Sphingosine 1-phosphate receptor 1

A sphingosine 1-phosphate receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P21453]

Synonyms

S1P receptor 1;
S1P1;
Endothelial differentiation G-protein coupled receptor 1;
Sphingosine 1-phosphate receptor Edg-1;
S1P receptor Edg-1

Research

Bioassay Publications (49)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	11 (22.45)	29.6817
2010's	32 (65.31)	24.3611
2020's	6 (12.24)	2.80

Compounds (16)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
fingolimod	Homo sapiens (human)	IC50	0.7219	2	2
sew2871	Homo sapiens (human)	IC50	0.0370	2	2
sphingosine 1-phosphate	Homo sapiens (human)	IC50	0.0008	6	6
fty 720p	Homo sapiens (human)	IC50	0.0001	4	4
fty 720p	Homo sapiens (human)	Ki	0.2117	1	5
jte 013	Homo sapiens (human)	IC50	1.0000	2	2
ponesimod	Homo sapiens (human)	IC50	0.0126	1	1
fty 720p	Homo sapiens (human)	IC50	0.0008	3	3
fty 720p	Homo sapiens (human)	Ki	0.2066	1	5

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
fingolimod hydrochloride	Homo sapiens (human)	EC50	3.0000	1	1
fingolimod	Homo sapiens (human)	EC50	4.0019	5	5
sew2871	Homo sapiens (human)	EC50	0.1415	2	2
sphingosine 1-phosphate	Homo sapiens (human)	EC50	0.0067	15	15
N-cyclohexyl-5-propyl-3-isoxazolecarboxamide	Homo sapiens (human)	EC50	50.0000	1	1
N,N-dicyclohexyl-5-propyl-3-isoxazolecarboxamide	Homo sapiens (human)	EC50	7.8700	1	1
fty 720p	Homo sapiens (human)	EC50	0.0013	16	16
auy 954	Homo sapiens (human)	EC50	0.0012	1	1
ponesimod	Homo sapiens (human)	EC50	0.0097	1	1
fty 720p	Homo sapiens (human)	EC50	0.0035	19	19
VPC 23019	Homo sapiens (human)	EC50	0.0580	1	1
gw9508	Homo sapiens (human)	EC50	31.6228	1	1
cs-2100	Homo sapiens (human)	EC50	0.0040	3	3
cym-5442	Homo sapiens (human)	EC50	0.0029	1	0
siponimod	Homo sapiens (human)	EC50	0.0004	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
fty 720p	Homo sapiens (human)	Activity	0.0072	2	2

Enables

This protein enables 5 target(s):

Target	Category	Definition
G protein-coupled receptor binding	molecular function	Binding to a G protein-coupled receptor. [GOC:ceb, GOC:dph]
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
sphingosine-1-phosphate receptor activity	molecular function	Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, PMID:12728273, Wikipedia:S1PR1]
sphingolipid binding	molecular function	Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [ISBN:0198506732]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
endosome	cellular component	A vacuole to which materials ingested by endocytosis are delivered. [ISBN:0198506732, PMID:19696797]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
external side of plasma membrane	cellular component	The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:dos, GOC:tb]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
membrane raft	cellular component	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

Involved In

This protein is involved in 30 target(s):

Target	Category	Definition
blood vessel maturation	biological process	A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state. [GOC:dph]
cardiac muscle tissue growth involved in heart morphogenesis	biological process	The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart. [GOC:mtg_heart]
sphingosine-1-phosphate receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by sphingosine-1-phosphate binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ascb_2009, GOC:signaling, PMID:14592418, PMID:22001186, Reactome:R-HSA-419428]
chemotaxis	biological process	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732]
cell adhesion	biological process	The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. [GOC:hb, GOC:pf]
G protein-coupled receptor signaling pathway	biological process	The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
brain development	biological process	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
cell population proliferation	biological process	The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb]
cell migration	biological process	The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
transmission of nerve impulse	biological process	The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission. [GOC:curators, ISBN:0815316194]
lamellipodium assembly	biological process	Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell. [GOC:mah, ISBN:0815316194]
actin cytoskeleton organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:dph, GOC:jl, GOC:mah]
regulation of cell adhesion	biological process	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix. [GOC:mah]
neuron differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah]
positive regulation of cell migration	biological process	Any process that activates or increases the frequency, rate or extent of cell migration. [GOC:go_curators]
regulation of bone mineralization	biological process	Any process that modulates the frequency, rate or extent of bone mineralization. [GOC:go_curators]
leukocyte chemotaxis	biological process	The movement of a leukocyte in response to an external stimulus. [GOC:add, GOC:jl]
regulation of bone resorption	biological process	Any process that modulates the frequency, rate or extent of bone tissue loss (resorption). [GOC:ai]
endothelial cell differentiation	biological process	The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium. [CL:0000115, GOC:go_curators]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
positive regulation of smooth muscle cell proliferation	biological process	Any process that activates or increases the rate or extent of smooth muscle cell proliferation. [CL:0000192, GOC:ebc]
positive regulation of positive chemotaxis	biological process	Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical. [GOC:ai]
negative regulation of stress fiber assembly	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts. [GOC:ai]
heart trabecula morphogenesis	biological process	The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue. [GOC:dph]
T cell migration	biological process	The movement of a T cell within or between different tissues and organs of the body. [CL:0000084, GOC:BHF, GOC:mah]
angiogenesis	biological process	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
regulation of metabolic process	biological process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. [GOC:go_curators]
adenylate cyclase-activating G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]