n-succinyl-chitosan and Necrosis

n-succinyl-chitosan has been researched along with Necrosis* in 1 studies

Other Studies

1 other study(ies) available for n-succinyl-chitosan and Necrosis

Article	Year
Antitumor effect of N-succinyl-chitosan nanoparticles on K562 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2010, Volume: 64, Issue:8 Polymer nanoparticles have become attractive for its prominent property recent years. In this paper, antitumor effects of N-succinyl-chitosan nanoparticles (NSCNP), a nanoparticles derivated from chitosan, were evaluated in K562 cells, including cell viability comparison, cell morphology analysis, DNA fragmentation detection, cell surface potential and mitochondrial membrane potential (MMP) measurement, intracellular ROS and Ca(2+) concentration evaluation. Our results revealed NSCNP could inhibit the proliferation of K562 with an IC(50) of 14.26 μg/ml (24h); decrease the zeta potential; disrupt the mitochondrial membrane potential; increase ROS generation and Ca(2+) concentration. Cytomorphology study and DNA fragment analysis reveal characteristics of apoptosis and necrosis, indicating that the antitumor effect of NSCNP achieved by necrosis and apoptosis induction in K562 cells. Topics: Antineoplastic Agents; Apoptosis; Calcium; Cell Culture Techniques; Cell Nucleus; Cell Proliferation; Cell Survival; Chitosan; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; K562 Cells; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Molecular Structure; Nanoparticles; Necrosis; Particle Size; Reactive Oxygen Species; Surface Properties	2010

Article

Year

Antitumor effect of N-succinyl-chitosan nanoparticles on K562 cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2010, Volume: 64, Issue:8

Polymer nanoparticles have become attractive for its prominent property recent years. In this paper, antitumor effects of N-succinyl-chitosan nanoparticles (NSCNP), a nanoparticles derivated from chitosan, were evaluated in K562 cells, including cell viability comparison, cell morphology analysis, DNA fragmentation detection, cell surface potential and mitochondrial membrane potential (MMP) measurement, intracellular ROS and Ca(2+) concentration evaluation. Our results revealed NSCNP could inhibit the proliferation of K562 with an IC(50) of 14.26 μg/ml (24h); decrease the zeta potential; disrupt the mitochondrial membrane potential; increase ROS generation and Ca(2+) concentration. Cytomorphology study and DNA fragment analysis reveal characteristics of apoptosis and necrosis, indicating that the antitumor effect of NSCNP achieved by necrosis and apoptosis induction in K562 cells.

Topics: Antineoplastic Agents; Apoptosis; Calcium; Cell Culture Techniques; Cell Nucleus; Cell Proliferation; Cell Survival; Chitosan; DNA Fragmentation; Dose-Response Relationship, Drug; Humans; K562 Cells; Membrane Potential, Mitochondrial; Microscopy, Electron, Transmission; Molecular Structure; Nanoparticles; Necrosis; Particle Size; Reactive Oxygen Species; Surface Properties

2010