Page last updated: 2024-09-20

iopromide

Description

iopromide: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

iopromide : A dicarboxylic acid diamide that consists of N-methylisophthalamide bearing three iodo substituents at positions 2, 4 and 6, a methoxyacetyl substituent at position 5 and two 2,3-dihydroxypropyl groups attached to the amide nitrogens. A water soluble x-ray contrast agent for intravascular administration. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID3736
CHEMBL ID1725
CHEBI ID63578
SCHEMBL ID24546
SCHEMBL ID23673810
MeSH IDM0115091

Synonyms (114)

Synonym
AC-535
MLS002154045
smr001233368
n,n'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-n-methyl-5-{[(methyloxy)acetyl]amino}benzene-1,3-dicarboxamide
iopromide
PRESTWICK2_000872
BPBIO1_001039
iopromidum [inn-latin]
1,3-benzenedicarboxamide, n,n'-bis(2,3-dihydroxypropyl)-5-((methoxyacetyl)amino)-n-methyl-2,4,6-triiodo-
n,n'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-n-methylisophthalamide
ultravist
brn 7085608
einecs 277-385-9
zk 35760
iopromida [inn-spanish]
shl 414c
1,3-benzenedicarboxamide, n,n'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-((methoxyacetyl)amino)-n-methyl-
NCGC00016923-01
cas-73334-07-3
NCGC00179367-01
BSPBIO_000943
PRESTWICK3_000872
AB00513942
proscope (tn)
73334-07-3
ultravist (tn)
iopromide (jan/usp/inn)
D01893
PRESTWICK0_000872
PRESTWICK1_000872
SPBIO_002864
proscope
chebi:63578 ,
zk-35760
CHEMBL1725
HMS1570P05
magnesium methanide propan-1-ide(1:1:1)
1-n,3-n-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-3-n-methylbenzene-1,3-dicarboxamide
n,n'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-n-methylisophthalamide
HMS2097P05
lopromid
ultravist 300
iopromid
ultravist (pharmacy bulk)
iopromide [usan:usp:inn:ban]
bay 86-4877
712bac33mz ,
iopromidum
ultravist 300 in plastic container
bay86-4877
unii-712bac33mz
ultravist 370
ultravist 240
iopromida
ultravist 150
tox21_110684
dtxsid0023163 ,
dtxcid503163
HMS2233O23
S3207
c18h24i3n3o8
FT-0627283
HMS3370M05
iopromide [mi]
iopromide [mart.]
iopromide [ep impurity]
iopromide [usan]
iopromide [who-dd]
iopromide [orange book]
iopromide [ep monograph]
iopromide [inn]
iopromide [jan]
iopromide [usp-rs]
iopromide [vandf]
iopromide [usp monograph]
CCG-220872
DGAIEPBNLOQYER-UHFFFAOYSA-N
SCHEMBL24546
tox21_110684_1
NCGC00179367-03
n1,n3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-n1-methylisophthalamide
AKOS025402129
DB09156
n-(2,3-dihydroxypropyl)-3-[(2,3-dihydroxypropyl)(methyl)carbamoyl]-5-[(1-hydroxy-2-methoxyethylidene)amino]-2,4,6-triiodobenzene-1-carboximidic acid
sr-01000841262
SR-01000841262-2
iopromide, united states pharmacopeia (usp) reference standard
iopromide, analytical standard
iopromide, european pharmacopoeia (ep) reference standard
iopromide for system suitability 2, european pharmacopoeia (ep) reference standard
iopromide for system suitability 1, european pharmacopoeia (ep) reference standard
HMS3714P05
HY-B1362
CS-0013103
iopromid 100 microg/ml in acetonitrile
BCP08449
Q4202805
BS-17441
mfcd00867924
EN300-19767813
n1,n3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-n1-methylbenzene-1,3-dicarboxamide
SCHEMBL23673810
iopromide (usan:usp:inn:ban)
iopromida (inn-spanish)
iopromidum (inn-latin)
iopromide (mart.)
iopromide (usp-rs)
iopromide (ep monograph)
n,n'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-((methoxyacetyl)amino)-n-methylisophthalamide
iopromide (ep impurity)
v08ab05
iopromide (usp monograph)
1,3-benzenedicarboxamide, n1,n3-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(2-methoxyacetyl)amino]-n1-methyl-
Z2681890595

Research Excerpts

Overview

ExcerptReference
"Iopromide is an X-ray and MRI contrast agent that is virtually non-biodegradable and persistent through typical wastewater treatment processes. "( Aga, DS; Keen, OS; Linden, KG; Love, NG, 2016)
"Iopromide was shown to be a well-tolerated contrast agent whose usage resulted in high image quality. "( Heinsohn, C; Kwon, ST; Lengsfeld, P; Liang, CH; Palkowitsch, P; Stauch, K; Zhang, SX, 2012)
"Iopromide is an X-ray contrast agent that has been detected frequently in effluents of wastewater treatment plants and in surface waters due to its persistence and high usage."( Aga, DS; Celiz, MD; Eichhorn, P; PĂ©rez, S, 2006)
"Iopromide is a new nonionic contrast medium that has been extensively studied for both intravenous (i.v.) and intraarterial indications."( Bettmann, MA; Druy, EM; Jeans, W, 1994)
"Iopromide is a nonionic monomeric contrast agent. "( Amis, ES; Goldman, S; Hedgcock, M; Khazan, R; Landman, J; Lang, E; Leder, R; Newhouse, JH, 1994)
"Iopromide is a new monomeric, nonionic contrast agent that exhibits low osmolality and low viscosity in high concentration in aqueous solutions. "( Abrahams, J; Bernardino, M; Brunetti, J; Drayer, BP; Goldberg, SN; Golding, S, 1994)
"Iopromide is a new nonionic monomeric contrast medium for cerebral arteriography. "( Drayer, BP; Haughton, VM; Hilal, SK; Hyland, D; Maravilla, K; Osborn, AG; Papke, RA, 1994)
"Iopromide is a nonionic, iodinated, monomeric, radiographic contrast agent used in various indications, including coronary angiography and visceral and peripheral arteriography. "( Graf, LL; Hinderling, PH; Jacob, GB; Kressin, DC; Marlar, RA; Young, DA, 2001)
"Iopromide proved itself to be an x-ray contrast medium with a low rate of side effects, which can be effectively eliminated from the body by means of conventional dialysis."( Hollmann, HJ; Kierdorf, H; Kindler, J; Speck, U; Vorwerk, D; Winterscheid, R, 1989)
"Iopromide 300 is a good candidate for this examination, on the basis of the safety and efficacy evaluated in this study."( Kasbarian, M, 1989)

Effects

ExcerptReference
"Iopromide has an efficacy, safety, and tolerance profile comparable to that of iopamidol and iohexol at 300 mg I/mL for head and body CECT. "( Abrahams, J; Bernardino, M; Brunetti, J; Drayer, BP; Goldberg, SN; Golding, S, 1994)
"Iopromide has an efficacy, safety, and tolerance profile comparable to that of iopamidol and iohexol at 300 mg I/mL for head and body CECT. "( Abrahams, J; Bernardino, M; Brunetti, J; Drayer, BP; Goldberg, SN; Golding, S, 1994)

Roles (4)

RoleDescription
radioopaque mediumA substance having the property of absorbing, and therefore being opaque to, electromagnetic radiation, particularly X-rays.
nephrotoxic agentA role played by a chemical compound exihibiting itself through the ability to induce damage to the kidney in animals.
xenobioticA xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
environmental contaminantAny minor or unwanted substance introduced into the environment that can have undesired effects.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
organoiodine compoundAn organoiodine compound is a compound containing at least one carbon-iodine bond.
dicarboxylic acid diamide
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
USP1 protein, partialHomo sapiens (human)Potency316.22800.031637.5844354.8130AID743255
farnesoid X nuclear receptorHomo sapiens (human)Potency0.37580.375827.485161.6524AID743220
pregnane X nuclear receptorHomo sapiens (human)Potency12.58930.005428.02631,258.9301AID1346985
importin subunit beta-1 isoform 1Homo sapiens (human)Potency29.09295.804836.130665.1308AID540253
snurportin-1Homo sapiens (human)Potency29.09295.804836.130665.1308AID540253
GTP-binding nuclear protein Ran isoform 1Homo sapiens (human)Potency29.09295.804816.996225.9290AID540253
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (91)

Assay IDTitleYearJournalArticle
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347425Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347424RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347407qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588216FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase2004Current drug discovery technologies, Dec, Volume: 1, Issue:4
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID588215FDA HLAED, alkaline phosphatase increase2004Current drug discovery technologies, Dec, Volume: 1, Issue:4
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID625284Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079946Presence of at least one case with successful reintroduction. [column 'REINT' in source]
AID1079937Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source]
AID625285Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079947Comments (NB not yet translated). [column 'COMMENTAIRES' in source]
AID540209Volume of distribution at steady state in human after iv administration2008Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID425652Total body clearance in human2009Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
Physicochemical determinants of human renal clearance.
AID588218FDA HLAED, lactate dehydrogenase (LDH) increase2004Current drug discovery technologies, Dec, Volume: 1, Issue:4
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID1079943Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source]
AID540212Mean residence time in human after iv administration2008Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID588214FDA HLAED, liver enzyme composite activity2004Current drug discovery technologies, Dec, Volume: 1, Issue:4
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID588217FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase2004Current drug discovery technologies, Dec, Volume: 1, Issue:4
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID625288Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079938Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source]
AID588219FDA HLAED, gamma-glutamyl transferase (GGT) increase2004Current drug discovery technologies, Dec, Volume: 1, Issue:4
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
AID1079944Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source]
AID625282Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079934Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source]
AID540210Clearance in human after iv administration2008Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID1079939Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source]
AID625290Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079933Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is
AID1079942Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source]
AID625287Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID540213Half life in human after iv administration2008Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID625286Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079945Animal toxicity known. [column 'TOXIC' in source]
AID1079941Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source]
AID625281Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID625283Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079948Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source]
AID425653Renal clearance in human2009Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
Physicochemical determinants of human renal clearance.
AID625291Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID625279Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079949Proposed mechanism(s) of liver damage. [column 'MEC' in source]
AID625289Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID625292Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079940Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source]
AID540211Fraction unbound in human after iv administration2008Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
AID1079931Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source]
AID625280Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis2011PLoS computational biology, Dec, Volume: 7, Issue:12
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
AID1079935Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source]
AID1079936Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source]
AID1079932Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source]
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (1,454)

TimeframeStudies, This Drug (%)All Drugs %
pre-199059 (4.06)18.7374
1990's216 (14.86)18.2507
2000's417 (28.68)29.6817
2010's719 (49.45)24.3611
2020's43 (2.96)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials219 (13.24%)5.53%
Reviews30 (1.81%)6.00%
Case Studies128 (7.74%)4.05%
Observational8 (0.48%)0.25%
Other1,269 (76.72%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Safety/Toxicity (43)

ArticleYear
Differences in Hypersensitivity Reactions to Iodinated Contrast Media: Analysis of the US Food and Drug Administration Adverse Event Reporting System Database.
The journal of allergy and clinical immunology. In practice, Volume: 11, Issue: 5
2023
Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Functio
Medical science monitor : international medical journal of experimental and clinical research, Sep-06, Volume: 23
2017
The impact of iodinated X-ray contrast agents on formation and toxicity of disinfection by-products in drinking water.
Journal of environmental sciences (China), Volume: 58
2017
Long-Term Adverse Effects of Low-Osmolar Compared With Iso-Osmolar Contrast Media After Coronary Angiography.
The American journal of cardiology, Oct-01, Volume: 118, Issue: 7
2016
Safety and efficacy of a novel iopromide-based paclitaxel-eluting balloon following bare metal stent implantation in rabbit aorta abdominalis.
Bio-medical materials and engineering, Volume: 26, Issue: 1-2
2015
Changes in mutagenicity and acute toxicity of solutions of iodinated X-ray contrast media during chlorination.
Chemosphere, Volume: 135
2015
Safety and tolerability of iopromide intravascular use: a pooled analysis of three non-interventional studies in 132,012 patients.
Acta radiologica (Stockholm, Sweden : 1987), Volume: 55, Issue: 6
2014
Contrast-induced neurotoxicity after coronary angiography.
Herz, Volume: 39, Issue: 4
2014
Contrast material-induced nephrotoxicity and intravenous low-osmolality iodinated contrast material.
Radiology, Volume: 267, Issue: 1
2013
The osmolality of nonionic, iodinated contrast agents as an important factor for renal safety.
Investigative radiology, Volume: 47, Issue: 9
2012
Intracoronary local paclitaxel delivery by X-ray contrast media for in-stent restenosis: a clinical pilot study to assess safety and tolerability.
Minerva cardioangiologica, Volume: 60, Issue: 4
2012
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
PLoS computational biology, Volume: 7, Issue: 12
2011
Safety and diagnostic image quality of iopromide: results of a large non-interventional observational study of European and Asian patients (IMAGE).
Acta radiologica (Stockholm, Sweden : 1987), Mar-01, Volume: 53, Issue: 2
2012
Toxic effects of a high dose of non-ionic iodinated contrast media on renal glomerular and aortic endothelial cells in aged rats in vivo.
Toxicology letters, May-10, Volume: 202, Issue: 3
2011
Is herniography useful and safe?
European journal of radiology, Volume: 80, Issue: 2
2011
Efficacy and safety of lanthanoids as X-ray contrast agents.
European journal of radiology, Volume: 80, Issue: 2
2011
The contrast media and nephrotoxicity following coronary revascularization by primary angioplasty for acute myocardial infarction study: design and rationale of the CONTRAST-AMI study.
Journal of cardiovascular medicine (Hagerstown, Md.), Volume: 11, Issue: 3
2010
Nephrotoxicity of iso-osmolar iodixanol compared with nonionic low-osmolar contrast media: meta-analysis of randomized controlled trials.
Radiology, Volume: 250, Issue: 1
2009
A prospective, double-blind, randomized, controlled trial on the efficacy and cardiorenal safety of iodixanol vs. iopromide in patients with chronic kidney disease undergoing coronary angiography with or without percutaneous coronary intervention.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Dec-01, Volume: 72, Issue: 7
2008
I.v. N-acetylcysteine and emergency CT: use of serum creatinine and cystatin C as markers of radiocontrast nephrotoxicity.
AJR. American journal of roentgenology, Volume: 189, Issue: 3
2007
Iodide mumps after contrast media imaging: a rare adverse effect to iodine.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, Volume: 99, Issue: 1
2007
Nephrotoxicity of iso-osmolar versus low-osmolar contrast media is equal in low risk patients.
Clinical nephrology, Volume: 66, Issue: 5
2006
Adverse events after unenhanced and monomeric and dimeric contrast-enhanced CT: a prospective randomized controlled trial.
Radiology, Volume: 240, Issue: 1
2006
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Current drug discovery technologies, Volume: 1, Issue: 4
2004
Universal use of nonionic iodinated contrast medium for CT: evaluation of safety in a large urban teaching hospital.
AJR. American journal of roentgenology, Volume: 184, Issue: 1
2005
Open radio-frequency thermal ablation of renal VX2 tumors in a rabbit model using a cooled-tip electrode: feasibility, safety, and effectiveness.
European radiology, Volume: 13, Issue: 6
2003
Comparative cytotoxicity of low-osmolar nonionic and high-osmolar ionic contrast media to dog gallbladder epithelial cells.
Gastrointestinal endoscopy, Volume: 55, Issue: 3
2002
[Stability of iodinated contrast media in UV-laser irradiation and toxicity of the photoproducts].
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, Volume: 169, Issue: 5
1998
Acute side effects of iopromide and diatrizoate in urography.
Acta radiologica (Stockholm, Sweden : 1987), Volume: 39, Issue: 6
1998
Iopentol (Imagopaque 300) compared with iopromide (Ultravist 300) in pediatric angiocardiography. A clinical trial assessing adverse events, ECG and diagnostic information.
European radiology, Volume: 7 Suppl 4
1997
Iopentol (Imagopaque 300) compared with iopromide (Ultravist 300) in abdominal CT. A multi-centre monitoring trial assessing adverse events and diagnostic information--results from 518 patients in Spain.
European radiology, Volume: 7 Suppl 4
1997
Preclinical safety assessment of contrast media: predictive value.
European radiology, Volume: 6 Suppl 2
1996
Neurotolerability of nonionic X-ray contrast media. The role of chemotoxicity.
Investigative radiology, Volume: 31, Issue: 6
1996
[Contrast media in peripheral angiography: does cost reduction mean loss of quality and safety? A reevaluation based on a randomized double-blind comparative study of ioxaglate versus iopromide].
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, Volume: 164, Issue: 5
1996
Double-blind study of the safety, tolerance, and diagnostic efficacy of iopromide as compared with iopamidol and iohexol in patients requiring aortography and visceral angiography.
Investigative radiology, Volume: 29 Suppl 1
1994
Safety and efficacy of iopromide in cerebral arteriography.
Investigative radiology, Volume: 29 Suppl 1
1994
Efficacy and safety of iopromide for excretory urography.
Investigative radiology, Volume: 29 Suppl 1
1994
Neurotoxicity of non-ionic X-ray contrast media after intracisternal administration in rats.
European journal of radiology, Volume: 19, Issue: 3
1995
[Undesirable side effects of contrast media during i.v. DSA--a comparison of 2 nonionic contrast media].
Rontgen-Blatter; Zeitschrift fur Rontgen-Technik und medizinisch-wissenschaftliche Photographie, Volume: 43, Issue: 4
1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (73)

ArticleYear
Diagnostic Performance of Adaptive 4D Volume Perfusion CT for Detecting Metastatic Cervical Lymph Nodes in Head and Neck Squamous Cell Carcinoma.
AJR. American journal of roentgenology, Volume: 211, Issue: 5
2018
Dual-Energy CT-Derived Volumetric Iodine Concentration for the Assessment of Therapeutic Response after Microwave Ablation in a Rabbit Model with Intrahepatic VX2 Tumor.
Journal of vascular and interventional radiology : JVIR, Volume: 29, Issue: 10
2018
Differentiation of renal cell carcinoma subtypes with different iodine quantification methods using single-phase contrast-enhanced dual-energy CT: areal vs. volumetric analyses.
Abdominal radiology (New York), Volume: 43, Issue: 3
2018
Whole-volume vs. segmental CT texture analysis of the liver to assess metachronous colorectal liver metastases.
Abdominal radiology (New York), Volume: 42, Issue: 11
2017
Increased image quality and reduced radiation dose and contrast media volume: a holistic approach to intracranial CTA.
Clinical radiology, Volume: 72, Issue: 9
2017
A semi-automated volumetric software for segmentation and perfusion parameter quantification of brain tumors using 320-row multidetector computed tomography: a validation study.
Neuroradiology, Volume: 59, Issue: 5
2017
Carotid and cerebral CT angiography using low volume of iodinated contrast material and low tube voltage.
Diagnostic and interventional imaging, Volume: 97, Issue: 11
2016
Computed Tomography Angiography of Coronary Artery Bypass Grafts: Low Contrast Media Volume Protocols Adapted to Tube Voltage.
Investigative radiology, Volume: 51, Issue: 4
2016
Cerebral CT Venography Using a 320-MDCT Scanner With a Time-Density Curve Technique and Low Volume of Contrast Agent: Comparison With Fixed Time-Delay Technique.
AJR. American journal of roentgenology, Volume: 205, Issue: 6
2015
Correlation of volumetric perfusion CT parameters with hypoxia inducible factor-1 alpha expression in a rabbit VX2 tumor model.
Acta radiologica (Stockholm, Sweden : 1987), Volume: 57, Issue: 6
2016
Comparison of volume perfusion computed tomography and contrast-enhanced ultrasound for assessment of therapeutic effect of transarterial chemoembolization in patients with hepatocellular carcinoma: a preliminary report.
Acta radiologica (Stockholm, Sweden : 1987), Volume: 57, Issue: 1
2016
Cerebral computed tomography angiography using a 70 kVp protocol: improved vascular enhancement with a reduced volume of contrast medium and radiation dose.
European radiology, Volume: 25, Issue: 5
2015
Revisiting the relationship between tumour volume and diameter in advanced NSCLC patients: An exercise to maximize the utility of each measure to assess response to therapy.
Clinical radiology, Volume: 69, Issue: 8
2014
Assessment of tumor grade and angiogenesis in colorectal cancer: whole-volume perfusion CT.
Academic radiology, Volume: 21, Issue: 6
2014
Low tube voltage and low contrast material volume cerebral CT angiography.
European radiology, Volume: 24, Issue: 7
2014
Contrast layering: late clearance of contrast dye--a novel angiographic phenomenon of early atherosclerosis.
Angiology, Volume: 66, Issue: 2
2015
128-slice acceletated-pitch dual energy CT angiography of the head and neck: comparison of different low contrast medium volumes.
PloS one, Volume: 8, Issue: 11
2013
Feasibility of semiautomated MR volumetry using gadoxetic acid-enhanced MRI at hepatobiliary phase for living liver donors.
Magnetic resonance in medicine, Volume: 72, Issue: 3
2014
Association between the volume of carotid artery plaque and its subcomponents and the volume of white matter lesions in patients selected for endarterectomy.
AJR. American journal of roentgenology, Volume: 201, Issue: 5
2013
Cerebral aneurysms: accuracy of 320-detector row nonsubtracted and subtracted volumetric CT angiography for diagnosis.
Radiology, Volume: 269, Issue: 3
2013
Evaluation of the relationship between extremity soft tissue sarcomas and adjacent major vessels using contrast-enhanced multidetector CT and three-dimensional volume-rendered CT angiography: a preliminary study.
Acta radiologica (Stockholm, Sweden : 1987), Volume: 54, Issue: 8
2013
Adaptive 4D volume perfusion CT of lung cancer: effects of computerized motion correction and the range of volume coverage on measurement reproducibility.
AJR. American journal of roentgenology, Volume: 200, Issue: 6
2013
Dynamic contrast-enhanced computed tomography to assess antitumor treatment effects: comparison of two contrast agents with different pharmacokinetics.
Investigative radiology, Volume: 48, Issue: 10
2013
A reduced contrast volume acquisition regimen based on cardiovascular dynamics improves visualisation of head and neck vasculature with carotid MDCT angiography.
European journal of radiology, Volume: 82, Issue: 2
2013
Perfusion and flow extraction product as potential discriminators in untreated follicular and diffuse large B cell lymphomas using volume perfusion CT with attempt at histopathologic explanation.
AJR. American journal of roentgenology, Volume: 198, Issue: 6
2012
Epithelial malignant pleural mesothelioma after extrapleural pneumonectomy: stratification of survival with CT-derived tumor volume.
AJR. American journal of roentgenology, Volume: 198, Issue: 2
2012
Usefulness of semi-automatic volumetry compared to established linear measurements in predicting lymph node metastases in MSCT.
Acta radiologica (Stockholm, Sweden : 1987), Jun-01, Volume: 52, Issue: 5
2011
Low-dose triple-rule-out using 320-row-detector volume MDCT--less contrast medium and lower radiation exposure.
European radiology, Volume: 21, Issue: 7
2011
CT tumor volume measurement in advanced non-small-cell lung cancer: Performance characteristics of an emerging clinical tool.
Academic radiology, Volume: 18, Issue: 1
2011
The ratio of contrast volume to glomerular filtration rate predicts outcomes after percutaneous coronary intervention for ST-segment elevation acute myocardial infarction.
Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, Aug-01, Volume: 78, Issue: 2
2011
Prediction of lymph node manifestations in malignant lymphoma: significant role of volumetric compared with established metric lymph node analysis in multislice computed tomography.
Journal of computer assisted tomography, Volume: 34, Issue: 4
2010
Risk factors for post-ERCP pancreatitis in high- and low-volume centers and among expert and non-expert operators: a prospective multicenter study.
The American journal of gastroenterology, Volume: 105, Issue: 8
2010
Dual-energy MDCT: comparison of pulmonary artery enhancement on dedicated CT pulmonary angiography, routine and low contrast volume studies.
European journal of radiology, Volume: 79, Issue: 2
2011
Comparison of volume and diameter measurement in assessing small abdominal aortic aneurysm expansion examined using computed tomographic angiography.
European journal of radiology, Volume: 79, Issue: 1
2011
Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry, Aug-13, Volume: 52, Issue: 15
2009
Effect of different saline chaser volumes and flow rates on intravascular contrast enhancement in CT using a circulation phantom.
European journal of radiology, Volume: 73, Issue: 3
2010
[Automated pulmonary nodule volumetry with an optimized algorithm. Accuracy at different slice thicknesses compared to unidimensional and bidimensional measurements].
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, Volume: 180, Issue: 9
2008
Dose reduction in dynamic perfusion CT of the brain: effects of the scan frequency on measurements of cerebral blood flow, cerebral blood volume, and mean transit time.
European radiology, Volume: 18, Issue: 12
2008
Cost-effectiveness and patient tolerance of low-attenuation oral contrast material: milk versus VoLumen.
AJR. American journal of roentgenology, Volume: 190, Issue: 5
2008
Radiotherapy of liver metastases. Comparison of target volumes and dose-volume histograms employing CT- or MRI-based treatment planning.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], Volume: 184, Issue: 5
2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals, Volume: 36, Issue: 7
2008
Left ventricular and left atrial dimensions and volumes: comparison between dual-source CT and echocardiography.
Investigative radiology, Volume: 43, Issue: 5
2008
Assessment of changes in non-calcified atherosclerotic plaque volume in the left main and left anterior descending coronary arteries over time by 64-slice computed tomography.
The American journal of cardiology, Mar-01, Volume: 101, Issue: 5
2008
Color-coded perfused blood volume imaging using multidetector CT: initial results of whole-brain perfusion analysis in acute cerebral ischemia.
European radiology, Volume: 17, Issue: 9
2007
Influence of partial volume on venous output and arterial input function.
AJNR. American journal of neuroradiology, Volume: 27, Issue: 1
2006
Gastric cancer staging at multi-detector row CT gastrography: comparison of transverse and volumetric CT scanning.
Radiology, Volume: 236, Issue: 3
2005
Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis.
Nature medicine, Volume: 10, Issue: 10
2004
Prospective comparison of 3-dimensional volume rendered computerized tomography and conventional renal arteriography for surgical planning in patients undergoing laparoscopic donor nephrectomy.
The Journal of urology, Volume: 170, Issue: 1
2003
Measurement of glomerular filtration rate by low-dose iopromide plasma clearance.
Acta radiologica (Stockholm, Sweden : 1987), Volume: 44, Issue: 2
2003
Lopromide one-sample clearance as a measure of glomerular filtration rate.
Clinical physiology and functional imaging, Volume: 22, Issue: 2
2002
Contrast media clearance in a single kidney measured on multiphasic helical CT: results in 50 patients without acute renal disorder.
AJR. American journal of roentgenology, Volume: 178, Issue: 1
2002
Measurement of single kidney contrast media clearance by multiphasic spiral computed tomography: preliminary results.
European journal of radiology, Volume: 39, Issue: 3
2001
Plasma clearance of iodine contrast media as a measure of glomerular filtration rate in critically ill patients.
Critical care medicine, Volume: 29, Issue: 8
2001
Quantitative and qualitative evaluation of volume of low osmolality contrast medium needed for routine helical abdominal CT.
AJR. American journal of roentgenology, Volume: 176, Issue: 3
2001
Pharmacokinetics and tolerability of iopromide 240 after lumbar myelography.
Investigative radiology, Volume: 34, Issue: 11
1999
Application of pharmacokinetics to electron-beam tomography of the abdomen.
Academic radiology, Volume: 6, Issue: 8
1999
[Transfemoral pelvic vein angiography with CO2: experiences with pressure- and volume-controlled injections].
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, Volume: 170, Issue: 4
1999
Clearance of iopromide during haemodialysis with high- and low-flux membranes.
Acta radiologica (Stockholm, Sweden : 1987), Volume: 40, Issue: 2
1999
Accuracy of cartilage volume and thickness measurements with magnetic resonance imaging.
Clinical orthopaedics and related research, Issue: 352
1998
[Evaluation of iopromide (Ultravist) clearance as a marker of glomerular filtration].
Polskie Archiwum Medycyny Wewnetrznej, Volume: 98, Issue: 7
1997
Dual-phase helical CT of the liver: effects of bolus tracking and different volumes of contrast material.
Radiology, Volume: 201, Issue: 2
1996
Dose proportionality of iopromide pharmacokinetics and tolerability after i.v. injection in healthy volunteers.
European journal of clinical pharmacology, Volume: 46, Issue: 4
1994
Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate.
Journal of the American Society of Nephrology : JASN, Volume: 6, Issue: 2
1995
Pharmacokinetics of iopromide liposomes in rabbits.
Pharmaceutical research, Volume: 12, Issue: 7
1995
Pharmacokinetics of iohexol, iopamidol, iopromide, and iosimide compared with meglumine diatrizoate.
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband, Volume: 128
1989
[Contrast medium clearance as a measure of kidney function in patients with renal artery stenoses].
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, Volume: 155, Issue: 1
1991
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (3)

ArticleYear
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, Volume: 96, Issue: 5
2019
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
The Journal of biological chemistry, 11-15, Volume: 294, Issue: 46
2019
Drug-coated percutaneous balloon catheters.
Critical reviews in biomedical engineering, Volume: 42, Issue: 3-4
2014
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (25)

ArticleYear
A new method for using radiopaque sclerosing foam to treat venous malformations.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], Volume: 41, Issue: 6
2015
Optimizing contrast media injection protocols in state-of-the art computed tomographic angiography.
Investigative radiology, Volume: 50, Issue: 3
2015
Dynamic contrast-enhanced computed tomography to assess antitumor treatment effects: comparison of two contrast agents with different pharmacokinetics.
Investigative radiology, Volume: 48, Issue: 10
2013
Isolation and identification of an iopromide-degrading strain and its application in an A2/O system.
Bioresource technology, Volume: 134
2013
The effect of iodinated contrast agent properties on renal kinetics and oxygenation.
Investigative radiology, Volume: 48, Issue: 4
2013
Dual-source CT coronary angiography involving injection protocol with iodine load tailored to patient body weight and body mass index: estimation of optimal contrast material dose.
Acta radiologica (Stockholm, Sweden : 1987), Mar-01, Volume: 54, Issue: 2
2013
Renal tolerability of iopromide and iodixanol in 562 renally impaired patients undergoing cardiac catheterisation: the DIRECT study.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Nov-22, Volume: 8, Issue: 7
2012
Contrast material injection protocol with the flow rate adjusted to the heart rate for dual source CT coronary angiography.
The international journal of cardiovascular imaging, Volume: 28, Issue: 6
2012
Changes of renal water diffusion coefficient after application of iodinated contrast agents: effect of viscosity.
Investigative radiology, Volume: 46, Issue: 12
2011
Factors influencing delay time and coronary arterial density during coronary angiography with DSCT.
Acta radiologica (Stockholm, Sweden : 1987), Feb-01, Volume: 52, Issue: 1
2011
Risk of nephropathy after consumption of nonionic contrast media by children undergoing cardiac angiography: a prospective study.
Pediatric cardiology, Volume: 31, Issue: 5
2010
Gastro intestinal tracking and gastric emptying of solid dosage forms in rats using X-ray imaging.
International journal of pharmaceutics, Mar-30, Volume: 388, Issue: 1-2
2010
Evaluation of contrast-enhanced digital mammography.
European journal of radiology, Volume: 78, Issue: 1
2011
Ozonation and reductive deiodination of iopromide to reduce the environmental burden of iodinated X-ray contrast media.
Water science and technology : a journal of the International Association on Water Pollution Research, Volume: 56, Issue: 11
2007
[A differentiated approach to the diagnosis of pulmonary embolism and deep venous thrombosis using multi-slice CT].
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, Volume: 174, Issue: 3
2002
Application of pharmacokinetics to electron-beam tomography of the abdomen.
Academic radiology, Volume: 6, Issue: 8
1999
Are iodinated contrast agents detrimental in acute cerebral ischemia? An experimental study in rats.
Radiology, Volume: 206, Issue: 1
1998
A double-blind study of iopromide 300 for peripheral arteriography. Results of a multi-institutional comparison of iopromide with iohexol and iopamidol.
Investigative radiology, Volume: 29 Suppl 1
1994
Iomeprol versus iopromide for intravenous urography.
The British journal of radiology, Volume: 67, Issue: 802
1994
[Optimizing intravenous bolus contrast medium injection in cervical CT diagnosis].
Aktuelle Radiologie, Volume: 4, Issue: 5
1994
[The chemoembolization of hepatocellular carcinoma: the computed tomographic findings and clinical results in prospective repetitive therapy].
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, Volume: 160, Issue: 5
1994
Iopromide dosage and urographic image quality: is there an optimal dose?
Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. Erganzungsband, Volume: 128
1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (5)

ArticleYear
Feasibility study of iterative model reconstruction combined with low tube voltage, low iodine load, and low iodine delivery rate in craniocervical CT angiography.
Clinical radiology, Volume: 73, Issue: 2
2018
Low-Dose Scanning Technology Combined with Low-Concentration Contrast Material in Renal Computed Tomography Angiography (CTA): A Preliminary Study.
Medical science monitor : international medical journal of experimental and clinical research, Sep-09, Volume: 23
2017
Evaluation of a High Concentrated Contrast Media Injection Protocol in Combination with Low Tube Current for Dose Reduction in Coronary Computed Tomography Angiography: A Randomized, Two-center Prospective Study.
Academic radiology, Volume: 24, Issue: 12
2017
[Applied research of CT angiography of lower extremities by using 100 kVp and iodixanol(270 mg I/ml) combined with iDose(4) iterative reconstruction technique].
Zhonghua yi xue za zhi, Dec-15, Volume: 95, Issue: 47
2015
Optimizing computed tomography pulmonary angiography using right atrium bolus monitoring combined with spontaneous respiration.
European radiology, Volume: 25, Issue: 9
2015
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]