Page last updated: 2024-08-07 15:44:31
Neprilysin
A neprilysin that is encoded in the genome of rat. [OMA:P07861, PRO:DNx]
Synonyms
EC 3.4.24.11;
Atriopeptidase;
Enkephalinase;
Neutral endopeptidase 24.11;
NEP;
Neutral endopeptidase;
Skin fibroblast elastase;
SFE
Research
Bioassay Publications (19)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 10 (52.63) | 18.2507 |
| 2000's | 5 (26.32) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
Compounds (13)
Drugs with Inhibition Measurements
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.Journal of medicinal chemistry, , Feb-10, Volume: 43, Issue:3, 2000
Novel selective thiol inhibitors of neutral endopeptidase containing heterocycles at P'2 position.Journal of enzyme inhibition, , Volume: 12, Issue:2, 1997
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.Journal of medicinal chemistry, , Dec-22, Volume: 38, Issue:26, 1995
Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.Journal of medicinal chemistry, , May-12, Volume: 38, Issue:10, 1995
N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Heterocyclic lactam derivatives as dual angiotensin converting enzyme and neutral endopeptidase 24.11 inhibitors.Journal of medicinal chemistry, , Nov-26, Volume: 36, Issue:24, 1993
A novel class of enkephalinase inhibitors containing a C-terminal sulfo group.Journal of medicinal chemistry, , Feb-07, Volume: 35, Issue:3, 1992
New bidentates as full inhibitors of enkephalin-degrading enzymes: synthesis and analgesic properties.Journal of medicinal chemistry, , Volume: 28, Issue:9, 1985
Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.Journal of medicinal chemistry, , Volume: 28, Issue:9, 1985
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.Journal of medicinal chemistry, , Feb-10, Volume: 43, Issue:3, 2000
Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme.Journal of medicinal chemistry, , Apr-23, Volume: 41, Issue:9, 1998
Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme.Journal of medicinal chemistry, , 05-28, Volume: 63, Issue:10, 2020
Computer-aided selection of potential antihypertensive compounds with dual mechanism of action.Journal of medicinal chemistry, , Jul-17, Volume: 46, Issue:15, 2003
Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.Journal of medicinal chemistry, , Feb-10, Volume: 43, Issue:3, 2000
Design and synthesis of potent, selective inhibitors of endothelin-converting enzyme.Journal of medicinal chemistry, , Apr-23, Volume: 41, Issue:9, 1998
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.Journal of medicinal chemistry, , Dec-22, Volume: 38, Issue:26, 1995
N-Phosphonomethyl dipeptides and their phosphonate prodrugs, a new generation of neutral endopeptidase (NEP, EC 3.4.24.11) inhibitors.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Synthesis and biological evaluation of phosphonamidate peptide inhibitors of enkephalinase and angiotensin-converting enzyme.Journal of medicinal chemistry, , Volume: 28, Issue:9, 1985
Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin-Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme.Journal of medicinal chemistry, , 05-28, Volume: 63, Issue:10, 2020
N-formyl hydroxylamine containing dipeptides: generation of a new class of vasopeptidase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-07, Volume: 10, Issue:3, 2000
Vasopeptidase inhibitors: incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides.Journal of medicinal chemistry, , Jan-28, Volume: 42, Issue:2, 1999
Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.Journal of medicinal chemistry, , May-23, Volume: 40, Issue:11, 1997