Page last updated: 2024-08-07 13:07:08
Liver carboxylesterase 1
A liver carboxylesterase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P23141]
Synonyms
Acyl-coenzyme A:cholesterol acyltransferase;
ACAT;
Brain carboxylesterase hBr1;
Carboxylesterase 1;
CE-1;
hCE-1;
3.1.1.1;
Cholesteryl ester hydrolase;
CEH;
3.1.1.13;
Cocaine carboxylesterase;
Egasyn;
HMSE;<
Research
Bioassay Publications (26)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 14 (53.85) | 29.6817 |
| 2010's | 10 (38.46) | 24.3611 |
| 2020's | 2 (7.69) | 2.80 |
Compounds (84)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| bis(4-nitrophenyl)phosphate | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| diacetyl | Homo sapiens (human) | Ki | 100.0000 | 3 | 8 |
| 6,7-dichloroquinoxaline-2,3-dione | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| tacrine | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| tacrine | Homo sapiens (human) | Ki | 100.0000 | 1 | 2 |
| ethacridine | Homo sapiens (human) | Ki | 58.5500 | 1 | 2 |
| benzophenone | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| valproic acid | Homo sapiens (human) | Ki | 363.0000 | 1 | 1 |
| donepezil | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| beta-lapachone | Homo sapiens (human) | Ki | 1.2200 | 1 | 1 |
| quinone | Homo sapiens (human) | Ki | 71.8579 | 2 | 7 |
| acenaphthenequinone | Homo sapiens (human) | Ki | 0.6466 | 3 | 5 |
| 9,10-phenanthrenequinone | Homo sapiens (human) | Ki | 0.0499 | 3 | 5 |
| 5-bromoisatin | Homo sapiens (human) | Ki | 41.6171 | 2 | 7 |
| isatin | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| chloranil | Homo sapiens (human) | Ki | 0.1185 | 2 | 6 |
| benzoin | Homo sapiens (human) | Ki | 47.9089 | 4 | 9 |
| dibenzoylmethane | Homo sapiens (human) | Ki | 59.3250 | 2 | 6 |
| benzil | Homo sapiens (human) | IC50 | 0.1467 | 3 | 3 |
| benzil | Homo sapiens (human) | Ki | 12.5450 | 10 | 16 |
| phenyl trifluoromethyl ketone | Homo sapiens (human) | IC50 | 0.0040 | 1 | 1 |
| 1,3-cyclohexanedione | Homo sapiens (human) | Ki | 100.0000 | 2 | 7 |
| oleanolic acid | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| dibromsalicil | Homo sapiens (human) | Ki | 66.6877 | 2 | 6 |
| 1,2-naphthoquinone | Homo sapiens (human) | Ki | 1.6375 | 2 | 4 |
| 1-acetylisatin | Homo sapiens (human) | Ki | 78.6667 | 2 | 6 |
| 1-phenyl-1,2-propanedione | Homo sapiens (human) | Ki | 31.7971 | 3 | 7 |
| 2,3-pentanedione | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| 5-methylisatin | Homo sapiens (human) | Ki | 87.7000 | 2 | 6 |
| 1,2-cyclohexanedione | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| n-methylisatin | Homo sapiens (human) | Ki | 58.1600 | 2 | 6 |
| 9-amino-6-chloro-2-methoxyacridine | Homo sapiens (human) | Ki | 52.9000 | 1 | 2 |
| acetylacetone | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| 5-Methoxyisatin | Homo sapiens (human) | Ki | 87.7833 | 2 | 6 |
| 3-methyl-1,2-cyclopentanedione | Homo sapiens (human) | Ki | 85.9500 | 2 | 6 |
| ursolic acid | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| alpha-furil | Homo sapiens (human) | Ki | 3.6083 | 2 | 3 |
| 4-benzoylbenzoic acid | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| 1,10-phenanthroline-5,6-dione | Homo sapiens (human) | Ki | 52.7000 | 2 | 4 |
| 2-chloranil | Homo sapiens (human) | Ki | 2.9433 | 2 | 6 |
| 3,5-di-tert-butyl-1,2-benzoquinone | Homo sapiens (human) | Ki | 33.7105 | 2 | 6 |
| gamma-glutamine-4-nitroanilide | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 5-Chloro-1H-indole-2,3-dione | Homo sapiens (human) | Ki | 36.9517 | 2 | 6 |
| 5-iodoisatin | Homo sapiens (human) | Ki | 46.2933 | 2 | 6 |
| 2,2-dimethoxy-2-phenylacetophenone | Homo sapiens (human) | Ki | 71.7667 | 2 | 6 |
| anisoin | Homo sapiens (human) | Ki | 85.6500 | 2 | 6 |
| hydrobenzoin | Homo sapiens (human) | Ki | 100.0000 | 2 | 6 |
| tanshinone | Homo sapiens (human) | Ki | 26.2500 | 1 | 1 |
| san 58035 | Homo sapiens (human) | IC50 | 19.8700 | 1 | 1 |
| 1,3-indandione | Homo sapiens (human) | Ki | 4.6450 | 2 | 4 |
| 3-octylthio-1,1,1-trifluoro-2-propanone | Homo sapiens (human) | IC50 | 0.0185 | 2 | 2 |
| 3-octylthio-1,1,1-trifluoro-2-propanone | Homo sapiens (human) | Ki | 0.0974 | 2 | 2 |
| miltirone | Homo sapiens (human) | Ki | 2.5300 | 2 | 2 |
| cryptotanshinone | Homo sapiens (human) | Ki | 0.5440 | 1 | 1 |
| ibuprofen acyl glucuronide | Homo sapiens (human) | Ki | 355.0000 | 1 | 1 |
| tanshinone ii a | Homo sapiens (human) | Ki | 6.8900 | 1 | 1 |
| naproxen glucuronide | Homo sapiens (human) | Ki | 707.0000 | 1 | 1 |
| 5-Fluoroisatin | Homo sapiens (human) | Ki | 100.0000 | 2 | 7 |
| lupeol | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione | Homo sapiens (human) | Ki | 10.1657 | 2 | 6 |
| 5-Nitroisatin | Homo sapiens (human) | Ki | 84.4050 | 2 | 6 |
| ol-135 | Homo sapiens (human) | IC50 | 0.6000 | 6 | 6 |
| Dihydrotanshinone I | Homo sapiens (human) | Ki | 0.3980 | 1 | 1 |
| t-tucb | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 23-hydroxybetulinic acid | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| tanshinone ii a sodium sulfonate | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-methylumbelliferyl acetate | Homo sapiens (human) | Km | 800.0000 | 1 | 1 |
| aniracetam | Homo sapiens (human) | Km | 90.0000 | 1 | 2 |
| camostat | Homo sapiens (human) | Km | 707.0000 | 1 | 1 |
| dilazep | Homo sapiens (human) | Km | 154.0000 | 1 | 1 |
| meperidine | Homo sapiens (human) | Km | 1,900.0000 | 1 | 1 |
| 4-nitrophenyl acetate | Homo sapiens (human) | Km | 359.0000 | 1 | 1 |
| quinapril | Homo sapiens (human) | Km | 134.0000 | 1 | 1 |
| cilazapril, anhydrous | Homo sapiens (human) | Km | 1,295.0000 | 1 | 1 |
| clopidogrel | Homo sapiens (human) | Km | 55.7000 | 1 | 1 |
| irinotecan | Homo sapiens (human) | Km | 1,453.0000 | 1 | 1 |
| capecitabine | Homo sapiens (human) | Km | 1,300.0000 | 1 | 1 |
| oseltamivir | Homo sapiens (human) | Km | 177.0000 | 1 | 1 |
| 4-nitrophenyl butyrate | Homo sapiens (human) | Km | 130.0000 | 1 | 1 |
| dexmethylphenidate | Homo sapiens (human) | Km | 43.8000 | 1 | 1 |
| temocapril | Homo sapiens (human) | Km | 786.0000 | 1 | 1 |
| cocaine | Homo sapiens (human) | Km | 120.0000 | 1 | 1 |
| delapril | Homo sapiens (human) | Km | 1,502.0000 | 1 | 1 |
| benazepril | Homo sapiens (human) | Km | 734.0000 | 1 | 1 |
| heroin | Homo sapiens (human) | Km | 6,300.0000 | 1 | 1 |
| 6-o-monoacetylmorphine | Homo sapiens (human) | Km | 8,300.0000 | 1 | 1 |
| imidapril | Homo sapiens (human) | Km | 287.0000 | 1 | 1 |
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| sterol esterase activity | molecular function | Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. [EC:3.1.1.13] |
| methylumbelliferyl-acetate deacetylase activity | molecular function | Catalysis of the reaction: 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H+. [EC:3.1.1.56, RHEA:12208] |
| carboxylesterase activity | molecular function | Catalysis of the reaction: a carboxylic ester + H2O = a carboxylate + an alcohol + H+. [RHEA:21164] |
| carboxylic ester hydrolase activity | molecular function | Catalysis of the hydrolysis of a carboxylic ester bond. [GOC:curators] |
Located In
This protein is located in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum lumen | cellular component | The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684] |
| lipid droplet | cellular component | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| lipid droplet | cellular component | An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins. [GOC:mah, GOC:tb] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
Involved In
This protein is involved in 16 target(s):
| Target | Category | Definition |
|---|---|---|
| cholesterol biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:ai] |
| cholesterol metabolic process | biological process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. [ISBN:0198506732] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| positive regulation of cholesterol efflux | biological process | Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle. [GOC:BHF, GOC:dph, GOC:tb] |
| negative regulation of cholesterol storage | biological process | Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:BHF, GOC:dph, GOC:tb] |
| epithelial cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751] |
| cholesterol homeostasis | biological process | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. [GOC:go_curators] |
| reverse cholesterol transport | biological process | The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism. [GOC:ecd, PMID:7751809] |
| medium-chain fatty acid metabolic process | biological process | The chemical reactions and pathways involving a medium-chain fatty acid. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. [Wikipedia:Fatty_acid_metabolisms] |
| regulation of bile acid biosynthetic process | biological process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. [GOC:BHF, GOC:mah] |
| cellular response to cholesterol | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus. [GOC:mah] |
| cellular response to low-density lipoprotein particle stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low-density lipoprotein particle stimulus. [GOC:mah] |
| cholesterol ester hydrolysis involved in cholesterol transport | biological process | The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport. [GOC:ascb_2009, GOC:dph, GOC:tb] |
| positive regulation of cholesterol metabolic process | biological process | Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:dph, GOC:sl, GOC:tb] |
| regulation of bile acid secretion | biological process | Any process that modulates the frequency, rate or extent of the controlled release of bile acid from a cell or a tissue. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:22767443] |
| lipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators] |