Proteins > Histone deacetylase 5
Page last updated: 2024-08-07 18:53:33

Histone deacetylase 5

A histone deacetylase 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UQL6]

Synonyms

HD5;
EC 3.5.1.98;
Antigen NY-CO-9

Research

Bioassay Publications (248)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.40)18.2507
2000's57 (22.98)29.6817
2010's140 (56.45)24.3611
2020's50 (20.16)2.80

Compounds (85)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
gamma-aminobutyric acidHomo sapiens (human)Ki8.190011
butyric acidHomo sapiens (human)IC502,000.000011
butyric acidHomo sapiens (human)Ki136.000011
celecoxibHomo sapiens (human)IC501.637011
ci 994Homo sapiens (human)IC5023.2175512
ci 994Homo sapiens (human)Ki0.095013
clioquinolHomo sapiens (human)IC5071.0857114
valproic acidHomo sapiens (human)IC502,808.750044
valproic acidHomo sapiens (human)Ki564.000011
ebselenHomo sapiens (human)IC503.400011
fluconazoleHomo sapiens (human)IC5040.000011
beta-thujaplicinHomo sapiens (human)Ki2.500011
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)IC500.833022
entinostatHomo sapiens (human)IC506.95282845
4-phenylbutyric acidHomo sapiens (human)IC502,000.000011
4-phenylbutyric acidHomo sapiens (human)Ki2.800011
pomiferinHomo sapiens (human)IC501.050011
pyroxamideHomo sapiens (human)IC505.100022
pyroxamideHomo sapiens (human)Ki4.750011
suberoyl bis-hydroxamic acidHomo sapiens (human)Ki9.500011
scriptaidHomo sapiens (human)IC500.430022
scriptaidHomo sapiens (human)Ki1.000011
4-phenylbutyric acid, sodium saltHomo sapiens (human)Ki6.340011
fenofibrateHomo sapiens (human)IC5075.000011
vorinostatHomo sapiens (human)IC504.0941196224
vorinostatHomo sapiens (human)Ki3.627855
benzohydroxamic acidHomo sapiens (human)IC5033.330011
acetylcysteineHomo sapiens (human)IC503,160.000011
camptothecinHomo sapiens (human)IC500.050011
bendamustineHomo sapiens (human)IC500.010011
ubenimexHomo sapiens (human)IC50550.000022
osajinHomo sapiens (human)IC506.530011
lapatinibHomo sapiens (human)IC50100.000011
n-hydroxy-2,2-diphenylacetamideHomo sapiens (human)IC5011.012055
trapoxin aHomo sapiens (human)IC500.004733
e-z cinnamic acidHomo sapiens (human)Ki0.008211
trichostatin aHomo sapiens (human)IC500.53323858
trichostatin aHomo sapiens (human)Ki1.286044
caffeic acidHomo sapiens (human)IC502,540.000011
caffeic acidHomo sapiens (human)Ki10.840011
curcuminHomo sapiens (human)IC50187.000011
chlorogenic acidHomo sapiens (human)IC50258.333333
chlorogenic acidHomo sapiens (human)Ki0.135011
zd 6474Homo sapiens (human)IC5010.000033
desmethylanethol trithioneHomo sapiens (human)IC500.450022
5-chloro-7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinolHomo sapiens (human)IC5025.195018
ex 527Homo sapiens (human)IC50100.000011
sodium butyrateHomo sapiens (human)IC50360.000033
sodium butyrateHomo sapiens (human)Ki365.000011
5'-o-caffeoylquinic acidHomo sapiens (human)IC50185.200022
harmineHomo sapiens (human)IC5010.000033
aureusidinHomo sapiens (human)IC5018.500011
romidepsinHomo sapiens (human)IC502.075255
romidepsinHomo sapiens (human)Ki0.550022
3',4'-dihydroxyauroneHomo sapiens (human)IC508.200011
psammaplin aHomo sapiens (human)IC500.027022
trichostatin cHomo sapiens (human)IC5023.630011
laq824Homo sapiens (human)IC500.056966
laq824Homo sapiens (human)Ki0.420022
indigo carmineHomo sapiens (human)IC50321.620022
tanespimycinHomo sapiens (human)IC501,000.000011
pd 404182Homo sapiens (human)IC500.110011
tubacinHomo sapiens (human)IC503.350044
tubacinHomo sapiens (human)Ki1.709822
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)IC500.014077
belinostatHomo sapiens (human)IC500.035755
belinostatHomo sapiens (human)Ki0.125033
sk-7041Homo sapiens (human)IC500.172011
panobinostatHomo sapiens (human)IC501.19711523
panobinostatHomo sapiens (human)Ki0.054444
hdac-42Homo sapiens (human)IC500.016011
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)IC507.6678624
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamideHomo sapiens (human)Ki0.167213
n1-(2-aminophenyl)-n7-phenylheptanediamideHomo sapiens (human)IC50129.000022
bml 210Homo sapiens (human)IC5091.400055
n-(2-amino-5-fluorobenzyl)-4-(n-(pyridine-3-acrylyl)aminomethyl)benzamideHomo sapiens (human)IC501.060033
givinostatHomo sapiens (human)IC500.532011
givinostatHomo sapiens (human)Ki0.600022
mocetinostatHomo sapiens (human)IC507.3350514
methyl 3,5-di-o-caffeoyl quinateHomo sapiens (human)IC506.290022
r 306465Homo sapiens (human)IC500.006622
quisinostatHomo sapiens (human)IC500.004944
quisinostatHomo sapiens (human)Ki0.003222
abexinostatHomo sapiens (human)IC500.048011
chidamideHomo sapiens (human)IC505.789032
hc toxinHomo sapiens (human)IC500.430011
azumamide eHomo sapiens (human)IC5010.000011
cnf 2024Homo sapiens (human)IC501.000022
pci 34051Homo sapiens (human)IC5055.000022
cudc 101Homo sapiens (human)IC500.156474
largazoleHomo sapiens (human)IC5010.000011
N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl esterHomo sapiens (human)IC500.050011
trichostatin rkHomo sapiens (human)IC50100.000011
jq1 compoundHomo sapiens (human)IC500.291011
tubastatin aHomo sapiens (human)IC5020.93041322
pracinostatHomo sapiens (human)IC502.619522
pracinostatHomo sapiens (human)Ki0.021011
acy-1215Homo sapiens (human)IC504.666799
cudc-907Homo sapiens (human)IC500.468455
rg2833Homo sapiens (human)IC50180.000011
4-((1-butyl-3-phenylureido)methyl)-n-hydroxybenzamideHomo sapiens (human)IC509.160044
osimertinibHomo sapiens (human)IC501.000011
santacruzamate aHomo sapiens (human)IC505.000011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ci 994Homo sapiens (human)EC503.810011
entinostatHomo sapiens (human)EC501.000011
imatinibHomo sapiens (human)EC50100.000011
vorinostatHomo sapiens (human)EC503.430066
belinostatHomo sapiens (human)EC500.030011
kd 5170Homo sapiens (human)EC500.045011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamideHomo sapiens (human)AC502.100011
pyroxamideHomo sapiens (human)AC507.900011
vorinostatHomo sapiens (human)AC503.100011
vorinostatHomo sapiens (human)INH0.188522
vorinostatHomo sapiens (human)Inhibition0.080011
trapoxin aHomo sapiens (human)AC500.010011
trichostatin aHomo sapiens (human)AC500.400011
trichostatin aHomo sapiens (human)Inhibition0.003511
romidepsinHomo sapiens (human)INH0.024411
largazoleHomo sapiens (human)INH0.572011

Enables

This protein enables 12 target(s):

TargetCategoryDefinition
RNA polymerase II cis-regulatory region sequence-specific DNA bindingmolecular functionBinding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]
transcription corepressor bindingmolecular functionBinding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. [GOC:krc]
chromatin bindingmolecular functionBinding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
histone deacetylase activitymolecular functionCatalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. [PMID:9893272, RHEA:58196]
protein kinase C bindingmolecular functionBinding to protein kinase C. [GOC:jl]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
protein lysine deacetylase activitymolecular functionCatalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]. [PMID:27296530, RHEA:58108]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]
histone deacetylase bindingmolecular functionBinding to histone deacetylase. [GOC:jl]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
RNA polymerase II-specific DNA-binding transcription factor bindingmolecular functionBinding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw]
DNA-binding transcription factor bindingmolecular functionBinding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]

Located In

This protein is located in 6 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasmcellular componentThe contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
Golgi apparatuscellular componentA membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nuclear speckcellular componentA discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
histone deacetylase complexcellular componentA protein complex that possesses histone deacetylase activity. [GOC:mah]

Involved In

This protein is involved in 18 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
inflammatory responsebiological processThe immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732]
response to xenobiotic stimulusbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc]
regulation of myotube differentiationbiological processAny process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:dph, GOC:tb]
negative regulation of myotube differentiationbiological processAny process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse. [GOC:dph, GOC:tb]
response to activitybiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus. [GOC:mtg_muscle]
neuron differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah]
B cell differentiationbiological processThe process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [GO_REF:0000022, GOC:mah]
cellular response to insulin stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
B cell activationbiological processThe change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [GOC:mgi_curators, ISBN:0781735149]
response to cocainebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:ef, GOC:jl]
regulation of protein bindingbiological processAny process that modulates the frequency, rate or extent of protein binding. [GOC:go_curators]
negative regulation of gene expression, epigeneticbiological processAn epigenetic process that silences gene expression at specific genomic regions through chromatin remodeling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the cytosine DNA methylation. [PMID:22243696]
negative regulation of DNA-templated transcriptionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of transcription by RNA polymerase IIbiological processAny process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
positive regulation of DNA-binding transcription factor activitybiological processAny process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription. [GOC:ai]
cellular response to lipopolysaccharidebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
negative regulation of cell migration involved in sprouting angiogenesisbiological processAny process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis. [GOC:BHF, GOC:dph, GOC:rl, GOC:tb]