Voltage-dependent T-type calcium channel subunit alpha-1G

A voltage-dependent T-type calcium channel subunit alpha-1G that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43497]

Synonyms

Cav3.1c;
NBR13;
Voltage-gated calcium channel subunit alpha Cav3.1

Research

Bioassay Publications (29)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (37.93)	29.6817
2010's	16 (55.17)	24.3611
2020's	2 (6.90)	2.80

Compounds (12)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tacrine	Homo sapiens (human)	IC50	17.0000	1	1
nimodipine	Homo sapiens (human)	IC50	14.0000	1	1
mibefradil	Homo sapiens (human)	IC50	1.0476	23	23
vexibinol	Homo sapiens (human)	IC50	1.0000	1	1
8-prenylnaringenin	Homo sapiens (human)	IC50	1.0000	1	1
2-phenoxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]acetamide	Homo sapiens (human)	IC50	2.5000	1	1
(S)-4',5,7-Trihydroxy-6-prenylflavanone	Homo sapiens (human)	IC50	1.0000	1	1
ith 4012	Homo sapiens (human)	IC50	20.0000	1	1
kys 05090	Homo sapiens (human)	IC50	0.1287	5	5
ulixacaltamide	Homo sapiens (human)	IC50	0.0370	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pimozide	Homo sapiens (human)	Kd	0.0400	1	1
flunarizine	Homo sapiens (human)	Kd	0.5300	2	2

Enables

This protein enables 5 target(s):

Target	Category	Definition
low voltage-gated calcium channel activity	molecular function	Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]
voltage-gated calcium channel activity involved in AV node cell action potential	molecular function	Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
voltage-gated calcium channel activity involved SA node cell action potential	molecular function	Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
scaffold protein binding	molecular function	Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein]
high voltage-gated calcium channel activity	molecular function	Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
voltage-gated calcium channel complex	cellular component	A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah]

Involved In

This protein is involved in 16 target(s):

Target	Category	Definition
sinoatrial node development	biological process	The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. [GOC:mtg_heart]
chemical synaptic transmission	biological process	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
response to nickel cation	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus. [GOC:sm]
regulation of membrane potential	biological process	Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
regulation of atrial cardiac muscle cell membrane depolarization	biological process	Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte. [GOC:dph, GOC:tb]
calcium ion import	biological process	The directed movement of calcium ions into a cell or organelle. [GOC:mah]
calcium ion transmembrane transport	biological process	A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
cardiac muscle cell action potential involved in contraction	biological process	An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
SA node cell action potential	biological process	An action potential that occurs in a sinoatrial node cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
AV node cell action potential	biological process	An action potential that occurs in an atrioventricular node cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
SA node cell to atrial cardiac muscle cell signaling	biological process	Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
AV node cell to bundle of His cell signaling	biological process	Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during AV node cell action potential	biological process	The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
membrane depolarization during SA node cell action potential	biological process	The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
regulation of heart rate by cardiac conduction	biological process	A cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
calcium ion import across plasma membrane	biological process	The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos]

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