Proteins > Potassium voltage-gated channel subfamily KQT member 5
Page last updated: 2024-08-08 00:17:55
Potassium voltage-gated channel subfamily KQT member 5
A voltage-gated potassium channel subunit KCNQ5 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NR82]
Synonyms
KQT-like 5;
Potassium channel subunit alpha KvLQT5;
Voltage-gated potassium channel subunit Kv7.5
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| flupirtine | Homo sapiens (human) | EC2 | 2.5400 | 2 | 2 |
| ezogabine | Homo sapiens (human) | EC2 | 0.3400 | 1 | 1 |
[no title available]Journal of medicinal chemistry, , 01-09, Volume: 63, Issue:1, 2020
[no title available]ACS medicinal chemistry letters, , Jun-13, Volume: 10, Issue:6, 2019
Discovery of Novel Retigabine Derivatives as Potent KCNQ4 and KCNQ5 Channel Agonists with Improved Specificity.ACS medicinal chemistry letters, , Jan-10, Volume: 10, Issue:1, 2019
Novel KBioorganic & medicinal chemistry letters, , 12-15, Volume: 28, Issue:23-24, 2018
Novel KBioorganic & medicinal chemistry letters, , 12-15, Volume: 28, Issue:23-24, 2018
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| voltage-gated potassium channel activity | molecular function | Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Part Of
This protein is part of 2 target(s):
| Target | Category | Definition |
|---|
| voltage-gated potassium channel complex | cellular component | A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah] |
| clathrin coat | cellular component | A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes. [GOC:mah, PMID:11252894, PMID:9531549] |
Involved In
This protein is involved in 1 target(s):
| Target | Category | Definition |
|---|
| potassium ion transmembrane transport | biological process | A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah] |