Page last updated: 2024-08-07 16:42:04
Plasmepsin-2
[no definition available]
Synonyms
EC 3.4.23.39;
Aspartic hemoglobinase II;
PFAPD
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 1,2-diphenylhydrazine | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 1.3750 | 3 | 4 |
| kynostatin 272 | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 1.0000 | 1 | 1 |
| kynostatin 227 | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.0360 | 1 | 1 |
| je 2147 | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.0300 | 1 | 1 |
| pepstatin | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.0006 | 2 | 2 |
| kni 10006 | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.0390 | 1 | 1 |
| kni 10006 | Plasmodium falciparum (malaria parasite P. falciparum) | Ki | 0.0005 | 4 | 4 |
Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present).Journal of medicinal chemistry, , 05-14, Volume: 63, Issue:9, 2020
Exploiting Structural Dynamics To Design Open-Flap Inhibitors of Malarial Aspartic Proteases.Journal of medicinal chemistry, , 10-24, Volume: 62, Issue:20, 2019
Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors.Journal of enzyme inhibition and medicinal chemistry, , Volume: 25, Issue:5, 2010
2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity.Bioorganic & medicinal chemistry, , 05-15, Volume: 26, Issue:9, 2018
Identification of acridinyl hydrazides as potent aspartic protease inhibitors.Bioorganic & medicinal chemistry letters, , May-01, Volume: 18, Issue:9, 2008
Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 20, Issue:16, 2010
alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases.Bioorganic & medicinal chemistry, , Aug-15, Volume: 17, Issue:16, 2009
Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin.Bioorganic & medicinal chemistry, , Dec-01, Volume: 16, Issue:23, 2008
Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 17, Issue:11, 2007