Cystathionine beta-synthase

A cystathionine beta-synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P35520]

Synonyms

EC 4.2.1.22;
Beta-thionase;
Serine sulfhydrase

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	4 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (8)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
aminooxyacetic acid	Homo sapiens (human)	IC50	5.2750	4	4
aurintricarboxylic acid	Homo sapiens (human)	IC50	181.8000	4	4
hypericin	Homo sapiens (human)	IC50	3.1000	1	1
agathisflavone	Homo sapiens (human)	IC50	17.1000	1	1
cupressuflavone	Homo sapiens (human)	IC50	11.5000	1	1
myricetin	Homo sapiens (human)	IC50	18.8000	1	1
podocarpusflavone a	Homo sapiens (human)	IC50	8.9000	1	1
rubrolide a	Homo sapiens (human)	IC50	108.0000	1	1

Enables

This protein enables 15 target(s):

Target	Category	Definition
cystathionine beta-synthase activity	molecular function	Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O. [EC:4.2.1.22]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
oxygen binding	molecular function	Binding to oxygen (O2). [GOC:jl]
enzyme binding	molecular function	Binding to an enzyme, a protein with catalytic activity. [GOC:jl]
heme binding	molecular function	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
pyridoxal phosphate binding	molecular function	Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. [GOC:mah, ISBN:0198506732]
ubiquitin protein ligase binding	molecular function	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
nitrite reductase (NO-forming) activity	molecular function	Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+. [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN]
carbon monoxide binding	molecular function	Binding to carbon monoxide (CO). [GOC:ecd]
nitric oxide binding	molecular function	Binding to nitric oxide (NO). [GOC:ecd]
modified amino acid binding	molecular function	Binding to a modified amino acid. [GOC:mah]
S-adenosyl-L-methionine binding	molecular function	Binding to S-adenosyl-L-methionine. [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 22 target(s):

Target	Category	Definition
endochondral ossification	biological process	Replacement ossification wherein bone tissue replaces cartilage. [GO_REF:0000034, ISBN:0878932437]
blood vessel remodeling	biological process	The reorganization or renovation of existing blood vessels. [GOC:hjd]
L-serine metabolic process	biological process	The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg]
L-serine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg]
superoxide metabolic process	biological process	The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. [GOC:jl]
regulation of nitric oxide mediated signal transduction	biological process	Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is The series of molecular signals mediated by the detection of nitric oxide (NO). [GOC:BHF, GOC:dph, GOC:tb]
cysteine biosynthetic process via cystathionine	biological process	The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine. [GOC:go_curators]
cysteine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid. [GOC:go_curators]
transsulfuration	biological process	The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. [MetaCyc:PWY-801]
L-cysteine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid. [GOC:jsg, GOC:mah]
cerebellum morphogenesis	biological process	The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
DNA protection	biological process	Any process in which DNA is protected from damage by, for example, oxidative stress. [GOC:jl]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
homocysteine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. [GOC:jl]
homocysteine metabolic process	biological process	The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine. [ISBN:0198506732]
response to folic acid	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus. [GOC:ai]
maternal process involved in female pregnancy	biological process	A reproductive process occurring in the mother that allows an embryo or fetus to develop within it. [GOC:dph]
cartilage development involved in endochondral bone morphogenesis	biological process	The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones. [GOC:dph]
hydrogen sulfide biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of hydrogen sulfide, H2S. [GOC:mah]
cellular response to hypoxia	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]
blood vessel diameter maintenance	biological process	Any process that modulates the diameter of blood vessels. [GOC:pr]
cysteine biosynthetic process from serine	biological process	The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine. [GOC:go_curators]