Single-stranded DNA cytosine deaminase

A single-stranded DNA cytosine deaminase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9GZX7]

Synonyms

EC 3.5.4.38;
Activation-induced cytidine deaminase;
AID;
Cytidine aminohydrolase

Research

Bioassay Publications (0)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0)	18.7374
1990's	0 (0)	18.2507
2000's	0 (0)	29.6817
2010's	0 (0)	24.3611
2020's	0 (0)	2.80

Compounds (33)

Drugs with Potency Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
hydroxylamine	Homo sapiens (human)	Potency	49.2215	2
aurintricarboxylic acid	Homo sapiens (human)	Potency	79.3735	2
chelerythrine	Homo sapiens (human)	Potency	50.1187	1
dequalinium	Homo sapiens (human)	Potency	89.1251	2
diphenyleneiodonium	Homo sapiens (human)	Potency	7.9433	1
dipyridamole	Homo sapiens (human)	Potency	79.4328	1
2,3-dimethoxy-1,4-naphthoquinone	Homo sapiens (human)	Potency	55.3026	2
hydralazine	Homo sapiens (human)	Potency	38.7284	2
phenelzine	Homo sapiens (human)	Potency	45.4947	2
beta-lapachone	Homo sapiens (human)	Potency	10.0000	1
mitoxantrone	Homo sapiens (human)	Potency	33.6698	2
protoporphyrin ix	Homo sapiens (human)	Potency	53.3427	2
sanguinarine	Homo sapiens (human)	Potency	50.1187	1
tyrphostin a9	Homo sapiens (human)	Potency	70.7946	1
1-naphthaldehyde	Homo sapiens (human)	Potency	56.2341	1
pyrazolanthrone	Homo sapiens (human)	Potency	79.4328	1
2,3,5-trimethylquinol	Homo sapiens (human)	Potency	50.1187	1
idarubicin	Homo sapiens (human)	Potency	67.1545	2
flupirtine	Homo sapiens (human)	Potency	28.1838	1
masoprocol	Homo sapiens (human)	Potency	44.6684	1
2-(4-aminophenyl)quinoline	Homo sapiens (human)	Potency	56.2341	1
IPA-3	Homo sapiens (human)	Potency	8.9125	1
2-[[2-methyl-5-(3-methyl-4-oxo-1-phthalazinyl)phenyl]sulfonylamino]acetic acid ethyl ester	Homo sapiens (human)	Potency	89.1251	1
(2'-(4-aminophenyl)-(2,5'-bi-1h-benzimidazol)-5-amine)	Homo sapiens (human)	Potency	9.6681	2
nemadipine-a	Homo sapiens (human)	Potency	50.1187	1
5-[[(1-cyclohexyl-5-tetrazolyl)thio]methyl]-3-phenyl-1,2,4-oxadiazole	Homo sapiens (human)	Potency	89.1251	1
ro 41-0960	Homo sapiens (human)	Potency	100.0000	1
tectochrysin	Homo sapiens (human)	Potency	100.0000	1
casein kinase ii	Homo sapiens (human)	Potency	89.1251	1
2-(2-methoxyanilino)-8-[(3-methyl-1-piperidinyl)-oxomethyl]-[1,3,4]thiadiazolo[2,3-b]quinazolin-5-one	Homo sapiens (human)	Potency	89.1251	1
CDN1163	Homo sapiens (human)	Potency	39.8107	1
hispidin	Homo sapiens (human)	Potency	15.8489	1
4-[[(4-oxo-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-2-yl)thio]methyl]benzoic acid methyl ester	Homo sapiens (human)	Potency	39.8107	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
cytidine deaminase activity	molecular function	Catalysis of the reaction: cytidine + H+ + H2O = uridine + NH4 and deoxycytidine + H+ + H2O = deoxyuridine + NH4+. [EC:3.5.4.5]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
ubiquitin protein ligase binding	molecular function	Binding to a ubiquitin protein ligase enzyme, any of the E3 proteins. [GOC:vp]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
P-body	cellular component	A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing. [GOC:clt, PMID:12730603]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 15 target(s):

Target	Category	Definition
mRNA processing	biological process	Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. [GOC:mah]
cytidine deamination	biological process	The removal of amino group in the presence of water. [GOC:sm]
somatic diversification of immunoglobulins	biological process	The somatic process that results in the generation of sequence diversity of immunoglobulins. [GOC:add, GOC:ma, ISBN:0781735149]
somatic hypermutation of immunoglobulin genes	biological process	Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins. [GOC:add, ISBN:0781735149, PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007]
B cell differentiation	biological process	The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity. [GO_REF:0000022, GOC:mah]
regulation of nuclear cell cycle DNA replication	biological process	Any process that modulates the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle. [GOC:mtg_cell_cycle]
defense response to bacterium	biological process	Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. [GOC:jl]
positive regulation of gene expression via chromosomal CpG island demethylation	biological process	An epigenetic gene regulation mechanism that positively regulates gene expression by demethylation of cytosine residues in chromosomal CpG islands. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes. [PMID:36150101, Wikipedia:Cpg_island]
isotype switching	biological process	The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus. [ISBN:0781735149]
cellular response to lipopolysaccharide	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
DNA cytosine deamination	biological process	The removal of an amino group from a cytosine residue in DNA, forming a uracil residue. [GOC:mah]
DNA demethylation	biological process	The removal of a methyl group from one or more nucleotides within an DNA molecule. [PMID:17208187]
cytidine to uridine editing	biological process	The conversion of a cytosine residue to uridine in an RNA molecule by deamination. [PMID:11092837]
negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate. [GOC:go_curators]
defense response to virus	biological process	Reactions triggered in response to the presence of a virus that act to protect the cell or organism. [GOC:ai]