory concentration causing 25% inhibition of cytopathic effect induced by Herpes simplex virus(HSV) -2 (thymidine kinase deficient) in HEp-2 cells1988Journal of medicinal chemistry, Sep, Volume: 31, Issue:9
Phosphonoformate and phosphonoacetate derivatives of 5-substituted 2'-deoxyuridines: synthesis and antiviral activity.
AID324730Antiviral activity against Vaccinia virus in HFF cells after 1 hr by plaque reduction assay2007Antimicrobial agents and chemotherapy, May, Volume: 51, Issue:5
Selective phosphorylation of antiviral drugs by vaccinia virus thymidine kinase.
AID167139Minimum inhibitory concentration required to reduce virus induced cytopathogenicity in primary rabbit kidney cell cultures by 50% against Vaccinia virus1983Journal of medicinal chemistry, Apr, Volume: 26, Issue:4
Synthesis and antiviral activity of water-soluble esters of acyclovir [9-[(2-hydroxyethoxy)methyl]guanine].
AID1079945Animal toxicity known. [column 'TOXIC' in source]
AID588210Human drug-induced liver injury (DILI) modelling dataset from Ekins et al2010Drug metabolism and disposition: the biological fate of chemicals, Dec, Volume: 38, Issue:12
A predictive ligand-based Bayesian model for human drug-induced liver injury.
AID68278Inhibitory concentration required for morphologic alteration in normal cell in human embryonic skin muscle (ESM) fibroblast cell culture1993Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.
AID1294504Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 72 hrs by MTS assay2016Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9
L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
AID85382Growth inhibition against HSV-1 virus in BSCL cells at the dose of 0.8 ug/mL and 22h time of treatment.1983Journal of medicinal chemistry, Jan, Volume: 26, Issue:1
Antiviral compounds. 1. Structure-activity relationship of some antiviral enediones derived from aldehydo sugars.
AID93932Minimum inhibitory concentration (MIC) required to inhibit proliferation of murine leukemia L1210 (wild type)1985Journal of medicinal chemistry, May, Volume: 28, Issue:5
Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.
AID216539Evaluation of antiviral activity against Vesicular stomatitis virus.1986Journal of medicinal chemistry, Jul, Volume: 29, Issue:7
Synthesis and antitumor and antiviral properties of 5-halo- and 5-(trifluoromethyl)-2'-deoxyuridine 3',5'-cyclic monophosphates and neutral triesters.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347424RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347407qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347425Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1347411qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Mechanism Interrogation Plate v5.0 (MIPE) Libary2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1745854NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C. elegans viability qHTS2023Disease models & mechanisms, 03-01, Volume: 16, Issue:3
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
AID1745855NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay2023Disease models & mechanisms, 03-01, Volume: 16, Issue:3
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (2,776)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902164 (77.95)18.7374
1990's349 (12.57)18.2507
2000's175 (6.30)29.6817
2010's74 (2.67)24.3611
2020's14 (0.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 46.89

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index46.89 (24.57)
Research Supply Index8.01 (2.92)
Research Growth Index4.07 (4.65)
Search Engine Demand Index87.18 (26.88)
Search Engine Supply Index2.18 (0.95)

This Compound (46.89)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials111 (3.82%)5.53%
Reviews181 (6.23%)6.00%
Case Studies70 (2.41%)4.05%
Observational0 (0.00%)0.25%
Other2,543 (87.54%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Positron Emitter I-124-Iododeoxyuridine to Follow DNA Metabolism on Scans and in Tumor Samples in Advanced Breast Cancer: Comparison to 18-F-2-Fluoro-2-Deoxy-(D)-Glucose, as a Tracer for Glycolysis [NCT00109785]Phase 18 participants (Actual)Interventional1997-03-31Completed
Treatment Protocol for Patients With Standard Risk Acute Myelogenous Leukemia and Its Variants: Induction Using High-Dose Cytarabine, Mitoxantrone and Ethyol; Consolidation With Cytarabine and Idarubicin and Maintenance With 13 Cis Retinoic Acid and Alpha [NCT00003405]Phase 20 participants (Actual)Interventional1998-04-30Withdrawn(stopped due to No enrollment)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]