Proteins > Voltage-dependent T-type calcium channel subunit alpha-1G
Page last updated: 2024-08-07 15:25:03
Voltage-dependent T-type calcium channel subunit alpha-1G
A voltage-dependent T-type calcium channel subunit alpha-1G that is encoded in the genome of human. [PRO:WCB, UniProtKB:O43497]
Synonyms
Cav3.1c;
NBR13;
Voltage-gated calcium channel subunit alpha Cav3.1
Research
Bioassay Publications (29)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (37.93) | 29.6817 |
| 2010's | 16 (55.17) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
Compounds (12)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| pimozide | Homo sapiens (human) | Kd | 0.0400 | 1 | 1 |
| flunarizine | Homo sapiens (human) | Kd | 0.5300 | 2 | 2 |
Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers.Bioorganic & medicinal chemistry, , 06-01, Volume: 28, Issue:11, 2020
Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies.Journal of medicinal chemistry, , 12-14, Volume: 60, Issue:23, 2017
In vitro synergistic anticancer activity of the combination of T-type calcium channel blocker and chemotherapeutic agent in A549 cells.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 26, Issue:3, 2016
Inhibition of cellular proliferation and induction of apoptosis in human lung adenocarcinoma A549 cells by T-type calcium channel antagonist.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 24, Issue:6, 2014
Synthesis and biological evaluation of 1-(2-hydroxy-3-phenyloxypropyl)piperazine derivatives as T-type calcium channel blockers.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 23, Issue:6, 2013
In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Synthesis and pharmacological evaluation of 1-alkyl-N-[2-ethyl-2-(4-fluorophenyl)butyl]piperidine-4-carboxamide derivatives as novel antihypertensive agents.Bioorganic & medicinal chemistry, , Sep-15, Volume: 19, Issue:18, 2011
Synthesis and biological evaluation of oxazole derivatives as T-type calcium channel blockers.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 20, Issue:14, 2010
Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers.Bioorganic & medicinal chemistry letters, , May-01, Volume: 20, Issue:9, 2010
Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity.Bioorganic & medicinal chemistry, , Aug-15, Volume: 18, Issue:16, 2010
Synthesis and evaluation of alpha,alpha'-disubstituted phenylacetate derivatives for T-type calcium channel blockers.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Novel T-type calcium channel blockers: dioxoquinazoline carboxamide derivatives.Bioorganic & medicinal chemistry, , Jan-01, Volume: 15, Issue:1, 2007
3D pharmacophore based virtual screening of T-type calcium channel blockers.Bioorganic & medicinal chemistry, , Jan-15, Volume: 15, Issue:2, 2007
Discovery of potent T-type calcium channel blocker.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 17, Issue:21, 2007
Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 17, Issue:2, 2007
Synthesis and biological evaluation of novel T-type calcium channel blockers.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 17, Issue:2, 2007
Lead discovery and optimization of T-type calcium channel blockers.Bioorganic & medicinal chemistry, , Feb-01, Volume: 15, Issue:3, 2007
Morpholin-2-one derivatives as novel selective T-type Ca2+ channel blockers.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 16, Issue:19, 2006
Synthesis and biological activity of 3,4-dihydroquinazolines for selective T-type Ca2+ channel blockers.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers.Bioorganic & medicinal chemistry letters, , Jul-05, Volume: 14, Issue:13, 2004
Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity.Bioorganic & medicinal chemistry, , Aug-15, Volume: 18, Issue:16, 2010
Synthesis and cytotoxic effects of 2-thio-3,4-dihydroquinazoline derivatives as novel T-type calcium channel blockers.Bioorganic & medicinal chemistry, , 06-01, Volume: 28, Issue:11, 2020
In vitro cytotoxicity on human ovarian cancer cells by T-type calcium channel blockers.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 23, Issue:24, 2013
3D QSAR studies on 3,4-dihydroquinazolines as T-type calcium channel blocker by comparative molecular similarity indices analysis (CoMSIA).Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 20, Issue:1, 2010
T-type Ca2+ channel blockers suppress the growth of human cancer cells.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Discovery of potent T-type calcium channel blocker.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 17, Issue:21, 2007
Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers.Journal of medicinal chemistry, , Sep-22, Volume: 59, Issue:18, 2016
Structure-Activity Relationship, Drug Metabolism and Pharmacokinetics Properties Optimization, and in Vivo Studies of New Brain Penetrant Triple T-Type Calcium Channel Blockers.Journal of medicinal chemistry, , 12-08, Volume: 59, Issue:23, 2016
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| low voltage-gated calcium channel activity | molecular function | Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099] |
| voltage-gated calcium channel activity involved in AV node cell action potential | molecular function | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| voltage-gated calcium channel activity involved SA node cell action potential | molecular function | Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| scaffold protein binding | molecular function | Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein] |
| high voltage-gated calcium channel activity | molecular function | Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| synapse | cellular component | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| voltage-gated calcium channel complex | cellular component | A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah] |
Involved In
This protein is involved in 16 target(s):
| Target | Category | Definition |
|---|
| sinoatrial node development | biological process | The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node. [GOC:mtg_heart] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |
| response to nickel cation | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus. [GOC:sm] |
| regulation of membrane potential | biological process | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] |
| regulation of atrial cardiac muscle cell membrane depolarization | biological process | Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in an atrial cardiomyocyte. [GOC:dph, GOC:tb] |
| calcium ion import | biological process | The directed movement of calcium ions into a cell or organelle. [GOC:mah] |
| calcium ion transmembrane transport | biological process | A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah] |
| cardiac muscle cell action potential involved in contraction | biological process | An action potential that occurs in a cardiac muscle cell and is involved in its contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| SA node cell action potential | biological process | An action potential that occurs in a sinoatrial node cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| AV node cell action potential | biological process | An action potential that occurs in an atrioventricular node cardiac muscle cell. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| SA node cell to atrial cardiac muscle cell signaling | biological process | Any process that mediates the transfer of information from an SA node cardiomyocyte to an atrial cardiomyocyte. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| AV node cell to bundle of His cell signaling | biological process | Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| membrane depolarization during AV node cell action potential | biological process | The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| membrane depolarization during SA node cell action potential | biological process | The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| regulation of heart rate by cardiac conduction | biological process | A cardiac conduction process that modulates the frequency or rate of heart contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] |
| calcium ion import across plasma membrane | biological process | The directed movement of calcium ions from outside of a cell, across the plasma membrane and into the cytosol. [GOC:dos] |