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Thymidine phosphorylase
A thymidine phosphorylase that is encoded in the genome of Escherichia coli K-12. [OMA:P07650, PRO:DNx]
Synonyms
EC 2.4.2.4;
TdRPase
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (9)
Drugs with Inhibition Measurements
Drugs with Other Measurements
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:6, 2008
Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.Journal of medicinal chemistry, , Jan-27, Volume: 48, Issue:2, 2005
The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 20, Issue:5, 2010
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:6, 2008
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.Journal of medicinal chemistry, , Jan-27, Volume: 48, Issue:2, 2005
Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Volume: 70, 2013
Structure-activity relationship of 2,4,5-trioxoimidazolidines as inhibitors of thymidine phosphorylase.European journal of medicinal chemistry, , Volume: 46, Issue:4, 2011
Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors.Bioorganic & medicinal chemistry, , Apr-15, Volume: 17, Issue:8, 2009
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.Journal of medicinal chemistry, , Jan-27, Volume: 48, Issue:2, 2005
Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004
Rational design of bis-indolylmethane-oxadiazole hybrids as inhibitors of thymidine phosphorylase.Bioorganic & medicinal chemistry, , 07-23, Volume: 26, Issue:12, 2018
Thymidine esters as substrate analogue inhibitors of angiogenic enzyme thymidine phosphorylase in vitro.Bioorganic chemistry, , Volume: 70, 2017
Synthesis and biological evaluation of novel oxadiazole derivatives: a new class of thymidine phosphorylase inhibitors as potential anti-tumor agents.Bioorganic & medicinal chemistry, , Feb-01, Volume: 22, Issue:3, 2014
Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Volume: 70, 2013
Synthesis of pyrazolo[1,5-a][1,3,5]triazine derivatives as inhibitors of thymidine phosphorylase.European journal of medicinal chemistry, , Volume: 65, 2013
Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors.Bioorganic & medicinal chemistry, , Apr-15, Volume: 17, Issue:8, 2009
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.European journal of medicinal chemistry, , Volume: 43, Issue:6, 2008
Biotransformation of (-)-ambrox by cell suspension cultures of Actinidia deliciosa.Journal of natural products, , Volume: 69, Issue:6, 2006
Aminoimidazolylmethyluracil analogues as potent inhibitors of thymidine phosphorylase and their bioreductive nitroimidazolyl prodrugs.Journal of medicinal chemistry, , Jan-27, Volume: 48, Issue:2, 2005
Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 14, Issue:21, 2004