Proteins > Carbonic anhydrase 5B, mitochondrial
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Carbonic anhydrase 5B, mitochondrial
A carbonic anhydrase 5B, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y2D0]
Synonyms
EC 4.2.1.1;
Carbonate dehydratase VB;
Carbonic anhydrase VB;
CA-VB
Research
Bioassay Publications (77)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (2.60) | 18.7374 |
| 1990's | 2 (2.60) | 18.2507 |
| 2000's | 35 (45.45) | 29.6817 |
| 2010's | 30 (38.96) | 24.3611 |
| 2020's | 8 (10.39) | 2.80 |
Compounds (136)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 4-hydroxybenzoic acid | Homo sapiens (human) | Ki | 252.3894 | 3 | 16 |
| hydrobromic acid | Homo sapiens (human) | Ki | 50,000.0000 | 2 | 2 |
| cadaverine | Homo sapiens (human) | Ki | 0.5400 | 1 | 1 |
| catechol | Homo sapiens (human) | Ki | 400.6786 | 3 | 14 |
| hydrochloric acid | Homo sapiens (human) | Ki | 78,000.0780 | 2 | 2 |
| coumarin | Homo sapiens (human) | Ki | 102.6000 | 2 | 2 |
| salicylic acid | Homo sapiens (human) | Ki | 186.5214 | 2 | 14 |
| gallic acid | Homo sapiens (human) | Ki | 9.9700 | 1 | 1 |
| hydrogen sulfide | Homo sapiens (human) | Ki | 10.0000 | 2 | 2 |
| 4-aminophenol | Homo sapiens (human) | Ki | 525.2214 | 2 | 14 |
| cyanic acid | Homo sapiens (human) | Ki | 20.0000 | 2 | 2 |
| carbonic acid | Homo sapiens (human) | Ki | 88,500.0000 | 2 | 4 |
| hydrogen cyanide | Homo sapiens (human) | Ki | 7.5000 | 2 | 2 |
| thiocyanic acid | Homo sapiens (human) | Ki | 740.0000 | 2 | 2 |
| hydroquinone | Homo sapiens (human) | Ki | 117.2850 | 2 | 14 |
| nitric acid | Homo sapiens (human) | Ki | 8,000.0080 | 2 | 2 |
| phenol | Homo sapiens (human) | Ki | 285.1500 | 5 | 16 |
| sulfurous acid | Homo sapiens (human) | Ki | 65,000.0000 | 2 | 2 |
| spermidine | Homo sapiens (human) | Ki | 1.4400 | 1 | 1 |
| spermine | Homo sapiens (human) | Ki | 0.8300 | 1 | 1 |
| sulfuric acid | Homo sapiens (human) | Ki | 340,000.3400 | 2 | 2 |
| catechin | Homo sapiens (human) | Ki | 4.0200 | 1 | 1 |
| acetaminophen | Homo sapiens (human) | Ki | 170.1154 | 2 | 13 |
| acetazolamide | Homo sapiens (human) | IC50 | 0.2300 | 2 | 2 |
| acetazolamide | Homo sapiens (human) | Ki | 7.3963 | 44 | 89 |
| bumetanide | Homo sapiens (human) | Ki | 18.3242 | 1 | 12 |
| celecoxib | Homo sapiens (human) | Ki | 0.0930 | 2 | 2 |
| chlorthalidone | Homo sapiens (human) | Ki | 1.2963 | 2 | 14 |
| coumaphos | Homo sapiens (human) | Ki | 3.4100 | 1 | 1 |
| dichlorphenamide | Homo sapiens (human) | Ki | 26.9369 | 10 | 34 |
| ethoxzolamide | Homo sapiens (human) | Ki | 8.0228 | 12 | 25 |
| furosemide | Homo sapiens (human) | Ki | 14.5855 | 2 | 14 |
| hydrochlorothiazide | Homo sapiens (human) | Ki | 18.6042 | 1 | 12 |
| hydroflumethiazide | Homo sapiens (human) | Ki | 20.3203 | 1 | 12 |
| indapamide | Homo sapiens (human) | Ki | 18.7829 | 2 | 14 |
| mafenide | Homo sapiens (human) | Ki | 13.0925 | 2 | 4 |
| methazolamide | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| methazolamide | Homo sapiens (human) | Ki | 8.6306 | 11 | 24 |
| metolazone | Homo sapiens (human) | Ki | 22.0639 | 1 | 12 |
| resorcinol | Homo sapiens (human) | Ki | 278.2214 | 2 | 14 |
| resveratrol | Homo sapiens (human) | Ki | 3.2400 | 1 | 1 |
| saccharin | Homo sapiens (human) | Ki | 7.2100 | 1 | 1 |
| imatinib | Homo sapiens (human) | Ki | 17.0050 | 1 | 1 |
| sulfanilamide | Homo sapiens (human) | Ki | 8.6380 | 3 | 5 |
| sulpiride | Homo sapiens (human) | Ki | 0.0180 | 1 | 1 |
| sulthiame | Homo sapiens (human) | Ki | 52.8233 | 1 | 12 |
| trichlormethiazide | Homo sapiens (human) | Ki | 43.7598 | 2 | 26 |
| trientine | Homo sapiens (human) | Ki | 49.0000 | 1 | 1 |
| wb 4101 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| zonisamide | Homo sapiens (human) | IC50 | 1.8600 | 1 | 1 |
| zonisamide | Homo sapiens (human) | Ki | 436.8304 | 7 | 19 |
| sulfamic acid | Homo sapiens (human) | Ki | 60.0001 | 2 | 2 |
| carbostyril | Homo sapiens (human) | Ki | 0.7500 | 2 | 2 |
| 4-toluenesulfonamide | Homo sapiens (human) | Ki | 2.4700 | 2 | 4 |
| quinethazone | Homo sapiens (human) | Ki | 18.1300 | 1 | 2 |
| benzenearsonic acid | Homo sapiens (human) | Ki | 7,400.0000 | 1 | 1 |
| benzenesulfonamide | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| diethylenetriamine | Homo sapiens (human) | Ki | 11.0000 | 1 | 1 |
| carzenide | Homo sapiens (human) | Ki | 1.4758 | 2 | 4 |
| sodium carbonate | Homo sapiens (human) | Ki | 95,000.0000 | 1 | 1 |
| syringic acid | Homo sapiens (human) | Ki | 35.4000 | 1 | 1 |
| herniarin | Homo sapiens (human) | Ki | 500.0000 | 1 | 1 |
| coumarin-3-carboxylic acid | Homo sapiens (human) | Ki | 34.3000 | 1 | 1 |
| 4-cyanophenol | Homo sapiens (human) | Ki | 242.2720 | 2 | 14 |
| hydrofluoric acid | Homo sapiens (human) | Ki | 241,000.0000 | 2 | 2 |
| n-(1-naphthyl)ethylenediamine | Homo sapiens (human) | Ki | 0.0610 | 1 | 1 |
| 1,6-diaminohexane | Homo sapiens (human) | Ki | 0.5800 | 1 | 1 |
| benzolamide | Homo sapiens (human) | Ki | 17.5304 | 3 | 8 |
| phosphoric acid, trisodium salt | Homo sapiens (human) | Ki | 6,870.0000 | 1 | 1 |
| nitrous acid | Homo sapiens (human) | Ki | 16,000.0000 | 2 | 2 |
| hydrazoic acid | Homo sapiens (human) | Ki | 150.0002 | 2 | 2 |
| hydroiodic acid | Homo sapiens (human) | Ki | 12,500.0125 | 2 | 2 |
| 7-ethoxycoumarin | Homo sapiens (human) | Ki | 9.0000 | 1 | 1 |
| dobutamine | Homo sapiens (human) | Ki | 0.8900 | 1 | 1 |
| foscarnet sodium | Homo sapiens (human) | Ki | 26,750.0000 | 2 | 2 |
| 4-chlorobenzenesulfonamide | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| benzeneboronic acid | Homo sapiens (human) | Ki | 1,516.6682 | 3 | 3 |
| 4-amino-6-chloro-1,3-benzenedisulfonamide | Homo sapiens (human) | Ki | 4.1662 | 2 | 4 |
| brinzolamide | Homo sapiens (human) | Ki | 0.0290 | 5 | 7 |
| 2,4-disulfamyl-5-trifluoromethylaniline | Homo sapiens (human) | Ki | 5.6457 | 2 | 4 |
| methanesulfonamide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 2-aminobenzenesulfonamide | Homo sapiens (human) | Ki | 8.6788 | 2 | 4 |
| 3,7-diazanonane-1,9-diamine | Homo sapiens (human) | Ki | 59.0000 | 1 | 1 |
| sulfamide | Homo sapiens (human) | Ki | 308.0003 | 3 | 3 |
| 5-amino-1,3,4-thiadiazole-2-sulfonamide | Homo sapiens (human) | Ki | 1.7620 | 3 | 5 |
| valdecoxib | Homo sapiens (human) | Ki | 0.0880 | 1 | 1 |
| 1-naphthylacetylspermine | Homo sapiens (human) | Ki | 1.0500 | 1 | 1 |
| chlorzolamide | Homo sapiens (human) | Ki | 0.0288 | 2 | 4 |
| 4-(2-aminoethyl)benzenesulfonamide | Homo sapiens (human) | Ki | 15.1150 | 2 | 4 |
| n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide | Homo sapiens (human) | Ki | 0.0350 | 2 | 4 |
| lacosamide | Homo sapiens (human) | Ki | 0.3410 | 1 | 1 |
| bortezomib | Homo sapiens (human) | Ki | 6.8300 | 1 | 1 |
| resveratrol | Homo sapiens (human) | Ki | 4.6400 | 1 | 1 |
| rwj 37947 | Homo sapiens (human) | Ki | 0.0360 | 1 | 1 |
| ferulic acid | Homo sapiens (human) | Ki | 10.5000 | 1 | 1 |
| bay 57-1293 | Homo sapiens (human) | Ki | 0.3890 | 1 | 1 |
| sodium bicarbonate | Homo sapiens (human) | Ki | 82,000.0000 | 1 | 1 |
| hydroxyphenethylferulate | Homo sapiens (human) | Ki | 0.6700 | 1 | 1 |
| 2-hydroxycinnamic acid | Homo sapiens (human) | Ki | 578.0000 | 1 | 1 |
| trans-4-coumaric acid | Homo sapiens (human) | Ki | 7.7600 | 1 | 1 |
| s 1033 | Homo sapiens (human) | Ki | 14.9200 | 1 | 1 |
| caffeic acid | Homo sapiens (human) | Ki | 9.0800 | 1 | 1 |
| 7-methoxy-2-oxo-1-benzopyran-3-carboxylic acid ethyl ester | Homo sapiens (human) | Ki | 500.0000 | 1 | 1 |
| formic acid, sodium salt | Homo sapiens (human) | Ki | 9,970.0000 | 1 | 1 |
| 4-azidosulfanilamide | Homo sapiens (human) | Ki | 0.0558 | 1 | 1 |
| sitagliptin | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | Ki | 11.9000 | 1 | 1 |
| ellagic acid | Homo sapiens (human) | Ki | 12.7000 | 1 | 1 |
| dorzolamide | Homo sapiens (human) | Ki | 41.4474 | 7 | 20 |
| topiramate | Homo sapiens (human) | Ki | 22.2735 | 15 | 37 |
| irosustat | Homo sapiens (human) | Ki | 54.4790 | 2 | 13 |
| 3-cyano-7-hydroxycoumarin | Homo sapiens (human) | Ki | 48.2209 | 1 | 11 |
| famotidine | Homo sapiens (human) | Ki | 5.3282 | 1 | 1 |
| 6-hydroxybenzothiazide-2-sulfonamide | Homo sapiens (human) | Ki | 0.0415 | 2 | 4 |
Drugs with Activation Measurements
Drugs with Other Measurements
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
New chemotypes acting as isozyme-selective carbonic anhydrase inhibitors with low affinity for the offtarget cytosolic isoform II.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Deciphering the mechanism of carbonic anhydrase inhibition with coumarins and thiocoumarins.Journal of medicinal chemistry, , Jan-14, Volume: 53, Issue:1, 2010
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 17, Issue:5, 2007
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , Mar-15, Volume: 21, Issue:6, 2013
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Discovery of a Potent and Highly Selective Dipeptidyl Peptidase IV and Carbonic Anhydrase Inhibitor as "Antidiabesity" Agents Based on Repurposing and Morphing of WB-4101.Journal of medicinal chemistry, , 10-27, Volume: 65, Issue:20, 2022
Mechanisms of the Antiproliferative and Antitumor Activity of Novel Telomerase-Carbonic Anhydrase Dual-Hybrid Inhibitors.Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.Journal of medicinal chemistry, , 02-11, Volume: 64, Issue:3, 2021
Azidothymidine "Clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors.Journal of medicinal chemistry, , 07-09, Volume: 63, Issue:13, 2020
Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy.Journal of medicinal chemistry, , 05-28, Volume: 63, Issue:10, 2020
Halogenated and di-substituted benzenesulfonamides as selective inhibitors of carbonic anhydrase isoforms.European journal of medicinal chemistry, , Jan-01, Volume: 185, 2020
Glycomimetic Based Approach toward Selective Carbonic Anhydrase Inhibitors.ACS medicinal chemistry letters, , May-14, Volume: 11, Issue:5, 2020
Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity.European journal of medicinal chemistry, , Sep-05, Volume: 157, 2018
Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Famotidine, an Antiulcer Agent, Strongly Inhibits ACS medicinal chemistry letters, , Oct-11, Volume: 9, Issue:10, 2018
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Lead Development of Thiazolylsulfonamides with Carbonic Anhydrase Inhibitory Action.Journal of medicinal chemistry, , 04-13, Volume: 60, Issue:7, 2017
Phosphate Chemical Probes Designed for Location Specific Inhibition of Intracellular Carbonic Anhydrases.Journal of medicinal chemistry, , Sep-24, Volume: 58, Issue:18, 2015
Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX.Journal of medicinal chemistry, , Nov-26, Volume: 57, Issue:22, 2014
Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 28, Issue:2, 2013
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry, , May-15, Volume: 19, Issue:10, 2011
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 21, Issue:18, 2011
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Inhibition of mammalian isoforms I-XIV with a series of natural product polyphenols and phenolic acids.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.Journal of medicinal chemistry, , Apr-23, Volume: 52, Issue:8, 2009
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
The protein tyrosine kinase inhibitors imatinib and nilotinib strongly inhibit several mammalian alpha-carbonic anhydrase isoforms.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Carbonic anhydrase inhibitors: thioxolone versus sulfonamides for obtaining isozyme-selective inhibitors?Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Jan-25, Volume: 50, Issue:2, 2007
Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 17, Issue:13, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 15, Issue:15, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Acetazolamide-like carbonic anhydrase inhibitors with topical ocular hypotensive activity.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
N-Substituted sulfonamide carbonic anhydrase inhibitors with topical effects on intraocular pressure.Journal of medicinal chemistry, , Volume: 29, Issue:8, 1986
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.Journal of medicinal chemistry, , Nov-26, Volume: 55, Issue:22, 2012
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.Journal of enzyme inhibition and medicinal chemistry, , Volume: 29, Issue:4, 2014
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
Polyamines inhibit carbonic anhydrases by anchoring to the zinc-coordinated water molecule.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Benzimidazole design, synthesis, and docking to build selective carbonic anhydrase VA inhibitors.Bioorganic & medicinal chemistry, , 02-01, Volume: 26, Issue:3, 2018
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 19, Issue:5, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: interactions of phenols with the 12 catalytically active mammalian isoforms (CA I-XIV).Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 18, Issue:5, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Synthesis and physicochemical properties of thiadiazolo[3,2-a]pyrimidinesulfonamides and thiadiazolo[3,2-a]triazinesulfonamides as candidates for topically effective carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Volume: 30, Issue:11, 1987
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.Bioorganic & medicinal chemistry, , Feb-01, Volume: 17, Issue:3, 2009
Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference.Journal of medicinal chemistry, , Jan-22, Volume: 52, Issue:2, 2009
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Substituted thieno[2,3-b]thiophenes and related congeners: Synthesis, β-glucuronidase inhibition activity, crystal structure, and POM analyses.Bioorganic & medicinal chemistry, , Dec-01, Volume: 22, Issue:23, 2014
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?Chemical biology & drug design, , Volume: 74, Issue:3, 2009
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 18, Issue:16, 2008
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 17, Issue:17, 2007
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different.Bioorganic & medicinal chemistry, , Nov-01, Volume: 15, Issue:21, 2007
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 17, Issue:5, 2007
Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different.Bioorganic & medicinal chemistry, , Nov-01, Volume: 15, Issue:21, 2007
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Sildenafil is a strong activator of mammalian carbonic anhydrase isoforms I-XIV.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 17, Issue:5, 2007
Binding site comparison for coumarin inhibitors and amine/amino acid activators of human carbonic anhydrases.European journal of medicinal chemistry, , Dec-15, Volume: 226, 2021
Carbonic anhydrase activators: kinetic and X-ray crystallographic study for the interaction of D- and L-tryptophan with the mammalian isoforms I-XIV.Bioorganic & medicinal chemistry, , Sep-15, Volume: 16, Issue:18, 2008
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 17, Issue:5, 2007
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 17, Issue:8, 2007
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Bortezomib inhibits mammalian carbonic anhydrases.Bioorganic & medicinal chemistry, , 10-01, Volume: 25, Issue:19, 2017
Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different.Bioorganic & medicinal chemistry, , Nov-01, Volume: 15, Issue:21, 2007
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different.Bioorganic & medicinal chemistry, , Nov-01, Volume: 15, Issue:21, 2007
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet.Bioorganic & medicinal chemistry letters, , Dec-06, Volume: 14, Issue:23, 2004
Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 18, Issue:8, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.ACS medicinal chemistry letters, , May-10, Volume: 9, Issue:5, 2018
(R)-/(S)-10-camphorsulfonyl-substituted aromatic/heterocyclic sulfonamides selectively inhibit mitochondrial over cytosolic carbonic anhydrases.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
The coumarin-binding site in carbonic anhydrase accommodates structurally diverse inhibitors: the antiepileptic lacosamide as an example and lead molecule for novel classes of carbonic anhydrase inhibitors.Journal of medicinal chemistry, , Jan-28, Volume: 53, Issue:2, 2010
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12, 2010
Carbonic anhydrase inhibitors. Identification of selective inhibitors of the human mitochondrial isozymes VA and VB over the cytosolic isozymes I and II from a natural product-based phenolic library.Bioorganic & medicinal chemistry, , Jan-01, Volume: 18, Issue:1, 2010
Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 18, Issue:15, 2008
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 18, Issue:16, 2008
Carbonic anhydrase inhibitors: 2-substituted-1,3,4-thiadiazole-5-sulfamides act as powerful and selective inhibitors of the mitochondrial isozymes VA and VB over the cytosolic and membrane-associated carbonic anhydrases I, II and IV.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 18, Issue:24, 2008
Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 17, Issue:15, 2007
Carbonic anhydrases as targets for medicinal chemistry.Bioorganic & medicinal chemistry, , Jul-01, Volume: 15, Issue:13, 2007
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.Journal of medicinal chemistry, , Nov-30, Volume: 49, Issue:24, 2006
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies.Bioorganic & medicinal chemistry letters, , May-02, Volume: 15, Issue:9, 2005
Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.Journal of medicinal chemistry, , Dec-01, Volume: 48, Issue:24, 2005
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| carbonate dehydratase activity | molecular function | Catalysis of the reaction: hydrogencarbonate + H+ = CO2 + H2O. [EC:4.2.1.1] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial matrix | cellular component | The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation. [GOC:as, ISBN:0198506732] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Involved In
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|
| response to bacterium | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium. [GOC:hb] |
| one-carbon metabolic process | biological process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. [GOC:hjd, GOC:mah, GOC:pde] |