Page last updated: 2024-08-07 13:07:08
Liver carboxylesterase 1
A liver carboxylesterase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23141]
Synonyms
Acyl-coenzyme A:cholesterol acyltransferase;
ACAT;
Brain carboxylesterase hBr1;
Carboxylesterase 1;
CE-1;
hCE-1;
3.1.1.1;
Cholesteryl ester hydrolase;
CEH;
3.1.1.13;
Cocaine carboxylesterase;
Egasyn;
HMSE;<
Research
Bioassay Publications (26)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (53.85) | 29.6817 |
| 2010's | 10 (38.46) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
Compounds (84)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| bis(4-nitrophenyl)phosphate | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| diacetyl | Homo sapiens (human) | Ki | 100.0000 | 3 | 8 |
| 6,7-dichloroquinoxaline-2,3-dione | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| tacrine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| tacrine | Homo sapiens (human) | Ki | 100.0000 | 1 | 2 |
| ethacridine | Homo sapiens (human) | Ki | 58.5500 | 1 | 2 |
| benzophenone | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| valproic acid | Homo sapiens (human) | Ki | 363.0000 | 1 | 1 |
| donepezil | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| beta-lapachone | Homo sapiens (human) | Ki | 1.2200 | 1 | 1 |
| quinone | Homo sapiens (human) | Ki | 71.8579 | 2 | 7 |
| acenaphthenequinone | Homo sapiens (human) | Ki | 0.6466 | 3 | 5 |
| 9,10-phenanthrenequinone | Homo sapiens (human) | Ki | 0.0499 | 3 | 5 |
| 5-bromoisatin | Homo sapiens (human) | Ki | 41.6171 | 2 | 7 |
| isatin | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| chloranil | Homo sapiens (human) | Ki | 0.1185 | 2 | 6 |
| benzoin | Homo sapiens (human) | Ki | 47.9089 | 4 | 9 |
| dibenzoylmethane | Homo sapiens (human) | Ki | 59.3250 | 2 | 6 |
| benzil | Homo sapiens (human) | IC50 | 0.1467 | 3 | 3 |
| benzil | Homo sapiens (human) | Ki | 12.5450 | 10 | 16 |
| phenyl trifluoromethyl ketone | Homo sapiens (human) | IC50 | 0.0040 | 1 | 1 |
| 1,3-cyclohexanedione | Homo sapiens (human) | Ki | 100.0000 | 2 | 7 |
| oleanolic acid | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| dibromsalicil | Homo sapiens (human) | Ki | 66.6877 | 2 | 6 |
| 1,2-naphthoquinone | Homo sapiens (human) | Ki | 1.6375 | 2 | 4 |
| 1-acetylisatin | Homo sapiens (human) | Ki | 78.6667 | 2 | 6 |
| 1-phenyl-1,2-propanedione | Homo sapiens (human) | Ki | 31.7971 | 3 | 7 |
| 2,3-pentanedione | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| 5-methylisatin | Homo sapiens (human) | Ki | 87.7000 | 2 | 6 |
| 1,2-cyclohexanedione | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| n-methylisatin | Homo sapiens (human) | Ki | 58.1600 | 2 | 6 |
| 9-amino-6-chloro-2-methoxyacridine | Homo sapiens (human) | Ki | 52.9000 | 1 | 2 |
| acetylacetone | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| 5-Methoxyisatin | Homo sapiens (human) | Ki | 87.7833 | 2 | 6 |
| 3-methyl-1,2-cyclopentanedione | Homo sapiens (human) | Ki | 85.9500 | 2 | 6 |
| ursolic acid | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| alpha-furil | Homo sapiens (human) | Ki | 3.6083 | 2 | 3 |
| 4-benzoylbenzoic acid | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| 1,10-phenanthroline-5,6-dione | Homo sapiens (human) | Ki | 52.7000 | 2 | 4 |
| 2-chloranil | Homo sapiens (human) | Ki | 2.9433 | 2 | 6 |
| 3,5-di-tert-butyl-1,2-benzoquinone | Homo sapiens (human) | Ki | 33.7105 | 2 | 6 |
| gamma-glutamine-4-nitroanilide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 5-Chloro-1H-indole-2,3-dione | Homo sapiens (human) | Ki | 36.9517 | 2 | 6 |
| 5-iodoisatin | Homo sapiens (human) | Ki | 46.2933 | 2 | 6 |
| 2,2-dimethoxy-2-phenylacetophenone | Homo sapiens (human) | Ki | 71.7667 | 2 | 6 |
| anisoin | Homo sapiens (human) | Ki | 85.6500 | 2 | 6 |
| hydrobenzoin | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| tanshinone | Homo sapiens (human) | Ki | 26.2500 | 1 | 1 |
| san 58035 | Homo sapiens (human) | IC50 | 19.8700 | 1 | 1 |
| 1,3-indandione | Homo sapiens (human) | Ki | 4.6450 | 2 | 4 |
| 3-octylthio-1,1,1-trifluoro-2-propanone | Homo sapiens (human) | IC50 | 0.0185 | 2 | 2 |
| 3-octylthio-1,1,1-trifluoro-2-propanone | Homo sapiens (human) | Ki | 0.0974 | 2 | 2 |
| miltirone | Homo sapiens (human) | Ki | 2.5300 | 2 | 2 |
| cryptotanshinone | Homo sapiens (human) | Ki | 0.5440 | 1 | 1 |
| ibuprofen acyl glucuronide | Homo sapiens (human) | Ki | 355.0000 | 1 | 1 |
| tanshinone ii a | Homo sapiens (human) | Ki | 6.8900 | 1 | 1 |
| naproxen glucuronide | Homo sapiens (human) | Ki | 707.0000 | 1 | 1 |
| 5-Fluoroisatin | Homo sapiens (human) | Ki | 100.0000 | 2 | 7 |
| lupeol | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione | Homo sapiens (human) | Ki | 10.1657 | 2 | 6 |
| 5-Nitroisatin | Homo sapiens (human) | Ki | 84.4050 | 2 | 6 |
| ol-135 | Homo sapiens (human) | IC50 | 0.6000 | 6 | 6 |
| Dihydrotanshinone I | Homo sapiens (human) | Ki | 0.3980 | 1 | 1 |
| t-tucb | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 23-hydroxybetulinic acid | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| tanshinone ii a sodium sulfonate | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
Drugs with Other Measurements
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.Bioorganic & medicinal chemistry, , Aug-01, Volume: 19, Issue:15, 2011
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition.Chemistry & biology, , Volume: 10, Issue:4, 2003
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").Journal of natural products, , Jan-25, Volume: 76, Issue:1, 2013
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").Journal of natural products, , Jan-25, Volume: 76, Issue:1, 2013
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.Bioorganic & medicinal chemistry, , Jun-01, Volume: 15, Issue:11, 2007
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.Journal of medicinal chemistry, , Aug-25, Volume: 48, Issue:17, 2005
Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 24, Issue:5, 2016
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").Journal of natural products, , Jan-25, Volume: 76, Issue:1, 2013
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.Bioorganic & medicinal chemistry, , Aug-01, Volume: 19, Issue:15, 2011
Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.Bioorganic & medicinal chemistry, , Jan-01, Volume: 17, Issue:1, 2009
Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).Bioorganic & medicinal chemistry, , Feb-15, Volume: 16, Issue:4, 2008
Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.Bioorganic & medicinal chemistry, , Jun-01, Volume: 15, Issue:11, 2007
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.Journal of medicinal chemistry, , Nov-15, Volume: 50, Issue:23, 2007
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.Journal of medicinal chemistry, , Aug-25, Volume: 48, Issue:17, 2005
Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones.Bioorganic & medicinal chemistry, , Aug-01, Volume: 19, Issue:15, 2011
Identification and characterization of novel benzil (diphenylethane-1,2-dione) analogues as inhibitors of mammalian carboxylesterases.Journal of medicinal chemistry, , Apr-21, Volume: 48, Issue:8, 2005
Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.Bioorganic & medicinal chemistry, , Jan-01, Volume: 17, Issue:1, 2009
Inhibition of carboxylesterases by benzil (diphenylethane-1,2-dione) and heterocyclic analogues is dependent upon the aromaticity of the ring and the flexibility of the dione moiety.Journal of medicinal chemistry, , Aug-25, Volume: 48, Issue:17, 2005
Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure-activity relationship analysis.Bioorganic & medicinal chemistry, , Jan-01, Volume: 17, Issue:1, 2009
Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).Bioorganic & medicinal chemistry, , Feb-15, Volume: 16, Issue:4, 2008
Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.European journal of medicinal chemistry, , Apr-10, Volume: 149, 2018
Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").Journal of natural products, , Jan-25, Volume: 76, Issue:1, 2013
Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.Journal of medicinal chemistry, , Aug-14, Volume: 51, Issue:15, 2008
Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 18, Issue:22, 2008
Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.Journal of medicinal chemistry, , Feb-28, Volume: 51, Issue:4, 2008
Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.Journal of medicinal chemistry, , Mar-08, Volume: 50, Issue:5, 2007
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 15, Issue:5, 2005
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| sterol esterase activity | molecular function | Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. [EC:3.1.1.13] |
| methylumbelliferyl-acetate deacetylase activity | molecular function | Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H+. [EC:3.1.1.56, RHEA:12208] |
| carboxylesterase activity | molecular function | Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+. [RHEA:21164] |
| carboxylic ester hydrolase activity | molecular function | Catalysis of the hydrolysis of a carboxylic ester bond. [GOC:curators] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum lumen | cellular component | The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684] |
| lipid droplet | cellular component | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|
| lipid droplet | cellular component | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
Involved In
This protein is involved in 16 target(s):
| Target | Category | Definition |
|---|
| cholesterol biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai] |
| cholesterol metabolic process | biological process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. [ISBN:0198506732] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| positive regulation of cholesterol efflux | biological process | Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb] |
| negative regulation of cholesterol storage | biological process | Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb] |
| epithelial cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751] |
| cholesterol homeostasis | biological process | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators] |
| reverse cholesterol transport | biological process | The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. [GOC:ecd, PMID:7751809] |
| medium-chain fatty acid metabolic process | biological process | The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. [Wikipedia:Fatty_acid_metabolisms] |
| regulation of bile acid biosynthetic process | biological process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. [GOC:BHF, GOC:mah] |
| cellular response to cholesterol | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. [GOC:mah] |
| cellular response to low-density lipoprotein particle stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. [GOC:mah] |
| cholesterol ester hydrolysis involved in cholesterol transport | biological process | The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport. [GOC:ascb_2009, GOC:dph, GOC:tb] |
| positive regulation of cholesterol metabolic process | biological process | Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:dph, GOC:sl, GOC:tb] |
| regulation of bile acid secretion | biological process | Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] |
| lipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators] |